Vinegar, Vc, B3, and Chinese medicinals is the best curative for

Vinegar, Vitamin C, B3, and Chinese medicinals is the best curative for 2019 new

已有 12071 次閱讀2020-2-8 08:14 |個人分類:medicine

   This is a version of translation-reedited from my Jan. 23 Mandarin article:

   食用醋、維生素和中藥能夠快速治愈新冠狀病毒肺炎 

   http://www.kwcg.ca/bbs/home.php?mod=space&uid=61910&do=blog&id=12233

Life is not easy, I wish all of families on the Earth healthier and happier.

    Frank Jan. 26, 2020 in Waterloo, Canada，  Updated in Jan. 27-30, Feb. 1 -> 29, Mar. 1 -> 15, 2020; Jan 13, 2021

    http://www.kwcg.ca/bbs/home.php?mod=space&uid=61910&do=blog&id=12339 

 This article tries to explore the best cure for COVID-19 pneumonia, especially helps people self-help in treatment when just starts the feeling of flu by daily diets and diet supplements that are home handy available for all people so that everyone can get treatment timely, and importantly takes daily as prevention, such as, vinegar, honey and vitamins. Though natural Chinese medicine is good, but not easy available.

The cure at the time that is just start of the onset of ill will be much easier, thereby avoids developing as acute ill into ICU with 50% chance finished and big burden for medical system. In China, at the start of epidemic control, the ratio of suspected cases confirmed as COVID-19 was 90%, after 4 days of use of Chinese medicinals massively, the diagnosed rate dropped under 30%, and a longer time, it dropped to 3%.

There were many reports that patients suddenly died in home and on street when were in the mild ill state. Even if patients cured from critical state, the sequelae are also terrible. The autopsy revealed that the lungs of died patients were filled with tiny blood clots, if the large-sized such blood clots fall off into the brain or heart will cause stroke or heart attack, which is also in killing and disabling people. 

But, for the use of hopeful easy self-help in treatment will be difficult due to customary thinking; it needs to update the consciousness in disease treatment, so that people can accept the treatments that used to be considered as unscientific and ineffective. Because of since Jan. 27, I have been posting the link of this article as comments on some Medias with feedback in less appreciation more criticism.

British lady Stacey who was COVID-19 infected on life-machine supporting in unconscious  and her families have made final seeing farewell, but, as a final effort, doctors tried experience method by placing her face down on stomach for 12 hours to make her lungs transferring oxygen into blood, she eventually recovered and later discharged.

For treating COVID-19, many recovered cases proved that killing-virus is not essential, but any curative that can improve the physical condition of patients will be effective. So that dogmatically looking for virus killer and convincing people to reject the use of experience-based therapies by the pretext of unscientific is evil manner in assisting virus killing people actually. 

For curing COVID-19, we must update guiding philosophy from Reductionism of western medicine to Daoism of Traditional Chinese Medicine - TCM, from looking for killing to be autoimmune boosting by people are handy available, such as, vinegar, honey, and vitamins, they all have function in boosting immunity.

A little trigger our autoimmune by healthy diet may help to reduce the harm of the virus.

 Contents 

General introduction

1.. Vinegar

1.1.. The LD50 of vinegar

1.2.. The mechanism of vinegar kill pathogen

1.2.1.. Vinegar raised hemoglobin, total erythrocyte counts and total leukocyte counts

  1.2.2.. Vinegar destroys cell walls, protein structure, nuclear proteins of the pathogenic organisms

  1.2.3.. 1 and 3% vinegar can inactivate avian influenza virus

  1.2.4.. 4 - 8% vinegar can inactivate H1N1 human influenza virus

  1.2.5.. Vinegar can decreased small intestine muscular thickness and abdominal fat

  1.2.6.. Vinegar has anti-obesity and anti-inflammatory effects

  1.2.7.. Vinegar may be as an adjunct treatment modality for Diabetes

  1.2.8.. Apple Cider Vinegar can thin sticky mucus and clears stuffy noses

  1.2.9.. Apple Cider Vinegar can increases oxygen in blood stream

  1.2.10.. Apple Cider Vinegar promotes oxygen to cells by promoting hemoglobin and myoglobin

  1.2.11.. Apple Cider Vinegar promotes energy consumption and leads to weight loss

  1.2.12.. Vinegar reduces body weight, body fat mass, and serum triglyceride levels

  1.2.13.. Vinegar lower blood sugar and insulin levels in people with diabetes

  1.2.14.. Vinegar prmotes insulin-producing cells and slows atherosclerosis

  1.2.15.. The medicinal application in TCM

  1.2.16.. Vinegar’s functions on health: constituents, sources, and formation mechanisms

1.3.. My friendly associates with vinegar

  1.3.1.. A case of wrongful use of vinegar

1.4.. Homemade portable anti-virus bag

2.. Vitamin C

     2.1.. The LD50 of Vitamin C

     2.2.. Role in immunity of Vitamin C

     2.3.. High Dose Vitamin C and Influenza: A Case Report

     2.4.. Vitamin C Is an Essential Factor on the Anti-viral Immune Responses

     2.5.. Vitamin C and Infections

     2.6.. Vitamin C in sepsis

     2.7.. Evidence is stronger than you think of vitamin C

     2.8.. High-dose Vitamin C as a Successful Treatment of Viral Infections.

     2.9.. Mechanism of action of vitamin C in sepsis: ascorbate modulates redox signaling in endothelium

     2.10.. Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

     2.11.. Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients-Review and Pragmatic Approach

     2.12.. About High-Dose Vitamin C from U.S. National Cancer Institute

    2.13.. Effect of Vitamin C on Serum Concentration of Brain-Derived Neurotrophic Factor

     2.14. The effect of vitamin C on Microbial Flora and blood morphology

3.. Vitamin B3

     3.1.. The LD 50 of B3

     3.2.. The Positive Side Effects of B3

     3.3.. Vitamin B3 May Help Kill Superbugs

     3.4.. The systematic report on B3 in Linus Pauling Institute

     3.5.. Myself test of the process of B3 taking effect

4.. Vitamin D

     4.1.. Vitamin D for influenza

     4.2.. Vitamin D, Minerals, and Toxic Elements: Exploring Interactions between Nutrients and Toxicants in Clinical Medicine

5.. Honey is a combo of the natural medicinals with broader range of therapeutic effect

6.. Melatonin can improve health by optimizing the composition of the gut microbiota

7.. Chinese medicine and its philosophy

     7.1.. A brief introduction of Chinese medicine

     7.2.. Daoism, the philosophy of TCM

     7.3.. The comparison in the symptoms of 2003 SARS and 2019 coronavirus

     7.4.. The convincing proof of the magic effect of autoimmune

     7.5.. A introduction of a herb that used in TCM for over 2000 years

     7.6.. A introduction of an over a thousand years classic formula of TCM

     7.7.. Phytomedicine Research in Germany  

8.. The origin of the Orthomolecular Medicine

     8.1.. Dr. Abram Hoffer, the initiator of the use of the megavitamin therapy

      8.2.. William Wilson, the setter for the promotion of megavitamins

     8.3.. Dr. Linus Pauling, the proposer of the Orthomolecular Medicine

9.. Why western medicine declines, why Chinese medicine rises

10.. The overcrowded hospitals of Canada

11.. The best doctor for treating social diseases

12.. My writings for proving the reliable of my talkative

Note：

1.. This topic is for changing people’s long used to traditional ideology and philosophy, and this is the most difficult, so that, I have to make a little more boring talkative.

2.. I am willing to provide further assistance in the implementation of my suggestions. Now, here, I want to specifically apologize for the poor wording or mistakes in this article. I am too anxious to spend more time to check.

3.. The bad news of widespread of new coronavirus in China and globally made me exhausted. Anxiety made me sleepless, and insomnia made me even more anxious. Mentally tired, extremely dizzy, my brain can't work on own wills.

4.. Please leave me message at:  https://www.facebook.com/people/Frank-Li/100015909153472    

I have sent this article to many people, but helpless, no one want uproot epidemic covid-19.

General Introduction

I put a story at first to show my basic purpose of this topic.

After the initial completion of this article, I once share it with several friends on Face Book with a reminding: Please forget killers for new coronavirus, but pick up human autoimmunity.‎ Humans can never keep up with the pace of virus mutation.

Feb. 11, 2020, 03:56 Morning, on Face Book, I found a message that my friend sent from Singapore.

   Bernie Yau 1:24 AM Powerful steps to combat the Coronavirus - Dr Alan Mandell, DC

The link is a video on You Tube, by which Dr Alan Mandell tells how to enhance autoimmunity to combat new coronavirus.

  Dr Alan Mandell motivationaldoc  https://www.facebook.com/motivationaldoc/   

      Please do not panic! Being healthy is staying knowledgeable regarding your surroundings and your body. The immune system is the body’s defense against infectious organisms and other invaders. Practice good eating habits and choose foods that strengthen the immune system. It is very important to make sure that our bodies are strong and fit to fight off those invaders.

      “There is no magic cure for this virus, antibiotics work on bacteria, not viruses, we have been exposed to many hundreds of virus in our life, and how we get well by a strong immune system. I'll teach you the best thing you can do the keep you immune system strong.”

      The facebook of Dr Alan Mandell: https://www.facebook.com/motivationaldoc/ 

        The speech of Dr. Alan Mandell reminds us that the key to treat 2019 New Coronavirus Pneumonia is not in finding new treatments, but in working smartly to improve our autoimmunity; and the improvement of the autoimmunity does not have to wait until the body getting stronger; but a simple diet that is conducive to improving immunity can help us achieve this goal quickly. Within tens of minutes, as long as we ate diet is absorbed by our body; it can help us to fight disease immediately.

                                                                    ---   Frank Feb. 11, 2020 in Waterloo, Canada

Don't blame the new coronavirus, it's trying to tell humans what is fair and reasonable, no matter Rich or Poor, Easterner or Westerner, it attacks equally with the purpose of telling mankind that everyone must give up hypocrisy and deception and turn to pragmatic self-help.

At the time that the epidemic is about to erupt globally, when humans need the research results of hopeful experts in western medicine for rescue, they surrender up their hands. Facts have proved that those experts, by the name of scientific, has conducted many meaningless studies but wasted a lot of social resources.

Please forget scientific or unscientific, that is an excuse that some people use for cheating money to make a living by playing scientific game, if we dig the issue in nature.

Please pick up the traditional medicine that some people have been scammed to crack down and reject by the excuse of unscientific. Many cases of being cured by traditional Chinese medicine have proven that ancient traditional medicine is reliable and can save humans.

 

Vitamins are the main ingredients in Chinese medicinals with the advantage of easily being absorbed and have been in playing significant role in restoring the balance of Yin and Yang of human body that was badly damaged and deteriorated by pathogens.  

 

The mistake of western medicine stems from its philosophy Reductionism that looks human body as a non-living mechanical assembly with an inhuman perspective, and by seeking killing as a cure, that is, it has been treating humans as non-living life. Under such a philosophy, humans would never get rid of the torture of pathogens.

 

Daoism of the holistic philosophy of traditional Chinese medicine is exactly in opposite of the Reductionism; it cherishes human body as a living life, and by trying to restore the balance of yin and yang of human body as the treatment. It is the correct philosophy in guiding Chinese medicine to successfully save lives.

                                                              ---   Frank Feb. 26, 2020 in Waterloo, Canada

 

The researchers in Melbourne University found that a COVID-19 patient recovered from symptoms of drowsiness, sore throat; dry cough and fever after naturally emergence of several kinds of immune cells in the blood, it was same as that of general flu, which revealed that boosting autoimmune is effective treatment.

 

Actemra is a drug for rheumatoid arthritis, but approved for treating "cytokine storm" of immune cells self-injury caused death from multiple organ failure in 2017, and it is testing in China. Seattle Dr. Ryan Padgett contracted with COVID19 relying on ventilator, his lungs, kidneys and heart started failing in a day or so to live, the doctors tried Actemra for him and saved him.

 

The drug Actemra cured Dr. Padgett proved that cytokine storm caused multiple organ failure is one of the reasons that is in causing death; which was also proved the magic of enhancing autoimmune at the time that immune cells nearly failure in fighting against virus to timely provide armors protecting them; which is effective treatments for COVID-19.

 

In Japan, by asthma drug steroid inhalant Ciclesonide cured oxygen supported patients in COVID-19 pneumonia according to the report Asthma drug seems effective for COVID-19 pneumonia in Mar. 3, 2020.

 

In a remote village of Iran, according to the advice of elderly, by bee stings cured six sufferers in COVID-19 pneumonia, which is from a post followed  article How to respond to COVID-19 on the Blog of Bill Gates.

 

In China, the combo of pure natural Chinese medicinals have massively cured patients by targeting on physical improvement rather than killing virus; the blood test found that recovered people have increased of many kind of immune cells that have been destructed by virus, such as, the lymphocyte count and white blood cell count.

 

The combo use of medicinals is essential, because that the studies showed the magic of the combine-use of the medicinals with the effect that is far greater of the effect of the individual medicinals. Many findings show that even if the single ingredient has no therapeutic effect, but once it is used in combination as combo, it will produce magical effects far beyond conventional sense.

 

Nov 22, 2013, article Plant Nutrient 'Cocktail' Kills Breast Cancer Cells reports that “researchers at Louisiana State University tested six known protective chemical nutrients from turmeric, soybeans, broccoli, grapes and tea. Individually, they were ineffective against cancer. But combined, they suppressed breast cancer cell growth in the lab by more than 80 percent, and eventually triggered the process leading to cell death.”

 

Sep. 30, 2019, a study reported that triple commonly used drugs combination has extended the lifespan of fruit flies by 48%. The researchers found that lithium, trametinib and rapamycin, each of them can extend the lifespan of the fruit flies by an average of 11%, but increased around 30% by two combined, and reached 48% by three combined, which suggests the magic effect of combined drug and German studies proved that combined botanical can produce synergistic effects with reducing side effects.

 

The Phytomedicine Research in Germany reports that, "in Germany since 1980, more than 300 clinical studies have been carried out with standardized phytopharmaceuticals and gotten promising results, “Several comparative clinical trials showed that these phytopharmaceuticals had full therapeutic equivalence with chemotherapeutics and had the simultaneus advantage of being devoid of any adverse effects." 

 

"The mechanism of action of herbal drugs and their extract preparations, which differ in many respects from that of synthetic drugs or mono substances, can be characterized as a polyvalent action and interpreted as additive or, in some cases, potentiating.”

 

 “In many cases, the overall pharmacologic effects and therapeutic efficacies derived not from a single compound but from several compounds generating additive or synergistic pharmacologic effects.”

 

The facts have made clear, the treatment of COVID-19 must give up looking for vaccine or virus-killer, which has been in killing people by scientific clinic trial, but turn to immune boosting and which will make the thorny problem simplified and can be easily achieved by daily available foods in home handy.

 

Boosting our autoimmune is much easier than common sense, it is not necessary by waiting our body growing stronger, but only by taking some immune enhancing foods, our body will produce immune cells to effectively fight against virus.

 

 Vitamin B3, experiments found that high doses of vitamin B3 can increase the killing ability of immune cells in 1000 times in killing staphylococci, the so-called "super bacteria", of course, such strong immune cells can kill the new coronavirus.

 

Vitamin D is called as hammer for killing influenza, in the dose of 50,000 IU once a day, or the dose of 10,000 IU three times a day, the cold symptoms can be completely relieved within 48 to 72 hours. It has never shown toxicity.

 

Vitamin C, activates and enhances body's autoimmunity and avoids multiple organ failure by gathering around immune cells to protect them from self-injury, and eliminates discomforts caused by viruses, such as, fatigue, soreness, loss of appetite, and more.

 

Dec. 21 2011, I once wrote article Chinese Medicine - A Promising Therapeutic Approach: “Chinese medicinals contain variety of immunoreactive substances, such as polysaccharides, saponins, alkaloids, volatile substances and organic acids, etc. They are a kind of immune enhancer. Their immunoregulatory role is mainly through activation of reticuloendothelial system, so that significantly increase the IL-content, and the level of antibodies and complement, activate the macrophages and T, B lymphocytes, and enhance cellular immunity and humoral immunity, thereby enhancing the body immune system and the capacity of anti-diseases.”

 

“More amazingly, Chinese medicinals can increase the weight of immune organs and intellectually take the bidirectional role for those under different immune status. That is, for those in the lower immune function play a catalytic role, for those in the over immune function play a disincentive role, and for those in healthy condition stop any action consciously. These are the reason that in treatment of 2003 and 2019 coronavirus pneumonia, it showed unique cure magic.”

 

The treatment of Chinese medicine does not focus on killing the virus, but restores physical fitness, which is more effective than that of killing the virus. Such as, the acupuncture needle cannot kill virus at all, but it rescued patients from critical state. Feb. 15, 2020, a Mandarin article Subversion: Who said that Chinese medicine can't save critical illness? you are wrong report that:  

 

In February 15th, 2020, at the Hankou Hospital of Wuhan China, an acute patient in novel coronavirus pneumonia developed into critical state of irritability, difficulty in breathing. The expert at the Guangdong Provincial Hospital of Traditional Chinese Medicine, Professor Zou Xu who immediately treats patient by acupuncture needles on four acupoints, after 10 minutes, the patient's vital signs gradually stabilized.

 

The doctors in western medicine, who participated in the process of rescue, said that if it is not seeing with own eyes, they would never believe that it is true and being convinced the magic of Chinese medicine.

 

Obviously, the needles of acupuncture cannot kill novel coronavirus, then where the magic of their curative effect came from. For this concern, in Mar. 15, 2020, I Googled by the key words of acupuncture and immune returned about 9,950,000 results (0.50 seconds) and shocked by the magic curative effect.

 

2014, Acupuncture modulates the neuro–endocrine–immune network

2014, Acupuncture on Leucopenia, Neutropenia, NK, and B Cells in Cancer Patients

2007, Effect of acupuncture treatment on the immune function impairment found in anxious women.

 

If Google, you will find a lot of therapeutic function of acupuncture in wide range of diseases.

 

The magic curative effect of acupuncture firmly showed that the treatment of 2019 novel coronavirus pneumonia should not only addict in killing virus, but also restore general physical condition. A restored physical condition with enhanced autoimmunity is the key. Just such a reason, in fighting against 2003 SARS and now in fighting against COVID-19 virus, Chinese medicinals are both played key role in curing patients massively.

 

Especially, in the treatment of COVID-19 patients, Chinese medicinals rescued patients from acute state and avoided mild ill patient developed as critical ill, thus avoided the use of ICU that is not only heavy economical and medical burden, but also 50% death from asphyxia.

 

The curative effect of acupuncture and Chinese medicinals are clear, but it is not easy available for the most of people, we must find easy handy cure for curing more patients. In this process, we should move out eyes from focusing on virus killing, to be focusing on immune boosting.

 

April 2017, article Honey and Health: A Review of Recent Clinical Research said that: Honey used by humans since 5500 years ago. Modern studies show that it has therapeutic role in the treatment of disease by phytochemical, anti-inflammatory, antimicrobial, and antioxidant properties with several health-beneficial effects including antioxidant, anti-inflammatory, antibacterial, antidiabetic, respiratory, gastrointestinal, cardiovascular, and nervous system protective effects. Traditionally, honey is used in the treatment of eye diseases, bronchial asthma, throat infections, tuberculosis, thirst, hiccups, fatigue, dizziness, hepatitis, constipation, worm infestation, piles, eczema, healing of ulcers, and wounds and used as a nutritious supplement. The ingredients of honey have been reported to exert antioxidant, antimicrobial, anti-inflammatory, antiproliferative, anticancer, and antimetastatic effects.

 

The extensive pharmacological functions of honey come from a wide range of bioactive ingredients. Pure honey consists of flavonoids, polyphenols, reducing compounds, alkaloids, glycosides, cardiac glycosides, anthraquinone, and volatile compounds. It consists of all nine essential amino acids and all nonessential amino acids. All of the water-soluble vitamins exist in honey, with Vitamin C being the most frequent. Approximately 31 variable minerals have been found in honey, including all of the major minerals and approximately 600 volatile compositions in honey that contribute to its potential biomedical effects. Flavonoids and polyphenols, which act as antioxidants, are two main bioactive molecules; there are nearly thirty types of polyphenols in honey.

 

Vinegar is most easy home handy one for all people.

 

A study by groups of mice were treated with daily oral doses of 0.17, 0.51 and 1.02 ml of the vinegar/kg body weight for 4 weeks. Cider vinegar induced a significant reduction in weight gain in animals treated with 0.51 ml/kg. Hemoglobin (Hb), total erythrocyte counts (TEC) and total leukocyte counts (TLC) were raised in all treated groups.

 

A stufy shows taht apple cider vinegar can help clear bacteria and yeast infections to potentially protect the body from harmful bacteria by stopping the growth of bad bacteria and fungus in its tracks, stopping the spread of these infections by destroying their cell walls, protein structure, nuclear proteins, metabolic enzymes altering their structure of the pathogenic organisms with a broad spectrum without distinction.

 

Googled vinegar in killing coronavirus got subjective assumptions without test data supporting, but Google vinegar boosts immunity and health benefits, got a lot. There is report that vinegar can destruct cell structure to kill bacteria and viruses. In Canada, vinegar is used to disinfect production equipment of meats foods - Chicken, pork, beef, fish, etc., they are all extremely susceptible to germs and viruses, which can indirectly prove the antiviral effect of vinegar. 

 

Though the property of vinegar killing COVID-19 is not clear yet, but its property in boosting immunity and enhancing physical condition will play a role as that of Chinese medicine in doing. I firmly believed that vinegar will be powerful bullet to finish 2019 novel coronavirus. 

 

According to my personal experience, vinegar can immediately stop a runny nose, stop cough by eliminating swelling and itching of the respiratory tract, eliminate sticky sputum that can't be coughed out in the throat, and thereby reducing snoring and apnea. The nasal cavity and throat are the main channels for the virus to invade, and vinegar can naturally kill them in there.

 

Autopsy showed that a large amount of mucus blocked the bronchial airway inside the lungs, and then asphyxia caused the death of patients with new coronary pneumonia. Vinegar can eliminate snot and sticky sputum; it certainly can reduce the mucus from the bronchial airway inside the lungs.

 

Vinegar and honey both have antiviral functions, but that may not be powerful enough. However, once combined with our autoimmunity, their effect may be better than any synthetic drug, and also there is no fatal harm from the side effects of synthetic drugs.

 

Here, I suggest a home remedy by daily 4 - 5 times 10 - 20 ml 5% vinegar adds 20 ml honey dilutes by 500 ml water orally drink (or outside smears diluted vinegar to be absorbed through the skin, which will take effect more quickly),  3 grams vitamin C in 6 times daily.

 

In Japan, by asthma drug steroid inhalant Ciclesonide cured oxygen supported patients in COVID-19 pneumonia according to the report Asthma drug seems effective for COVID-19 pneumonia in Mar. 3, 2020.

 

In a remote village of Iran, according to the advice of elderly, by bee stings cured six sufferers in COVID-19 pneumonia, which is from a post followed  article How to respond to COVID-19 on the Blog of Bill Gates.

 

I suggest daily diet and natural medicinals as below.

 

For convenient concern, only vinegar combines with vitamin C and B3 will be effective, in consideration of the Chinese medicinals are not easy available for the most of westerners.

 

1.. Vinegar: 1 g / 50 kg adds 20 ml honey 5 times per day (20 ml 5% vinegar adds 20 ml honey dilutes with 500 ml water for orally taking)

2.. Vitamin C: 3 g / 50 kg, 6 times per day,  Or 1 g /  kg by the intravenous 1 time daily

3.. Vitamin B3: 500 mg / 50 kg, 6 times daily

4.. Vitamin D: 5,000 IU / 50 kg 3 times daily

5.. Astragalus 6 g / 50 kg, 6 times per day (pinyin: Huangqi, in the form of OTC pill or injection)

6.. Salvia combo  2 g / 50 kg (pinyin: Fu Fang Dan Shen Pian, OTC tablet or injection)

7.. Xuefu Zhuyu Decoction 3 g / 50 kg, 4 times per day (pinyin: Xue Fu Zhu Yu Tang, OTC powder or injection)

 

Above items as combo takes by 20 ml 5% vinegar dilutes with 500 ml water orally.

 

I dare say that for 2019 new coronary pneumonia, vinegar and vitamin C alone can avoid death.

 

Edible vinegar has broad-spectrum sterilization, it is the only food that can be used internally to kill new coronaviruses. It also has wider range of benefits, especially benefits intestinal probiotic flora in kills bad to protect good.  

 

Vitamin C, activates and enhances the body's autoimmunity and avoids multiple organ failure by gathering around immune cells to protect them from self-injury, and eliminates discomforts caused by viruses, such as, fatigue, soreness, loss of appetite, and more.

 

Vitamin B3. Experiments found that high doses of vitamin B3 can increase the killing ability of immune cells in 1000 times in killing staphylococci, the so-called "super bacteria", of course, such strong immune cells can kill the new coronavirus.

 

Vitamin D, in the dose of 50,000 IU once a day, or the dose of 10,000 IU three times a day, the cold symptoms can be completely relieved within 48 to 72 hours. It has never shown toxicity.

 

Chinese medicinals can enhance immunity and protect various organs of the body with restoration of physical health. In treatment of 2003 and 2019 coronavirus pneumonia, it showed unique cure magic.

 

50 kg body weight refers to all adults without strict restrictions. A dose of 3 grams of vitamin C is used at the beginning of a cold in just feels a little uncomfortable. For severe cases, it should be in 1 gram per kilogram of body weight intravenously.

 

The key is at that above items must be used as combo. The treatment is to improve the physiological function of the human body from a basic level, so that it can restore the ill deteriorated body from the physiological basis and will be effective for the treatment of the most diseases in both of acute and chronic, including mental disorder and withdrawal effects of various abusers.

 

We may try it in critically ill patients firstly. Intravenous infusion will take effect in a few minutes.

 

I feel that vinegar has a stimulating effect on the esophagus and intestine, especially when taken in capsules. If the concentration is too high in local area, it may cause intestinal swelling and affect the discharge of food after digestion. Therefore, it is best to take vinegar diluted with water.

 

No intravenous use has been reported with vinegar. The irritation of vinegar may cause swelling of the inner walls of blood vessels, which is bad for capillaries. But, this is just my personal subjective judgment, because drinking diluted vinegar caused discomfort in the throat and the esophagus and seemed to have caused swell. After drinking vinegar, it needs to rinse mouth with water.

 

It is need of careful test before use of vinegar by the intravenous.

 

I suggest homemade portable hand-sanitizing bag

 

There have been report of 2019 new coronavirus was detected on the door handles in families, and there many sufferers were from same family, which reminds us to avoid the infection between the family members.

 

In this concern, Vinegar can kill bacteria and virus by chemically changing their cell structure; it is fewer sanitizers that can kill all kind pathogens. In Canada, it is used to sanitize the equipment in food production.

 

1.. Homemade a portable sanitizing tool. Put vinegar saturated handkerchief in the plastic bag for sanitizing own hands and utilities in handy.

2.. Please disinfect inside the home by boil-evaporating vinegar, and put utensils separate-individually with proper sanitizing.

3.. With vinegar wiping tools and the places where easily common accessible.

 

In home, family members must treat each other as New Coronavirus infected, before and after touching something, or opening door from outside, please sanitize hands by the vinegar saturated handkerchief.

                                                      Frank  Feb. 12, 2020, in Waterloo, On. Canada    

 

 

 

 

1.. Vinegar

 

1.1.. The LD50 of vinegar

 

The LD50 (the dose that will kill 50% of a population) of vinegar is 3,320 mg/kg, it will be 165g for a people of 50 kilo.

 

1.2.. The mechanism of vinegar kill pathogens

 

Jan. 11, 2018, article Does vinegar really kill household germs? said that: ”Vinegar, be it white or malt or rosemary-infused, is about 5 per cent acetic acid. The acid kills bacteria and viruses, by chemically changing the proteins and fats that make up these nasties and destroying their cell structures.”

 

It can be seen that the virus-killing function of vinegar has a broad spectrum without distinction. Surprisingly, we may Google a lot health benefits of vinegar.

 

 

As my view, the pathgonic killing effect of Vinegar comes from two oxygen atoms with negative charges of polar bonds that can attract electrons from other atoms, which can easily kill bacteria and virus by destroying their weaker covalent bonds. 

      

 

   1.2.1.. Vinegar raised hemoglobin, total erythrocyte counts and total leukocyte counts

 

    April 11, 2001, research report The effect of cider vinegar on some nutritional and physiological parameters in mice said that vinegar raises hemoglobin (Hb), total erythrocyte counts (TEC) and total leukocyte counts (TLC); while significant increases in both mean liver and spleen weight.

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   1.2.2.. Vinegar destroys cell walls, protein structure, nuclear proteins of the pathogenic organisms

 

   2018 Jan 29, research report Apple cider vinegar can help clear bacteria and yeast infections; a natural cure said that vinegar could potentially protect the body from harmful bacteria by stopping the growth of bad bacteria and fungus in its tracks, stopping the spread of these infections by destroying their cell walls, protein structure, nuclear proteins, metabolic enzymes altering their structure of the pathogenic organisms.

