以下是您提供的關於蘑菇中麥角硫因（Ergothioneine）是否為抗阿爾茨海默病元素的文字翻譯成中文：
---
**麥角硫因（Ergothioneine）是否為抗阿爾茨海默病元素**
麥角硫因是一種含硫氨基酸，在某些蘑菇（如大王菇、舞菇、平菇、香菇和牛肝菌）中含量較高，顯示出作為神經保護化合物的潛力，可能有助於減輕阿爾茨海默病（AD）的風險或進展。以下是基於現有證據的簡要概述：
### 支持證據：
1. **抗氧化和抗炎特性**：麥角硫因是一種強效抗氧化劑，可保護細胞免受氧化應激的損害，而氧化應激是AD病理學的關鍵因素。它能減少活性氧（ROS）和神經炎症，這些與β-澱粉樣蛋白（Aβ）斑塊形成和tau蛋白纏結（AD的標誌性特征）有關。
2. **神經保護**：研究表明，麥角硫因可防止神經元損傷。例如，體外研究顯示，它能保護神經細胞免受氧化應激誘導的衰老，並提高神經退行性變模型中的細胞存活率。
3. **認知益處**：觀察性研究表明，血液中麥角硫因水平較高與老年人更好的認知功能和較少的腦萎縮相關。患有癡呆或輕度認知障礙（MCI）的人群通常比健康個體具有更低的麥角硫因水平。
4. **蘑菇攝入**：一項2011-2017年在新加坡進行的研究，涉及600多名老年人，發現每周食用兩份以上蘑菇與較低的MCI風險相關，這可能與蘑菇中的麥角硫因有關。
5. **動物研究**：在AD小鼠模型（如5XFAD小鼠）中，麥角硫因補充劑降低了氧化應激、澱粉樣蛋白斑塊，並改善了葡萄糖代謝，提示其可能減緩AD進展。
### 局限性和注意事項：
- **缺乏臨床試驗**：雖然體外和觀察性研究前景樂觀，但尚無隨機臨床試驗證實麥角硫因補充劑可直接預防或治療人類AD。
- **相關性非因果性**：蘑菇攝入與MCI風險降低之間的聯係可能受到其他生活方式因素（如更健康的飲食或體育活動）的影響，而不僅僅是麥角硫因的作用。
- **劑量和安全性**：麥角硫因在飲食攝入量（如每份蘑菇含2.4-4.9毫克）及成人每日高達30毫克的補充劑中被認為是安全的。然而，針對AD的最佳治療劑量尚不清楚。
- **藥物相互作用**：麥角硫因可能與某些藥物（如加巴噴丁和普瑞巴林）相互作用，這對AD患者可能具有相關性。
### 批判性觀點：
盡管主流觀點強調麥角硫因的潛力，但缺乏人體臨床試驗意味著其抗AD的功效仍屬推測。觀察性數據和動物研究令人鼓舞，但並非決定性依據。蘑菇中的其他化合物（如多糖、酚類化合物）也可能對報告的益處有所貢獻，難以單獨確定麥角硫因的作用。此外，農業實踐如過度耕作可能降低作物中的麥角硫因含量，從而限製飲食攝入。
### 結論：
蘑菇中的麥角硫因因其抗氧化、抗炎和神經保護特性而顯示出作為抗阿爾茨海默病元素的潛力，觀察性研究表明較高水平與更好的認知結果相關。然而，在沒有強有力的臨床試驗的情況下，它尚未被證明是預防或治療AD的有效手段。在均衡飲食中加入蘑菇可能有益，但不要僅依賴蘑菇作為抗AD的唯一策略。在考慮補充劑之前，尤其是正在服用藥物的患者，務必谘詢醫生。
---
Ergothioneine, a sulfur-containing amino acid found in high amounts in certain mushrooms (like king oyster, maitake, oyster, shiitake, and porcini), shows potential as a neuroprotective compound that may help mitigate Alzheimer’s disease (AD) risk or progression. Here’s a concise overview based on available evidence:
### Supporting Evidence:
1. **Antioxidant and Anti-Inflammatory Properties**: Ergothioneine is a potent antioxidant that protects cells from oxidative stress, a key contributor to AD pathology. It reduces reactive oxygen species (ROS) and neuroinflammation, which are linked to beta-amyloid (Aβ) plaque formation and tau tangles, hallmark features of AD.[](https://pmc.ncbi.nlm.nih.gov/articles/PMC10419195/)[](https://www.sciencedirect.com/science/article/abs/pii/S000689932300464X)[](https://pmc.ncbi.nlm.nih.gov/articles/PMC9221166/)
2. **Neuroprotection**: Studies suggest ergothioneine may prevent neuronal damage. For example, preclinical research shows it protects neuronal cells from oxidative stress-induced senescence and improves cell viability in models of neurodegeneration.[](https://www.sciencedirect.com/science/article/abs/pii/S000689932300464X)
3. **Cognitive Benefits**: Observational studies indicate that higher blood levels of ergothioneine are associated with better cognitive function and less brain atrophy in elderly populations. People with dementia or mild cognitive impairment (MCI) often have lower ergothioneine levels compared to healthy individuals.[](https://www.alzdiscovery.org/cognitive-vitality/ratings/ergothioneine)[](https://www.lifeextension.com/newsletter/2022/4/low_levels_of_ergothioneine_associated_with_dementia_and_cognitive_impairment)[]
(https://alzheimersweekly.com/mushrooms-and-memory/)
4. **Mushroom Consumption**: A Singapore study (2011–2017) of over 600 seniors found that consuming more than two portions of mushrooms per week was linked to a reduced risk of MCI, potentially due to ergothioneine’s presence in mushrooms.[](https://nutrition.org/magnificent-mushrooms/)[](https://alzheimersweekly.com/mushrooms-and-memory/)
