對,用藥當然要考慮benefit vs risk.我不是說要盲目用藥。但我知道對精神疾病的掩飾和對有關藥物的忌諱,本身就是治療的巨大障礙。
我過去的一篇文章供參考。謝謝。
https://blog.wenxuecity.com/myblog/80301/202307/7763.html
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回複 '唐宋韻' 的評論 : 用任何藥,都會weigh benefit and risk, 我不否認抗抑鬱藥的效果,需要吃藥的時候一定要吃。我那後來做了院長的同學已經出現強直木僵狀態了,藥物可以說救了他的命。這個boxed warning 僅是針對青少年,用藥初需密切關注。我工作中經常開cymbalta, 因為這是目前臨床試驗認為這是治療藥物引起的周圍神經病變最有效的方法,我們用藥也是data driven,但是藥物引起的周圍神經病變真的太難治了。
Boxed warnings (formerly known as Black Box Warnings) are the highest safety-related warning that medications can have assigned by the Food and Drug Administration, 藥廠哪願意自己貼上這個標簽。醫生每次開藥查詢劑量時手都得抖一下。
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回複 '風鈴在非洲' 的評論 : 你好!Serengeti National Park 是我特別想去的地方,五年前遇到一個在坦桑尼亞開廠的女子,這草就瘋狂種上了。但膽小怕瘧疾怕黃熱病怕登革。
回複 '唐宋韻' 的評論 :拿Zoloft 舉例,
ALERT: US Boxed Warning
Suicidality and antidepressant drugs:
Antidepressants increased the risk of suicidal thoughts and behavior in pediatric and young adult patients in short-term studies. Closely monitor all antidepressant-treated patients for clinical worsening, and for emergence of suicidal thoughts and behaviors.
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回複 '唐宋韻' 的評論 : 謝謝clarify. 如果有嚴重的抑鬱症,確實要用藥。N年前曾目擊電休克治療,當時就想病人得多絕望才同意這種治療。我不做精神病科,在美也隻是許多年前住院醫時在那個科輪轉了二周。據up to date: The advantage of antidepressants over placebo is typically 2 to 4 points on a standard rating scale, such as the 17-item Hamilton Rating Scale for Depression. The small advantage of antidepressants over placebo in depressed patients is due in part to the nonspecific clinical effects of placebo treatment; receiving placebos in clinical trials is not equivalent to receiving no treatment. the FDA found that among the 74 registered trials, only 51 percent were positive. A pooled analysis of four randomized trials found that the mean time to improvement (reduction of baseline symptoms ≥20 percent) in patients treated with antidepressants (n>2000) was approximately 13 days