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   1.2.3.. 1 and 3% vinegar can inactivate avian influenza virus

 

   June 2009, study report Inactivation of avian influenza virus using four common chemicals and one detergent: “Five disinfectant chemicals were tested individually for effectiveness against low pathogenic avian influenza virus (LPAIV), A/H7N2/Chick/MinhMa/04, on hard, nonporous surfaces. The tested agents included acetic acid, calcium hydroxide, sodium carbonate, sodium hydroxide, and a powdered laundry detergent without bleach. Multiple common chemicals including acetic acid (1 and 3%), sodium hydroxide (2%), and calcium hydroxide (1%) effectively inactivated LPAIV on a metal surface.

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   1.2.4.. 4 - 8% vinegar can inactivate H1N1 human influenza virus

 

   Feb. 1, 2010, Effectiveness of Common Household Cleaning Agents in Reducing the Viability of Human Influenza A/H1N1: A British Standard was adapted to assess the ability of various household cleaning agents to kill or reduce the infectivity of an H1N1 human influenza virus A/PuertoRico/8/34 (PR8, H1N1, Cambridge lineage). A low concentration of vinegar (1%) was no more effective than hot water alone. Malt vinegar (4–8% acetic acid) was effective down to a dilution of 10%. Previously 5% acetic acid has been demonstrated to be effective at inactivating an A/H7N2 strain of influenza and it has been known for some years that acid-based media cause inactivation and aggregation of HA glycoprotein spikes and virus, by triggering the low pH-dependent conformational change in the HA that normally only occurs in late endosomes.

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   1.2.5.. Vinegar can decreased small intestine muscular thickness and abdominal fat

 

   Jan. 3, 2018, study report Effect of probiotic and vinegar on growth performance, meat yields, immune responses, and small intestine morphology of broiler chickens: 30 day-old broiler chicks drinking water diluted vinegar significantly decreased small intestine muscular thickness (MT) and abdominal fat.

 

   1.2.6.. Vinegar has anti-obesity and anti-inflammatory effects

   

   Jul. 27, 2017, study report Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice: vinegar reduced lipid deposition, improved the serum lipid profile, increased adipokine expression and suppressed inflammation in the obese mice.

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    1.2.7.. Vinegar may be as an adjunct treatment modality for Diabetes

 

    May 6, 2015, study report Vinegar Consumption Increases Insulin-Stimulated Glucose Uptake by the Forearm Muscle in Humans with Type 2 Diabetes: vinegar reduces postprandial hyperglycaemia, hyperinsulinaemia, and hypertriglyceridaemia without affecting lipolysis. Vinegar's effect on carbohydrate metabolism may be partly accounted for by an increase in glucose uptake, demonstrating an improvement in insulin action in skeletal muscle.

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   1.2.8.. Apple Cider Vinegar can thin sticky mucus and clears stuffy noses

 

   Sep 10, 2017, on the website; Lung Health Institute posts article Apple Cider Vinegar and COPD: Clears Stuffy Noses – Apple cider vinegar contains potassium that thins mucus. Also, the acidic PH prevents bacteria growth. Directions: Mix a teaspoon of apple cider vinegar with a glass of water and drink.

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   1.2.9.. Apple Cider Vinegar can increases oxygen in blood stream

 

   In Jan 15, 2021, I found an article Nine Benefits of Apple Cider Vinegar; it said that Apple Cider Vinegar can increases oxygen as it releases iron from the food you eat into your blood stream supplying more oxygen throughout the body.

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   1.2.10.. Apple Cider Vinegar promotes oxygen to cells by promoting hemoglobin and myoglobin

 

   Dec. 6, 2013, articel The Surprising Benefits of Apple Cider Vinegar said that apple cider vinegar helps release iron from the food you eat, so it can be used throughout the body. This is important because iron is a key component of hemoglobin and myoglobin. Both hemoglobin and myoglobin are responsible for carrying oxygen to cells throughout the body.

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   1.2.11.. Apple Cider Vinegar promotes energy consumption and leads to weight loss

 

   Dec. 6, 2013, articel The Surprising Benefits of Apple Cider Vinegar said that apple cider vinegar helps release iron from the food you eat, so it can be used throughout the body. The iron is a key component of hemoglobin and myoglobin. Both hemoglobin and myoglobin are responsible for carrying oxygen to cells throughout the body.

   Just as oxygen is essential to burn a fire in your fireplace, oxygen is also essential to burn energy (calories) in your body. Because apple cider vinegar helps the body release iron, it also helps your body's ability to burn calories, which is critical for weight loss.

   Iron absorption leads to oxygen utilization, which leads to energy consumption, which leads to weight loss.

 

1.2.11.. Apple Cider Vinegar promotes energy consumption and leads to weight loss

Dec. 6, 2013, articel The Surprising Benefits of Apple Cider Vinegar said that apple cider vinegar helps release iron from the food you eat, so it can be used throughout the body. The iron is a key component of hemoglobin and myoglobin. Both hemoglobin and myoglobin are responsible for carrying oxygen to cells throughout the body.
Just as oxygen is essential to burn a fire in your fireplace, oxygen is also essential to burn energy (calories) in your body. Because apple cider vinegar helps the body release iron, it also helps your body's ability to burn calories, which is critical for weight loss.
Iron absorption leads to oxygen utilization, which leads to energy consumption, which leads to weight loss.
                                                                                                                       
1.2.12.. Vinegar reduces body weight, body fat mass, and serum triglyceride levels

 
Aug. 7, 2009, Vinegar intake reduces body weight, body fat mass, and serum triglyceride levels in obese Japanese subjects
Acetic acid (AcOH), a main component of vinegar, recently was found to suppress body fat accumulation in animal studies. Hence we investigated the effects of vinegar intake on the reduction of body fat mass in obese Japanese in a double-blind trial.
The subjects were randomly assigned to three groups of similar body weight, body mass index (BMI), and waist circumference. During the 12-week treatment period, the subjects in each group ingested 500 ml daily of a beverage containing either 15 ml of vinegar (750 mg AcOH), 30 ml of vinegar (1,500 mg AcOH), or 0 ml of vinegar (0 mg AcOH, placebo). Body weight, BMI, visceral fat area, waist circumference, and serum triglyceride levels were significantly lower in both vinegar intake groups than in the placebo group. In conclusion, daily intake of vinegar might be useful in the prevention of metabolic syndrome by reducing obesity.
                                                                                                                       
1.2.13.. Vinegar lower blood sugar and insulin levels in people with diabetes

Oct. 6, 2018, article Is Vinegar Good for You said that: In a 2015 Greek study of 11 people with diabetes, those who had an ounce of vinegar and then consumed a ham and cheese sandwich, orange juice, and a cereal bar had slightly lower blood sugar and insulin levels afterward than those who drank water instead of vinegar.
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1.2.14.. Vinegar prmotes insulin-producing cells and slows atherosclerosis

In a few very small studies, gourmet-quality balsamic vinegars improved the function of insulin-producing cells in the pancreas in rats and slowed atherosclerosis-promoting damage to LDL cholesterol in a tiny Japanese study with five people. But there’s no research suggesting inexpensive balsamic vinegar has the same effects.
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1.2.15.. The medicinal application in TCM

In ancient time, vinegar has been widely used in TCM: promote digestion; improve appetite; kill roundworms; eliminate carbuncle swelling; nourish liver; strengthen muscles; sober up drunkenness; relieve anxiety; dispel blood stasis; stop bleeding; detoxify; kill insects; treat fainting; nourish lungs; stop diarrhea; treat postpartum haemorrhage; treat jaundice; stop yellow sweat; stop vomiting blood; stop epistaxis; stop blood in stool; treat genital itching, treat carbuncle and sore, relieve poison in fish, meat and vegetable; and so on.
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1.2.16.. Vinegar’s functions on health: constituents, sources, and formation mechanisms

Sep. 28, 2016, Vinegar Functions on Health: Constituents, Sources, and Formation Mechanisms: “Vinegars are one of only a few acidic condiments throughout the world. Vinegars can mainly be considered grain vinegars and fruit vinegars, according to the raw materials used.”

Functional ingredients: Organic acids; Ligustrazine; Dihydroferulic acid; Dihydrosinapic acid; Tryptophol;  Melanoidins; Ligustrazine.

Physiological functions: antibacteria, anti-infection, antioxidation, blood glucose control, lipid metabolism regulation, weight loss, and anticancer activities.
“The antibacteria and anti-infection abilities of vinegars are mainly due to the presence of organic acids, polyphenols, and melanoidins. The polyphenols and melanoidins also provide the antioxidant abilities of vinegars, which are produced from the raw materials and fermentation processes, respectively. The blood glucose control, lipid metabolism regulation, and weight loss capabilities from vinegars are mainly due to acetic acid. Besides caffeoylsophorose (inhibits disaccharidase) and ligustrazine (improves blood circulation), other functional ingredients present in vinegars provide certain health benefits as well.”
“Regarding anticancer activities, several grain vinegars strongly inhibit the growth of some cancer cells in vivo or in vitro, but related functional ingredients remain largely unknown, except tryptophol in Japanese black soybean vinegar. Considering the discovering of various functional ingredients and clarifying their mechanisms, some vinegars could be functional foods or even medicines, depending on a number of proofs that demonstrate these constituents can cure chronic diseases such as diabetes or cardiovascular problems.”

                                                                                                                     

   

1.3.. My friendly associates with vinegar

 

   Since about my 30, my teeth has been in the state of uncertainty of sore when eating or drinking of cold, hot, or sour. Tried with various medicinal toothpastes to brush them harder, but still doesn't work well. When about my 40, there two of my most left lower adjacent teeth were broken and being pulled down. About two months later, the lower gum where the teeth being pulled down were pressed by the two upper teeth, then I had doctor let them go, it seems the only way without any choice available.

 

 

After seeing that the four teeth had gone, the other teeth did not take lessons, and were still in the state of uncertainty of sore from time to time.

 

 

In about 2015, the second tooth on the upper middle left was exposed. I had a dentist to expand the hole, killed the nerve, added a supporting bar in, and cover it by something.

 

 

I wonder that how long time of the cover will be last, doctor said that he cannot sure; maybe, the two years will be the best.

Oh, my god.

 

 

In 2017, the tooth surfaces of the lower most left and right were exposed, and were in painful. I had the same dentist cover them, but they were in loose of periodontitis. At the same time, the two lower teeth in the middle are loose, and they have been in the state of trying to split up with me. When eating, I had to be very careful.

 

 

Dear my teeth, please don't split up with me, please, I beg you all.

 

 

Oh my god.

 

 

One day, I thought that since vinegar can kill bacteria, why not try to gargle my teeth with vinegar, the effect is very good. Later, I bought a small toothbrush, after eating something, I cleaned the teeth with the toothbrush dipped in 0.05% vinegar and gargle my mouth with 0.05% vinegar, then rinsed my mouth with water to wash the vinegar away. Otherwise, the teeth feel bad.

 

 

  The small toothbrush The third tooth on the upper middle right was exposed with nerves at the gum area, with a white lumps growing, but it was unstable and easy to lost when brushing. In any case, the teeth didn't pain and the exposed area didn't expand in the state of stable.

 

 

The picture below shows the lower teeth of right now, which just taken with a mobile phone when I writing to here. The gums have grown and are firm. The roots are not dark anymore. I was no longer worrying about them splitting with me since the start of gargling my teeth with vinegar. 

 

 

                           

 

 

 

 

 

     Now, please take a look at the consequences of high concentrations of vinegar.

 

 

     Since cleaning my teeth with vinegar, the cold, hot, and sour are all powerless to my teeth, and I have been enjoying the most comfortable teeth since my 30. 

 

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     1.3.1.. An case of wrongful use of vinegar

 

 

    On Hong Kong Med J. 2002 Oct;8(5):365-6, there was a report Corrosive oesophageal injury following vinegar ingestion.

 

     “A 39-year-old woman experienced a foreign body sensation and pain in the left side of her throat after eating crab at dinner. She suspected a small piece of crab shell might be lodged in her throat. She drank one tablespoon of household rice vinegar (usually used for cooking) in the belief that it would dissolve the shell. The sensation of foreign body and pain persisted, however.”

 

     “The patient attended a general out-patient clinic the next day and was referred to the accident and emergency department. She enjoyed good health with no history of heartburn, regurgitation, dysphagia, odynophagia, epigastric distress, or gastrointestinal bleeding. There was no retching or vomiting before or after the foreign body sensation. Neither had she probed her throat or tried to induce vomiting. Vital signs were normal. She did not have a fever. Examination revealed scattered whitish patches on the posterior pharyngeal wall. No foreign body was identified.”

 

     “Lateral X-ray of the neck did not reveal any abnormality. She was discharged with an endoscopy appointment for the next morning. The endoscopic finding was inflammation of the oropharynx and second-degree caustic injury of the oesophagus from 22 to 30 cm (Fig 1) and the cardia (Fig 2). There was no evidence of a foreign body. The rest of the stomach and duodenum were normal.”

 

 

                The Fig 1 and Fig 2.

 

 

     “She was discharged with antacids. Since she was entirely symptom-free at the follow-up visit 1 week later, endoscopy was not repeated. At another follow-up visit 4 months later, she remained symptom-free.”

 

     She had an uneventful recovery.

 

     Now, there are reports that vinegar can erode teeth, so use it with caution. My personal experience proved that this statement is not reliable. Maybe vinegar will really erode our teeth, but as long as we don't brush teeth after using vinegar, it won't cause harm.

 

     More importantly, vinegar can remove the calculus, and then the self-growth of the teeth will offset the corrosion. According to the dentist, for cleaning up the calculus, it needs to be divided into several times, the gum has to cut for open, and the roots of teeth are polished with a brush; thus once a year, it is in paying good money for bad suffering.

 

     The fact was clear that vinegar is intelligent and friendly to humans and can help to solve many thorny problems. It kills pathogens from the physiological structure and does not harm our body, but with great many benefits to humans if you Google right now.

 

     Though the use of vinegar is safe, but when used by intravenous infusion requires a suitably low concentration to 

avoid swelling of the inner wall of the blood vessel.

 

     I drunk 20ml 5% vinegar after diluted by 500ml water, it is 0.002% vinegar, but I still feel the irritation of vinegar, if I don’t gargle mouth by water, I would feel uncomfortable in my throat.

 

     So, it needs to take special caution when using it by intravenous infusion.

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     1.4.. Homemade portable anti-virus bag

 

     There have been report of 2019 new coronavirus was detected on the door handles in families, reminding us to avoid this type of infection.

 

     1.4.1.. Please disinfect inside the home by boil-evaporating vinegar, and put individual bowls and chopsticks separately with proper sanitizing.

 

     1.4.2.. With vinegar wiping tools and the places where easily common accessible.

 

     1.4.3.. Homemade a portable anti-virus tool. Put a handkerchief saturated with vinegar in the bag and wipe own hands from time to time.

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  2.. Vitamin C

 

     2.1.. The LD50 is generally accepted to be 11900 milligrams (11.9 grams) /kg. The American Association of Poison Control Centers has reported zero deaths from vitamin C.

 

     Google will find many health benefits of Vc.

  2.2.. Role in immunity of Vitamin C

 

     Linus Pauling Institute, Oregon State University

     https://lpi.oregonstate.edu/mic/vitamins/vitamin-C#role-in-immunity

 

     Vitamin C affects several components of the human immune system in vitro; for example, vitamin C has been shown to stimulate both the production and function of leukocytes (white blood cells), especially neutrophils, lymphocytes, and phagocytes. Specific measures of functions stimulated by vitamin C include cellular motility, chemotaxis, and phagocytosis.

 

 

Neutrophils, mononuclear phagocytes, and lymphocytes accumulate vitamin C to high concentrations, which can protect these cell types from oxidative damage. In response to invading microorganisms, phagocytic leukocytes release non-specific toxins, such as superoxide radicals, hypochlorous acid ("bleach"), and peroxynitrite; these reactive oxygen species kill pathogens and, in the process, can damage the leukocytes themselves. Vitamin C, through its antioxidant functions, has been shown to protect leukocytes from self-inflicted oxidative damage.

 

 

Phagocytic leukocytes also produce and release cytokines, including interferons, which have antiviral activity. Vitamin C has been shown to increase interferon production in vitro. Additional studies have reported that vitamin C enhances the chemotactic and microbial killing capacities of neutrophils and stimulates the proliferation and differentiation of B- and T-lymphocytes.

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2.3.. High Dose Vitamin C and Influenza: A Case Report

 

From the Journal of Molecular Biology, Volume 34, Number 2, 2019.

 

M.G., a 25-year-old forensic psychologist from Ponce, Puerto Rico, was in his baseline state of excellent health when he began to notice classical flu-like symptoms, including fever, chills, muscle aches and pains, headaches, and nausea. He fought these symptoms as best as he could for a week. However, by the time this period had passed, he only had the energy to stay in bed with constant headaches and body pain. As it was, he went from approximately 170 pounds down to 155 pounds.

 

 

A rapid flu swab test was done which turned out positive.  We treated him with Intravenous Vitamin C (IVC) therapy which consisted of 1,000 cc of lactated Ringer’s solution containing 50 grams of sodium ascorbate, a pH-eutral form of vitamin C. This was infused over about one and a half hour. This same regimen was repeated for a total of 3 infusions over 3 days. All of the infusions were clinically uneventful and without discernible side effects.

 

 

The morning following the first IV, the patient noted that his body strength had improved dramatically. He also noticed that his headaches were gone. The morning after the second IV his appetite was improving and he was eating more as well.

 

 

All of the IVC infusions were given at the patient’s home. On day four he felt normal, but Vitamin C was continued to be given orally (2 g tid). The patient was also instructed to start taking a high potency multivitamin and mineral (1qd) in addition to CoQ10 (100mg qd) on a regular basis orally. In addition to Echinacea (500 mg bid for ten days).

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2.4.. Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-α/β at the Initial Stage of Influenza A Virus (H3N2) Infection

 

From Immune Netw. 2013 Apr; 13(2), online 2013 Apr 30,

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659258/

 

"L-ascorbic acid (vitamin C) is one of the well-known anti-viral agents, especially to influenza virus. Since the in vivo anti-viral effect is still controversial, we investigated whether vitamin C could regulate influenza virus infection in vivo by using Gulo (-/-) mice, which cannot synthesize vitamin C like humans. First, we found that vitamin C-insufficient Gulo (-/-) mice expired within 1 week after intranasal inoculation of influenza virus (H3N2/Hongkong). Viral titers in the lung of vitamin C-insufficient Gulo (-/-) mice were definitely increased but production of anti-viral cytokine, interferon (IFN)-α/β, was decreased. On the contrary, the infiltration of inflammatory cells into the lung and production of pro-inflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-α/β, were increased in the lung. Taken together, vitamin C shows in vivo anti-viral immune responses at the early time of infection, especially against influenza virus, through increased production of IFN-α/β.

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2.5.. Vitamin C and Infections

 

From the Nutrients. 2017 Apr; 9(4) online 2017 Mar 29

 

"In the early literature, vitamin C deficiency was associated with pneumonia. After its identification, a number of studies investigated the effects of vitamin C on diverse infections. A total of 148 animal studies indicated that vitamin C may alleviate or prevent infections caused by bacteria, viruses, and protozoa. The most extensively studied human infection is the common cold. Vitamin C administration does not decrease the average incidence of colds in the general population, yet it halved the number of colds in physically active people. Regularly administrated vitamin C has shortened the duration of colds, indicating a biological effect. However, the role of vitamin C in common cold treatment is unclear. Two controlled trials found a statistically significant dose–response, for the duration of common cold symptoms, with up to 6–8 g/day of vitamin C. Thus, the negative findings of some therapeutic common cold studies might be explained by the low doses of 3–4 g/day of vitamin C. Three controlled trials found that vitamin C prevented pneumonia. Two controlled trials found a treatment benefit of vitamin C for pneumonia patients. One controlled trial reported treatment benefits for tetanus patients. The effects of vitamin C against infections should be investigated further."

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2.6.. Vitamin C in sepsis.

 

Wilson Jhon  Subcell Biochem. 2012;56:67-83.

https://www.ncbi.nlm.nih.gov/pubmed/22116695 

Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, NY, 14214-8028, USA, [e-mail].

 

 

Bacterial bloodstream infection causes septic syndromes that range from systemic inflammatory response syndrome (SIRS) and encephalopathy to severe sepsis and septic shock. Microvascular dysfunction, comprising impaired capillary blood flow and arteriolar responsiveness, precedes multiple organ failure. Vitamin C (ascorbate) levels are low in critically ill patients. The impact of ascorbate administered orally is moderate because of its limited bioavailability. However, intravenous injection of ascorbate raises plasma and tissue concentrations of the vitamin and may decrease morbidity. In animal models of polymicrobial sepsis, intravenous ascorbate injection restores microvascular function and increases survival. The protection of capillary blood flow and arteriolar responsiveness by ascorbate may be mediated by inhibition of oxidative stress, modulation of intracellular signaling pathways, and maintenance of homeostatic levels of nitric oxide. Ascorbate scavenges reactive oxygen species (ROS) and also inhibits the NADPH oxidase that synthesizes superoxide in microvascular endothelial cells. The resulting changes in redox-sensitive signaling pathways may diminish endothelial expression of inducible nitric oxide synthase (iNOS), tissue factor and adhesion molecules. Ascorbate also regulates nitric oxide concentration by releasing nitric oxide from adducts and by acting through tetrahydrobiopterin (BH4) to stimulate endothelial nitric oxide synthase (eNOS). Therefore, it may be possible to improve microvascular function in sepsis by using intravenous vitamin C as an adjunct therapy.

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2.7.. Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis

Crit Care. 2018; 22: 258. Published online 2018 Oct 11

 

This meta-analysis reveals a positive correlation between incorporating vitamin C in the treatment of sepsis and favorable patient outcomes, including better survival and shorter duration of vasopressor use.

Below article may the best in introduction of the use of Vitamin C.

 

2.8.. High-dose Intravenous Vitamin C as a Successful Treatment of Viral Infections.

https://riordanclinic.org/2014/02/high-dose-intravenous-vitamin-c-as-a-successful-treatment-of-viral-infections/

 

Do you know that injections of mega doses of vitamin C were successfully used in treating polio, diphtheria, herpes zoster (shingles), herpes simplex, chicken pox, influenza, measles, mumps, and viral pneumonia in the middle of the 20th century? Most of these treatments are described in the book “Injectable Vitamin C: Effective Treatment for Viral and Other Diseases.” This book is a tribute to and acknowledgment of the important thinking and work of Dr. Fred R. Klenner and other physicians and researchers who worked in medicine from the 1930s to the 1970s. They made the pioneering efforts on the medical use of injectable vitamin C in the treatment of viral infection. One of the first studies in the inactivation of poliomyelitis virus in an in vitro setting using crystalline vitamin C (ascorbic acid) was designed by C. W. Jungeblut, MD in 1935.

 

 

In 1949, Dr. Klenner reported successful treatment of polio, diphtheria, herpes zoster, herpes simplex, chicken pox, influenza, measles, mumps, and viral pneumonia with injections of large doses of vitamin C. “The results,” he wrote, “which we have reported in virus diseases using vitamin C as the antibiotic may seem fantastic.”

 

 

Our data provide evidence that high dose (7.5 to 50 grams) intravenous vitamin C (IVC) therapy may have a positive effect on disease duration and may reduce viral antibody levels. The benefit seems to be dependent upon the number of IVC treatments given, as patients given ten or more IVCs had significantly greater reduction in viral antibody load when compared to untreated controls.

 

 

Several mechanisms for vitamin C’s antiviral effect are known or suggested from these studies. First, the antioxidant property of vitamin C promotes a reducing environment in the bloodstream and tissues, enhancing the body’s response to oxidative stress from inflammation, thereby helping to fight microbes and viruses that propagate in stressful conditions.

 

 

Research photoViral infections often lead to oxidative stress to the infected cells, and therefore, antioxidants are expected to suppress oxidative stress and work as antivirals or ‘drugs,’ improving inflammatory symptoms. Among these substances, the protective effect of ascorbic acid has been assumed due to its powerful scavenging and antioxidative property.

 

 

Vitamin C is also involved in enhancing several functions of the immune system. Cells of the immune system have one of the highest concentrations of vitamin C: white blood cells have an 80 times concentration of vitamin C in their cytoplasm, allowing them to create a vitamin C concentration surplus at the site of infection. Vitamin C can also enhance the production of interferon, which helps prevent cells from being infected by a virus, stimulate the activity of antibodies and cytokines, and in mega-doses, play a role in mitochondrial energy production. It can enhance the ability of specialized immune cells to ingest bacteria.

 

 

In addition to this general neutralizing effect, vitamin C interferes with the assembly of viral RNA and DNA. In a recent study (2012), in vitro experiments showed ascorbate’s ability to kill isolated influenza viruses, as well as viruses from normal human bronchial epithelial cells. There was a dosedependent effect—a concentration of 2.5mM was able to eliminate 90% of the virus present and a 20 mM solution completely stopped the replication of the virus. The antiviral effect of ascorbate is greater when introduced in the early stages of infection.

 

 

2.9.. Mechanism of action of vitamin C in sepsis: ascorbate modulates redox signaling in endothelium.

 

Wilson JX.  Biofactors. 2009 Jan-Feb;35(1):5-13. doi: 10.1002/biof.7.

https://www.ncbi.nlm.nih.gov/pubmed/19319840

 

Circulating levels of vitamin C (ascorbate) are low in patients with sepsis. Parenteral administration of ascorbate raises plasma and tissue concentrations of the vitamin and may decrease morbidity. In animal models of sepsis, intravenous ascorbate injection increases survival and protects several microvascular functions, namely, capillary blood flow, microvascular permeability barrier, and arteriolar responsiveness to vasoconstrictors and vasodilators.

 

 

The effects of parenteral ascorbate on microvascular function are both rapid and persistent. Ascorbate quickly accumulates in microvascular endothelial cells, scavenges reactive oxygen species, and acts through tetrahydrobiopterin to stimulate nitric oxide production by endothelial nitric oxide synthase.

 

 

A major reason for the long duration of the improvement in microvascular function is that cells retain high levels of ascorbate, which alter redox-sensitive signaling pathways to diminish septic induction of NADPH oxidase and inducible nitric oxide synthase.

These observations are consistent with the hypothesis that microvascular function in sepsis may be improved by parenteral administration of ascorbate as an adjuvant therapy.

 

2.10.. Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis.

 

Hemilä H1, Chalker E2. Nutrients. 2019 Mar 27;11(4). pii: E708. doi: 10.3390/nu11040708

https://www.ncbi.nlm.nih.gov/pubmed/30934660

 

A number of controlled trials have previously found that in some contexts, vitamin C can have beneficial effects on blood pressure, infections, bronchoconstriction, atrial fibrillation, and acute kidney injury. However, the practical significance of these effects is not clear. The purpose of this meta-analysis was to evaluate whether vitamin C has an effect on the practical outcomes: length of stay in the intensive care unit (ICU) and duration of mechanical ventilation. We identified 18 relevant controlled trials with a total of 2004 patients, 13 of which investigated patients undergoing elective cardiac surgery. We carried out the meta-analysis using the inverse variance, fixed effect options, using the ratio of means scale. In 12 trials with 1766 patients, vitamin C reduced the length of ICU stay on average by 7.8% (95% CI: 4.2% to 11.2%; p = 0.00003). In six trials, orally administered vitamin C in doses of 1?3 g/day (weighted mean 2.0 g/day) reduced the length of ICU stay by 8.6% (p = 0.003). In three trials in which patients needed mechanical ventilation for over 24 hours, vitamin C shortened the duration of mechanical ventilation by 18.2% (95% CI 7.7% to 27%; p = 0.001). Given the insignificant cost of vitamin C, even an 8% reduction in ICU stay is worth exploring. The effects of vitamin C on ICU patients should be investigated in more detail.

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2.11.. Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients-Review and Pragmatic Approach.

 

Hill A, Wendt S, Benstoem C

https://www.ncbi.nlm.nih.gov/pubmed/30060468

 

The pleiotropic biochemical and antioxidant functions of vitamin C have sparked recent interest in its application in intensive care. Vitamin C protects important organ systems (cardiovascular, neurologic and renal systems) during inflammation and oxidative stress. It also influences coagulation and inflammation; its application might prevent organ damage. The current evidence of vitamin C's effect on pathophysiological reactions during various acute stress events (such as sepsis, shock, trauma, burn and ischemia-reperfusion injury) questions whether the application of vitamin C might be especially beneficial for cardiac surgery patients who are routinely exposed to ischemia/reperfusion and subsequent inflammation, systematically affecting different organ systems. This review covers current knowledge about the role of vitamin C in cardiac surgery patients with focus on its influence on organ dysfunctions. The relationships between vitamin C and clinical health outcomes are reviewed with special emphasis on its application in cardiac surgery. Additionally, this review pragmatically discusses evidence on the administration of vitamin C in every day clinical practice, tackling the issues of safety, monitoring, dosage, and appropriate application strategy.