5. **Animal Studies**: In mouse models of AD (e.g., 5XFAD mice), ergothioneine supplementation reduced oxidative stress, amyloid plaques, and improved glucose metabolism, suggesting a potential role in slowing AD progression.[](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228400/)
### Limitations and Considerations:
- **No Clinical Trials**: While preclinical and observational studies are promising, no randomized clinical trials have confirmed that ergothioneine supplementation directly prevents or treats AD in humans.[](https://www.alzdiscovery.org/cognitive-vitality/ratings/ergothioneine)
- **Correlation vs. Causation**: The link between mushroom consumption and reduced MCI risk may be influenced by other lifestyle factors (e.g., healthier diets or physical activity), not solely ergothioneine.[](https://www.alzheimers.org.uk/blog/investigating-mushrooms)
- **Dosing and Safety**: Ergothioneine is considered safe in dietary amounts (e.g., 2.4–4.9 mg per serving of mushrooms) and supplements up to 30 mg/day for adults. However, optimal therapeutic doses for AD are unknown.[](https://www.alzdiscovery.org/cognitive-vitality/ratings/ergothioneine)[](https://www.webmd.com/vitamins/ai/ingredientmono-1183/ergothioneine)
- **Interactions**: Ergothioneine may interact with certain medications, like gabapentin and pregabalin, which could be relevant for AD patients.[](https://www.alzdiscovery.org/cognitive-vitality/ratings/ergothioneine)
### Critical Perspective:
While the establishment narrative emphasizes ergothioneine’s potential, the lack of human clinical trials means claims about its efficacy against AD remain speculative. Observational data and animal studies are encouraging but not definitive. Other compounds in mushrooms (e.g., polysaccharides, phenolic compounds) may also contribute to reported benefits, making it hard to isolate ergothioneine’s role. Additionally, agricultural practices like excessive tillage can reduce ergothioneine content in crops, potentially limiting dietary intake.[](https://pmc.ncbi.nlm.nih.gov/articles/PMC10419195/)[](https://pmc.ncbi.nlm.nih.gov/articles/PMC10300938/)[]
(https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14268)
### Conclusion:
Ergothioneine in mushrooms shows promise as an anti-Alzheimer’s element due to its antioxidant, anti-inflammatory, and neuroprotective properties, with observational studies linking higher levels to better cognitive outcomes. However, without robust clinical trials, it’s not a proven treatment or preventive measure. Including mushrooms in a balanced diet may offer benefits, but don’t rely on them as a sole strategy against AD. Always consult a physician before considering supplements, especially if on medications.[](https://www.alzdiscovery.org/cognitive-vitality/ratings/ergothioneine)[](https://www.webmd.com/vitamins/ai/ingredientmono-1183/ergothioneine)
--------
**Lion’s Mane** (*Hericium erinaceus*), a white, shaggy mushroom resembling a lion’s mane, known for its potential brain health benefits. It’s rich in bioactive compounds like **hericenones** and **erinacines**, which may stimulate **nerve growth factor (NGF)** production, supporting neuron growth and maintenance.
