TheBurgessreagent(methylN-(triethylammoniumsulfonyl)carbamate)isamildandselectivedehydratingreagentoftenusedinorganicchemistry.ItwasdevelopedinthelaboratoryofEdwardM.BurgessatGeorgiaTech.TheBurgessreagentisusedtoconvertsecondaryandtertiaryalcoholswithanadjacentprotonintoalkenes.Dehydrationofprimaryalcoholsdoesnotworkwell.Thereagentissolubleincommonorganicsolventsandalcoholdehydrationtakesplacewith...[
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“替罪羊”源於《聖經》的《舊約》，有一個非常有趣的小典故。在摩西時代，依據法規，猶太人在新年過後的第10天，還有一個非常重要的節日Atonement/YomKippur（贖罪日）。在這一天，猶太人徹底齋戒，並在聖殿舉行祭祀儀式，以此祈求上帝赦免他們在過去一年中所犯的罪過。祭祀時，教徒們拿來兩頭山羊，一頭為theLord'sgoat（“獻給上帝的羊”，不言而喻，小[
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提起保護基化學，什麽Boc，Cbz，Fmoc，Alloc，TFAA等等立刻湧入腦海，這些都是胺的保護基。相較於胺基保護，羧酸很多時候也需要保護。常見的羧酸保護基有叔丁酯，甲酯，乙酯，苄酯，烯丙醇酯，還有三氯乙醇酯等等。叔丁酯用酸脫保護，甲酯/乙酯一般用堿脫保護，苄酯一般用氫解脫保護，烯丙醇酯可以用四三苯基膦鈀搭配親核試劑脫保護，三氯乙醇酯可以用鋅粉搭配氯化銨[
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結晶和重結晶詳細操作步驟
1.將需要純化的化學試劑溶解於沸騰或將進沸騰的適宜溶劑中；
2.將熱溶液趁熱抽濾，以除去不溶的雜質；
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ThePictet–Spenglerreactionisachemicalreactioninwhichaβ-arylethylamineundergoescondensationwithanaldehydeorketonefollowedbyringclosure.Thereactionwasfirstdiscoveredin1911byAméPictetandTheodorSpengler(February22,1886-August18,1965).Traditionallyanacidiccatalystinproticsolventwasemployedwithheating,howeverthereactionhasbeenshowntoworkinaproticmediainsuperioryieldsandsometimeswithout...[
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TheBischler–Napieralskireactionisanintramolecularelectrophilicaromaticsubstitutionreactionthatallowsforthecyclizationofβ-arylethylamidesorβ-arylethylcarbamates.Itwasfirstdiscoveredin1893byAugustBischlerandBernardNapieralski,inaffiliationwithBasleChemicalWorksandtheUniversityofZurich.Thereactionismostnotablyusedinthesynthesisofdihydroisoquinolines,whichcanbesubsequentlyoxidizedtoiso...[
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TheDuffreactionorhexaminearomaticformylationisaformylationreactionusedinorganicchemistryforthesynthesisofbenzaldehydeswithhexamineastheformylcarbonsource.ItisnamedafterJamesCooperDuff,whowasachemistattheCollegeofTechnology,Birmingham,around1920–1950.TheelectrophilicspeciesinthiselectrophilicaromaticsubstitutionreactionistheiminiumionCH2+NR2.Theinitialreactionproductisaniminiumwhichishydrolyz...[
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Silicon-basedprotectinggroupsarecommonplaceinsyntheticroutestocomplexorganicmolecules.Theirabilitytobeintroducedundermildconditions,aswellastheirstabilitytowardharshreactionconditions,hasmadethemawidespreadtoolinorganicsynthesis.Smallsilylprotectinggroups,suchasthetrimethylsilylgroup,canberemovedunderbasicoracidicconditions,butlargersilylprotectinggroupsaregenerallyremovedunderfluoride-mediatedcon...[
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