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2.12.. About High-Dose Vitamin C from U.S. National Cancer Institute

https://www.cancer.gov/about-cancer/treatment/cam/patient/vitamin-c-pdq

 

Vitamin C is a nutrient found in food and dietary supplements. It is an antioxidant and also plays a key role in making collagen.

 

 

High-dose vitamin C may be taken by mouth or given by an intravenous (IV) infusion (through a vein into the bloodstream). When taken by IV infusion, vitamin C can reach higher levels in the blood than when the same amount is taken by mouth.

 

 

Some studies of IV high-dose vitamin C in patients with cancer have shown improved quality of life, as well as fewer side effects.

 

 

In general, high-dose vitamin C given by IV has caused very few side effects in clinical trials. However, IV vitamin C may cause serious side effects in patients with kidney disease, G6PD deficiency, or hemochromatosis.

 

 

The U.S. Food and Drug Administration (FDA) has not approved the use of IV high-dose vitamin C as a treatment for cancer .

 

 

Questions and Answers About High-Dose Vitamin C

 

 

What is high-dose vitamin C?

 

 

Vitamin C is a nutrient that is found in food, such as oranges, grapefruit, papaya, peppers, and kale, or in dietary supplements. Vitamin C is an antioxidant and helps prevent damage to cells caused by free radicals. It also works with enzymes to play a key role in making collagen. Vitamin C is also called L-ascorbic acid or ascorbate.

 

 

How is high-dose vitamin C given or taken?

 

 

Vitamin C may be given by IV infusion or taken by mouth. Much higher blood levels are reached when vitamin C is given intravenously. When given by intravenous (IV) infusion, vitamin C can reach higher levels in the blood than when it is taken by mouth.

 

 

Have any laboratory or animal studies been done using high-dose vitamin C?

 

 

In laboratory studies, tumor cells are used to test a substance to find out if it is likely to have any anticancer effects. In animal studies, tests are done to see if a drug, procedure, or treatment is safe and effective. Laboratory and animal studies are done in animals before a substance is tested in people.

 

 

Laboratory and animal studies have tested the effects of high-dose vitamin C. Laboratory studies suggest that high levels of vitamin C may kill cancer cells. See the Laboratory/Animal/Preclinical Studies section of the health professional version of High-Dose Vitamin C for information on laboratory and animal studies done using high-dose vitamin C.

 

 

Have any studies of high-dose vitamin C been done in people?

 

 

Several studies of high-dose vitamin C given alone or in combination with other drugs in patients with cancer include the following:

 

 

Studies of IV vitamin C alone

 

 

Two studies found that patients who received IV vitamin C had better quality of life and fewer side effects than those who did not. In a study of healthy volunteers and cancer patients, vitamin C was shown to be safe at doses up to 1.5 g/kg in patients who do not have kidney stones, other kidney diseases, or G6PD deficiency. Studies have also shown that vitamin C levels in the blood are higher when given by IV than when taken by mouth, and last for more than 4 hours.

 

 

Studies of IV vitamin C combined with other drugs

 

 

Studies of IV vitamin C combined with other drugs have shown mixed results.

 

 

In a small study of 14 patients with advanced pancreatic cancer, IV vitamin C was given along with chemotherapy and targeted therapy (erlotinib). Five patients did not complete the treatment because the tumor continued to grow during treatment. The nine patients who completed the treatment had stable disease as shown by imaging studies. Patients had very few side effects from the vitamin C treatment.

 

 

In another small study of 9 patients with advanced pancreatic cancer, patients were given chemotherapy once a week for 3 weeks along with IV vitamin C twice a week for 4 weeks during each treatment cycle. The disease did not progress over an average of 6 months in these patients. No serious side effects were reported with the combined treatment.

 

 

In a 2014 study of 27 patients with advanced ovarian cancer, chemotherapy alone was compared with chemotherapy and IV vitamin C. IV vitamin C was given during chemotherapy and for 6 months after chemotherapy ended. Patients who received IV vitamin C had fewer side effects from the chemotherapy.

 

 

Patients with refractory metastatic colorectal cancer or metastatic melanoma were treated with IV vitamin C combined with other drugs. The treatment had no anticancer effect, the tumor continued to grow during treatment, and patients had serious side effects. These studies did not have a comparison group, so it is unclear how much the IV vitamin C affected the side effects.

 

 

Patients with non-small cell lung cancer or glioblastoma multiforme in two pilot trials were given standard therapy plus IV vitamin C. Patients had better overall survival and fewer side effects compared to the control groups.

 

 

More studies of combining IV high-dose vitamin C with other drugs are being done. These include a number of clinical trials combining IV vitamin C with arsenic trioxide, showing mixed results.

 

 

Have any side effects or risks been reported from high-dose vitamin C?

 

 

IV high-dose vitamin C has caused very few side effects in clinical trials. However, high-dose vitamin C may be harmful in patients with certain risk factors. In patients with a history of kidney disease, kidney failure has been reported after treatment with high-dose vitamin C. Patients who are likely to develop kidney stones should not be treated with high-dose vitamin C.

 

 

Case reports have shown that patients with an inherited disorder called G6PD deficiency should not be given high doses of vitamin C, because it may cause hemolysis (a condition in which red blood cells are destroyed).

 

 

Because vitamin C may make iron more easily absorbed and used by the body, high doses of vitamin C are not recommended for patients with hemochromatosis (a condition in which the body takes up and stores more iron than it needs).

 

 

Have any drug interactions been reported from adding high-dose vitamin C to treatment with anticancer drugs?

 

 

A drug interaction is a change in the way a drug acts in the body when taken with certain other drugs. When high-dose vitamin C is combined with certain anticancer drugs, the anticancer drugs may not work as well. So far, these effects have been seen only in some laboratory and animal studies. See the Adverse Effects section of the health professional version of High-Dose Vitamin C for information on drug interactions while using high-dose vitamin C.

 

 

Is high-dose vitamin C approved by the U.S. Food and Drug Administration for use as a cancer treatment in the United States?

 

The U.S. Food and Drug Administration (FDA) has not approved the use of high-dose vitamin C as a treatment for cancer. The FDA does not approve dietary supplements as safe or effective before they are sold. The company that makes the dietary supplements is responsible for making sure they are safe and that the claims on the label are true and do not mislead the consumer. The way that supplements are made is not regulated, so all batches and brands of high-dose vitamin C may not be the same.

 

There were other proofs also.

 

July 26, 1941, Raymond Young at University of Maryland publishes article Action of Intestinal Microörganisms on Ascorbic Acid indicates that in 1936 a patient of hemorrhagic scurvy did not respond to a diet rich in vitamin C; however, upon intramuscular injection of a solution of the vitamin, the patient recovered rapidly. The case suggests that bacterial destruction of ascorbic acid in the gastro-intestinal tract before absorption can take place.

 

The cured case in 80 years ago suggested that supplementing vitamin C with food alone is not enough and additional adding is exactly necessary, especially when patient is in illness.

 

The synthetic drugs of Western medicine have been staged game of marketing – killing - delisting, Chinese medicine has also the records of poisoning, but the death caused by vitamin C was zero according to American Association of Poison Control Centers.

 

Vitamin C is a statutory diet supplement by the FDA, the EU, and Canada, and it is free to eat and sell like food. In fact, Chinese medicine has same miraculous effect as vitamin C, and is also a diet supplement legalized by the FDA, the EU and Canada. In the treatment of SARS patients in 2003, the treatment by pure Chinese medicine did not have death and sequelae.

 

3.. Vitamin B3:

 

3.1.. The LD 50 of B3

 

The LD 50 is 4.5 grams/kilo. This is equivalent to 225 grams for a 50 kg people; which is approximately 100 times as much as is normally recommended.

 

3.2.. The Positive Side Effects of B3

 

From the webpage of Orthomolecular Vitamin

 

If a person takes niacin to normalize blood lipids and as a result of the vitamin activity feels very much better in other areas such as more energy, faster healing, etc, this is a positive side effect. There are other positive side effects that often occur. For example if the person takes niacin to deal with his arthritis and at the same time his cholesterol levels decease, this result would be a major positive side effect or, better still, side benefit. Niacin lowers C-reactive protein. This is one of the markers of inflammation. The statins also lower CRP, but in contrast to the statins, niacin is not toxic.

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3.3.. Vitamin B3 May Help Kill Superbugs

 

https://www.medicalnewstoday.com/articles/249511.php#1

 

“Nicotinamide, commonly known as vitamin B3, may help the innate immune system kill antibiotic-resistant staph bacteria, the so-called "superbugs". In lab work done with mice and human blood, researchers found high doses of the vitamin increased the ability of immune cells to kill the bacteria by 1,000 times.”

 

 

The article did not provide the exact number of the “high doses of the vitamin”. On Jan. 26, 2020, at 1:44 PM, I wrote on the webpage of one of the writers:

 

 

?“Dear George Y. Liu, I want to know the exact dosage of B3 in the test of. The paper was too academic to be understood. I would like to get suggestions about the treatment of 2019 new coronavirus, which vitamins will be effective with the dosage and clinical effects. Thank you very much, Frank from Canada.”

 

 

Replied in Jan. 26, 2020, 18:56

 

 

Hi Frank, We do not have any data suggesting that vitamin B3 can be effective against coronavirus unfortunately.  It is not expected to be effective against viruses.

 

 

Jan. 26, 202, I replied with that: “Thanks for kind reply, but, only the dosage of B3 in your test will be fine.”

Until now, I did not get reply.

 

3.4.. The systematic report on B3 in Linus Pauling Institute, Oregon State University

 

https://lpi.oregonstate.edu/mic/vitamins/niacin#toxicity

3.5.. Myself test of the process of B3 taking effect

it said that the side effects of B3 are itching and redness of the skin. There are reports describing turning whites into Indian celebrities. In order to verify its safety tolerance, on Jan. 25, 2020, I bought a bottle of B-3 (Niacin), see the photo. I took 500mg x 2 in one time.

 

                     

 

12:10, Orally took 500mg x 2with water.

12:27, I started to feel a slight hot and itching ...

12:38, Face, forehead, back of neck, outside of arms, were obviously hot, itchy ...

12:48, My thighs were hot and itching. There was a desire to scratch the outside of the arms.

12:50, I start to scratch the back, both sides of the belly. My thighs were obvious hot, itchy, and swollen.

13:05, The hot and itching begin to subside.

14:05, I still have the feeling of hot and itchy.

15:39, The skin of thighs and calves seems to be in slightly overheated water.

17:19, The skin of thighs and calves still felt hot, and the face was hot.

19:01, Only the face was hot, no itching all over the body.

The overall feeling was warm, itchy and was bearable.

Thanks B-3.

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4.. Vitamin D

The LD50 oral in rat of vitamin D (or D3) is 42 mg/kg, and 50 kg of body weight is 2100 mg. 

1000 IU is 25 mcg = 0.025 mg, and 10,000 IU is 250 mcg, which is 0.25 mg.

https://www.chemicalbook.com/ChemicalProductProperty_CN_CB6104867.htm

4.1.. Vitamin D for influenza

Jun, 2015, Vitamin D for influenza

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463890/

A colleague of mine and I have introduced vitamin D at doses that have achieved greater than 100 nmol/L in most of our patients for the past number of years, and we now see very few patients in our clinics with the flu or influenzalike illness. In those patients who do have influenza, we have treated them with the vitamin D hammer, as coined by my colleague. This is a 1-time 50 000 IU (1.25 mg) dose of vitamin D3 or 10 000 IU 3 times daily for 2 to 3 days. The results are dramatic, with complete resolution of symptoms in 48 to 72 hours. One-time doses of vitamin D at this level have been used safely and have never been shown to be toxic.8 We urgently need a study of this intervention. The cost of vitamin D is about a penny for 1000 IU, so this treatment costs less than a dollar.

4.2.. Vitamin D, Essential Minerals, and Toxic Elements: Exploring Interactions between Nutrients and Toxicants in Clinical Medicine.

https://www.ncbi.nlm.nih.gov/pubmed/26347061

Schwalfenberg GK1, Genuis SJ2.

1..Department of Family Medicine, University of Alberta, No. 301, 9509-156 Street, Edmonton, AB, Canada T5P 4J5.

2..Department of Medicine, University of Calgary, 2935-66 Street, Edmonton, AB, Canada T6K 4C1.

Scientific World Journal. 2015; 2015 Jul 29.

Abstract

 

In clinical medicine, increasing attention is being directed towards the important areas of nutritional biochemistry and toxicant bioaccumulation as they relate to human health and chronic disease. Optimal nutritional status, including healthy levels of vitamin D and essential minerals, is requisite for proper physiological function; conversely, accrual of toxic elements has the potential to impair normal physiology. It is evident that vitamin D intake can facilitate the absorption and assimilation of essential inorganic elements (such as calcium, magnesium, copper, zinc, iron, and selenium) but also the uptake of toxic elements (such as lead, arsenic, aluminum, cobalt, and strontium). Furthermore, sufficiency of essential minerals appears to resist the uptake of toxic metals. This paper explores the literature to determine a suitable clinical approach with regard to vitamin D and essential mineral intake to achieve optimal biological function and to avoid harm in order to prevent and overcome illness. It appears preferable to secure essential mineral status in conjunction with adequate vitamin D, as intake of vitamin D in the absence of mineral sufficiency may result in facilitation of toxic element absorption with potential adverse clinical outcomes.

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5.. Honey is a combo of the natural medicinals with broader range of therapeutic effect

April 2017, article Honey and Health: A Review of Recent Clinical Research said that: “Honey used by humans since 5500 years ago. Modern studies show that it has therapeutic role in the treatment of disease by phytochemical, anti-inflammatory, antimicrobial, and antioxidant properties with several health-beneficial effects including antioxidant, anti-inflammatory, antibacterial, antidiabetic, respiratory, gastrointestinal, cardiovascular, and nervous system protective effects. Traditionally, honey is used in the treatment of eye diseases, bronchial asthma, throat infections, tuberculosis, thirst, hiccups, fatigue, dizziness, hepatitis, constipation, worm infestation, piles, eczema, healing of ulcers, and wounds and used as a nutritious supplement. The ingredients of honey have been reported to exert antioxidant, antimicrobial, anti-inflammatory, antiproliferative, anticancer, and antimetastatic effects.”

“The extensive pharmacological functions of honey come from a wide range of bioactive ingredients.”

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6.. Melatonin can improve health by optimizing the composition of the gut microbiota

 

The new finding of Gut–brain axis triggered the updating of medical Philosophy from Reductionism to Holism with the revolution in the way of diseases treatment, such as, nutritional psychiatry will be the future of mental health treatment.

 

Melatonin not only can improve sleep, but also have broader physiological functions

 

May 08, 2020, the clinical Psychologist of the American Board of Sleep Medicine, Michael J Breus Ph.D. reviewed the recent studies about melatonin in article Could Melatonin Help Protect Against COVID-19? I excerpt as below.

 

Melatonin is not a sedative; instead, melatonin regulates sleep through its influence over the body’s bio clock and sleep-wake cycles. Besides that, Melatonin has broad spectrum of functions in the body from diabetes and heart disease to cancer and neurodegenerative disorders. The important functions are its work as an antioxidant and anti-inflammatory agent, and its ability to modulate immune activity. Studies show that Melatonin can suppress the action of the inflammasome NLRP3, counteract severe inflammatory responses, lower production of proinflammatory cytokines, lower infiltration of immune cells into lungs, and reduce lung tissue injury.

 

April 8, 2019, researchers at University of Ferrara, Ferrara, Italy published article Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care. I excerpt as below.

 

Melatonin has intrinsic properties, including high cell permeability, the ability to easily cross both the blood–brain and placenta barriers, and its role as an endogenous reservoir of free radical scavengers (with indirect extra activities), confer it beneficial uses as an adjuvant in the biomedical field. Melatonin can exert its effects by acting through specific cellular receptors on the plasma membrane, similar to other hormones, or through receptor-independent mechanisms that involve complex molecular cross talk with other players.

 

There is increasing evidence regarding the extraordinary beneficial effects of melatonin, also via exogenous administration. Melatonin is a ubiquitous molecule with natural and powerful antioxidant proprieties and administration of exogenous melatonin is safe. Melatonin exerts anti-inflammatory effects mainly by inhibiting inflammasome activation. Melatonin exerts its antiapoptotic activities mainly by blocking caspase 3 cleavage and mPTP opening.

 

Now, from above reports, we can easily understand the significant effect of Melatonin is that it can effectively suppress the cytokine storm that causes death with bodily suicidal nature. It is the most terrible killer at the time when the patient’s physical condition is in full of hope.

 

Melatonin can influence the immune and nervous systems

 

Studies show that Gut microbiota regulates intestinal function and health. Mounting evidence indicates that they can also influence the immune and nervous systems and vice versa. Studies proved that human digestive system - Gut is second brain in producing 95% of Serotonin, neurons and most neurotransmitters, which means that we can treat diseases by improving Gut-microbiome.

 

Some medical experts have revolutionarily suggested that Nutrition Psychiatry is the future of mental health treatment; which means that any diets or medicinals that can improve human Gut-microbiome or intestinal flora can be used as medication to cure Covid-19 infections and other diseases.

 

July 2015, the Lancet Psychiatry published article Nutritional medicine as mainstream in psychiatry with a summary: “Psychiatry is at an important juncture, with the current pharmacologically focused model having achieved modest benefits in addressing the burden of poor mental health worldwide. Although the determinants of mental health are complex, the emerging and compelling evidence for nutrition as a crucial factor in the high prevalence and incidence of mental disorders suggests that diet is as important to psychiatry as it is to cardiology, endocrinology, and gastroenterology.”

 

“Evidence is steadily growing for the relation between dietary quality (and potential nutritional deficiencies) and mental health, and for the select use of nutrient-based supplements to address deficiencies, or as monotherapies or augmentation therapies. We present a viewpoint from an international collaboration of academics (members of the International Society for Nutritional Psychiatry Research), in which we provide a context and overview of the current evidence in this emerging field of research, and discuss the future direction. We advocate recognition of diet and nutrition as central determinants of both physical and mental health.”

 

Sept 2020, the researchers in the Chinese University of Hong Kong published study report Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization. They found the persistent alterations in the fecal microbiome of Covid-19 patients compared with controls. Fecal microbiota alterations were associated with fecal levels of the COVID-19 severity. The findings revealed the decisive role of the Gut Microbiota in the recovery of covid-19 infections.

 

Melatonin can improve health by optimizing the composition of the gut microbiota

 

Studies show that Gut microbiota regulates intestinal function and health. Mounting evidence indicates that they can also influence the immune and nervous systems and vice versa. Studies proved that human digestive system - Gut is second brain in producing 95% of Serotonin, neurons and most neurotransmitters, which means that we can treat diseases by improving Gut-microbiome.

 

Some medical experts have revolutionarily suggested that Nutrition Psychiatry is the future of mental health treatment; which means that any diets or medicinals that can improve human Gut-microbiome or intestinal flora can be used as medication to cure Covid-19 infections and other diseases.

 

July 2015, the Lancet Psychiatry published article Nutritional medicine as mainstream in psychiatry with a summary: “Psychiatry is at an important juncture, with the current pharmacologically focused model having achieved modest benefits in addressing the burden of poor mental health worldwide. Although the determinants of mental health are complex, the emerging and compelling evidence for nutrition as a crucial factor in the high prevalence and incidence of mental disorders suggests that diet is as important to psychiatry as it is to cardiology, endocrinology, and gastroenterology.”

 

“Evidence is steadily growing for the relation between dietary quality (and potential nutritional deficiencies) and mental health, and for the select use of nutrient-based supplements to address deficiencies, or as monotherapies or augmentation therapies. We present a viewpoint from an international collaboration of academics (members of the International Society for Nutritional Psychiatry Research), in which we provide a context and overview of the current evidence in this emerging field of research, and discuss the future direction. We advocate recognition of diet and nutrition as central determinants of both physical and mental health.”

 

Sept 2020, the researchers in the Chinese University of Hong Kong published study report Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization. They found the persistent alterations in the fecal microbiome of Covid-19 patients compared with controls. Fecal microbiota alterations were associated with fecal levels of the COVID-19 severity. The findings revealed the decisive role of the Gut Microbiota in the recovery of covid-19 infections.

 

Melatonin prevents obesity through modulation of gut microbiota in mice

 

Feb. 15, study report Melatonin prevents obesity through modulation of gut microbiota in mice: “Recent evidence demonstrates that gut microbiota dysbiosis contributes to obesity and its comorbidities. The body weight‐reducing and energy balancing effects of melatonin have been reported in several studies, but to date, no investigations toward examining whether the beneficial effects of melatonin are associated with gut microbiota have been carried out. In this study, we show that melatonin reduces body weight, liver steatosis, and low‐grade inflammation as well as improving insulin resistance in high fat diet (HFD)‐fed mice. High‐throughput pyrosequencing of the 16S rRNA demonstrated that melatonin treatment significantly changed the composition of the gut microbiota in mice fed an HFD. The richness and diversity of gut microbiota were notably decreased by melatonin. HFD feeding altered 69 operational taxonomic units (OTUs) compare with a normal chow diet (NCD) group, and melatonin supplementation reversed 14 OTUs to the same configuration than those present in the NCD group, thereby impacting various functions, in particular through its ability to decrease the Firmicutes‐to‐Bacteroidetes ratio and increase the abundance of mucin‐degrading bacteria Akkermansia, which is associated with healthy mucosa. Taken together, our results suggest that melatonin may be used as a probiotic agent to reverse HFD‐induced gut microbiota dysbiosis and help us to gain a better understanding of the mechanisms governing the various melatonin beneficial effects.”

 

Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: A therapeutic target to reduce intestinal inflammation

 

Aug. 17, 2019, Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: A therapeutic target to reduce intestinal inflammation

https://onlinelibrary.wiley.com/doi/abs/10.1002/med.21628

 

 

Nowadays, melatonin, previously considered only as a pharmaceutical product for rhythm regulation and sleep aiding, has shown its potential as a co‐adjuvant treatment in intestinal diseases, however, its mechanism is still not very clear. A firm connection between melatonin at a physiologically relevant concentration and the gut microbiota and inflammation has recently established. Herein, we summarize their crosstalk and focus on four novelties. First, how melatonin is synthesized and degraded in the gut and exerts potentially diverse phenotypic effects through its diverse metabolites. Second, how melatonin mediates the activation and proliferation of intestinal mucosal immune cells with paracrine and autocrine properties. By modulating T/B cells, mast cells, macrophages and dendritic cells, melatonin immunomodulatory involved in regulating T‐cell differentiation, intervening T/B cell interaction and attenuating the production of pro‐inflammatory factors, achieving its antioxidant action via specific receptors. Third, how melatonin exerts antimicrobial action and modulates microbial components, such as lipopolysaccharide, amyloid‐β peptides via nuclear factor κ‐light‐chain‐enhancer of activated B cells (NF‐κB) or signal transducers and activators of transcription (STAT1) pathway to modulate intestinal immune function in immune‐pineal axis. The last, how melatonin mediates the effect of intestinal bacterial activity signals on the body rhythm system through the NF‐κB pathway and influences the mucosal epithelium oscillation via clock gene expression. These processes are achieved at mitochondrial and nuclear levels to control the host immune cell development. Considering unclear mechanisms and undiscovered actions of melatonin in gut‐microbiome‐immune axis, it's time to reveal them and provide new insight for the outlook of melatonin as a potential therapeutic target in the treatment and management of intestinal diseases.

 

7.. Chinese medicine and its philosophy

 

 

7.1.. A brief introduction of Chinese medicine

 

 

Traditional Chinese Medicine (TCM) is an accumulation of the experiences of medical practices in Far East China. Because it was initiated from primitive Era in thousands years ago, so there were no concepts and terms of modern anatomy and biology, its medical descriptions were using the terms and the principle of its philosophy - Daoism. Therefore, for the people who were educated with modern Western medicine, it is difficult to understand and to have caused the sense of mystery even misunderstood as sorcery.

 

Jan. 2019, the Magazine of The Future of Medicine of National Geographic Society, published article How ancient remedies are changing modern medicine with a subtitle Long overlooked by Western science, traditional Chinese treatments are yielding cutting-edge cures, said that: “Few subjects ignite more heated debate in health circles than traditional Chinese medicine. It’s further complicated by the work of researchers like Iaizzo and many others who are looking at traditional cures through the lens of cutting-edge science and finding some interesting surprises—surprises that could have profound impacts on modern medicine. Cultures from the Arctic to the Amazon and Siberia to the South Pacific have developed their own medicine chests of traditional cures. But China, with one of the oldest continuous accumulations of documented medical observations, offers the biggest trove for scientists to sift through.”

 

“The Chinese record dates back to the third century B.C., when healers began analyzing the body, interpreting its functions, and describing its reactions to various treatments, including herbal remedies, massage, and acupuncture. For more than 2,200 years, generations of scholars added to and refined the knowledge. The result is a canon of literature dealing with every sort of health problem, including the common cold, venereal disease, paralysis, and epilepsy. This knowledge is contained in books and manuscripts bearing such enigmatic titles as The Pulse Classic (third century), Prescriptions Worth a Thousand Pieces of Gold (seventh century), and Essential Secrets From Outside the Metropolis (eighth century).”

 

Modern studies have unknowingly and indirectly proven that TCM was the best medical system world widely so far in compared with that of those existences, especially Western Medicine (WM).

 

Here I try to use the terms of western medical terminology such as modern biology and pharmacology to crack down the mystery through introducing the basic principle of its philosophy - Daoism, modern researches, and therapeutic mechanism of TCM. Thereby convince people to enjoy the ancient civilization willingly.

 

Thus, many incurable diseases will be curable, especially, the degenerative diseases that have no pathogenic origin, and the cost on the medications will largely lower down socially. More significantly, we can radically reduce the pressure of the working-class in health care by helping them self-help in diseases-treating and health keeping with affordable natural Chinese medicinals; thereby get rid of fully relying on the troublesome hospitals and synthetic medications to live a happier life with lesser burden on economy and psychology on health care.

 

WM has been taking Reductionism as philosophical guidance, it looks human body as an assembly of parts, and tries to study and diagnose diseases through the isolated part by reducing human body as micro as protein, gene and even peptides and treating diseases by looking for killing.

 

However, because human body is a complex system that various organs are closely interconnected with interdependent and interacting, there may be many unpredictable factors in affecting the development of diseases, especially the psychological factors. Many objective facts have proven that the medical route under the guidance of Reductionism is not sustainable feasibly. It is very disappointed but is a corollary under the misleading of Reductionism and irrational commercialization.

 

In as much Reductionism cannot work well, we should introduce new philosophy into medical system. The hopeful one is Holism – a philosophy that macro-views human body as whole, and considers all the affecting factors, including psychology. However, “There Are Two Sides to Everything.” Compared with Reductionism, Holism is too macro that may induce to ignore the factors of micro. Therefore, the best way is to combined use them to make up the disadvantages by the advantages of each other’s, and avoid their disadvantages. Thereby we can get rid of the current predicament in Western medicine. However, distant water cannot solve the immediate thirsty. We need to find another way out.

 

There are many experience-based therapies have been developed and accumulated in the populace’s daily life with the advantages of effective, safe, handy, cheaper, and easy to use. They are good resources for developing alternative therapies. Among them, TCM is outstanding.

 

TCM has been developing under the guidance of Daoism - an ancient philosophy of China.

 

Daoism is contrary with Reductionism. It is similar with Holism and consistent with systems biology. Suppose that Reductionism focuses on a specific grass on the Himalayas, and then the Daoism is not only focusing on the entire grass, but also concerning those fators that would affect the growth of grass, such as, destructive pests, the greenhouse effect and the reduction of glacier cover, etc.

 

Under the guidance of Daoism, human life has been viewing taken as one of such a component of unity of opposites. It believes that human body is an organic whole that all components are closely interacted. A well-balanced human bodies will form an effective self-defence system that can handle the most of pathogenic agents. The diseases could happen only if there are some unbalanced parts in a human body. The treatments do not directly target to kill pathogenic but to bring back the natural balance. It achieves the purpose by natural therapeutic approaches, such as, natural drugs, acupuncture and physical exercises, etc.

 

Compared with Western medicine, TCM was believed as most primitive, most unscientific, and most unreliable. However, many modern researches have inadvertently proven the outstanding of TCM. Its holistic perspective with emphasizing the decisive role of psychological factors on the development of diseases is most rational and scientific.

 

Until last century, in west medicine, the study on the relation of psychology and human health is activated.

 

Such as, Henry K. Beecher’s The Powerful Placebo (1955), George Engel’s Biopsychosocial model (1977), the crossing disciplines research proved that Stress Causes Everything (2008), Ohio State University’s Socially active environment can cause cancer tumors to shrink and even disappear (2010) and British Man with 'Locked-in' syndrome makes amazing recovery by his will for survival (2010), etc. Those findings clearly indicated that, for most diseases, negative psychological plays inducement effect and positive psychological has therapeutic effect.

 

On this point, TCM is much admirable. In thousand years ago, TCM practitioners have found the similar fact that diseases treatment is seven-tenths in psychotherapy and only three-tenths in medication. Suppose we take the placebo effect as a kind of psychotherapy, then the proportion of seven-tenths in psychotherapy is close to the modern scientific statistics from the double-blind clinical trials, which was “placebos are effective in 50 or 60 percent of subjects with certain conditions.” And “some researchers maintain that there is not adequate evidence from studies to prove that the new (antipsychotic) drugs are more effective than placebos.”