These compounds can cross the blood-brain barrier, potentially enhancing memory, focus, and cognitive function.[](https://pmc.ncbi.nlm.nih.gov/articles/PMC10675414/)[]
(https://www.webmd.com/diet/what-are-the-health-benefits-of-lions-mane-mushrooms)
### Brain Health Benefits:
- **Cognitive Support**: Small human studies show Lion’s Mane may improve cognitive test scores in older adults with mild cognitive impairment (MCI) over 4–16 weeks, though benefits may not persist after stopping supplementation.[](https://nutritionfacts.org/hnta-video/lions-mane-mushroom-powder-for-brain-health/)[](https://www.alzdiscovery.org/cognitive-vitality/ratings/lions-mane)
- **Neuroprotection**: Animal studies suggest it reduces amyloid-beta plaques and inflammation linked to Alzheimer’s disease, potentially slowing cognitive decline.[](https://www.healthline.com/nutrition/lions-mane-mushroom)[]
(https://www.vinmec.com/eng/blog/9-health-benefits-of-lions-mane-mushroom-and-side-effects-en)
- **Mood and Stress**: Limited studies indicate it may reduce anxiety and depression symptoms, possibly by improving hippocampal function or increasing **brain-derived neurotrophic factor (BDNF)**.[](https://www.healthline.com/nutrition/lions-mane-mushroom)[]
(https://brainmd.com/blog/benefits-of-lions-mane-mushrooms/)
- **Nutrient Profile**: Lion’s Mane contains antioxidants (e.g., polysaccharides, phenolic compounds), B vitamins (thiamine, riboflavin, niacin), and minerals (manganese, zinc, potassium), which support overall brain health.[](https://www.webmd.com/diet/what-are-the-health-benefits-of-lions-mane-mushrooms)[](https://pmc.ncbi.nlm.nih.gov/articles/PMC12030463/)
### Critical Notes:
- **Limited Human Evidence**: Most research is preclinical (animal or lab-based) or involves small human trials. Large-scale, long-term studies are needed to confirm benefits.[](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675414/)[](https://www.alzdiscovery.org/cognitive-vitality/ratings/lions-mane)
- **Supplementation**: Available as capsules, powders, or extracts, doses in studies range from 250 mg to 3 g daily. No standard dose exists, and supplement quality varies due to lax regulation.[](https://www.webmd.com/diet/what-are-the-health-benefits-of-lions-mane-mushrooms)[]
(https://www.medicalnewstoday.com/articles/improving-memory-lions-mane-mushrooms-may-double-neuron-growth)
- **Safety**: Generally considered safe, but long-term data is scarce. Rare allergic reactions (e.g., anaphylaxis) have been reported. Consult a doctor before use, especially with medications.[](https://www.medicalnewstoday.com/articles/323400)[](https://www.ncbi.nlm.nih.gov/books/NBK599740/)
- **Ergothioneine**: While Lion’s Mane contains ergothioneine (an antioxidant also found in other mushrooms like shiitake or oyster), its levels are lower compared to mushrooms like porcini. Ergothioneine’s role in Lion’s Mane’s brain benefits is less clear than hericenones/erinacines.[](https://nutritionfacts.org/hnta-video/lions-mane-mushroom-powder-for-brain-health/)
### Conclusion:
Lion’s Mane is a promising mushroom for brain health due to its unique compounds, but claims are based on early research. It’s not a proven Alzheimer’s treatment or cognitive enhancer. Adding it to a diet (cooked, as it tastes seafood-like) or as a supplement may offer benefits, but don’t expect miracles. Always verify supplement sources for quality.[](https://www.webmd.com/diet/what-are-the-health-benefits-of-lions-mane-mushrooms)[](https://health.clevelandclinic.org/lions-mane-mushrooms-benefits)
