膠體銀有用也可能有害

我對膠體銀不是很熟悉，不懷疑有很多用處。已有很多文獻記敘了膠體銀的用途和危害。這裏，我隻是猜測如果把膠體銀喝下去，一種可能的危害。體內的蛋白和其他分子可牢固地吸附在膠體銀表麵，蛋白構形會因吸附而有所改變。表麵吸附了蛋白的納米級膠體銀，可以進入血液，進入各組織後很難排出。由於膠體銀是免疫佐劑（增強抗原的免疫反應），有可能使吸附了構形改變的自身蛋白的膠體銀，成為自身抗原，時間久了，可能會導致自身免疫疾病。長期沉積在體內，難以排除引發自身免疫病的可能性。下麵的文獻1，綜述膠體銀的用途並提到膠體銀可用作動物實驗疫苗佐劑。文獻2 是一個內服膠體銀致病的案例報告。    

我的看法純屬猜測。我對製備納米膠體金及其應用有過長期的經驗。

參看：

1. The Impact of Engineered Silver Nanomaterials on the Immune System，https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712063/
2. Colloidal Silver Ingestion Associated with Leukocytoclastic Vasculitis in an Adolescent Female, Published online 2019 May 23. doi: 10.12659/AJCR.915499

文獻2 節錄和機器翻譯：

患者：女性，19 歲

最終診斷：白細胞破碎性血管炎

症狀：疲勞 • 關節 • 疼痛 • 肌肉 • 疼痛 • 瘙癢 • 皮疹

背景：

白細胞破碎性血管炎是一種小血管疾病，在兒童中並不常見。在本病例報告中，我們介紹了一個與攝入膠體銀（一種自然療法藥物）相關的白細胞破碎性血管炎的青少年病例。該報告強調了患者的表現和誘導劑的罕見性。

案例報告：

一名 19 歲女性因麵部和頸部出現嚴重皮疹而在急診科就診，隨後在就診當天繼續以顱尾方式擴散，累及軀幹、背部、上肢和下肢。最近沒有旅行，沒有寵物，也沒有風濕病或自身免疫性疾病的陰性家族史。在急診科就診前，她的家庭藥物包括用於“內部清潔”的膠體銀 4 周。一旦臨床醫生意識到膠體銀的持續攝入，建議患者停藥。患者開始使用甲基強的鬆龍，初步診斷為血管炎，同時使用秋水仙堿治療。注意到皮疹在 24 小時內從麵部消退。在 5 天的住院期間，患者的皮疹和瘙癢繼續緩慢改善。

結論：

攝入一種自然療法藥物膠體銀導致我們的患者出現大量白細胞破碎性血管炎，由於疾病的嚴重程度需要住院治療。停止攝入膠體銀後症狀消失。由於未知的安全攝入濃度和潛在的副作用，應不鼓勵使用膠體銀。

Patient: Female, 19

Final Diagnosis: Leukocytoclastic vasculitis

Symptoms: Fatigue • joint • pain • muscle • pain • pruritis • rash

Background:

Leukocytoclastic vasculitis is a disease of the small vessels and is uncommon in children. In this case report, we present an adolescent case of leukocytoclastic vasculitis associated with the ingestion of colloidal silver, a naturopathic drug. This report highlights the rarity of the patient’s presentation and inducing agent.

Case report:

A 19-year-old female presented in the Emergency Department with severe rash on the face, and neck, and then continued to spread in a craniocaudal fashion during the day of presentation to involve trunk, back, upper and lower extremities. There was no recent travel, no pets and a negative family history for rheumatologic or autoimmune diseases. Her home medications included colloidal silver for “internal cleansing” for 4 weeks prior to Emergency Department presentation. Once the clinicians were aware of the continued ingestion of colloidal silver, the patient was advised to discontinue the drug. The patient was started on methylprednisolone with preliminary diagnosis of vasculitis, as well as concurrent therapy with colchicine. The rash was noted to be receding from the face within 24 hours. Over a hospital course of 5 days, the patient’s rash and pruritus continued to slowly improve.

Conclusions:

The ingestion of a naturopathic drug, colloidal silver, caused vast leukocytoclastic vasculitis in our patient warranting hospitalization due to the extent of the disease. The symptoms resolved after discontinuation of colloidal silver ingestion. Due to unknown safe ingestion concentrations and potential side effects, use of colloidal silver should be discouraged.