 

The emergence of system biology is showing that Western medicine is starting to step toward the Holistic way with enlarging the scope of medical analysis. Essentially says, it was that Western medicine is from philosophical root turning its heads toward the ancient holistic medical approach of TCM after its hitting on the wall.

 

TCM has developed unique methods in diseases diagnosis and treatment by natural ways, such as Pulse diagnosis, Tongue diagnosis, Acupuncture, Massage, especially a large number choice of natural drugs. According to the statistic of national investigation of mainland China in the 80's of 20th century, there are 11,146 plants, 1581 animals and 80 minerals as medicinal using. The <Dictionary of Traditional Chinese Medicine Prescription> selected nearly 100 thousands of experience-based formulas from prescriptions of TCM since there are written records in the history of China, which covering almost all known diseases. Thanks the scientists of China, they have made many useful modern researches on Chinese medicinals by emulating the methods of western medicine, and to have had those experience-based formulas updated and produced great many OCT drugs in the forms of convenient for using. Such as, injections and sugar covered tablets with the labels of providing treated-ranges, precautions and dosages.

 

The medicinal materials (natural drugs) used in TCM are all from nature. Modern studies from the level of molecular, protein and gene found those natural drugs containing a wide range of bioactive constituents. Some of them have therapeutic effect that is similar to that of synthetic ones in killing the pathogenic agents directly, and some of them have nutritional effect that is similar to that of orthomolecular medicine. For ill-debilitated patients, nutrition is even more important than that of drugs. I think that this is the unique advantages of natural drugs, and also it is the unique advantages of TCM.

 

Modern researches revealed that some of Chinese medicinals can improve human immunity, such as, boosting the weight gains of immune organs, increasing the number and activity of the phagocytes, NK cells and so on. Therefore, in subjective viewing, TCM is to regulate the physical balance, but in objective practicing, the process of the regulations plays a role of improving the immune function, then the pathogenic agents to be killed by enhanced immune system.

 

Although, in TCM there are no concepts of modern immunology, such as, immune organs or immune cells, the experience-based formulas were never to have considered on immunity, however, some of preparations by those formulas are playing the therapeutic role through enhancing human immunity. More significant is that when the physical balance of patient is restored, the most of uncomfortable symptoms of patient would be largely improved, such as, poor appetite, angst and insomnia, patient would feel much better not only in physical but also in psychological. Indeed, the physical improvement also plays the role of psychotherapy. The recovery of the diseases can certainly be accelerated.

 

The compound prescription is unique therapeutic method of TCM, which is to put many different natural drugs together as one dose. Studies have proved that drugs in compound using are able to generate synergy effect of multiplying the positive effect of each other. The findings revealed the mystery that preparations by experience-based formulas of TCM are more effective on some specific diseases and provided clear guidance for selecting effective natural drugs aiming on specific pathogenic.

 

This is the reason that, in my hand, Chinese natural drugs seem to have gained magic in treating some thorny diseases, such as, Schizophrenia, fat liquefaction of incision and so on. Chinese medicinals will be a powerful therapeutic approach on the diseases both communicable and non-communicable, which not satisfied by the treatment of synthetic drugs. Clearly, Chinese medicine is promising resource in developing new therapeutic approaches both drugs and therapies. Also it has huge market potential.

 

However, since that TCM is accumulation of the experiences from medical practices started in thousands years ago, there are no concepts and terms of modern anatomy and biology. The medical descriptions of TCM are using the terms and the principle of its philosophy - Daoism, such as, Yin & Yang, and cold & Hot. The diagnosis and the treatment of diseases are from this philosophical perspective to regulate the balance of the unity of opposites. It is very different with that of Western Medicine (WM) that is only focusing on the specific ill organ or pathogenic. As the same way, Chinese medicinals are sorted and used to restore the physical balance of human body rather than focusing on any ill organ or pathogenic. Therefore, it can not be easily understood according to the way of WM.

 

Due to there is no corresponding English words; it is difficult to directly translate TCM into English in accordance with its original meaning accurately. In addition, TCM are based on great many written records from different historical period spanning thousands of years, many of those records wrote in Classical Chinese even in Oracle bone script, which is similar to that of some thing written in Old English, they are not easy to be understood. So that the unique philosophy and therapeutic efficacy of TCM was not be well understood & applied as it should be.

 

Even so, I firmly believed that, with my articles of together, the medical vision of readers would unconsciously advance into a broader Holistic scope from that of Reductionism. The advancement of the philosophical approach would release huge medical potential that can help us to learn properly about our life physically and psychologically, thereby to help more people living healthier and happier by advancing the prevention and treatment of the diseases.

 

The holistic view on human life mainly embodied following areas:

 

Human beings self, people and people, people and society, and people and nature is all in the state of unity of opposites. They must maintain in harmonious balance, once occurs deviation, people would fall into ill, between the people would conflict, the human society would fall into disorder and the nature would punish humankind. Those thoughts play a directing role in the diseases treatment.

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7.1.1.. Emphasis on the restoration of physical balance

 

TCM believes that human body is an organic whole that all components are closely interacted. A well-balanced human bodies will form an effective self-defence system that can handle the most of pathogenic agents. The diseases could happen only if there are some unbalanced parts in a human body. The treatments do not directly target to kill pathogenics but to bring back the natural balance. It achieves the purpose by natural therapeutic approaches, such as, natural drugs, acupuncture and physical exercises, etc.

 

Jan. 12 2011, a report that H1N1 and other seasonal influenza swept France and caused many deaths. According to the experiences of China, if the treatment integrates with some Chinese medicinals to improve suffered symptoms of the patient holistically, the patients who fall into critical would be largely reduced. There is a simple method for rescuing critical patients. I will introduce it later.

 

Talking about the restoration of physical balance, we must make clear the physiological effect of nutritional ingredients in Chinese medicinals.

 

A good example is Orthomolecular medicine (OM). It was coined by Linus Paulin who was enlightened from the successful practice of Canadian doctors who cured mental illness by megadose Vitamin B3 after read the paper of that wrote by Bill Wilson, a Canadian Physician, in December 1965, that was A communication to A.A.’s Physicians, not for public quotation or use.

 

The OM was originally intended to treat the “mental disease by the provision of the optimal molecular environment of the mind, especially the optimal concentrations of substances normally present in the human body.” OM currently is called as diet supplements that have developed many products, such as, Vitamins, minerals and so on.

 

In TCM, there are variety of nutritional constituents that are far more than that of in OM, which come from more than 10 thousands of plants, minerals and animals, such as, Ginseng, Gypsum and Placenta. They are certainly playing a significant role in the diseases treatment, but their unique contribution seems to have been ignored both clinically and academically. The reason may come from the TCM itself because that it never distinguishes the medicinal and nutritional, even without the concepts and terms, they were generally called as medicine. 

 

In western medicine, Chinese medicinals generally called as alternative or diet supplements. I think that there is necessary to make a definition, such as, those with the effect of killing pathogenic agents should be called as medicinal, and those without the effect of killing pathogenic directly but with the role of physiological improvement should be called as nutritional, include those in Western medicine. A clear concept with a exact term will not only help clear describing, but also conducive to efficient thinking. The determination of a definition is difficult that need to be discussed carefully because of the ingredient of many single herbs is compound that contains both medicinal and nutritional. Even if a single constituent also has a dual role, such as, some peptide is nutritional but also an antibiotic. The nutritionals in Chinese medicinals is a promising medical potential to be an attractive research direction.

 

Acupuncture is a treatment method based on Meridian. Modern researches showed that it could stimulate the blood circulation in some certain area of body by acupuncture on some specific acupoints to achieve the therapeutic effect. Clinical practices show it work well on many diseases, such as, stroke, pain, etc.

 

There are many physical exercises methods in TCM for enhancing physical strength. The Taijiquan (Tai Chi Quan) is the one of them. Researches show that it can improve human immune function and treatment of many diseases. See articles: Benefits of Taijiquan Strongly Supported by Science. Comprehensive therapeutic benefits of Taiji: a critical review.

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7.1.2.. Emphasis on therapeutic effect of psychological factor

 

Modern researches have proven that human psychology acts as a double-edged sword that positive side can promote health with curative effect; negative side can damage the health with pathogenic effect. TCM has found the same fact in thousands years ago, and has indicated that the process of the disease treatment is seven-tenths in psychotherapy, only three-tenths in medication.

 

Such as, Henry K. Beecher’s The Powerful Placebo (1955), George Engel’s Biopsychosocial model (1977), the crossing disciplines research that Stress Causes Everything (2008), Ohio State University’s Socially active environment can cause cancer tumors to shrink and even disappear (2010) and British Man with 'Locked-in' syndrome makes amazing recovery by his will for life (2010), etc.

 

1955, H. K. Beecher published ." He indicated that there 35% of 1,082 patients were satisfactorily relieved by a placebo alone. “Other studies have since calculated the placebo effect as being even greater than Beecher claimed. For example, studies have shown that placebos are effective in 50 or 60 percent of subjects with certain conditions. It is close to that estimation of seven-tenths in psychotherapy of TCM.

 

1977, George Engel coined Biopsychosocial model: “a general model or approach that posits that biological, psychological (which entails thoughts, emotions, and behaviors), and social factors, all play a significant role in human functioning in the context of disease or illness. Indeed, health is best understood in terms of a combination of biological, psychological, and social factors rather than purely in biological terms.”

 

2008, a report that a research crossing the disciplines of psychology, medicine, neuroscience, and genetics revealed that “stress causes deterioration in everything from your gums to your heart and can make you more susceptible to everything from the common cold to cancer.” The results mean that psychology plays a decisive role in diseases inducement.

 

2010, the scientists in Ohio State University published <socially active environment can cause cancer tumors to shrink and even disappear>.They found that there were 5% cancer-infected mice’s tumors disappeared and 77% of them decreased the tumors’ volume by 43% only from living in an socially active environment for 3 weeks.

 

2010, a report that Mr.Graham who once paralyzed with Locked-in syndrome and medical staff have left him to die, but he never gave up the desire for life and firstly tried to move his toe by will and succeed in months later, then to move the finger and then he has stood up again. Actually, it was that the positive psychology cured the disease of Western medicine believed incurable.

 

If the idea of seven-tenths in psychotherapy and three-tenths in medication can be universalized the diagnosis and treatment of human diseases can be humanized greatly. More pleasant is that the positive psychology can create by the positive activities of social and physical. No doubt, it is a feasible self-help therapeutic approach with broad-spectrum feature. It is a true panacea that can be produced when we enjoying the life. It may be an only fair thing in the world, which can be shared by all people, no matter who is poor or rich, old or young.

 

In China, some doctors will use ingenious methods to adjust the patient's psychological state. For example, for those patients who diagnosed as serious diseases, they would not tell the truth to patient, but tell their families, thereby to avoid the psychological burden for patients. However, in the eyes of Western doctors, this thoughtful manner is cheating and immoral.

Chinese medicinals can improve overall physical strength of patients through improving appetite, sleep, and many other uncomfortable conditions, so that the psychological state of patient will be improved largely from the physiological root.

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7.1.3.. Emphasis on the disease prevention

 

Huang Di Nei Jing a most important medical book of TCM in two thousands years ago said that the highly skilled doctor treats the diseases before its outbreak and indicated that medication after disease’s outbreak is similar to dig the well when felt thirsty and to forge the sword when the fighting has started, it is too late. This means that we should rather focus on the diseases’ prevention than focus on the treatment. The idea has a practical significance in modern society.

 

TCM has developed many physical exercise methods for diseases prevention and treatment. Such as, Taijiquan (Tai Chi Quan) mentioned above.

 

Above are only rough examples. The Holistic view on human life in TCM is much comprehensive not only above three points. I raised them here are intended to arouse public boldly to find more effective natural therapeutic ways, just as that of ancient people of China.

 

Although, the trend of medical philosophical approach toward Holistic has been emerging in western medical field, such as, the development of system biology, FDA has accepted the idea of traditional Chinese medicine idea.[1] [2] in their drugs regulations, and some super drug makers have dug into CM. However, there are much improvement room for comprehending and applying the Holistic therapeutic principle of TCM.

 

In the current process of study and application of TCM, people are still trying to find the bioactive ingredients and apply them in single constituent to treat diseases clinically as doing with that of synthetic drugs. Essentially speaking, it is not get rid of the leash of Reductionism.

 

No doubt, that treat the diseases in purified constituent is a great progress by promoting the use of the natural medicinals accurately and safely. However, if the bioactive constituents are not being used in compound, it will lose the synergy effect, the therapeutic efficacy would be largely reduced. More worse is that may lose the advantage of eliminating the drugs’ negative effect from/by each other, there may be some side effects occurred as same as that of synthetic one. Such as, Tamiflu is extracted from star anise – a pure Chinese herb. It has showed serious inverse effect clinically.

 

By emulating the methods of Western medicine, scientists of China has done a lot of researches on Chinese medicine, and achieved many promising results. Although the most of individual study is one-sided, but when string those research results together, we would pleasantly find that the medicinal constituent, nutritional constituent and therapeutic effects of natural drugs are so extensive and effective. Even some single natural drug has broad spectrum of pharmacological effects because it is a compound of medicinal and nutritional. Later, you will share my feelings.

 

Evidence-based medicine (EBM) is a new trend developed in recent years. It “aims to apply the best available evidence gained from the scientific method to clinical decision making.” Some people say that experience-based medicine changes to the EBM are a profound revolution in clinical medicine of twenty-first century, and will be an inevitable trend. Those medical researches under the guidance of Reductionism, cells, proteins, genes and double-blind clinical trials, have made many people believes that kind of researches are real scientific and pure science, so the research results are reliable without any reason to doubt. Driven by this kind of superstitions, some people have begun to question the correctness of TCM, and said it is an experience-based medicine to have outdated, even there were people repeated the same old tune of appealing to abandon it in China recently.

 

In fact, TCM does not come from the magic fantasy. besides its medical description with the terms and principle of its Philosophy - Daoism, which are not easier to be understood; many of other parts are from a lot of therapeutic experiences of trial and error in long time massive clinical practice, which are similar to that of Western medicine from scientific studies experimentally. Some of the therapeutic experiences of TCM are reasonable and some may be not, which is similar to that of some synthetic drugs are effective and some killed people although they were all proven safe by so called scientific experiments and supported by the scientific data from strict double-blind clinical trial. More important is that those drugs are all to have approved by FDA. No one doubts that FDA is one of the most trusted authorities on the drug’s regulations. Its effective work has created a safer medical environment and increased the confidence of people on medicines. However, in view of some of their approved drugs have still killed people, we have reason to question that, are the FDA dereliction of duty or is medical philosophy improper to have lead the problem in medical methods?

 

Three-tenths in medication and seven-tenths in psychotherapy were simply estimated result according to the personal experience of ancient doctors of China. However, it is close to that of the scientific data from modern clinical practices. Modern scientific researches proved that those natural medicinal materials of TCM were sorted obvious scientific by unscientific primitive methods of seeing the color, smelling the smell, tonguing the tastes and clinical trials. For example, those were sorted as enhancing digestion are rich in Ca, Zn and Fe. Those were sorted as enhancing male sexual ability are rich in Mn and Cu. The therapeutic experiences got by primitive tools and methods under the guidance of the right philosophy are not worse, even better than that of got by expensive and sophisticated modern equipments with being considered as most scientific methods. The development of Medicine is for saving life, effective one is scientific and ineffective one is not scientific, no matter how it is made. We need to consider seriously that what the scientific is and what it is for.

 

Scientific has been using by some self-crowned master as a label to mark some thing correct or not. TCM is one of the victims. I think that, human civilization has evolved into today, even consumes whole lifetime, there is no one could learn through any discipline, I mean to make it clear entirely. No one could have enough knowledge to be a master or authority for declaring to abandon any fruit of human civilization, although in today's perspective, many of them may be not perfect.

 

There are two sides to everything. We must look at anything dialectically and practically to avoid going into a dogmatic dead end. We should not completely abandon the experience-based medicine when promote the evidence-based medicine, and vice versa. We should reserve the reasonable portion from every thing and use them integrated.

 

I must special point out that, due to the difference of physical and diet, when using the same natural drug, the physiological reactions may be different from people to people, especially for those who are in different ethnic groups or in different region. For some people are effective; some may be ineffective or even have side effects. We should pay serious attention before use them and study on it. It is better to increase the dose gradually to reach the level that recommended. Generally say that some of natural drugs have side effect, but it is much minor then that of synthetic ones or caused by improper use only.

 

There are reports that some Chinese medicinals contain heavy metals and pesticide residues. I think that compared with no drugs to use, the metals and pesticide may be not a serious concern, so that those drugs with problems should not be forbidden but give warning, use or not, leave the choice to patients.

 

For a long times, WM have been playing an important role in the prevention and treatment of diseases world widely. It qualified to be called as mainstream medicine. However, now it is unable to extricate itself from trouble quagmire.

 

Such as, for the infectious diseases, it has failed in updating the antibiotics due to that fast mutation of super bugs has shortened the effective life of antibiotics and caused increasingly high research spending. Now some drug-makers abandoned their research into antibiotics. For the non-communicable diseases, it is much disappointed since no satisfied drugs, too.

 

On other hand, the inverse effects of synthetic drugs have become the life fatal threat. Such as, Britain has issued a warning on more than 60 cough and cold medicines that can not be given to children after causing dozens of deaths. There was a report that Newer Antipsychotics Have Same Increased Risk of Sudden Cardiac Death as Older Ones. The drugs were developed for saving life rather than to kill life, however, as same as a lot of other things in the actual world, they are deviating from the will of kind-hearted people and are going farther.

 

Recent years, the system biology has been developed. It eliminated the deficiency of Holism and Reductionism by making up the gap between them. I called them as three medical philosophical brothers. Only the three works together, we can properly understand our body and the nature of development and recovery of the diseases. They have paved a new Medical Boulevard by forming an integrated medical philosophical system.

 

Here, I would like to make clear that, I promote the Holistic medical approach is intended to improve the balance of Philosophical approaches of Medicine by promoting the reasonable share that Holistic should take rather than to shoot Reductionism to die. When we are continuing to search human beings deepen into the microscopic, also we should take into account the macroscopic equally to understand human life comprehensively on physical, psychological and social. The thinges will develop in the opposite direction when they become extreme. It is not sensible that focuses on either extremely. I prefer the dialectical thought of Daoism in maintaining the balance between Yin and Yang universally. It has the value far beyond the medical issue. 

 

If it can be universalized, the world would have developed according to the will of kind-hearted people; there are more harmony and lesser conflict. It will never be worse like today, even the essential daily safe for life has been destroyed. The ghost of the barbaric killers of Colonial expansion era is still wandering with a new deceive cloak; the world will never have peace.

 

Because that deadly side effect of WM, more and more people are looking for the hope from alternative medicines. Among the existing alternatives, Chinese Medicine (CM) is receiving increasing attention and welcomed world widely. Now it is becoming the hope in helping us to get out of the dilemma in health care. The door is opened widely for CM.

 

There were cases that are worth to mention here for demonstrating the magical therapeutic effect of CM.

 

A 36 years old male psychotic who was more than 10 years maintained by 20 mg Zyprexa daily after first time onset and cured quickly at his 16, did nothing besides eating and sleeping emotionlessly. It was that my preparation of Chinese medicinals called back his emotion in days – talkative, listening music, curious-asking and willingly doing house works. He was sent to English language school after months due to his parents were bored by his endless curious-asking. Then he went to school everyday willingly alone, and he seemed to have restored the memory of his previously learned English because of his study progress showed as jumping. The result surprised me very much, although I believed some of Chinese medicinals in compound-use can work on psychotic, but I never expected that it took effect so quick. I’ll discuss the case detailed in another article.

 

Other one was happened on my younger brother who hipbone fractured in a car accident 10 years ago. After one week of operation there was still 50 mm unhealed on incision suture and happened fat liquefaction. Besides the replacement of medical gauze and adjustment of the intravenous antibiotics conventionally, the doctors could not give more help. I worried about the wound infection or necrosis, so I hammered some dried raw herbs into coarse powder, then sprinkling on the watering area without sterilization. After 3 hours when I curiously opened the gauze found that the unhealed incision has crusted entirely. The appearance showed that the crust formed much earlier than 3 hours. Now more than 10 years has past without any sequel. The only logical explanation for fast heeling is that Chinese medicinalshave updated the recognized wounds healing process.

 

The successful cases made me deeply believe the magic effect of CM and gave me a strong confidence to help more people to enjoy the medical fruit from the ancient oriental civilization according to my more then 3 decades studies and experiences of successful cases with selected and self-designed prescriptions of CM.

 

I would like to make some apologies here: 1. For those possible mistakes in the article. Because of my literary culture both mandarin and English is too poor to convey the original meaning properly. 2, For those lost the links of tracking original resources cited in my article. I am no mean to prettify myself by stealing the works of others. I only did some sorting works to make existing medical literatures to be easier enjoyable. I would like to salute to those researchers for their excellent works, no matter their work cited or not in my paper, no matter which country they came from. Thank you for your hard working and great contribution to the advances of human civilization.

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7.1.4.. The holistic view of life of TCM

 

It embodied that hunan body itself, human and nature, human and society, human and spirit is all unified whole and interacted each other.

 

TCM believes that human body is a unified whole, which is composed of tissues and organs that performs different functions, and they are organic links between each other. The components of constitute the human body are indivisible in the morphological structure, coordinated in the physiological function, interrelated in the metabolism and mutually affected in the pathological changes.

 

Man and nature is a unified whole. Human beings are the product of nature developed to a certain stage. Nature exist the necessary condition for human survival. The motion and changes of the natural world are bound to affect human.

People and society is a unified whole, and many social factors may be directly or indirectly influence on human psychology, physiology and pathology.

 

Human spirit and the body is a unified whole. Mental activity is the advanced activities of human. Physical is the foundation of spirit, and the spirit is the product of physical. In turn, mental activity can significantly impact on the physical.

 

7.1.5..Therapeutic Principle:

 

 “TCM has a macro view to most diseases: well-balanced human bodies can usually handle most everyday bacteria and virus, which are ubiquitous and quickly changing; diseases happens only if there are some unbalanced parts in a human body. Due to this macro philosophy, TCM usually does not care what exact bacteria or virus are causing the symptoms, but tries the best to find which parts of the body are unbalanced as well as to find a strategy to bring back the balance. At the meantime, TCM believes only symptoms matter because irregular symptoms from the human bodies are the only faithful sources to deduce the unbalanced parts in a dynamic, complex system like a human body. Consequently, the treatments in TCM do not directly target to kill bacteria or virus but to bring back the balance of human bodies. It is very surprising but understandable that a TCM doctor may give very different herb prescriptions to patients affected by a same type of bacteria, because the different symptoms from the patients indicate different unbalanced parts in their bodies”.

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7.1.6.. Diagnose Method:

 

Perhaps the biggest advantage of TCM is its diagnosis. Many diseases diagnosed by TCM can not diagnose out by WM. Many patients have felt significant discomfort, but the results of pathological analysis of WM show no signs of any disease.

 

The difference of TCM & WM:

 

In TCM the “Signs and symptoms are the first clinical indication when treating human diseases. Elimination of such signs and symptoms is the first priority in providing effective treatments. Any biomedical measurements relating to any diseases must be relevant to the signs and symptoms exhibited by any patient.”

 

“Western Medicine is not a perfect medical system. Its significance lies on its pathogenic theories. However, clinical signs and symptoms are only superficial phenomena, they do not represent contemporary pathogenic theories.”

 

“In Chinese Medicine, every diagnosis relies entirely on signs and symptoms. Differentiation of Hot and Cold, Deficient and Excess is the crucial foundation in determining a patient’s medical kilter. Eliminating such signs and symptoms is the ultimate goal in Chinese Medicine. It also aims at improving the biomedical measurements as indicated by pathogenic analysis.” – Commenter: [e-mail]

 

Western drug and Chinese drug has different therapeutic mechanisms due to the difference of their philosophy. Western drug's entity is manmade single constituent, take the single effect on specific target. The allopathic is the main therapeutic mechanism. Chinese drug's entity is a group of natural bioactive constituent, take the multi-effect on multiple targets with the specificity. The physiological regulatory is the main therapeutic mechanism.

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7.1.7. Example of doctors’ work manner of TCM and WM:

 

Now take a patient who is suffering from stomach disease as example to show the different in their works.

TCM doctors would try to find the causes by diagnosing the type of symptom. Does it induced by the improper diet or psychological pressure or excessive physical exertion, and or seasonal changes? Also patient has what kind of problems require to be adjusted? They will eventually restore the overall balance?

 

WM doctors would try to find the causes by the gastro-scope and biochemical examination to find disease area and lesion extent as well as the source of pathogenic, such as helicobacter pylori. Then try to restore the health by killing the pathogenic microbe with WM drugs.

 

However, now we have made clear that some of digestion problems caused by psychological factors rather than the pathogenic microbe. Such as irritable bowel syndrome, is lack of abnormalities of morphological and biochemical, and closely related to the emotional changes or psychological factors, in which case that WM drugs can not work. Fortunately, TCM has been working well for either infectious or non-infectious with very cheap natural preparations for a thousands years.

 

“"Traditional Chinese medicine," sometimes shortened to TCM, involves the treatment of patients using the fundamental approaches of healing developed over the last 4000 years in China. The treatments in Chinese medicine include acupuncture, Chinese herbs, and Tui-Na, which resembles massage therapy combined with therapeutic touch. Chinese medicine has the longest history, and the most practical application, of any system of medicine in the world, outdating Western medicine by about 3800 years. In China, doctors were practicing relatively advanced medicine before the birth of Christ. Western medicine, in response, dismisses everything under Chinese medicine, ignoring the long history of safe and effective use of Chinese herbs, acupuncture, and other philosophies espoused by Traditional Chinese Medicine.”

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7.1.8. Preventive attitude:

 

TCM emphasizes that cure diseases before serious onset. This is one of its advantages. For the most of slight illness was diagnosed by TCM doctor, could not be detected out by the doctors or the means in WM.

 

TCM pays much attention on the prevention of diseases, and developed comprehensive preventive measures, such as, natural drugs, physical exercise methods, etc.

 

There is a research about the effect of Tai Chi Chuan exercise on subgroup of T Lymphocyte and NK Cells. After 25 min exercise performance in the group those have been exercising Tai Chi Chuan for many years, the percentage of the CD3, CD4 cell increased, the ratio of CD4/CD8 increased and the percentage of CD16 cells decreased. In quiet state, compared with that of non-Tai Chi Chuan group, those in Tai Chi Chuan group, the percentage of CD3 and CD4 cells is higher; the percentage of CD8 cells is higher but without statistical significance. So that Tai Chi Chuan exercise can enhance the regulatory capacity of the cellular immune, and improve the body's cellular immune function.

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7.1.9. TCM & Psychology

 

3.1.9.1. Psychological & diseases: December 1, 2004, CBC News reported Stress speeds up aging of immune cells.

 

A study of crossing the disciplines of psychology, medicine, neuroscience, and genetics reveals that stress causes deterioration in everything from your gums to your heart and can make you more susceptible to everything from the common cold to cancer.

 

And those optimistic people have lower incidence of heart disease, better prognosis after heart surgery, and longer life.

 

Now, many researches have made clear that our health is closely associated with psychological factors or so called stress, and it is the main inducement for various diseases. Such as obesity, cancer, diabetes, heart attack, stress ulcer, mind disorder, Irritable Bowel Syndrome, retard the wound healing, and so on.  

 

TCM has been giving much attention to the factors of psychological, social and environmental, etc., especially emphasizing that therapy is made up of the three tenth by medication and the seven tenth by recuperation psychologically.

 

“Chinese medicine poetically emphasizes the harmful role of stress in upsetting the emotional and physical imbalance leading to a weakened immune system. Western medicine is just beginning to tap into stress as the root cause of many illnesses and as a major obstacle in disease management. Chinese medicine has been doing it for over 5,000 years”.

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7.1.10. Chinese drug & compound prescription

 

In TCM, there were different kinds of botanicals, animals and minerals have been riddled and sorted as medicinal use according to their therapeutic effect. They were used to treat diseases last thousands years in China.

 

7.1.11..  Statistic on Chinese medicinals

 

According to the largest national investigation in the 80's of 20th century mainland China, there are 12,807 kinds of Chinese medicinals in total. Among them, 11,146 kinds are the medicinal plants, 1581 kinds are medicinal animal, and 80 kinds are medicinal minerals. However, according to the preliminary statistics in recent years Taiwan, the total number of medicinal plants was about 8000 kinds. There about 700 kinds were frequently used. The statistical data from Taiwan is lesser, may be derived from the geographical limits.

 

Here I’d like to emphasize that although the medicinal animals and minerals are lesser in number, however their therapeutic effects are powerful, so they could not be ignored. I will demonstrate them later by true examples. I’m sure that the readers would be attracted and fallen addicted for their excellent therapeutic performance.