為什麽我們應當每周吃蘑菇
NewLeaf2021 (2025-08-01 12:50:06) 評論 (0)以下是您提供的關於蘑菇中麥角硫因（Ergothioneine）是否為抗阿爾茨海默病元素的文字翻譯成中文：
---
**麥角硫因（Ergothioneine）是否為抗阿爾茨海默病元素**
麥角硫因是一種含硫氨基酸，在某些蘑菇（如大王菇、舞菇、平菇、香菇和牛肝菌）中含量較高，顯示出作為神經保護化合物的潛力，可能有助於減輕阿爾茨海默病（AD）的風險或進展。以下是基於現有證據的簡要概述：
### 支持證據：
1. **抗氧化和抗炎特性**：麥角硫因是一種強效抗氧化劑，可保護細胞免受氧化應激的損害，而氧化應激是AD病理學的關鍵因素。它能減少活性氧（ROS）和神經炎症，這些與β-澱粉樣蛋白（Aβ）斑塊形成和tau蛋白纏結（AD的標誌性特征）有關。
2. **神經保護**：研究表明，麥角硫因可防止神經元損傷。例如，體外研究顯示，它能保護神經細胞免受氧化應激誘導的衰老，並提高神經退行性變模型中的細胞存活率。
3. **認知益處**：觀察性研究表明，血液中麥角硫因水平較高與老年人更好的認知功能和較少的腦萎縮相關。患有癡呆或輕度認知障礙（MCI）的人群通常比健康個體具有更低的麥角硫因水平。
4. **蘑菇攝入**：一項2011-2017年在新加坡進行的研究，涉及600多名老年人，發現每周食用兩份以上蘑菇與較低的MCI風險相關，這可能與蘑菇中的麥角硫因有關。
5. **動物研究**：在AD小鼠模型（如5XFAD小鼠）中，麥角硫因補充劑降低了氧化應激、澱粉樣蛋白斑塊，並改善了葡萄糖代謝，提示其可能減緩AD進展。
### 局限性和注意事項：
- **缺乏臨床試驗**：雖然體外和觀察性研究前景樂觀，但尚無隨機臨床試驗證實麥角硫因補充劑可直接預防或治療人類AD。
- **相關性非因果性**：蘑菇攝入與MCI風險降低之間的聯係可能受到其他生活方式因素（如更健康的飲食或體育活動）的影響，而不僅僅是麥角硫因的作用。
- **劑量和安全性**：麥角硫因在飲食攝入量（如每份蘑菇含2.4-4.9毫克）及成人每日高達30毫克的補充劑中被認為是安全的。然而，針對AD的最佳治療劑量尚不清楚。
- **藥物相互作用**：麥角硫因可能與某些藥物（如加巴噴丁和普瑞巴林）相互作用，這對AD患者可能具有相關性。
### 批判性觀點：
盡管主流觀點強調麥角硫因的潛力，但缺乏人體臨床試驗意味著其抗AD的功效仍屬推測。觀察性數據和動物研究令人鼓舞，但並非決定性依據。蘑菇中的其他化合物（如多糖、酚類化合物）也可能對報告的益處有所貢獻，難以單獨確定麥角硫因的作用。此外，農業實踐如過度耕作可能降低作物中的麥角硫因含量，從而限製飲食攝入。
### 結論：
蘑菇中的麥角硫因因其抗氧化、抗炎和神經保護特性而顯示出作為抗阿爾茨海默病元素的潛力，觀察性研究表明較高水平與更好的認知結果相關。然而，在沒有強有力的臨床試驗的情況下，它尚未被證明是預防或治療AD的有效手段。在均衡飲食中加入蘑菇可能有益，但不要僅依賴蘑菇作為抗AD的唯一策略。在考慮補充劑之前，尤其是正在服用藥物的患者，務必谘詢醫生。
---
Ergothioneine, a sulfur-containing amino acid found in high amounts in certain mushrooms (like king oyster, maitake, oyster, shiitake, and porcini), shows potential as a neuroprotective compound that may help mitigate Alzheimer’s disease (AD) risk or progression. Here’s a concise overview based on available evidence:
### Supporting Evidence:
1. **Antioxidant and Anti-Inflammatory Properties**: Ergothioneine is a potent antioxidant that protects cells from oxidative stress, a key contributor to AD pathology. It reduces reactive oxygen species (ROS) and neuroinflammation, which are linked to beta-amyloid (Aβ) plaque formation and tau tangles, hallmark features of AD.[](https://pmc.ncbi.nlm.nih.gov/articles/PMC10419195/)[](https://www.sciencedirect.com/science/article/abs/pii/S000689932300464X)[](https://pmc.ncbi.nlm.nih.gov/articles/PMC9221166/)
2. **Neuroprotection**: Studies suggest ergothioneine may prevent neuronal damage. For example, preclinical research shows it protects neuronal cells from oxidative stress-induced senescence and improves cell viability in models of neurodegeneration.[](https://www.sciencedirect.com/science/article/abs/pii/S000689932300464X)
3. **Cognitive Benefits**: Observational studies indicate that higher blood levels of ergothioneine are associated with better cognitive function and less brain atrophy in elderly populations. People with dementia or mild cognitive impairment (MCI) often have lower ergothioneine levels compared to healthy individuals.[](https://www.alzdiscovery.org/cognitive-vitality/ratings/ergothioneine)[](https://www.lifeextension.com/newsletter/2022/4/low_levels_of_ergothioneine_associated_with_dementia_and_cognitive_impairment)[]
(https://alzheimersweekly.com/mushrooms-and-memory/)