 

Compound prescription: For TCM, the most important therapeutic approach is compound prescription (multi-pharmacy, compound formula). That is by putting many different kinds of Chinese medicinals in one prescription to treat disease by focusing on symptoms of syndrome. Some advantages are as following.

 

Firstly, I would prefer to point out that, the meaning of symptom in TCM is very different with that of in WM. In TCM, it is more in macro perspective of philosophical and dialectical rather than that of specific changes of anatomical and physiological physically in WM, such as, cold (of Yin) and hot (of Yang). The following content is only an example from my personal understanding roughly; it is not the same as the original intent of TCM because that completely understanding and exactly translating the medical theory of TCM is too difficult for me. It may need to extend my life to 199 years at least to learn starting from epigraphy on Oracle bone script in TCM and wording and new words coin in English. Once again, the purpose of this article is to promote the core of TCM – the Holistic medical approach rather than clinical reference.

 

Focus on the symptoms: the most disease is a syndrome that appeared many different symptoms at the same time or at the different development stage. Such as, fever, no appetite, rhinitis, faucitis, headache, coprostasis, insomnia and so on, TCM prescription may put many different Chinese medicinals for treating each symptom at the same time.  

 

Support each other: Some Chinese drug in compound prescription are not focused on the specific symptom, only enhance others’ therapeutic effect, For instance, some drugs may make other drug’s absorption faster, and the elimination slower. Some may increase the content of other drugs in blood to help absorption. Some can enlarge the drugs’ delivery amount by vasodilatation effect. Some even can make produce new therapeutic constituents in blood.

 

Relieve side effects: Such as, some natural drugs may has side effect of causing coprostasis, so put some Chinese drug of enhancing peristalsis of the alimentary canal to relieve it, at same time improve the appetite and nutrition supply, too.

 

Improve the appetite & digestion: The condition of appetite & digestion also affects the therapeutic effect of the drugs. Unfortunately, that the appetite and digestion get worse for the most patient. So some drugs that can improve the appetite & digestion could also enhance the effect of other drugs. Also the improvement of appetite & digestion can enhance the nutrition supply to promote the recovery of patient.

 

Generate the new substance: General process method of Chinese drug is cook, and then drinks the soup. There were reports that some characteristic spectrums of new substance were found in the liquids from boiling mixed Chinese medicinals, it shows some new constituent were generated during the drugs were being processing.

 

Correctness proven for compound prescription: Cocktail therapy for AIDS: That is the simultaneous use of two nucleoside drugs and a non-nucleoside drugs to treat AIDS, make the HIV virus no where to escape. The inventor, David D. Ho, M.D., the scientific director and CEO of Aaron Diamond AIDS Research Center in New York, said, that he got inspiration from principle of the TCM compound formula. So, in fact, the achievement of the AIDS Cocktail Therapy is the success of the principle of compound prescription of TCM, although it was more in Reductionistic rather than Holistic.

 

Some content of TCM will be continuously discussed in MCM section.

 

Experience-based prescriptions: May 1st 2002 the Volume 1 of <Dictionary of Traditional Chinese Medicine Prescriptions> was published in China. It is a referential book that carefully sorted and compiled from the experience-based prescriptions of Chinese medical books in history. The dictionary is about 18 million words with nearly 100 thousands prescriptions in 11 volumes, which shows the industrious and wisdom of ancient Chinese people by large amount of medical records. It has significant referential value for the modern medicine.

 

If you go to any Chinese Pharmacy in China or abroad, you will find many bottled tablets OTC Chinese medicinals (CD): 1 Prescriptions Resources: Some of them are experience-based prescriptions and some of them have been updated according to modern researches.2 Making Methods: The most of them made by modern processing methods, Such as, Supercritical Carbon Dioxide Extraction, Sugar coating, Tablets, Injections and so on. Few of them made by old methods: such as, Powder, Pill, Salve and so on. 3 Therapeutic range: Various diseases from Internal, Surgical, Gynecological to ENT. The most of them are focusing on specific diseases with the role of broad-spectrum treatment, some are for general physical enhancement. 4Application Level: The most of Chinese families reserve some often used Chinese medicinals for some common diseases, such as common cold, headache, indigestion, diarrhea, wounds and so on. The most of Chinese hospital treat diseases by WM integrating CD.

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7.1.12.. Modern studies on Chinese Medicine

 

Modern Chinese Medicine - MCM has been developing based on the TCM by integrating modern biotechnology. Recent decades China, government made much effort to promote the research of TCM by modern biotechnology, introduced and developed many modern medical equipments and research methods, largely stimulated the development of Chinese medicinals. And have gotten many valuable results. Now we can explain the therapeutic effects of Chinese drug more clearly in modern biological terms from the level of proteins, cells and gene.

 

Constituents: For the most Chinese medicinals, such as, herbs, only a single one is a compound that contains dozens or hundreds of different constituents. So the bioactive constituents are complex and plenty. Obviously, the nature has prepared what we need and ready to be explored out.

 

Classification: The researches show that the Chinese medicinals have been sorted scientifically. For example, those were sorted as enhancing the digestion are rich in Ca, Zn and Fe, and those as enhancing male sexual ability are rich in Mn and Cu. It has wonderful orderliness not only in chemical elements but also in bioactive constituents. Such as, Wahaha, a therapeutic drink made of Chinese medicinals, has been in hot selling nearly two decades in China. Massive application has proven that it is effective in treating poor appetite for kids. No precocious puberty happened. Test results proved it rich in Ca, Zn and Fe.

 

Bioactivity: The medicinal constituents are more active in natural drugs than that of any other kind of existence, so that human body can easily absorb them. For instance, in China, some researchers compared biological activity of gypsum in the form of nature and manmade，The results showed that only natural gypsum has therapeutic effect, although the manmade one is in 99.9% pure.

 

Antibacterial: Various active constituents in Chinese medicinals could kill bacteria or virus directly as well as that of most Western drug does, fast and accurately at the time regulating the body balance. The Chinese medicinals have showed the both advantages, one is the therapeutic effects that is similar to the Western drugs and second is the nutritional effect that is similar to the Orthomolecular Medicine.

 

Antiviral: Chinese medicinals is the best anti-viral medicine. It can directly block the synthesis of virus nucleic acid, which can kill the virus, promote the formation of antibodies, and can enhance phagocytosis of macrophages to kill pathogenic rapidly and take a lasting effect.

 

Synergistic effect: Researches indicate that some pure extracts reduced their therapeutic effects compared with that were used in the completely original compound. These maybe caused by losing the potentiating synergistic effect when some constituents were being filtered away.

 

Therapeutic mechanisms: Western drug and Chinese drug has different therapeutic mechanisms due to the difference of their philosophy. Western drug's entity is manmade single constituent; take the single effect on specific target. The allopathic is main therapeutic mechanism. Chinese drug's entity is a group of natural bioactive constituent, take the multi-effect on the multiple targets with the specificity. The physiological regulatory is the main therapeutic mechanism.

 

Smart cure ability: Some Chinese drug can take intelligent therapeutic effect. For a normal body condition, it does not take effect; only for an ill body it takes regulatory effect. Some even take bidirectional regulatory effect. The so-called bidirectional regulatory effect means that the same drug in same dose can make the unbalanced body condition return to normal level. Such as: whether the hypertension or hypotension both can be regulated back to normal level. And no matter is sleepy or insomnia, all can be regulated back to normal sleep status, and so on.

 

Brain diseases: Some Chinese medicinals molecular are very small, easily go through the blood-brain barrier to enter the cerebral cortex directionally and selectively. It can improve the brain blood circulation, increase the oxygen metabolism of brain cells, and increase energy supply for cranial nerve system, removal the wastes of the brain metabolites. Effectively restore the synthesis and metabolism of nerve media and the central nervous conduction and separation.

 

Alleviate stress: Chinese drug can reduce the negative effects of psychological stress largely. Because it can alleviate the stress symptoms by releasing endorphins, decreasing the stress hormone cortisol, eliminating the oxygen free radicals, lowering the blood pressure, reducing the heart rate, relaxing the muscle tissue, improving the digestion and sleeping, and bringing more fresh oxygen to body tissues by improving the circulation of blood and lymphatic fluids. This increased blood flow will eliminate the waste products from inside the body and enhance the nutrition supply to accelerate the recovery. This advantage can be used to prevent great many diseases since it reduce the inducement of diseases.

 

Anti-aging: Chinese medicinals can prolong the life span of organism by many ways, such as anti-oxidation, immunoregulation, neuro-regulation, endocrine secretion regulation, anti-DNA injury, etc. It can relieve all the fatigue impairs for men and women, enhance the ability of hearing and seeing, and restore the color of beard and hair for elderly.

 

Broad cure ability: The most often used Chinese medicinals are with have none or little negative effect. Even the little negative effects can be eliminated easily by compound prescription. It is effective for both diseases, no matter is communicable or non-communicable. Some examples are as following:

 

Resist cancer development.

Inhibit the cells apoptosis.

Improve the transduction of cellular signal.

Relieve cytotoxic.

Restore the organ or nerve system.

Reduce the psychic stress.

Improve the digestion and metabolism.

Relieve the chronic fatigue syndrome.

Relieve the irritable bowel syndrome.

Improve the male erectile dysfunction.

Relieve or heal the psychosis.

Detox the drug addiction disorders.

Relieve the snore and apnea.

Prevent or heal heart attack and stroke.

Substitute blood-dialyze of uremia patient.

Activate blood flow and removing blood stasis.

Protect the injury of cerebral or heart ischemia-reperfusion

Anti-agging.

Prevent or heal cough.         

Relieve neurasthenic.

Cure and prevent the ulcer of alimentary canal.

Heal chronic tracheitis.

Smooth wound scars.

Relieve or heal arthritis.

Increase white or red blood cells.

Bi-immunoregulatory effect

And so on.

 

The list can be made much longer. But those are enough to make any people understand the wonderful therapeutic effect of Chinese medicinals.

 

Poison & Safety:  Although the Chinese drug came from nature, however, some of them are not safe for using because of instant or long-term poison. If we use it correctly, it would be a very good medicine. Contrariwise, it will cause unexpected results. Now the poison Chinese medicinals have been identified already and have found some special usage in treating diseases, such as, the arsenic (As2O3) can be used to cure cancer.

 

Natural Chinese medicinals are a huge natural pharmaceutical resource, which Western drug does not have presently.

CM integrating WM: Besides bad negative effects that synthesize drugs have their specific advantages aiming at some diseases.

Xu Shou (1818-1884), was a pioneer of modern chemistry China. In his paper "The medical theory" of 1876, had been put forward the proposition of CM integrate with WM. He wisely pointed out a promising therapeutic avenue by using both advantages of the CM and the WM to patch up the disadvantages each other.

 

Bob Flaws, an active interpreter and practitioner of Chinese   medicine with western background, said in An Interview, “that the combination of Western medicinals and Chinese medicinals is, for many disease processes, better than either of them individually. Typically, you get a better therapeutic effect with a smaller dosage of Western meds and have to take the Western meds for a shorter period of time. Clinicians know that most of the side-effects of Western drugs are dose-related and that, if you can keep the dosage minimal and the duration as short as possible, you'll get the therapeutic result without the adverse reactions. Chinese medicinals taken with Western medicines seem, in many cases, to achieve that therapeutic goal.”

 

In China, it is common in CM integrating WM clinically. That is, at the same time, a patient being treated by two types of medicine. The advantages of WM are to take the effect quickly toward the main symptoms and the advantages of CM are to take the effect in eliminating the negative effects of WM by improving the patient's immunity and overall physical condition. Greatly enhanced the therapeutic effect and made the patient recover earlier. Also it greatly improved the life quality of patients. The good example is the treatment of SARS.

 

SARS: During the outbreak of SARS in 2003 in China, among 5326 were confirmed SARS cases, 3104 were treated by WD integrating CM. The wonderful therapeutic effect of Chinese drug is manifested.

 

1. Relieve fever and shorten the duration.       

2. Improve weakness, breath shortness, dry cough and clinical symptoms of poisoning.

3. Eliminate the toxicity and the negative effects of Western drug, such as steroid in large doses use.

4. Help to reduce the amount of using in hormones.

5. Improve hematopoietic function and hypoxic conditions.

6. Protect the organs function and avoid organs failure.

7. Reduce the systemic complications.                  

8. Promote the absorption of inflammation to avoid the bad sequels. Such as the femoral head necrosis of bad sequelae of SARS. That the causes are still in debating, one is SARS virus, and another one is the use of glucocorticoids in large dose.

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As a result, no one was dead in the group of intervening with Chinese medicinals.

 

N1H1 flu: The successful experience of mainland China on the treatment of A H1N1 flu was that, if the treatment focuses on each symptom of the patient to improve their physical condition by Chinese medicinals besides killing the A H1N1 flu viruses. The number of developing into the critical and death was largely reduced.

 

It is easy to get some OTC Chinese medicinals in the forms of pill or sugar coated tablets from Chinese pharmacies closing to your home by consulting seller or Chinese doctor. Please start with a half of pill or tablet then gradually reach the dose recommended on the label to avoid the happening of heavy side effect. Also there are injections that can be used for intravenous infusion, but needs the help of highly skilled Chinese doctors. Any way flu should not be a deadly disease.

 

Critical patients: For those patients in severe critical states, such as, MODS, whatever the causes but no urinate and defecate for a while, and have no effect on any existing therapies, we may carefully try to smear the alcohol tincture of Aloe leaf in the navel and surrounding area about 16 square centimeter, then covering with a plastic film and massaging to make the medicinals transdermal absorption into the blood vessel. After about 10 hours, there will be diarrhea-like defecation and then the patients will feel much better. Smearing several times will be enough. I am not certain safe or not for the long term smearing. If there is no diarrhea-like defecation, it may need enlarge the smearing area or check the quality of the Aloe, whether have enough yellow colored medicinals’ secretions on the cut section of Aloe leaf. As a safe consideration, firstly smear small area to watch the patient’s reaction, whether there is side effect. The aloe must be more than 3 years old so that it has enough yellow colored medicinal.

 

The navel is a holographic acupuncture area that can connect human organs of whole body. The Aloe smearing can restore the digestive system; boost the physiological activities and immune function with a magical reviving effect.

 

Above idea enlightened from the Rhubarb (Dahuang, Jiangjun), a pure Chinese herb with the proven therapeutic effect for critical patients, such as, for MODS, especially with gastrointestinal dysfunction. Although the reports of Aloe to be used for critical patients are less than that of Rhubarb, however, their main medicinal constituent is similar, so that their medicinal effect will be similar. On the other hand, compared with Rhubarb, Aloe is easier to be gotten due to it is being home planted world widely. I will introduce my experience about it home planting in another article.

 

Talking about Aloe Vera, the Editor of NaturalNews.com, Mike Adams wrote that “When I say aloe vera is the most impressive medicinal herb invented by nature, I don't make that statement lightly. Of all the herbs I've ever studied -- and I've written thousands of articles on nutrition and disease prevention -- aloe vera is the most impressive herb of them all.”

 

A natural, cheaper and simple method may pull back a person who has stepped into the door of another world with his or her one foot. The process is just like that makes a nearly stopped-pendulum re-swing again. There will be much more this kind of simple experience-based methods in public daily life that is better than those recommended by so called medical authorities. This is why that I said medical issue is the public issue, and it should be taken down from the mysterious Altar.

 

The method can also be used to treat children malnutrition, poor appetite, constipation and emaciated, etc. Please do not long term use.

 

I do not recommend the use of Rhubarb unless prescribed by a doctor.

 

Now I’ll take some individual medicinal plants, animals and minerals in Chinese medicinals as example to demonstrate the magical therapeutic effect that has revealed by modern researches.

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7.1.13. Medicinal plant      

                                                                 

Here let us look at the goldthread (Coptis chinensis), a frequently used Chinese plant drug to learn how an herb works.

 

Goldthread  

                                                            

Firstly I would like to introduce a book in which the goldthread was first recorded. The Shen nong ben cao jing, an earliest pharmacy monograph of TCM, which systematically summarized the clinical experience of Chinese medicinals firstly. It has been hailed as classics and essence of Chinese pharmacy.

 

For the publish age, there is a different legend, one was in the Warring States period 476 BC - 221 BC, and the second was in the age of Qin and Han Dynasties 221 BC – 220 AD. The authors are unknown.

 

      

 

Biochemical constituents

 

The biochemical constituent include: Berberine, coptisine, epiberberine, Palmatine, berberis red alkali, berberis alkali methyl, ferulic acid, magnolia flower alkali, phellodendron ketones and yellow-corktree bark lactones, etc.

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Pharmacological effects

 

Antibacterial: Goldthread preparations have a strong antibacterial effect on pneumococcus, staphylococcus aureus, streptococcus hemolyticus, comma bacillus, anthrax bacillus and bacillus dysenteriae, etc. Also has inhibitory effect on the bacteria of diphtheria, pertussis, tuberculosis and brucella, etc. The coptis decoction and water extract have inhibitory effect on violet trichophyton, floccus epidermal mentagrophytes, Candida albicans and Yanuca star bacteria, etc. And in vitro, show inhibitory effect on mice entamoeba parasite, chlamydi trachomatis and trichomonas.        

         

Blood glucose: Coptis Decoction and berberine gavages may reduce the blood glucose in normal mice. The hypoglycemic effect may be by inhibiting gluccneogenesis or promoting glycogen glycolysis.              

    

Platelet and thrombus: Berberine has significant inhibitory effect on the contraction of clot enriched with the platelet. After inhibiting the clot contraction, take a significant catalytic effect on clot lyses caused by urokinase and streptokinase. It is conducive to save the patients with heart artery thrombosis or cerebral artery thrombosis.

 

Heart Function: Berberine intravenous has a strong positive inotropic effect on canine heart. So that the rhythm slowed down, the diastolic blood pressure decreased, the pulse pressure increased, the total external resistance decreased, the blood output of per pulse increased.

 

Hypertension: Berberine can lower down the arterial pressure, particularly diastolic pressure with the dose correlated. The mechanism is mainly competitive blocking β2 receptor on vascular smooth muscle to reduce the peripheral vascular resistance. The effect is weaker for stage Ⅲ hypertension and severe hypertension. Such as:

 

Berberine tablets 0.6 – 0.8 g.d-1 have good effect on hypertension in stage I & stageⅡ. Also have effect on secondary hypertension of renal and pre-eclamposia and eclamposia, etc.

 

Oral Berberine tablets 0.4 ~ 0.5 g per time, 3 times daily for 4 weeks. Results: (1) 13 cases in stage I, 8 cases were marked effect, 5 cases were some effect. (2) 19 cases of stage Ⅱ, 10 cases were marked effect, 6 cases were some effect, and 3 cases were no effect. (3) 10 cases of stage Ⅲ, 2 cases were some effect, 8 cases were no effect. The total effective rate is 73.8%.

 

Hyperlipidemia: The hypolipidemic effect is primarily found at the experiment of treatment of non-diabetic animal models. It significantly reduced the content of serum triglyceride (TG), total cholesterol (TC) and low density lipoprotein cholesterol (VLDL2C).

 

Berberine tablets 0.5 g TID after meals orally treat hyperlipidemia, the effective rate was 90%.

 

Myocardial ischemia: Berberine can enhance the mice’s ability of hypoxia tolerance. Reduce the scope and extent of rabbits’ myocardial infarction.

 

Arrhythmia: Oryzanol significantly increase the oral bioavailability of Berberine. Oral administration of the blend of two drugs can reduce the arrhythmia of rats induced by aconitine and coronary artery ligation. The mechanism is inhibiting outward potassium current and the tail current.

 

Brain Injury: Cerebral ischemia can cause the increase of the brain excitatory amino acids, such as, glutamate. Berberine can improve the brain injury by inhibiting glutamate-induced high expression of brain cells’ C-fos and the increase of intracellular calcium.

 

Cancer: Both in vitro and in vivo test, berberine shows a significant inhibiting effect for sarcoma S180 in mice. Also has inhibitory effect on nasopharyngeal carcinoma, cervical cancer and transplanted tumors of nude mice.

 

Toxicity: LD50 is 24.3mg/kg by mice intraperitoneal injection.

 

Clinic applications

 

Atrophic gastritis: Blend preparation of Berberine with other Chinese herbs treat atrophic gastritis, except 1 patient self terminated, 23 of 24 cases, the gastric mucosal atrophy was restored to normal, the stomach pain and the gastrectasia symptoms disappeared, the appetite improved. Gastric analysis: fasting total acidity and free acidity reached the normal level.     

   

Stomach and duodenal: Blend preparation of Berberine and other herbs treats gastritis, gastric ulcer and duodenal ulcer. Total 18 cases, 12 cases cured in one day and 6 cases in 2 days. Follow-up found relapse patients were re-cured in 1 ~ 2 days.

 

Ulcerative Colitis:  With metal pipe directly spray Coptis powder and positioning enema with Coptis powder aqueous solution treat 18 cases of Ulcerative Colitis, cured 15 cases. Spray method, Coptis powder 2 ~ 2.5 g one time daily total 9 times for a course of treatment. Enema method, Coptis powder mixed in 150ml warm water and then poured into. Except pain in first 2 or 3 times, there is no other side effect. The pain can be avoided by adding appropriate amount of Procaine.

 

Diabetes: Type II diabetes 60 cases, oral Berberine 0.3～0.5g X 3 times daily, unknown the time of treatment course. After treatment, the fasting blood glucose is 117.19 ± 25.98mg/dl, that is significantly decreased than pre-treatment of 208.65 ± 51.68mg/dl (P<0.01). Patients’ clinical symptoms disappeared, serum insulin levels increased significantly (P<0.01), total effective rate was 90%. Had no significant effect on those blood glucose level is in normal.  Follow-up 17 cases, there 11 cases were maintained in the level of treatment efficacy. In the experimental study showed a marked hypoglycemic effect, and demonstrated the promotion effect on pancreatic β-cell repair.

 

Suppurative otitis: Powder of Berberine with other herbs, blowing into the ear canal, and goes through the perforation of tympanic membrane, 2 times daily, five days for a treatment course. Total 41 cases, 36 cases fully recovered, 4 cases improved, 1 case was no effect.

 

In view of the public Knowledge on Chinese herbal medicine have been a lot. Here, I’ll introduce the rare one - medicinal animals.

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7.1.14.. Medicinal animals

 

4000 years ago, there medicinal animals were used in China. The records were found on the tortoise shells. The animal names on shells include snake, musk deer, rhino and so on.

 

Currently, there were 1574 (1581?) kind medicinal animal’s recorded. Among them, the terrestrial animals are 1295 kinds; the marine animals are 275 kinds. The vertebrates are about 62% in the medicinal animal species. The invertebrates are 606 kinds.

 

Because the therapeutic effect of animals’ drug is powerful, so that it can take a significant effect by only a small doses. In addition, their resource is richer, toxicity is lower, and is capable to treat a wide range of diseases. Therefore, as same as the herbs, the medicinal animals are an important component of Chinese medicinals.

 

Here I’ll take the ants as example to demonstrate their wonderful therapeutic effect.

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 Ants

In China, 3000 years ago has started to use ants. In book< Zhou LI Tian Guan> described that ants was as food for king. Some other TCM books have described ants, includes Compendium of Materia Medica《Ben Cao Gang Mu》.

 

In TCM, the ants are used for treating many diseases, such as, kidney inefficiency, rheumatic pain, stroke hemiplegia, hand-foot numbness, dizziness, tinnitus, insomnia, dreamy, impotence, emission, lupus, scleroderma, dermatomyositis, carbuncle, swollen pain and snakebite, etc.

                      

 

 

Bioactive constituents

 

Ants aldehyde, formic acid, fatty acid, protein, free amino acids, alkaloids, histamine, terpenoids, variety of hormones, variety of enzymes, and ant antibiotic. Vitamin A, C, D, B1, B12, E. There are more than 20 kinds of minerals, Ca, P, Fe, Zn, Se, etc. In particularly the Zn content is prominent, per 1000g ants containing 100-200mg Zn, the Zn content is 8 times than that of soybean, 2 times than that of pig livers.

 

Pharmacological effects.

 

Immunoregulatory: Ants can bi-directional regulate the cellular immune function to the normal level.

 

 

Immune synergy:  Promote hyperplasia of thymus, spleen and other organs. Increase the number of blood leukocytes, can enhance the activity of macrophage and lymphocyte, and improve antibody cell count and serum antibody levels after antigen stimulation.

 

Inhibit inflammation: Experiments show that ants can significantly inhibit the inflammation induced by xylene and formaldehyde. This provides a reliable theoretical basis for clinical application of ant to treat rheumatic diseases.

 

Rheumatoid arthritis: Ants have immunoregulatory effect, adrenal cortex-like effect and anti-inflammatory effect. Has obvious therapeutic effect on joint swelling, morning stiffness and erythrocyte sedimentation rate.

 

The preparation of ants and herbs treats rheumatoid arthritis 35 cases,  17 cases cured, 12 cases were marked effect, 5 cases were some effect, 1 case was no effect. The longest treatment course was 15 months, the shortest was 20 days.

 

Asthma: Ants preparation can relieve the bronchial asthma and intestinal spasm induced by ethylene choline. And can relieve the intestinal spasm induced by barium chloride.

 

Sedative effect: Ants preparation can reduce the times of spontaneous activity of mice, showed certain sedative effect.

 

Painkiller: Experiment in mouse acetic acid writhing response showed that ants have very significant effect in relieving throes. The pain threshold was increased 4.347 times.

 

Liver:  Ants preparation can lower down the activity of rat’s serum glutamicpyruvictransaminase enhanced by carbon tetrachloride. Show that ants can inhibit the hepatocyte fatty change.

 

Anti-aging: Ants can increase the content of intracellular DNA and RNA, enhance the phagocytosis capacity of the macrophage, and scavenge free radicals.

 

Sex:  Ants are a sexual enhancer to promote the sexual ability by making following improvements: (a) Increase the weight of the testes and ovary. (b) Increase the content of DNA, RNA in leydigscells and spermatocytes of convoluted suminiferous tubule. (c) Promote the cell division. Experiment show that ants can increase the weight of semen capsule prostate and glandulae preputiales of castrated male mice, increase the weight of spermary and epididymis of normal mice markedly and significantly increase the number of sperm. For aged mice increase the weight of testes and thymus.

 

This kind of sexual enhance is based on the enhancement of the overall physical strength healthily. It will obviously reduce or even avoid the deadly sequelae during enjoy the pleasure of sex by the assist of WM drugs. Such as, 109 'have been killed by Viagra'.

 

Fertility: Ants have a significant effect in the promotion and protection for the fetal rat growth. And have satisfactory effect on the treatment of infertility of men and women. Such as, azoospermia; oligospermia; non-ejaculation; varicocele; endometriosis; amenorrhea; ovarian cysts; uterine hypoplasia; irregular menstruation; no-ovulation; polycystic ovary syndrome and bilateral tubal barrier.

 

The United States does have infertility rate-17 percent, and this rate continues going up. However, China have the lowest infertility rate, less that 3 percent. The contribution of lower infertility rate came from the natural Chinese medicinals.

 

Diabetes：Ants can regulate the disorder of endocrine function in vivo, enhance the metabolism of the sugar, protein and fat, and stimulate the cell function. Thus, enhance the activity of insulin and inhibit the generation of insulin antibody. Improve the fatigue phenomenon. In China, more and more patients use ants and herbs compound to treat diabetic syndrome.

 

Total 56 out-diabetes patients, 21 males and 35 females, 9 were over 60, 26 were 45-60, and 21 were less than 45. The course of disease was from 6 months to 4 years. All these patients had varying degrees of oral thirst, rapid hungering, polyuria, obesity or emaciation, and generalized lack of strength. Fasting blood glucose was equal to or more than 7 mmol/L (126mg/dL) and glycosuria was +-++++.

 

Ants 60g and another 19 Chinese herbs ground into fine powder and disinfected. 10 capsules (0.3g/capsules) X 3 times daily, 3 months equaled one course of treatment. After 2-5 such courses, outcomes were assessed.

 

There were 38 patients (67.9%) were marked effect, 12 patients (21.4%) were some effect, and 6 patients (10.7%) were no effect, for a total amelioration rate of 89.3%. However, these effects were most significant in those with the early stage of disease in asymptomatic. According to the Chinese authors of this study, there were no observable side effects from this protocol.

 

Note: As a opinion of mine, that the amelioration rate will be over 95% without side effect if the dose doubled especially in the increase the amount of ants.

 

Antibiotics:   Researches indicated that the waxy substance of ants’ secrete contains antibiotics. This "ant antibiotic" may assist the human body to resist variety of pathogenic microorganisms, especially in case of fungal infection and staphylococcus.

 

“Researchers at Princeton and Harvard Universities believe that the discovery of two key proteins guiding one of the two groups of pathogenic bacteria that make up an ant's outer shell could pave the way to the development of new antibiotics.” ”the antibiotics would be particularly effective against gram-negative bacteria, such as E coliand Salmonella, and would destroy these pathogens by disabling the mechanism that produces the ants' protective coating.”

 

Cancer: Radiotherapy and chemotherapy will seriously damage the patients’ immune system. Ants can provide compensation to restore being destructed immune system. At the same time, those increased natural killer cells can kill cancer cells directly.

 

Here is a miracle recover case of liver cancer.

 

Beijing Medical University, Yu Guo An, a 75 years old male, suffered multiple liver tumors, was no longer able to carry out removal operation. In which case, he took large dose ants preparations competing for one year. When one year after he went to hospital review, surprisingly found that tumors reduced.

 

Suppose that Mr. Yu took the conventional treatment with radiotherapy or chemotherapy, he would be died already. Even if alive he would be at counting his remaining survival days or months on bed by bending his finger according to the general experience, because that the liver cancer is a badly malignant one, so that it is being called the king of cancers’.

 

Indeed, in above case, it was that incurable cancer is cured by animal drug without help of conventional medical means. Obviously no any constituents that can kill cancer cell directly in ant powder. However, it was that the ants killed incurable cancer cell indirectly by enhancing Mr. Yu’s immune ability. Therefore, it is the success of holistic philosophical approach. The fact has provided a powerful evidence to prove the system biology is a prospective philosophical approach and that the nature killer cells kill cancer cell is effective in vivo.

 

Suppose take the ants regularly as preventatives before, Mr. Yu would not be suffered in cancer.

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Safety evaluation: In mice model carried out safety evaluation for Ant Powder. The results as following:

 

Acute toxicity test: LD50>215000mg/kg.

 

Ames test: No findings on cancer mutagenicity in following test. the concentration of Ant powder in 1.0 mg/plate. 2.0 mg/plate 3.0 mg/plate and 4.0 mg/plate orderly were studied with TA97(a), TA98, TA100, TA102 bacterial, at the same time, mutagenic were used as the control groups. The test was repeated under the action of metabolic activated enzyme. The bacterial numbers at every concentration had no significant differences than the control groups.

 

Micronucleus test: No significant different with control group in bone marrow cytogenetic test: Micronucleus rate at 5000mg/kg, 10000mg/kg, 20000mg/kg and positive were 0.2%, 0.16%, 0.18%, 0.2%, 3.26% respectively.

 

The sperm shape abnormality test: No significant different with control group in following tests: 5000mg/kg, 10000mg/kg、 20000mg/kg and positive were 1.94%, 1.98%, 2.24%, 12.84%.

 

Thirty days feeding test: All histopathologic and biochemical indexes were in normal after 30 days feeding. Including blood, liver, kidney, stomach, intestines, growth status, all results were negative. The facts indicated that Ant powder is non-toxic.

 

Following are some studying articles for ants in medicinal practice.

U.N. Conference Promotes Insect-Eating for Everyone From Famine Victims to Astronauts

Colombia's Big-Butt Ants Entice Gourmets

'Big-Butt' Ant Delicacy Goes Global

Ants Have Much More Efficient Antibiotics Than Humans Do

Extracts in Chinese Ants May Fight Against Arthritis and Others

New Slant On Ants: Eat Them And Stay Healthy, Chinese Say.

BEIJING - A handful of ants a day keeps the doctor away, according to Chinese scientists.

The consumption of ants as part of a healthy diet or for medicinal purposes has a history in China that goes back at least 3,000 years.

Ants May Help Researchers Unlock Mysteries of Human Aging Process

Insects and other arthropods used as drugs in Korean traditional medicine

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7.1.15.. Medicinal Minerals

 

The first record of the medicinal use of minerals was found in <Zhou LI>. The publish time was estimated at the age of 725 BC - 645 BC according to the book has mentioned the economic activity of Guan Zhong of a famous ancient politician China.

 

Although there are 80 kinds mineral drugs were used in TCM, however only 30 kinds were commonly used.

Gypsum

 

Gypsum (Shi Gao) (CaSO4·2H2O), a mineral we are most familiar since it is used to fix the bone fracture by doctors. Also being used to treat various diseases for a long times due to its wonderful therapeutic effect in China.

                

 

 

 

The record of Gypsum’s medicinal use was found in Ming Yi Lu firstly, a book published in Tang Dynasty. It was a biographies for 120 famous doctors from San Huang (3000 BC - 2700 BC) to Tang Dynasty (618 AD-907 AD), which covered thousands years historical span in China. The book mentioned the gypsum as medicinal use. It said that a female patient with hyperpyrexia and cold. Failed in treatment by many TCM doctors, however she was cured by a TCM doctor with gypsum finally. The case maybe happened much earlier than that of book publish age. It means that gypsum used as a drug is much earlier, too.

 

In TCM, the gypsum has been using to treat diseases as following.

 

Orally administration: chronic hyperpyrexia，exanimation, delirious speech, fidget, thirst, dry throat，wheeze，heatstroke, spontanous sweating，headache，toothache，exanthesis，ulcers in the mouth and on the tongue, etc.

 

External smear with baked powder: Treat the scald, fire burns and chronic fester by promoting the tissue regeneration.

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Pharmacological effects

 

Antipyretic effect: Gypsum can inhibit the over-excited thermoregulation central nerve system during fever to take a strong and quick cooling effect. Gypsum Decoction has disincentive effect on inducing iatrogenic fever by leukocyte. Gavages 2g/kg raw gypsum has an antipyretic effect on rabbit fever caused by E. coli endotoxin. Has no effect on normal rabbit.

 

Anti-inflammatory: Gypsum react with the gastric acid, partially become the soluble calcium salt. It can increase the concentration of the serum calcium after being absorbed into the blood in intestine. The increased serum calcium can inhibit the nerve stress energy (including thermoregulation central nerve system), reduce the excitability of the skeletal muscle, alleviate the muscle spasm and reduce the vascular permeability to take the effect of detoxification, anti-spasm and anti-inflammatory.

 

Immunity: Gypsum decoction 1:4 concentration 4ml gavages can increase the content of macrophages cAMP of spleen and peritoneal for Burned rats. Gypsum preparations can increase the number of T lymphocytes, increase the rate of lymphocyte transformation and enhance the phagocytosis of peritoneal macrophages.

 

Convergence role:  External use calcined gypsum has an effect of converging mucosa to reduce the secretion.

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Anti-virus: By dot-blot hybridization experiments, 25%-100% concentration of gypsum decoction, have the effect on lower the content of deoxyribonucleic acid (HBV DNA) in the poison of Hepatitis B.

 

Diuretic and choleretic: Increase the urine output for mice and increase the bile output of rats and cats.

 

Cardiac excitatory and inhibitory: Low-dose gypsum infusion has an excitatory effect on isolated heart of toads and rabbits and inhibitory effect in large doses.

 

Analgesic：Gypsum injection can inhibit the evoked potentials in cortical somatosensory areas, which caused by afferent impulse of C saphenous nerve fibers of cat. So that it can take a selective central nerve analgesic effect.

 

Muscle cramps: Gypsum preparations can inhibit the excitability of skeletal muscle, reduce the vascular permeability and ease muscle cramps.

 

Thirsty: Gypsum decoction can reduce the thirsty status of the rats.

 

Clinical Applications:

 

Zhang Xichun (1860 -1933), a modern famous TCM Doctor in China, since he was good at using large doses of gypsum to treat diseases and successful again and again, so that he was called Zhang Shi Gao (Gypsum). He once said, gypsum has cooling ability and be able to dissipate the body heat. It is capable to penetrate the skin to ease the ill in internal muscles. You may use gypsum boldly with the rest assured to treat those patients with hyperpyrexia, the curative effects will exceed over that of the elixir.

 

Professor Zhang Qi (1922 – Present), a doctoral tutor,  Heilongjiang Academy of TCM, is long time engaged in the internal medicine research for acute severe diseases. He is well-known by his unique therapeutic skills of TCM in China.

 

He clinically comprehended that the hyperpyrexia is the acute severe diseases. The most patients were turning to seek hope in TCM after failed in WM treatment. They are all in poor prognosis in complex condition. Clinical symptom of those patients are the temperature sustained over 39℃, the fever degree is asymmetry on the body bilaterally. Patient is anhidrotic, and the blood leukocyte is in normal level usually. It may be the central hyperpyrexia caused by dysfunction of central thermoregulation nerve system. In which situation, the general physical cooling methods and the WM antipyretic drugs are usually ineffective. And the hibernation therapy has many side effects, unfortunately.  

              

For above symptom, the primary step is antipyretic treatment by Chinese medicinals, Professor Zhang Qi believed firmly. He treats them mainly by large dose of raw gypsum and raw rhubarb. The curative effects were confirmed by the substantial cured cases. There additional benefits are that it is not only being able to effective cooling, but also be able to reduce the complications, improve the prognosis and life quality for patients largely.

 

Professor Zhang usually used to treat hyperpyrexia with large dose of gypsum.The lowest dose is 50 g, and the highest one is 200 g. The excessive gypsum easily leads to diarrhea. However, the diarrhea will be stopped after gypsum giving stopped.

 

Application in Farm:

 

Miscellaneous chicken 300, all were infected with chicken infectious bursal disease, died 92 in five days, there were 91 could not stand up. After gavaging decoction of gypsum 210 g and brown sugar 420 g, all chickens’ ill symptoms were improved. Next day one more time decoction gavaging, all chickens was survived.

 

Only natural gypsum has antipyretic effect although the manmade one is in 99.9% pure. The fact shows that the calcium is not the main constituent of the actual pharmacological effect. Then, what is it?  It still is a mystery waiting to be answer.

 

Poison of Gypsum?

 

Mammals - Acute oral LD50 (mg kg-1)  5050 E4 Rat

 

Mammals - Dermal  LD50 (mg kg-1) 8480 Q3 Rat 

 

For the safety of gypsum, we can evaluate out a positive answer from dozens cases of suicide by gypsum, which happened in Iran. No one died and no any sequelae.

 

“A 48-year-old-male patient attempted suicide by ingesting a large amount （more than three glass≥750 ml） of a solution composed of plaster in water. The patient had experienced mild abdominal cramping (restricted to the epigasteric region) and watery diarrhea following ingestion. Ten days after, he developed melena, nausea, and vomiting. On arrival at the emergency ward, two weeks post-ingestion, he was alert, and was admitted suspecting for bowel obstruction.”

 

“Vital signs were blood pressure 120/70 mm Hg, temperature 36.6 ℃, heart rate 76/min, and respiratory rate 16/min. On clinical examination, there was no abdominal distention, tenderness or rebound tenderness, and also no abdominal mass was palpable.” “He did not present with a toxic syndrome consistent with other ingestants.”     

 

“three masses of plaster were totally removed （measuring 3cm × 3cm × 3 cm, 5cm × 3cm × 3cm and 7cm × 7cm × 7cm） by an anterior gastrotomy.” “The patient resumed oral intake on the second post-operative day and returned to normal activity on the 3rd post-operative day.”

 

“a 37 year-old woman presenting with plaster ingestion and gastric outlet obstruction, who underwent surgery. At six months follow-up the patient was fully recovered. The authors concluded that plaster has no toxic or erosive effects.”

 

“Calcium sulfate hemihydrate has been used for many years and is still used extensively in both industrial and consumer areas. While bowel obstruction has been considered as a consequence of plaster ingestion, documentation of recent such case reports in the medical literature are lacking and therefore, we report such a case for the first time to our knowledge. Our investigation of literature identified one large review on suicide attempt by plaster ingestion in an Iranian national journal （Iranian Journal of Legal Medicine）. In this only previous study, the authors reviewed demographic features and endoscopic results of forty patients admitted to a general hospital in one of the western states of Iran （Kordestan）, with a history of plaster ingestion between 1997 and 2000. Twenty-three of the patients （57.5%） were female and 17 （42.5%） were male. The majority of patients （45%） were in the range of 10~19 years, which correlates well with previous data on the prevalence of suicidal behavior. 37.5% of the victims were student and 35% were housekeeper. All of the suicide attempts were by ingestion and in the form of water soluble. In their report of these forty cases, Yeganeh, et al. found that the most common symptom was abdominal pain （42.5%） followed by vomiting （15%）. The most commonly reported sign was a palpable abdominal mass, which was detected in the 17.5% of the patients. Fifty percent of patients had no remarkable sign or symptom. No toxicological data were given, but there were no remarkable abnormality in the laboratory and biochemical analysis of the patients.”

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7.1.16.. Meridians & Acupuncture

 

Meridian: is a network system throughout our body with therapeutic function.

 

Source: https://upliftconnect.com/science-proves-meridians-exist/

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2,500-year ago, the Huang Di Nei Jing, a masterpiece of Chinese medicine, firstly coined the Meridian, and forged cornerstone of acupuncture and Chinese medicine in comprehensive written. In recent decades, some historical literature of Meridians has been unearthed from the tomb gradually. Such as Silk Books, bamboo slips books and men's Meridian model made in copper and wooden.

 

They described that throughout our body has a network system that consists of 12 regular meridians and 8 extraordinary meridians.

 

The 12 regular meridians consist of 6 Yin Meridians and 6 Yang Meridians, which connect to specific splanchnic organ separately. The feature of their distributing on the surface of human body is as following:

a. Distributed symmetrically and lengthways.

 

b. The 6 Yin Meridians distributed on the chest, abdominal and medial side of limbs. There are five connect to lung, heart, spleen, liver and kidney separately, and the other ones* connects to the part that surrounds the heart.

 

c. The 6 yang Meridians distributed on face, head, trunk and lateral side of limbs. There are five connect to stomach, large intestine, small intestine, bladder and gallbladder separately, and the other ones* connects to the organs inside of the chest and the abdomen.

 

*. The concept of the other ones can not be explained detailedly due to it is very complicated.

 

In the 8 extraordinary meridians, the two have their own sets of acupoints, and the other 6 interconnect across with the 12 standard meridians and share the acupoints with them. They enhance the links between 12 regular Meridians. The feature of their distributing is as following:

 

a. No connect with splanchnic organs directly.  

b. No connect between each other directly. 

c. No distribute on arms.

 

Meridian system is Similar to the modern highway networks. The difference is that Meridian network on the surface of the body have linked with splanchnic organs to form a complex three-dimensional network while modern highway network being a plane one.

 

Acupuncture: The acupuncture points were located on the meridians. The therapeutic mechanism of acupuncture is that will get response on the specific organ or area by stimulating specific acupoints to realize therapeutic purposes physically.

 

Then, what is the nature of Meridian system? It is difficult to explain currently. Because of Meridians were not found visually in modern anatomy. 

 

However, research results for examining Meridians by the means of biological physics, indirectly proved that it is there. For instance:  

                                             

By gamma camera filming, found that the track of isotope movement on body is consistent with distribute direction of the specific meridian channel. By measuring the electrical resistance, found that there is very little resistance between the two acupoints on the same Meridian Channel. However, there is a great resistance between the two acupoints that is not on the same Meridian Channel although they are very close. And so on.

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Effective evaluation of acupuncture

 

May 11, 2009, The Herald-Mail reported that Area moms say acupuncture helped them to conceive in Hagerstown city, Maryland State, USA. Those moms are failed in pregnancy after various attempts. However they were conceived and gotten healthy babies with the help of acupuncture and Chinese herbs. Following photo is Kelly Morton with her lovely daughter.

 

Kelly Morton, 37, of Hagerstown holds daughter Sadie, 8 weeks, in front the wall of children who have been conceived using Chinese medicine. Sadie was conceived with the help of acupuncture and Chinese herbs.

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Effects of acupuncture on rates of pregnancy and live birth among women undergoing in vitro fertilisation: systematic review and meta-analysis

 

BMJ, doi:10.1136/bmj.39471.430451.BE, (Published 7 Feb. 2008)

 

Abstract: Objective: To evaluate whether acupuncture improves rates of pregnancy and live birth when used as an adjuvant treatment to embryo transfer in women undergoing in vitro fertilisation.

 

Data sources: Medline, Cochrane Central, Embase, Chinese Biomedical Database, hand searched abstracts, and reference lists.

 

Review methods: Eligible studies were randomised controlled trials that compared needle acupuncture administered within one day of embryo transfer with sham acupuncture or no adjuvant treatment, with reported outcomes of at least one of clinical pregnancy, ongoing pregnancy, or live birth. Two reviewers independently agreed on eligibility; assessed methodological quality; and extracted outcome data. For all trials, investigators contributed additional data not included in the original publication (such as live births). Meta-analyses included all randomised patients.

 

Data synthesis: Seven trials with 1366 women undergoing in vitro fertilisation were included in the meta-analyses. There was little clinical heterogeneity. Trials with sham acupuncture and no adjuvant treatment as controls were pooled for the primary analysis. Complementing the embryo transfer process with acupuncture was associated with significant and clinically relevant improvements in clinical pregnancy (odds ratio 1.65, 95% confidence interval 1.27 to 2.14; number needed to treat (NNT) 10 (7 to 17); seven trials), ongoing pregnancy (1.87, 1.40 to 2.49; NNT 9 (6 to 15); five trials), and live birth (1.91, 1.39 to 2.64; NNT 9 (6 to 17); four trials). Because we were unable to obtain outcome data on live births for three of the included trials, the pooled odds ratio for clinical pregnancy more accurately represents the true combined effect from these trials rather than the odds ratio for live birth. The results were robust to sensitivity analyses on study validity variables. A prespecified subgroup analysis restricted to the three trials with the higher rates of clinical pregnancy in the control group, however, suggested a smaller non-significant benefit of acupuncture (odds ratio 1.24, 0.86 to 1.77).

 

Conclusions: Current preliminary evidence suggests that acupuncture given with embryo transfer improves rates of pregnancy and live birth among women undergoing in vitro fertilization.

 

Acupuncture could obviously improve the cerebral vasomotoricity of the patients with cerebral ischemic stroke. The mechanism is Acupuncture could improve the cerebrovascular function, improve the cerebral blood circulation, so as to provide abundant blood for the focal area and the neighboring ischemic area, to prevent the nerve cell from necrosis and accelerate recovery of the impaired neural system, thus obtain the therapeutic purpose.

 

Germany has conducted the largest clinical trials of acupuncture ever undertaken. About 500,000 patients were included in these ambitious projects, which are sponsored by four large health insurance companies. As an aftereffect, now, there are five big acupuncture research centers are financed by the German government. German insurance companies spend some 600 million marks a year for acupuncture therapy. Also it will be paid by the German social insurance scheme if administered by a qualified acupuncture physician for chronic low back pain and osteoarthritis of the knee.  

                          

A study conducted in UK has shown that the acupuncture is definitely effective in chronic headache, and is reported in the British Medical Journal.

 

Acupuncture in patients with chronic low back pain: a randomized controlled trial.

 

Methods: Patients were randomized to treatment with acupuncture, minimal acupuncture (superficial needling at non-acupuncture points), or a waiting list control. Acupuncture and minimal acupuncture were administered by specialized acupuncture physicians in 30 outpatient centers, and consisted of 12 sessions per patient over 8 weeks. Patients completed standardized questionnaires at baseline and at 8, 26, and 52 weeks after randomization. The primary outcome variable was the change in low back pain intensity from baseline to the end of week 8, as determined on a visual analog scale (range, 0-100 mm).

 

Results: A total of 298 patients (67.8% female; mean +/- SD age, 59 +/- 9 years) were included. Between baseline and week 8, pain intensity decreased by a mean +/- SD of 28.7 +/- 30.3 mm in the acupuncture group, 23.6 +/- 31.0 mm in the minimal acupuncture group, and 6.9 +/- 22.0 mm in the waiting list group. The difference for the acupuncture vs minimal acupuncture group was 5.1 mm (95% confidence interval, -3.7 to 13.9 mm; P = .26), and the difference for the acupuncture vs waiting list group was 21.7 mm (95% confidence interval, 13.9-30.0 mm; P<.001). Also, at 26 (P=.96) and 52 (P=.61) weeks, pain did not differ significantly between the acupuncture and the minimal acupuncture groups.

 

Conclusion: Acupuncture was more effective in improving pain than no acupuncture treatment in patients with chronic low back pain, whereas there were no significant differences between acupuncture and minimal acupuncture.

 

The minimal acupuncture by superficial needling at non-acupuncture points was being called as sham acupuncture. It does make therapeutic action. From this kind of phenomenon, some people questioned the validity of Meridian theory. I think that main reason of the phenomenon is placebo effect psychologically and others are that the mechanism of acupuncture is not quite clear.

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7.1.17.. Chinese medicine in going to popular

 

Nowadays, Western medicine has shown helplessness for many diseases, not only the 2019 coronavirus, but also for the degenerative diseases. So that Chinese medicine get popular.

 

World Health Organization (WHO), European Community (UC), United States (US), Canada and many other countries have issued some Guidance or policies for promoting the use of traditional medicine. They suggested that although the constituents and therapeutic mechanism are not very clear in some traditional medicine, since it has exact therapeutic effect and safe, which has been proven by long time use clinically. These policies allow it to enter medicine market. 

 

FDA accepted the idea of traditional Chinese medicine idea 

 

WHO -- Strategy for Traditional Medicine 2002-2005.

 

E.U.----- DIRECTIVE 2004/24/EC OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL amending, as regards traditional herbal medicinal products, Directive 2001/83/EC on the Community code relating to medicinal products for human use.

 

U.S. ----- Guidance for Industry Botanical Drug Products.

 

Canada - About Natural Health Product Regulation

 

Traditional Chinese medicine has entered clinical applications and market sales under the title of food additive or nutrient supplements.

 

I have seen many times that some Chinese medicine tablets are out of stock in the pharmacy of Chinese medicine in Toronto. The clerk said that those were bought by local white people at one time. Facts have shown that patients, especially who with cardio-cerebral vessels have experienced the good medical effects of Chinese medicinals. Compared with Western synthetic one, it is highly effective without side effects and is cheaper affordable.

 

It turns out the fact that white Canadian patients are easily receptive to Chinese medicinals.

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7.2.. Daoism, the philosophy of TCM

A humanized civilization is a complex system with the mutual support of various branch cultural structures. Among them, the rational philosophy is the basis for the rational practice by guiding people rational reasoning and judging with lesser mistaking. Since ancient China, Daoism has been as leading philosophy.

 

Daoism, was born in about 400 BC China, and has been continuously developed last about centuries. It consists of two parts - philosophy and religion, here I only introduce about the part of philosophy.

 

Daoism is symbolized by the Tai-Ji Diagram as following, in which the black fish represents the Yin, but its eyes are white that means yang, white fish represents Yang, but its eyes are black that means Yin. The outermost circle is called as Taiji or Wuji, which indicates that every thing universally is in metaplasia from vitality and movement in cycling endlessly. 

                     

                  
                

                        Photo source: http://www.prayercast.com/daoism.html

 

The whole symbol means that Yin can’t leave Yang, and Yang can’t leave Yin. They are opposites of each other with contradiction and also reunification. Each is understood to be an integral part of the others in coexistence that can’t exist separately. The main task of Dao is to make Yin and Yang keep in the state of harmonious balance.

 

This point is very important when dealing with the contradiction in reality. The strong and weak positions of the contradictions can convert to each other. One party disappears and the other part does not exist.

 

Daoism dialectically views everything is in the unity of opposites universally and the universe is a system of the unity of opposites, which is composed of many components in subsystem with own feature of unity of opposites. The components are all in the state of dynamic balance through continuous self-regulation.

 

This primitive philosophical view generated thousands of years ago is well coinciding with the modern science in nature world. For example：

 

In micro perspective, as small as atom, extranuclear electrons cloud with the nucleus are both in the state of attraction and repulsion, the electronics rotating around the nucleus in dynamic equilibrium. They are in the state of unity of opposites. Atoms are the components to compose of natural materials. 

 

                   

                 

         Photo source: http://www.engineeringarchives.com/les_chem_atom.html

 

In macro perspective, the planets with the sun in solar system, and the solar system with other galaxies are all in the continuously rotating in the state of self-regulation by attraction and repulsion of each other. They are also in the state of dynamic equilibrium of unity of opposites.

 

              

             

          Photo source: http://www.astronomytrek.com/solar-system/

 

Daoism is with dialectical thinking and well consistent with objective reality. The concept of dialectical thinking encourages people to look at problems from different angles, at different sides and at different levels in detailed without any omissions. This point is very important when dealing with the contradiction in reality.

 

Under the conduct of Daoism, the people of China are carefully dealing with anything with lesser mistake, which was the reason that China built Great Wall to avoid wars, rather than simply fight back to conquer or occupation.  

 

A rational philosophy is the basis for the development of true human civilization by guiding people to think rationally, thereby avoid mistakes, and which was the reason that China has eliminated the wars that caused by the vassal states in 221 BC after reunited from 550 years wars, which was to govern in county and province by gov-appointed officials with ombudsman. 

 

In comparison, without the guidance of a right philosophy, the most of Westerners are to look problem from intuitive appearance, rarely touches the deep level, and rarely takes into account of the bad consequences, which was the one of reasons that West has been in the torture of endless wars of the aristocracy that was lasting about 2000 years longer than that of China and that U.S. has been at war for all but 16 years of its 242-year history.

 

Indeed, the wars under the aristocracy in Europe was as similar as that of the wars under the vassal states of China, the difference was in the name and the process in their formation. It was the irrational philosophical ideas produced under distorted civilization in the West further jeopardize the civilization of the West sustained in the barbaric state in the wars and kills for faith until to today.  

The facts are clear, the civilization of the West is composed of long wars of people endlessly provoking killing for looting or for faith, viewing from anyway, such a civilization is questionable as humanized one.

 

Please Google the article < The Remains of Hundreds of Jews Found in Nazi-Era Mass Grave in Belarus>, and look at inhuman did of the West in last century.

 

The contribution of a correct philosophy Daoism is multifaceted, it is not only that help the people of China to have enjoyed a peaceful life, but also enjoyed healthy life by Traditional Chinese medicine that promoted by Daoism.

 

Daoism embodies that human body itself, human and nature, human and society, human and spirit is all unified whole with interacting each other.

 

Man and nature is a unified whole. Human beings are the product of naturally developed to a certain stage. Nature provides the necessary condition for human survival. The motion and changes of the natural world are bound to affect human beings.

 

Since that people and society is a unified whole, and many social factors may be directly or indirectly influence on human psychology, physiology and pathology.

 

Since that human spirit and the body is a unified whole. Mental activity is the advanced activities of human. Physical is the foundation of spirit, and the spirit is the product of physical. In turn, mental activity can significantly impact on the physical.

 

The medical descriptions of Traditional Chinese Medicine – TCM are using the terms and the principle of its philosophy, such as, Yin & Yang, and cold & Hot. Daoism is contrary with Reductionism. It is similar with Holism and consistent with systems biology. Suppose that Reductionism focuses on a specific grass on the Himalayas, and then the Daoism is not only focusing on the entire grass, but also concerning the factors that would affect the growth of grass.

 

Under the holistic philosophy, TCM has long been recognized that human body was an organic whole that all components were closely interconnected and mutually interacted with ability of self-rebalance and self-restoration, the treatment is seven tenth in psychotherapy only three tenth in medication, so the treatment of TCM is mainly on the promotion of self-rebalance and self-restoration with the consideration of the interactions of various existing factors' from all components including the social and psychological.

 

TCM believes that a well-balanced human bodies will form an effective self-defence system that can handle the most of pathogenic agents. The diseases could happen only if there are some unbalanced parts in a human body. So, the treatments do not directly target to kill pathogens but to bring back the natural balance. It achieves the purpose by natural therapeutic approaches, such as, natural medicines, acupuncture and physical exercises, etc.

 

The role of psychology affecting physiology has been found in ancient and to be modern clinic proved. Many modern researches have inadvertently proven the correctness of TCM.

 

Dec. 24, 1955, the Western Medicine practitioner Henry K. Beecher, M.D. who published article The Powerful Placebo to have indicated that placebos are effective in 50 or 60 percent of subjects with certain conditions. In Jan. 2008, a study of crossing-disciplines of psychology, medicine, neuroscience, and genetics reveals that Stress Causes Everything from gums to heart and make more susceptible to everything from the common cold to cancer.

 

Suppose we take the placebo effect as a kind of psychotherapy, then the proportion of seven-tenths in psychotherapy is close to the modern double-blind clinical trials that are effective in 50 or 60 percent.

 

In the field of medicine, the emergence of systems biology and evidence-based medicine shows that western medicine is gradually increasing the components of holistic part, and it is quietly approaching from Reductionism to Daoism.

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7.3.. The comparison in the symptoms of 2003 SARS and 2019 coronavirus

2003 SARS:

 

 Fever above 38°C, dizziness, shortness of breath, dyspnea, hypoxia, pneumonia, cough, headache, muscle stiffness, loss of appetite, general weakness, mental disorders, rash, diarrhea, chills, tremors.

 

2019 coronavirus:  

 

Mild appetite loss, fatigue, poor mentality, nausea, fever, insanity, sore throat, snot, vomiting, diarrhea; headache; palpitation, chest tightness; conjunctivitis; muscle pain, cough, shortness of breath, impaired organ function, acute kidney injury, septic shock, mild sore in limbs or lower back muscles.

 

They are same in major, which shows that based on effective Chinese medicinals, adds vinegar, Vitamin C and vitamin B3, will be many times powerful to quickly cure new coronavirus pneumonia.

 

More significantly, the symptoms of 2003 SARS and 2019 coronavirus pneumonia are common in the most of diseases, the different is at more or less.