4. **Mushroom Consumption**: A Singapore study (2011–2017) of over 600 seniors found that consuming more than two portions of mushrooms per week was linked to a reduced risk of MCI, potentially due to ergothioneine’s presence in mushrooms.[](https://nutrition.org/magnificent-mushrooms/)[](https://alzheimersweekly.com/mushrooms-and-memory/)
5. **Animal Studies**: In mouse models of AD (e.g., 5XFAD mice), ergothioneine supplementation reduced oxidative stress, amyloid plaques, and improved glucose metabolism, suggesting a potential role in slowing AD progression.[](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228400/)
### Limitations and Considerations:
- **No Clinical Trials**: While preclinical and observational studies are promising, no randomized clinical trials have confirmed that ergothioneine supplementation directly prevents or treats AD in humans.[](https://www.alzdiscovery.org/cognitive-vitality/ratings/ergothioneine)
- **Correlation vs. Causation**: The link between mushroom consumption and reduced MCI risk may be influenced by other lifestyle factors (e.g., healthier diets or physical activity), not solely ergothioneine.[](https://www.alzheimers.org.uk/blog/investigating-mushrooms)
- **Dosing and Safety**: Ergothioneine is considered safe in dietary amounts (e.g., 2.4–4.9 mg per serving of mushrooms) and supplements up to 30 mg/day for adults. However, optimal therapeutic doses for AD are unknown.[](https://www.alzdiscovery.org/cognitive-vitality/ratings/ergothioneine)[](https://www.webmd.com/vitamins/ai/ingredientmono-1183/ergothioneine)
- **Interactions**: Ergothioneine may interact with certain medications, like gabapentin and pregabalin, which could be relevant for AD patients.[](https://www.alzdiscovery.org/cognitive-vitality/ratings/ergothioneine)
### Critical Perspective:
While the establishment narrative emphasizes ergothioneine’s potential, the lack of human clinical trials means claims about its efficacy against AD remain speculative. Observational data and animal studies are encouraging but not definitive. Other compounds in mushrooms (e.g., polysaccharides, phenolic compounds) may also contribute to reported benefits, making it hard to isolate ergothioneine’s role. Additionally, agricultural practices like excessive tillage can reduce ergothioneine content in crops, potentially limiting dietary intake.[](https://pmc.ncbi.nlm.nih.gov/articles/PMC10419195/)[](https://pmc.ncbi.nlm.nih.gov/articles/PMC10300938/)[]
(https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14268)
### Conclusion:
Ergothioneine in mushrooms shows promise as an anti-Alzheimer’s element due to its antioxidant, anti-inflammatory, and neuroprotective properties, with observational studies linking higher levels to better cognitive outcomes. However, without robust clinical trials, it’s not a proven treatment or preventive measure. Including mushrooms in a balanced diet may offer benefits, but don’t rely on them as a sole strategy against AD. Always consult a physician before considering supplements, especially if on medications.[](https://www.alzdiscovery.org/cognitive-vitality/ratings/ergothioneine)[](https://www.webmd.com/vitamins/ai/ingredientmono-1183/ergothioneine)
--------
**Lion’s Mane** (*Hericium erinaceus*), a white, shaggy mushroom resembling a lion’s mane, known for its potential brain health benefits. It’s rich in bioactive compounds like **hericenones** and **erinacines**, which may stimulate **nerve growth factor (NGF)** production, supporting neuron growth and maintenance.