 

There were reports that the government of China has learned the lessons of the treatment of the atypical pneumonia 2003, this time the doctors in Chinese medicine directly participated in the formation of the treatment team and achieved great results. However, in compared with the immediate effect of Vc and B3, the effect of any Chinese medicine is a little slower. It's still too slow for treating emergency patients that is to race against time.

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7.4.. The convincing proof of the magic effect of autoimmune

Nov. 15, 2019, article World's Oldest People May Have Supercharged Immune Cells said that: The secret to living past 110 may be an increase in killer cells in the bloodstream.

 

New research from the universities of Japan finds that "supercentenarians," or people who make it to 110 years of age or older, have higher-than-typical concentrations of a particularly rare type of T helper cell in their blood. These immune cells might protect the oldest of the old against viruses and tumors, leaving them in remarkably fine health throughout their long life spans.

 

The samples netted more than 41,000 immune cells from the seven supercentenarians and nearly 20,000 more from the younger control subjects. The standout finding, the authors said, was that a large proportion of the supercentenarians' immune cells were from a subset called CD4 CTLs, a kind of T helper cell that can directly attack and kill other cells.

 

The broad group of CD4 cells, or T helper cells, are generally not fighters. These cells are more like commanders, telling other immune cells what to do by releasing inflammatory chemicals called cytokines. But CD4 CTLs are cytotoxic, meaning they're capable of actually attacking and destroying invaders themselves.

 

Usually just a few percent of all T helper cells are cytotoxic; the younger people in the new study showed an average of just 2.8%. But in the supercentenarians, about 25% of all helper Ts consisted of this deadly version, the researchers reported Tuesday (Nov. 12) in the journal Proceedings of the National Academy of Sciences.

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7.5.. A introduction of a herb that used in TCM for over 2000 years

 

This translated from the article in Mandarin Astragalus immune regulation mechanism and clinical application progress

By Nie Ziwen, Wei Qianghua,  The First People's Hospital of Shanghai Jiaotong University

https://www.google.ca/url?sa=t&rct=j&q=&esrc=s&source

 

Astragalus contains a variety of saponins, flavones, polysaccharides, as well as amino acids, linoleic acid, alkaloids, choline and other chemical components, of which saponin, flavones, polysaccharides and other components have immunomodulatory effects.

 

6.5.1.. Immune enhancement

 

Astragalus can increase the weight of the spleen and thymus and improve the immune function of the body. For example, if astragalus polysaccharides are given to mice, the spleen and thymus indexes of cyclophosphamide can be significantly increased.

 

6.5.1.1 Non-specific immunity

 

6.5.1.1.1 Macrophages

 

Astragalus polysaccharide can induce and activate macrophages to express nitric oxide synthase and produce nitric oxide (NO), thereby promoting the effect of macrophages on target cells and the phagocytosis of macrophages.

 

6.5.1.1.2 Natural killer cells

 

Astragalus can increase the activity and killing effect of natural killer cells (NK cells). Studies have shown that astragalus can increase the activity of NK cells in patients with acute viral myocarditis.

 

6.5.1.1.3 Dendritic cells

 

Astragalus polysaccharide can induce umbilical cord blood mononuclear cells (dendritic cell precursor cells) to differentiate into functional (mature) dendritic cells (DCs) in vitro; DCs induced by astragalus polysaccharide can obviously stimulate allogeneic T lymphocytes The ability to proliferate, and the effect increases with the increase in the number of DCs cells.

 

6.5.1.2 Specific immunity

 

6.5.1.2.1 Cytokines

 

Astragalus total glucosides (10, 20 mg / L) decreased the schistosomiasis egg antigen (10 mg / L) in a concentration-dependent manner, stimulated the expression of TNF-α messenger ribonucleic acid (mRNA) in rat peritoneal macrophages and the supernatant TNF-α content.

 

6.5.1.2.2 Cell immunity

 

Astragalus has a significant weight-increasing effect on the thymus of normal mice, and can significantly increase the proliferation of T lymphocytes stimulated by concanavalin A. Studies by Liu and others show that the preliminary treatment results of astragalus injection on children with allergic purpura show that astragalus can not only increase Th1 cytokine, but also reduce Th2 cytokine.

 

6.5.1.2.3 Humoral immunity

 

In the study of the ability of mice to resist Listeria monocytogenes, mice injected with astragalus polysaccharides had significantly higher serum immunoglobulin G (IgG) titers than the control group. Oral astragalus can significantly increase the levels of IgG1 and IgG3 in the serum of children with IgG subclass deficiency compared with before treatment.

 

6.5.2.. Immunosuppression and two-way regulation

 

Astragalus decoction not only promotes normal mouse lymphocyte transformation, reduces the destruction of mouse spleen B cells, and induces IL-2 levels, but high-concentration astragalus inhibits IL-2 induction, indicating that astragalus has two-way immunity.

 

6.5.3.. Clinical applications

 

6.5.3.1.. Poor immunity

 

A controlled study of 29 patients with chronic renal failure and maintenance hemodialysis found that the hemoglobin and hematocrit in the blood of patients treated with astragalus injection were significantly improved, and significantly improve patients' immunity.

 

6.5.3.2.. Autoimmune diseases

 

A small sample of studies has shown that after discontinuing other anti-rheumatic western medicines, total astragalus glycosides alone are used to treat rheumatoid arthritis, the total effective rates at 4, 6, and 8 weeks were 45.5%, 54.5%, and 55.6%, respectively.

At the 8 week, the patient's resting pain, morning stiffness, number of swelling joints, and index can be significantly improved without significant adverse reactions.

7.5.4.. Conclusion

In summary, astragalus has a certain immune-enhancing effect, and it has a certain enhancement effect on non-specific and specific immunity, including enhancing the phagocytosis of dendritic cells and phagocytic cells, increasing NK cell activity and killing effect, and regulating the content of cytokines, increase the number and activity of T cells.

7.6.. A introduction of an over a thousand years classic formula of TCM

Pharmacological analysis of a classical formula and its component of traditional Chinese medicine

      Frank  Oct. 26, in Waterloo Canada

      http://www.kwcg.ca/bbs/home.php?mod=space&uid=61910&do=blog&id=7794 

This is translate and reedited by googled information form internet in Mandarin.

7.6.1.. Classical formula Xiaoyao San and its components of Traditional Chinese medicine

Xiaoyao San is a famous and popular classic experience-based formula that has been using in traditional Chinese medicine for over a thousand years in China. Xiaoyao San is the name in phonetic alphabet of Mandarin, in which Xiaoyao means enjoyful and comfortable, San means powder. In TCM, that smashes dried phyto-pharmaceuticals into a powder for easy in-taking is one of the methods of drug application in Ancient and today.

 

In the treatment of diseases, the doctors of Chinese medicine are never cares about pathogens but trying to diagnose the imbalance of Yin and Yang by fingers perceiving the pulse wave, looking at the color and surface pattern of tongue of the patients integrated with smelling and asking; then, prescribe the prescription of Chinese medicinals to treat the patients by regulating the balance of the body's yin and yang, according to the principles and the terms of the philosophy Daoism.

The prescription of Xiaoyao San was also based on this principle, targeted on Yin-Yang balance, rather than specific pathogens.

However, for Xiaoyao San and any Chinese medicine, the process of physiological healing by re-balancing Yin and Yang, essentially, is the process of re-balancing the physiological condition by working on the expression of brain-derived Neurotrophic factor (BDNF) and various physiological processes of metabolism, endocrine and so on.

For achieving a better therapeutic effect of Chinese medicinals, it is better to understand the pharmaceutical actions of Chinese medicinals on regulating the physiological conditions.

In this concern, Xiaoyao San is a good representation for well understanding the pharmaceutical effects of Chinese medicine physiologically.

 

Xiaoyao San firstly seen in or  that compiled by Imperial Medical Bureau of the government of Song Dynasty in 1151 China.

 

Imperial Medical Bureau was the Gov-operated highest medical education institution with medicinals making and selling in Song dynasty (AD 960 - 1279) China.

 

In 1076, the government of Song opened a Gov-run pharmacy in the capital city – Bianliang (today’s Kaifeng city of Henan Province), the pharmacy called as “Imperial Medical Bureau”, also known as the “Drug Selling Factory” that was established for avoiding counterfeit drugs, the government implements monopoly on the purchase and sale of medicinals, and banned individuals or other organizations to make drugs for sale.

 

At that time, the price of drugs sold was treated differently. For those people who live in poverty, the Factory gives medicinals for free; for those general people, the Factory sells drugs at low prices; for the Rich people, the Factory sell at the normal price of drugs, at the time of helping the poor and also ensured the quality of the medications.

 

The Imperial Medical Bureau was continuously developed, and by 1103, it had grown to seven branches.

 

In 1130, the government of Southern Song rebuilt the Imperial Medical Bureau and later changed its name as Bureau of Taiping People's Welfare Pharmacy.

 

The book is a widely published and influential clinical book in TCM until to today.

 

The first issue was published in 1078, which is a handbook for the prescription of medicines owned by Imperial Medical Bureau and has been supplemented and revised several times with the title and volume have been adjusted also, finally, there ten volumes were added in succession and the prescriptions were divided into 14 category in diseases with 788 formulas as existing popular version today.

 

Currently, in China, there are a variety of existing block-printed versions from Ming and Qing dynasties. There is typographical printed version after 1949.

 

All of the formulas in book were collected from the civil experience-based formulas that were effective and often used publically, with descriptions in the indications of the diseases, the compatibility of the medicinals and the methods of specific revision. In the book, there were many famous popular formulas often used until today, and Xiaoyao San is one of them to be often used for the treatment of depression

 

The Xiaoyao San is composed of 8 kinds of herbs: Bupleurum, Angelica, White Peony, Atractylodes, Licorice, Alfalfa, Ginger and Peppermint, follow is their pictures searched from Internet.

 

Judging from the artificial painting, the pictures are from ancient books of Chinese medicine. For easily identifying medicinal plants, Ancient people of China draw their feature of appearance as detailed as possible.

 

      Bupleurum Angelica

       White PeonyAtractylodes

       LicoriceAlfalfa 

      Ginger Peppermint

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 Follow is the links of the sources of above pictures.

 

 Bupleurum –- https://www.fortticonderoga.org/blog/new-featured-annual-bupleurum/

 Angelica ---    https://en.wikipedia.org/wiki/Angelica

 White Peony- https://www.rjwhelan.co.nz/herbs%20A-Z/peony.html

 Atractylodes- http://www.luminescents.net/shop/herbal/traditional-herbs/chinese-herbal/bhai-zhu-root-atractyloides-macrocephala/

 Licorice   ---   https://en.wikipedia.org/wiki/Liquorice

 Alfalfa     ---   https://en.wikipedia.org/wiki/Alfalfa

 Ginger    ---   https://en.wikipedia.org/wiki/Ginger

 Peppermint - https://www.medicinetraditions.com/mentha-mint-bo-he-free.html

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7.6.2.. Medicinal description of Xiaoyao San in traditional Chinese medicine

 

https://baike.baidu.com/item/%E9%80%8D%E9%81%A5%E6%95%A3

 

Xiaoyao San is a reconciliation agent with the effect of reconciling the liver and spleen, soothing the liver and relieving depression, nourishing the blood and strengthening the spleen.

 

Indications of stagnation of liver blood, spleen weakness, headache, dizziness, dry mouth and throat, fatigue, poor appetite, irregular menstruation, breast pain, both sides of the flank pain,…..

 

Clinical use of Xiaoyao San

 

https://baike.baidu.com/item/%E9%80%8D%E9%81%A5%E6%95%A3

 

The treatment of chronic hepatitis, cirrhosis, cholelithiasis, gastric and duodenal ulcer, chronic gastritis, gastrointestinal neurosis, premenstrual tension, breast lobular hyperplasia, etc.

 

7.6.3.. Modern studies of pharmaceutical and physiological effects on Xiaoyao San

 

Research progress on Xiaoyao San and its anti-depression mechanism – a Review report in Mandarin

By Zhou Haobo, Yao Lu, Lo Tengfei, et al.   Feb. 2017

 

Tianjin University of Traditional Chinese Medicine, National Natural Science Foundation of China

 

This article searches the relevant literature for the past five years, and summarizes the main mechanism of action of Xiaoyao Powder in the treatment of depression. It is found that Xiaoyao Powder may exert antidepressant effects by affecting the expression of monoamine neurotransmitters, pathways and receptors, hypothalamic-pituitary-adrenal axis, liver tissue metabolism, etc. Among them, that interferes with key molecules of BDNF/CREB signaling pathway in the expression and function, improve stress-induced neuronal status, has an important guiding role in the study of Xiaoyao San's anti-depressant mechanism.

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7.6.3.1.. Affecting monoamine neurotransmitters

 

Studies have shown that Xiaoyao San can increase the levels of 5-HT and NE in the brain of rats, and block the reuptake of 5-HT and NE by serotoninergic nerve endings and noradrenergic nerve endings, thus enabling the brain Increased neurotransmitter concentration in the synaptic cleft of neurons, enhances intersynchronous neurotransmitter transmission, and improves depression.

 

95% ethanol extract of Xiaoyao San has antidepressant effects on rat behavior and has a significant improvement on callbacks of NE, 5-HT, 5-hydroxyindole acetic acid and 5-HIAA neurotransmitters. In comparison, the effect of using 95% ethanol alone is not obvious.

 

Xiaoyao San can effectively improve the levels of serum monoamine neurotransmitters (NE, AD and 5-HT), up-regulate the expression of 5-HT1A mRNA in hippocampus and cortex, and the expression level of 5-HT1A receptor protein, and down-regulate 5-HT2A receptor mRNA. The regulation of body mRNA expression plays a role in the treatment of depression and sleep disorders by regulating 5-HT nerves, but it does not affect thyroid hormone levels.

 

Through regulating hocus ceruleus-norepinephrine / sympathetic-adrenal medulla axis and LC-NE, Xiaoyao San can repair damaged neurons caused by stress, enhance the function of catecholamine neurotransmitters, increase the secretion of NE and DA, and stimulate sympathetic nerves, and inhibit the parasympathetic nerve to achieve antidepressant effects.

 

7.6.3.2. Influence the expression of pathways and receptors

 

Xiaoyao San can influence the expression of multiple pathways, receptor proteins and genes, and through this specific expression, release neurotrophic factors, or directly improve synaptic plasticity, etc., to affect neuronal status, thereby exerting antidepressant effects.

 

Xiaoyao Powder can increase brain-derived neurotrophic factor in hippocampus, increase expression level of cyclophosphamide-responsive element binding protein mRNA and cortical BDNF mRNA, and increase the expression of pERK1 / 2 in hippocampus. Regulates the expression and function of key molecules of the BDNF / CREB signaling pathway, repairs stress-damaged neurons, and achieves antidepressant effects.

 

Xiaoyao San may affect synaptic plasticity by regulating the expression of multiple receptors and related proteins in hippocampus and amygdala of rats, and the role of CA3 and DG in hippocampus is most obvious.

 

Xiaoyao San can effectively reverse the expression of P450scc protein in hippocampal CA3 and DG regions of rat model, further regulate neuroactive corpus callosum function, regulate the excitability of related proteins in hippocampus and amygdala, and achieve the regulation of synaptic plasticity and antidepression.

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7.6.3.3 .. Affecting the hypothalamic-pituitary-adrenal axis

 

It is generally accepted that the hyperfunction of hypothalamic-pituitary-adrenal axis, HPA is one of the neuroendocrine mechanisms of depression.

 

Xiaoyao San can down-regulate the expression of CRH mRNA in hypothalamus, decrease the content of CORT and ACTH in plasma, up-regulate the expression of GR and its mRNA, increase the secretion of GC, reverse the decline of glucose tolerance in rats, decrease the excitability of HPA axis, and strengthen negative Feedback adjustment, to achieve the role of antagonistic HPA axis hyperfunction.

 

Xiaoyao San has a two-way regulation of AMPA receptors GluR1 and GluR2, and down-regulates the role of AMPA receptor-associated protein kinase C-protein-positive reactants. Protecting the negative stimuli induced by chronic stress into the hippocampus, regulating synaptic transmission. Anchore the AMPA receptor containing the GluR2 subunit to the postsynaptic membrane, to affect the feedback function of the HPA axis.

 

Xiaoyao Powder can effectively reduce the glycine content in the depression model rats, inhibit the activation process, and affect the neuroendocrine HPA axis to resist depression.

 

7.6.3.4 .. Affect liver tissue metabolism

 

Traditional Chinese medicine believes that depression is mainly caused by liver stagnation and spleen deficiency. Modern research literatures also indicate the degeneration, necrosis and fibrosis of liver tissue in the rat depression model.

 

Xiaoyao San can affect the inflammatory factors, increases the number of hepatic sinusoidal endothelium, prevents vascularization of the sinusoidal endothelium, and affects the metabolism and function of liver tissue.

 

Xiaoyao San can reduce the content of serum necrosis factor-Alfa, reduce its binding to TNF receptor, inhibit the activation of indoleamine 2,3-dioxygenase in liver tissue, and inhibit the activation of tryptophan2, 3-dioxygenase in liver tissue, which affects the metabolism disorder of liver, achieves antidepressant effects.

 

Xiaoyao Powder can increase the expression of IRS-2 and PI3-K mRNA in liver tissue and reduce hepatocyte apoptosis; inhibit the synthesis and secretion of collagen fibrin, and clear the free radical, which reduces the expression of transgenic SREBP1 and nuclear translocation. Reduce the induced expression of the lipid-related enzyme gene activated by SREBP1 in the nucleus to prevent lipid peroxidation and reduce hepatocyte degeneration, necrosis and inflammatory infiltration. Improve cell membrane permeability and restore metabolic pathways such as partial amino acid metabolism, tricarboxylic acid cycle, and urea cycle. Promote liver cell regeneration and improve liver fibrosis to achieve antidepressant effects.

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7.6.3.5.. Hope for future study

 

Xiaoyao San is widely used as a basic prescription for the treatment of depression in clinical practice. It can effectively alleviate the symptoms of insomnia and gastrointestinal discomfort, and at the same time, it can relieve the liver and strengthen the spleen and achieve the therapeutic effect.

 

In recent years, there have been a large number of experimental studies on the anti-depression mechanism of Xiaoyao San, and the research direction of depression mechanism based on monoamine neurotransmitter hypothesis and HPA axis has been proposed.

 

Studies on pathways and receptors have emerged, demonstrating that Xiaoyao San can regulate neurotrophic factors by affecting the expression levels of certain pathways, receptor proteins and genes, and affect synaptic plasticity to achieve antidepressant effects.

 

7.6.4.. Modern studies on therapeutic mechanism of single medicinal plants used in Xiaoyao San

 

Follow is the modern research reports in English regarding the pharmaceutical and physiological mechanism of single medicinal plants used in Xiaoyao San.

 

7.6.4.1.. Bupleurum, Radix Bupleuri, Bupleurum chinensis DC

 

7.6.4.1.1.. Anti-Inflammatory Effect and Chemical Composition of Bupleurum chinense and Bupleurum kaoi

 

https://www.omicsonline.org/open-access/antiinflammatory-effect-and-chemical-composition-of-bupleurum-chinense-and-bupleurum-kaoi-2329-6836.1000139.php?aid=27457

 

Abstract

Bupleurum species represent one of the most successful and widely used herbal drugs for treatment of many diseases over the past 2000 years. Bupleurum chinense (B. chinense) is officially listed in China and Bupleurum kaoi (B. kaoi) is the only indigenous Bupleurum plant in Taiwan. Therefore, the aim of our study is to investigate the chemical components, anti-inflammatory, and antioxidants of B. kaoi and B. chinense.

 

We report highly sensitive and specific assay for anti-inflammatory with a TNF-α luciferase plasmid vector. In preliminary experiments, we found that B. kaoi have stronger anti-inflammatory effects than B. chinense.

 

Conclusion

In traditional chinense medicine, Bupleuri Radix possesses many biological effects, such as anti-inflammatory, antipyretic, antihepatitis activity [1,2,12]. Anti-inflammatory action of saikosaponins (SSs) isolated from the root of Bupleurum falcatum L were examined using female albino rats. Among saikosaponins isolated from Bupleurum falcatum, SSa and d, not c, were demonstrated to have anti-inflammatory action [13]. In recently studies demonstrated that the Tumor necrosis factor-alpha (TNF-α) is primarily produced by macrophages, lymphocytes, neutrophils, endothelial cells, keratinocytes, and fibroblasts during acute inflammatory reactions. Therefore, to clarify the anti-inflammatory activity, we establish a highly sensitive and specific assay for TNF-α gene transcription. This assay is based on the use of TNF-α reporter cell line, which was created by stable transfection of a macrophage cell line (RAW264.7) with a TNF-α luciferase plasmid vector. In preliminary experiments, we found that B. kaoi have stronger anti-inflammatory effects than B. chinense. However, it was no significant difference in the free radical scavenging activities of B. kaoi and B. chinense.

 

We demonstrated that SSa, SSc and d are the major compounds of B. kaoi and B. chinense in TLC analysis. The SSa, SSc and SSd content in B. kaoi has been reported to be higher than that in B. chinense. We combined TLC chromatograms with hierarchical clustering analysis to differentiate the different species of Bupleuri Radix. Theses studies showed that, HCA could be classified into Cluster I (B. chinense) and Cluster II (B. kaoi).The major impact feature were Rf 0.58(SSd) and Rf 0.44(SSc) .This method could be as tool in to differentiation and identify different species of herbal medicine in the future.

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7.6.4.1.2.. Radix Bupleuri: A Review of Traditional Uses, Botany, Phytochemistry, Pharmacology, and Toxicology

https://www.hindawi.com/journals/bmri/2017/7597596/

 

Abstract

Radix Bupleuri (Chaihu) has been used as a traditional medicine for more than 2000 years in China, Japan, Korea, and other Asian countries. Phytochemical studies demonstrated that this plant contains essential oils, triterpenoid saponins, polyacetylenes, flavonoids, lignans, fatty acids, and sterols. Crude extracts and pure compounds isolated from Radix Bupleuri exhibited various biological activities, such as anti-inflammatory, anticancer, antipyretic, antimicrobial, antiviral, hepatoprotective, neuroprotective, and immunomodulatory effects. However, Radix Bupleuri could also lead to hepatotoxicity, particularly in high doses and with long-term use. Pharmacokinetic studies have demonstrated that the major bioactive compounds (saikosaponins a, b2, c, and d) were absorbed rapidly in rats after oral administration of the extract of Radix Bupleuri. This review aims to comprehensively summarize the traditional uses, botany, phytochemistry, pharmacology, toxicology, and pharmacokinetics of Radix Bupleuri reported to date with an emphasis on its biological properties and mechanisms of action.

 

Summary of Pharmacological Effects

Radix Bupleuri possesses a wide spectrum of pharmacological effects, including anti-inflammatory effect, anticancer effect, antiviral effect, antipyretic effect, antibacterial effect, hepatoprotective effect, and immunomodulatory effect (Table 3). Based on these pharmacological effects, we can conclude that the extracts and the compounds from this plant can prevent or treat certain diseases, such as cancer, fever, malaria, hepatitis, and AD. However, there is not enough systemic data of these chemical compounds and their pharmacological effects. Thus, in the future, the pharmacological effects and the possible molecular mechanisms of the pharmacological activities of Radix Bupleuri must be urgently explored on our modern understanding of these diseases’ pathophysiologies.

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7.6.4.2.. Angelica, Angelica sinensis

 

7.6.4.2.1.. Phytochemical and pharmacological studies on Radix Angelica sinensis

https://www.sciencedirect.com/science/article/pii/S1875536413600679

 

Abstract

The roots of Angelica sinensis (RAS), are a Chinese herbal medicine traditionally used in prescriptions for replenishing blood, treating abnormal menstruation, and other women's diseases. It has also been widely marketed as health food for women's care in Asia, and as a dietary supplement in Europe and America. RAS is well-known for its hematopoietic, antioxidant, and immunoregulatory activities. RAS also possesses anti-cancer, memory, radioprotective, and neuroprotective effects. Phytochemical investigations on this plant led to organic acids, phthalides, polysaccharides, and other metabiolites. Based on recent animal studies and clinical trials, RAS has been used in the treatment of gynecologic diseases, cardio-cerebrovascular disease, nervous system diseases, and nephrotic syndrome. In this review, the recent phytochemical and pharmacological studies, drug-drug interactions, clinical applications, and toxicity of RAS are summarized.

 

7.6.4.2.2.. Effects of volatile oils of Angelica sinensis on an acute inflammation rat model

https://www.tandfonline.com/doi/full/10.3109/13880209.2015.1133660?src=recsys

 

Abstract

Context Despite several pharmacological studies of volatile oils of Angelica sinensis (Oliv.) Diels (Umbelliferae) (VOAS), its anti-inflammatory mechanism remains unknown.

 

Results 

Compared with the model group, VOAS and Dex significantly accelerated the recovery of the exterior behaviour, the liver pathological changes of rats, and increased the level of IL-10, but decreased the level of WBC, NE%, GOT, GPT, ALP, TNF-α, IL-1β, IL-6, HIS, 5-HT, NO, PGE2, iNOS and COX-2 (p < 0.05).

 

Conclusion 

VOAS exhibits anti-inflammatory and liver protection effects by inhibiting the secretion of the pro-inflammatory cytokines (TNF-α, IL-1β and IL-6), the inflammatory mediators (HIS, 5-HT, PGE2 and NO), the inflammation-related enzymes (iNOS and COX-2), as well as promoting the production of the anti-inflammatory cytokines IL-10.

 

7.6.4.3.. peony

 

7.6.4.3.1.. Research progress of pharmacokinetics and pharmacodynamics of total glucosides of peony in hepatoprotective effects

https://www.ncbi.nlm.nih.gov/pubmed/29243418

 

Abstract

Total glucosides of peony (TGP), containing the effective components of paeoniflorin (Pae), albiflorin (Alb) and so on, are effective parts of Radix Paeoniae Alba. And it possesses extensive pharmacological actions, one of which is hepatoprotective effect. In recent years, abundant of pharmacokinetics and pharmacodynamics research of TGP in hepatoprotective effects have been performed. However, the relative medicine of TGP in hepatoprotective effect has not been developed for clinical application. In order to provide reference for the development and rational clinical application of TGP, the research progresses of pharmacokinetics and pharmacodynamics of TGP in hepatoprotective effect were summarized in this paper. Pharmacokinetics research has clarified the process of absorption, distribution, metabolism and excretion of TGP in vivo, and liver injury disease can significantly influence its metabolic processes. Pharmacodynamics studies suggested that TGP can protect against acute liver injury, non-alcoholic fatty liver diseases (NAFLD), chronic liver fibrosis and liver cancer. However, the action mechanism and in vivo process about hepatoprotective effects of TGP have not been clearly revealed. How liver injury influences the metabolism of TGP and its integrated regulation through multiple targets need to be further studied. The combined pharmacokinetics and pharmacodynamics studies should be performed in favour of medicine development and clinical application of TGP in hepatoprotective effects.

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7.6.4.3.2.. Anti-Inflammatory and Immunomodulatory Effects of Paeonia Lactiflora Pall., a Traditional Chinese Herbal Medicine

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108611/

 

Abstract

In China, Korea, and Japan, a decoction of the dried root without bark of Paeonia lactiflora Pall. has been used in the treatment of rheumatoid arthritis, systemic lupus erythematosus, hepatitis, dysmenorrhea, muscle cramping and spasms, and fever for more than 1200 years. A water/ethanol extract of the root is now known as total glucosides of peony (TGP), which contains more than 15 components. Paeoniflorin is the most abundant ingredient and accounts for the pharmacological effects observed with TGP in both in vitro and in vivo studies. The analgesic effect of TGP was confirmed in various animal models of pain, which may be mediated partly by adenosine A1 receptor. The direct anti-inflammatory effects of TGP were observed in animal models of both acute and subacute inflammation, by inhibiting the production of prostaglandin E2, leukotriene B4, and nitric oxide, and by suppressing the increase of intracellular calcium ion concentration. TGP was also reported to have protective effects of cells against oxidative stress. In vitro, dual effects of TGP were noted on the proliferation of lymphocytes, differentiation of Th/Ts lymphocytes, and the production of proinflammatory cytokines and antibodies. In vivo, TGP inhibited the delayed-type hypersensitivity in immuno-activated mice, and enhanced the delayed-type hypersensitivity in immuno-suppressed mice. In adjuvant arthritis rats, paeoniflorin exerted immunosuppressive effects. The beneficial effects of TGP in treating rheumatoid arthritis were verified by randomized controlled trials. The adverse events of TGP were mainly gastrointestinal tract disturbances, mostly mild diarrhea.

 

Figure 1 Paeonia lactiflora Pall. (A) overground part of the plant; (B) root; (C)scheme of an intact plant.