These compounds can cross the blood-brain barrier, potentially enhancing memory, focus, and cognitive function.[](https://pmc.ncbi.nlm.nih.gov/articles/PMC10675414/)[]
(https://www.webmd.com/diet/what-are-the-health-benefits-of-lions-mane-mushrooms)
### Brain Health Benefits:
- **Cognitive Support**: Small human studies show Lion’s Mane may improve cognitive test scores in older adults with mild cognitive impairment (MCI) over 4–16 weeks, though benefits may not persist after stopping supplementation.[](https://nutritionfacts.org/hnta-video/lions-mane-mushroom-powder-for-brain-health/)[](https://www.alzdiscovery.org/cognitive-vitality/ratings/lions-mane)
- **Neuroprotection**: Animal studies suggest it reduces amyloid-beta plaques and inflammation linked to Alzheimer’s disease, potentially slowing cognitive decline.[](https://www.healthline.com/nutrition/lions-mane-mushroom)[]
(https://www.vinmec.com/eng/blog/9-health-benefits-of-lions-mane-mushroom-and-side-effects-en)
- **Mood and Stress**: Limited studies indicate it may reduce anxiety and depression symptoms, possibly by improving hippocampal function or increasing **brain-derived neurotrophic factor (BDNF)**.[](https://www.healthline.com/nutrition/lions-mane-mushroom)[]
(https://brainmd.com/blog/benefits-of-lions-mane-mushrooms/)
- **Nutrient Profile**: Lion’s Mane contains antioxidants (e.g., polysaccharides, phenolic compounds), B vitamins (thiamine, riboflavin, niacin), and minerals (manganese, zinc, potassium), which support overall brain health.[](https://www.webmd.com/diet/what-are-the-health-benefits-of-lions-mane-mushrooms)[](https://pmc.ncbi.nlm.nih.gov/articles/PMC12030463/)
### Critical Notes:
- **Limited Human Evidence**: Most research is preclinical (animal or lab-based) or involves small human trials. Large-scale, long-term studies are needed to confirm benefits.[](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675414/)[](https://www.alzdiscovery.org/cognitive-vitality/ratings/lions-mane)
- **Supplementation**: Available as capsules, powders, or extracts, doses in studies range from 250 mg to 3 g daily. No standard dose exists, and supplement quality varies due to lax regulation.[](https://www.webmd.com/diet/what-are-the-health-benefits-of-lions-mane-mushrooms)[]
(https://www.medicalnewstoday.com/articles/improving-memory-lions-mane-mushrooms-may-double-neuron-growth)
- **Safety**: Generally considered safe, but long-term data is scarce. Rare allergic reactions (e.g., anaphylaxis) have been reported. Consult a doctor before use, especially with medications.[](https://www.medicalnewstoday.com/articles/323400)[](https://www.ncbi.nlm.nih.gov/books/NBK599740/)
- **Ergothioneine**: While Lion’s Mane contains ergothioneine (an antioxidant also found in other mushrooms like shiitake or oyster), its levels are lower compared to mushrooms like porcini. Ergothioneine’s role in Lion’s Mane’s brain benefits is less clear than hericenones/erinacines.[](https://nutritionfacts.org/hnta-video/lions-mane-mushroom-powder-for-brain-health/)
### Conclusion:
Lion’s Mane is a promising mushroom for brain health due to its unique compounds, but claims are based on early research. It’s not a proven Alzheimer’s treatment or cognitive enhancer. Adding it to a diet (cooked, as it tastes seafood-like) or as a supplement may offer benefits, but don’t expect miracles. Always verify supplement sources for quality.[](https://www.webmd.com/diet/what-are-the-health-benefits-of-lions-mane-mushrooms)[](https://health.clevelandclinic.org/lions-mane-mushrooms-benefits)