 

A water/ethanol extract of Radix Paeoniae Alba is known as total glucosides of peony (TGP), which contains more than 15 components, including paeoniflorin, albiflorin, oxypaeoniflorin, benzoylpaeoniflorin, oxybenzoyl-paeoniflorin, paeoniflorigenone, lactiflorin, galloylpaeoniflorin, paeonin, paeonolide, and paeonol (Zhang et al., 2001; Tan et al., 2010). Most of them are monoterpene glucosides, and their structures are shown in Figure ?Figure2.2. Among them, paeoniflorin (C23H28O11, with a molecular weight of 480.45), a water-soluble compound, is the most abundant (>90%) and accounts for the pharmacological effects observed with TGP in both in vitroand in vivo studies. So the content of paeoniflorin is used for the standardization of the dosage of TGP. A preparation of TGP was approved by State Food and Drug Administration of China to enter market as a disease-modifying drug for rheumatoid arthritis in 1998. In recent years, a lot of studies describing the chemistry and the pharmacology of TGP have been published, but often in Chinese. Here, we briefly reviewed the immunomodulatory and anti-inflammatory effects of TGP.

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Figure 2

 

Concluding Remarks

A water/ethanol extract of the dried root without bark of P. lactiflora Pall. is now known as TGP, and paeoniflorin is the most abundant component (>90%) of TGP. TGP is effective to relieve the pain in various animal models. TGP also inhibits both acute and subacute inflammation by suppressing the increase of intracellular calcium ion concentration, and inhibiting the production of inflammatory mediators, such as PGE2, LTB4, and NO. There are dual effects of TGP on the proliferation of lymphocytes, differentiation of Th/Ts lymphocytes, and production of proinflammatory cytokines and IgM-antibodies, which depend on the activity of immuno-responses. The underlying mechanisms of TGP responsible for the unique immunomodulatory effects need to be further studied.

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7.6.4.4.. Atractylodes

 

7.6.4.4.1.. Therapeutic potential and pharmacological activities of Atractylodes lancea (Thunb.) DC.

 

https://www.ncbi.nlm.nih.gov/pubmed/25066389

 

Abstract

The rhizome of Atractylodes lancea (A. lancea) (Thunb.) DC. (AL) is extensively used in Chinese, Thai, and Japanese traditional medicines as crude extracts/decoctions or a component in various herbal formulations. Various pharmacological activities of AL and its major constituents have been demonstrated in vitro, ex vivo, and in animal models. Results from the toxicity studies in animal models suggest safety profile of AL and its active constituents. Despite extensive use with positive impression in many diseases, there has not been a clinical study that can conclusively support its efficacy and safety profile in human. This review comprehensively summarizes current information on the pharmacological activities of AL and their active constituents including anticancer, anti-inflammatory, antimicrobial and antipyretic activities, as well as activities on central nervous, cardiovascular, and gastrointestinal systems.

 

7.6.4.4.2.. Anti-cancer effect of Atractylodes macrocephala extract by double induction of apoptotic and autophagic cell death in head and neck cancer cells

https://www.banglajol.info/index.php/BJP/article/view/31238

 

Abstract

The apoptosis resistance restricts the efficacy of traditional therapies of head and neck squamous cell carcinoma (HNSCC). To overcome this problem, Atractylodes macrocephala, a traditional Korean and Chinese herbal medicine, has been used in clinical practice. In the present study, the anticancer effect of A. macrocephala extract was investigated and its underlying mechanisms using head and neck cancer KB cell line. The extract-induced cytotoxicity was mediated by autophagic cell death as well as apoptosis in HNSCC cells though extrinsic apoptotic pathway and the Akt/mTOR autophagic pathway. This study suggests that A. macrocephala extracts can be a potential drug to overcome side effects and susceptibility for head and neck carcinoma by double induction of apoptosis and autophagy.

 

Conclusion

A. macrocephala induces autophagy via inhibition of mTOR requires Akt inhibition, not the AMPK activation in KB cells. 

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7.6.4.5.. licorice

 

7.6.4.5.1.. The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629407/

 

Abstract

Licorice is a common herb which has been used in traditional Chinese medicine for centuries. More than 20 triterpenoids and nearly 300 flavonoids have been isolated from licorice. Recent studies have shown that these metabolites possess many pharmacological activities, such as antiviral, antimicrobial, anti-inflammatory, antitumor and other activities.

 

Many studies found that several components were responsible for the antiviral and antimicrobial activities through different mechanisms. Licorice contains more than 20 triterpenoids and nearly 300 flavonoids. Among them, only two triterpenes, GL and GA have been reported to have antiviral effects. They can weaken virus activities by inhibiting virus gene expression and replication, reducing adhesion force and stress, and reducing HMGB1 binding to DNA. They can also enhance host cell activities by blocking the degradation of IκB, activating T lymphocyte proliferation and suppressing host cell apoptosis. In contrast, flavonoids, especially chalcones, play an important role in the treatment of bacterial infection by decreasing expression of bacterial genes, inhibiting bacterial growth and reducing the production of bacterial toxin.

 

Many studies have reported that the six active compounds listed in this paper, GL, GA, LCA, LCE, GLD and LTG, possess other activities. For example, GL and GA also have antitumor39, 40, anti-inflammatory41, 42, and immunoregulatory activities12, 43, 44. LCA, LCE, LTG and GLD also have inhibitory effects on diabetes45, 46, 47, 48. All of these reports demonstrate potentially broad applications for these agents. In addition, there are many other compounds isolated from licorice with different pharmacological activities. For example, isoliquiritigenin (ISL) shows effective immunoregulatory activity49, glabrol has an inhibitory effect on diabetes50, and dehydroglyasperin C (DGC) has hepatoprotective activity51.

 

Among the six compounds listed in this paper, only GL has been clinically developed as a drug. As the most important marker component in licorice, the development of GL preparations has a long history in China, from GL tablets to ammonium glycyrrhizinate, diammonium glycyrrhizinate and magnesium isoglycyrrhizinate (MgIG). All of the above GL preparations possess antiviral and antimicrobial activities. Diammonium glycyrrhizinate inhibits cell infection by pseudorabies virus (PrV) and decreases cell apoptosis during PrV infection52. Compared with diammonium glycyrrhizinate, the fourth generation GL preparation, MgIG, has better lipophilic properties, higher targeting activity and fewer adverse reactions. It has been used in treating liver disease53, 54, 55, pulmonary fibrosis56 and testicular injuries57. However, reports about mechanisms of antiviral and antimicrobial activities of MgIG are still very limited. The development of new licorice preparations will improve the safety and efficacy of licorice-related products.

 

In many African countries with poorly developed health care systems, viruses and bacteria are significant sources of disease. More than 2 billion people have been exposed to HBV over the world, and the situation in some areas of Africa is much more serious58. The development of effective and affordable licorice-related medicines could introduce dramatic improvements in treating the many prevalent diseases of third world populations. It is hoped that the present work will facilitate the development of improved licorice preparations with antiviral and antimicrobial activities.

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7.6.4.5.2.. Pharmacological Activities on Glycyrrhiza Glabra-A review

https://innovareacademics.in/journal/ajpcr/Vol6Suppl1/1532.pdf

 

ABSTRACT

Indisputably the third millennium is witnessing the worldwide changes in healthcare. Ayurvedic system of healthcare has gained good popularity.

 

Ayurveda is a profound and comprehensive system of health care that originated in India. This system endeavors to rationalize the all phenomena governing empirical experiences with natural products in medicine. Ayurvedic medicare system has attained popularity at global level to replace.

 

The synthetic chemicals as they have shown less adverse reactions. Numbers of plants have been mentioned in classical text of Ayurveda for the management of several diseases. Numbers of plants have been mentioned in classical text of Ayurveda for the management of several diseases. No dought that several researcher had given their contributions for the renaissance of hidden therapeutic potential of number of ayurvedic drugs, But still number of plants need a thorough work on them. Therefore the present study is focused on the review on Glycyrrhiza glabra.

 

7.6.4.6.. Poria

 

7.6.4.6.1.. Chemical constituents and pharmacological properties of Poria cocos

https://www.ncbi.nlm.nih.gov/pubmed/21347995

 

Abstract

Poria cocos (Polyporaceae) is a saprophytic fungus that grows in diverse species of Pinus. Its sclerotium, called fu-ling or hoelen, is used in traditional Chinese and Japanese medicine for its diuretic, sedative, and tonic effects. Various studies of this fungus have demonstrated its marked anti-inflammatory activity in different experimental models of acute and chronic inflammation. It is widely used as a constituent of many preparations in Asian medicine, but the number of research papers on its clinical properties is insufficient for establishing its efficacy and safety from a scientific point of view. In this review, we have compiled all the published data concerning the chemistry, pharmacology, and clinical uses of this drug in order to evaluate its clinical interest for future use against various pathologies in which inflammation and immunodepression are implicated. We selected the papers for review on the basis of their ethnopharmacological relevance, using the most relevant databases for the biomedical sciences. 

 

Studies on various fungus extracts as well as on the major phytochemical compounds (polysaccharides and triterpenoids) present in Poria cocos comprised the principal objectives of this review. In several of the studies reviewed, the inhibitory effects of triterpenes on phospholipase A (2) (PLA (2)) have been clearly demonstrated. In addition, the inhibitory effects of Poria cocoson the secretion of different cytokines from human peripheral blood monocytes have also been described. Triterpenoids are known to have a pivotal influence on certain diseases such as rheumatoid arthritis, psoriasis, autoimmune uveitis, septic shock, and possibly bronchial asthma, while polysaccharides can potentiate the immune response. Reviewing the literature, we found that polysaccharides from Poria cocos enhanced the secretion of immune stimulators and suppressed the secretion of immune suppressors, thus potentiating the immune response. In addition, they showed antitumor activity against different cancer cell lines. This activity is associated with their capacity to inhibit angiogenesis by downregulating both NF- κB and the induction of NF- κB/Rel translocation.

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7.6.4.7.. Ginger

 

7.6.4.7.1.. Pharmacological studies on ginger. I. Pharmacological actions of pungent constitutents, (6)-gingerol and (6)-shogaol.

https://www.ncbi.nlm.nih.gov/pubmed/6335723

 

Abstract

General pharmacological studies were performed on (6)-gingerol and (6)-shogaol which are the pungent constituents of ginger (Zingiber officinale Roscoe). Intravenous (i.v.) administration of (6)-gingerol (at 1.75-3.5 mg/kg) or (6)-shogaol (at 1.75-3.5 mg/kg) and oral administration of them (at 70-140 mg/kg) produced an inhibition of spontaneous motor activity, an antipyretic and analgesic effects, prolonged hexobarbital-induced sleeping time, and these effects of (6)-shogaol were mostly more intensive than that of (6)-gingerol. (6)-Shogaol showed an intense antitussive effect in comparison with dihydrocodeine phosphate. In the electro-encephalogram of cortex, the low amplitude fast wave pattern was observed for 5 min after i.v. administration of (6)-shogaol, and then changed to the drowsy pattern, which was restored after 60 min. In the gastro-intestinal system, (6)-shogaol intensively inhibited the traverse of charcoal meal through the intestine in contrast with (6)-gingerol after i.v. administration of 3.5 mg/kg, but (6)-shogaol facilitated such an intestinal function after oral administration of 35 mg/kg. Both (6)-shogaol and (6)-gingerol suppressed gastric contraction in situ, and the suppression by the former was more intensive than that by the latter. In the cardiovascular system, both (6)-shogaol and (6)-gingerol produced depressor response at lower doses on the blood pressure. At high doses, both drugs produced three phase pattern.

 

7.6.4.7.2.. Pharmacological basis for the medicinal use of ginger in gastrointestinal disorders

https://www.ncbi.nlm.nih.gov/pubmed/16187193

 

Abstract

Ginger (rhizome of Zingiber officinale) has been widely used for centuries in gastrointestinal disorders, particularly dyspepsia, but its precise mode of action has yet to be elucidated. This study was undertaken to study the prokinetic action of ginger and its possible mechanism of action. Prokinetic activity of ginger extract (Zo.Cr) was confirmed in an in vivo test when it enhanced the intestinal travel of charcoal meal in mice. This propulsive effect of the extract, similar to that of carbachol, was blocked in atropine-pretreated mice, a standard cholinergic antagonist. Likewise, Zo.Cr showed an atropine-sensitive dose-dependent spasmogenic effect in vitro as well as in isolated rat and mouse stomach fundus tissues. In atropinized tissue, it showed spasmolytic activity as shown by the inhibition of 5-HT- and K+-induced contractions. A spasmolytic effect was also observed in other gut preparations either as noncompetitive inhibition of agonist dose-response curves, inhibition of high K+(80 mM)-induced contractions, or displacement of Ca2+ dose-response curves to the right, indicating a calcium antagonist effect. Phytochemical analysis revealed the presence of saponins, flavonoids, and alkaloids in the crude extract. These data indicate that Zo.Cr contains a cholinergic, spasmogenic component evident in stomach fundus preparations which provides a sound mechanistic insight for the prokinetic action of ginger. In addition, the presence of a spasmolytic constituent(s) of the calcium antagonist type may explain its use in hyperactive states of gut like colic and diarrhea.

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7.6.4.8.. peppermint

 

7.6.4.8.1.. Physiological and pharmaceutical properties of peppermint as a multipurpose and valuable medicinal plant

https://www.researchgate.net/publication/286456268_Physiological_and_pharmaceutical_properties_of_

peppermint_as_a_multipurpose_and_valuable_medicinal_plantAbstract

 

Peppermint is one of the oldest and most highly regarded herbs for appeasing digestion and may also restore digestive efficiency. In addition, peppermint has been known as disorders improving including: analgesic, ulcer, anti-spasmodic, anti-bloat, irritable bowel syndrome or gastrointestinal motility, and immune system stimulant and etc. Peppermint essential oil has biological activities, such as antibacterial, antifungal and antioxidant properties. In animal studies peppermint essential oil along chromium picolinate improved blood parameters in broiler chicks reared under heat stress condition. Peppermint essential oil stimulated immune system in broiler chicks. Furthermore peppermint not only improved disorder's digestive system, also peppermint had antimicrobial and antioxidant effects. Moreover peppermint was efficient in blood parameters improvement and immune system stimulation in birds. To achieve these goals with regard to sustainable medical uses, we reviewed a summary of introduction, history, active constituents physiological and pharmacology uses of peppermint with concerning on essential oil in this paper. 

 

Pharmacological Activities of Mentha piperita

 

Antimicrobial activity

Extracts of Folium Menthae Piperitae have antibacterial and antiviral activity in vitro. Addition of ground leaves to the agar medium inhibited the growth of Salmonella typhimurium, Staphylococcus aureus and Vibrio parahaemolyticus at concentrations of 0.1–2.0% (w/v). Aqueous and ethanol extracts of the leaves reduced the number of plaques of the rinderpest virus at concentrations of 4–8mg/ml1. Aqueous extracts of the leaves demonstrated activity against the following viruses in egg and cell culture: Newcastle disease, herpes simplex, vaccinia, Semliki Forest and West Nile2.

 

Smooth muscle contraction. 

A 31% ethanol extract of the leaves inhibited both acetylcholine- and histamine-induced smooth muscle contractions in guinea-pig ileum in vitro at a concentration of 10 ml/l. The results were similar to those obtained with 0.13 mg atropine3,4. An aqueous flavonoid fraction isolated from a leaf extract inhibited barium chloride-induced muscle contractions of guinea-pig ileum in vitro at a concentration corresponding to 0.5 g leaves/ml5.

 

Choleretic activity

Injection of a leaf infusion (0.5 ml) or a flavonoid fraction (equivalent to 3.3 g leaves/kg body weight)increased the amount of bile acids in cannulated rats and dogs (dose 0.4 mg/kg body weight)5,6. A mixture of flavonoids, isolated from the leaves, had choleretic activity in dogs (2mg/kg body weight)7.

 

Flavomentin, a flavonoid isolated from the leaves, stimulated bile secretion and the synthesis of bile acids in dogs (2mg/kg body weight)8. Intragastric administration of a 30% ethanol extract of the leaves to rats (1ml/kg body weight) increased bile flow by 43%. The extract did not induce sedation in mice at doses up to 10 ml/kg body weight4.

 

Anti-oedema activity

Topical application of a methanol leaf extract to mice (2.0mg/ear) inhibited ear oedema induced by 12-

O-tetradecanoylphorbol-13-acetate.

 

Analgesic activity

Intragastric administration of a 30% ethanol extract of the leaves inhibited phenylbenzoquinoneinduced

writhing in mice (ED50 2.1 ml/kg body weight)4.

 

Toxicology

Intragastric administration of a leaf extract (50 g leaves infused with 500 ml hot water for 10 minutes,then spray-dried) to 12 mice (4 g/kg body weight as a single dose) did not result in central nervous system depression, toxic effects or mortality.

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7.6.4.8.2.. Pharmacological and therapeutic effects of Mentha Longifolia L. and its main constituent, menthol

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171855/

 

Abstract

Mentha longifolia (wild mint) is a popular folk remedy. Some parts of this plant have been used in traditional medicine of Iran and other countries. Many studies have shown various pharmacological and therapeutic effects of the plant. Our aim in preparing this study was to review the traditional uses of M. longifolia together with the pharmacological and therapeutic effects of its entire extract and major compounds. Mentha longifolia is an herb with a wide range of pharmacological properties such as antimicrobial, gastrointestinal, and nervous system effects. Pulegone is the main compound of the plant responsible for most of its pharmacological effects followed by menthone, isomenthone, menthol, 1, 8-cineole, borneol, and piperitenone. Moreover, the plant may dose-dependently exert toxic effects in different systems of the body. Based on the review of various studies, it can be concluded that M. longifolia is a potential natural source for the development of new drugs.

 

7.6.5.. The advantages of compound use of medicinals in traditional Chinese medicine

 

Xiaoyao San is a typical example of the compound use of natural medicinals of Traditional Chinese medicine. Modern pharmacological studies have shown that this compound use of medicinals can produce synergistic effects between drugs and increase their efficacy.

 

For well understanding of synergistic effects, in Sept 26, 2018, I reproduced two articles to post on my Blog named The rational practice of Germany on phytomedicine application.

 

1.. Phytomedicine research in Germany. - NCBI - NIH, 

2.. Natural products chemistry and phytomedicine in the 21st century

 

The writer is the one of the leading scientists in phytotherapy worldwide, Professor, Dr. Hildebert Wagner, at the Centre of Pharma Research, University of Munich, Butenandtstr, Germany. His Research Interests are as follow.

 

1.. Chemistry, quality proof and pharmacology of medicinal plants of Tradtional Chinese Medicine.

2.. Synergy effects of herbal drug combinations for multitarget therapy.

3.. Genomic and Proteonomic biotechnology for evaluation of synergy effects of drug combinations.

 

In the article Phytomedicine research in Germany. - NCBI - NIH, Professor Wagner indicates that,”further insights into the mechanisms of action of herbal drugs have been obtained by novel bioguided phytochemical investigations with Echinacea, Hypericum, and Crataegus drugs. In many cases, the overall pharmacologic effects and therapeutic efficacies derived not from a single compound but from several compounds generating additive or synergistic pharmacologic effects.”

 

 “As shown in several comparative clinical trials, several phytopreparations that were selected according to the above criteria showed full therapeutic equivalence with chemotherapeutics and had no adverse effects.”

 

“If one compares the concentrations of the active compounds of an herbal drug with those of a strongly acting chemotherapeutic drug, it is evident that most phytopreparations exert their effects at a much lower concentration. The ratio can be 1:10 or more. This difference can be explained by potentiating synergistic effects caused by the various compounds in a raw herbal drug or extract when no interactions between the several compounds are likely or when interactions can be excluded on the basis of pharmacologic experiments.”

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7.7.. Phytomedicine Research in Germany 

Environmental Health Perspectives, Volume 107, Number 10, October 1999, published article Phytomedicine Research in Germany, it is a very good article for understanding how the naturals do works and how they were accepted by German society legally. It would be helpful for understanding the therapeutic mechanism of Chinese medicinals and promoting their wider application.

 

“Abstract: In Germany since 1980, more than 300 clinical studies have been carried out with standardized phytopharmaceuticals, including Crataegus, Silybum, Ginkgo, Hypericum, Sabal, Urtica, Kava-Kava, Allium sativum, Valeriana, Aesculus, Echinacea, and Viscum drugs. These studies assessed the efficacy of phytopharmaceuticals for the treatment of moderate or moderately severe diseases and prevention. Several comparative clinical trials showed that these phytopharmaceuticals had full therapeutic equivalence with chemotherapeutics and had the simultaneus advantage of being devoid of any adverse effects. The mechanism of action of herbal drugs and their extract preparations, which differ in many respects from that of synthetic drugs or mono substances, can be characterized as a polyvalent action and interpreted as additive or, in some cases, potentiating. Currently, a rationale for the observed reversal effects and optimal effects with very low doses after a long-term application has not been developed, but is under investigation by systematic research at the molecular level.”

 

“In Germany, there are two reasons phytopharmaceuticals are of high standard and are classified primarily as conventional drugs by law. One reason is that during the last 50 years traditional medicine has been kept alive by both medical practitioners and the increasing interest of patients in herbal drugs. The other reason is that shortly after World War II the pharmaceutical industry specialized in and relied on herbal drugs and also developed and supported projects aimed at optimizing the quality of herbal drugs by standardization and scientific basic research. This development was paralleled by an intensified evaluation of herbal drugs and a search for the active principles of phytopreparations.” 

 

“The fight for the acceptance and registration of phytopharmaceuticals as drugs has been successful. Today in Germany most of the herbal drugs, even mixtures of herbal drugs, are registered as conventional drugs (1); this means that they meet the same stringent criteria of quality, efficacy, and safety as synthetic drugs. These requirements of the German drug law have stimulated the search for the active principles in medicinal plants and phytopreparations, the development of standardization methods of phytopreparations, and the performance of clinical trials.”

 

“The search for the active principles was an important prerequisite for the standardization procedure. In contrast to investigations carried out 10 or 20 years ago, most extract fractionations were performed using bioguided methods and the diode array high-performance liquid chromatography (HPLC) technique (2,3). These techniques may be quickly performed and allow researchers to focus on those fractions or compounds that are expected to be responsible for the pharmacologic activity of an herbal drug. Because of the use of new target models in pharmacology, there has been remarkable progress in determining the mechanisms of action and the true active constituents of herbal drugs. For example, the well-known antitumor activity of garlic derives partly or totally from apoptosis induced by reactive oxygen species via the transcription nuclear factor B of the tumor cell (4). In another experiment, Dirsch et al. (5) revealed that allicin and ajoene, the major constituents of fermented garlic extracts, inhibit the nitric oxide-synthase of macrophages and, by this, the generation of NO species, which in turn may be involved in the pathophysiology of atherosclerosis. In a new approach to elucidate the antiprostatic active principle of the roots of Urtica dioica (stinging nettle) root, we showed that one major constituent in the water extract of this herbal drug, the Urtica lectin UDA (Urtica dioica agglutinin), binds to the epidermal growth factor receptor of the prostatic cell and thus inhibits prostate growth (6).”

 

“Further insights into the mechanisms of action of herbal drugs have been obtained by novel bioguided phytochemical investigations with Echinacea, Hypericum, and Crataegus drugs (7-9). In many cases, the overall pharmacologic effects and therapeutic efficacies derived not from a single compound but from several compounds generating additive or synergistic pharmacologic effects. This means that the standardization method to be applied should include at least two or more compounds according to methods established by the national pharmacopoeias or additional specific herbal drug monographs. Because the criteria for the quality proof of an herbal drug differ from country to country, steps should be taken toward a global harmonization of the guidelines, e.g., by the International Federation of Pharmaceutical Manufacturers Association (IFPMA), which represents the global research-based pharmaceutical industry and aims to ensure the same standards of safety, quality, and efficacy for new medicines and more efficient registration for use worldwide. These endeavors are handicapped when the active principles are only partly known or when a mixed preparation contains several raw drugs or extracts. In this case, a fingerprint chromatogram of the extract or preparation obtained by HPLC, gas chromatography (GC), or thin-layer chromatography (TLC) is the most appropriate way to document the quality (3). This fingerprint should demonstrate identity and purity of a drug and should guarantee the therapeutic equivalence of extracts from the same herbal drug. Single marked constituents can be quantified. An exact chemical characterization of all major constituents of an extract can only be achieved by specific and selective analytical methods such as HPLC with diode array detection, HPLC-mass spectrometry, or capillary GC with mass detector. If a phytopreparation contains more than four or five drugs or extracts, it is more reliable to characterize the individual drugs or extracts by HPLC before mixing them. For publication and registration of phytomedicines in Germany, it is mandatory that pharmacologic experiments be performed with at least two or three batches of the phytopreparation from different time periods to confirm reproducible processing and to guarantee stability and the same efficacy of the preparation.”

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 “Before initiating a clinical trial, all toxicity studies necessary to establish the safety of the trial must be performed. From 1970 to 1985, the first phase of herbal drug investigations in Germany was completed; this involved proving quality of these phytopreparations and a thorough search for the various active principles. This phase was followed by clinical trials that initially focused on about 10 herbal drugs or phytopreparations which were already on the market, but for which sufficient good clinical practice studies were lacking.”

 

The herbal drugs include

· Hawthorn leaf with flower (Crataegus monogyna, C. laevigata)

· Garlic (Allium sativum)

· Ginkgo biloba leaf

· St. John`s wort herb (Hypericum perforatum)

· Valeriana root (Valeriana officinalis)

· Echinacea purpurea herb

· Kava-Kava root (Piper methysticum)

· Milk thistle fruit (Silybum marianum)

· Saw palmetto fruit (Serenoa repens)

· Nettle root (Urtica dioica).

 

“One of the first clinical trials was performed with hawthorn extract (Crataegus sp.), which was standardized on flavonoids and procyanidins. It has been suggested that both classes of compounds are the major active principles and are involved in the positive inotropic and coronary artery-dilating effect described for Crataegus extract (10,11). Meanwhile, an angiotensin-I-converting enzyme (ACE) -inhibiting effect could be demonstrated for the oligomeric procyanidins (12). The results of the trials were accepted by the German Drug Administration for the treatment of nondigitalis -dependent patients with heart insufficiency stage I and II according to the New York Heart Association. In a double-blind study of the standardized Crataegus extract and captopril, the mean score values of complaints recorded after 8 weeks of treatment showed the same degree of improvement in both groups (13).”

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 “Other trials were performed with the same positive results, e.g., with standardized Ginkgo, Hypericum (St. John's wort), Kava-Kava, Sabal, Urtica, and Echinacea preparations (1).”

 

“Forty-four double-blind studies indicate the efficacy of various Ginkgo extracts for the treatment of cognitive disorders. Kleijnen and Knipschild (14) described eight of these studies and determined that they were performed correctly and without methodologic shortcomings. A recently published double-blind study performed with a Ginkgo extract showed promising results when the extract was applied for the treatment of dementia and, in particular, for Alzheimer disease (15).”

 

“The Hypericum extract, which is now widely used for the treatment of moderate and less severe depression, was investigated in several placebo-controlled double-blind studies (16). Some of these studies were also performed in parallel with the synthetic psychopharmaceuticals imipramine and maprotiline (17). Surprisingly, a 6-week treatment with Hypericum extract with one of the synthetic drugs in parallel resulted in the same significant reduction of the Hamilton Depression Anxiety (HAMDA) score values, with the advantage that there were no side effects with the Hypericum medication (17).”

 

“Another accepted use of herbal drugs is for the treatment of benign prostatic hyperplasia. Germans spend approximately 250 million deutsche marks (wholesale price) per year on prostate remedies, whereas in the United States, surgical treatment is the gold standard in urology. In Germany, many urologists believe that treatment should not target primarily benign prostatic hyperplasia as such, but only the associated symptoms, especially the distressing symptoms of obstructive and irritative urination (1). In the last 10 years, many clinical and pharmacologic studies have confirmed the observations made when extracts of Urtica root, Serenoa repens fruits (saw palmetto), Cucurbita pepo (pumpkin) seeds, and Hypoxis rooperi were used to treat prostate symptoms (1). The Sabal, Cucurbita, and Hypoxis drugs; sterins; and other lipids have been suggested to be responsible for the antiinflammatory and cell proliferation-inhibiting effect of the extracts. Similar positive effects observed with Urtica extracts may be caused by a synergism of polar compounds such as UDA and polysaccharides (18). 

 

In recent years, Echinacea preparations have developed into the best selling herbal immunostimulants for the adjuvant therapy of recurrent infections of the respiratory and urinary tracts and for the prevention and therapy of common colds and flu (19). Thorough phytochemical investigations have revealed cichoric acid, alkylamides, and polysaccharides to be the putative major active principles responsible for the enhancement effect on the unspecific immune system (7). Six clinical studies performed with Echinacea preparations, reviewed by a meta-analysis, have confirmed the therapeutic efficacy, but further investigations are necessary to find the optimal dosage and application form (20). The list of herbal drugs that have been intensively investigated in the last 10 years by phytochemists, pharmacologists, and clinicians includes Silybum marianum (milk thistle), Allium sativum (garlic), Viscum album (mistletoe), Piper methysticum (Kava-Kava), Harpagophytum procumbens, Aesculus hippocastanum (horse chestnut), and Valeriana officinalis. Clinical studies have been performed for these phytopreparations (1).”

 

“Other than the clinical proof of efficacy, several new scientific findings have arisen from the many pharmacologic and clinical investigations that have been performed with the various phytopreparations. They provide insight to the mechanism of action of herbal drugs, which in many respects differs from that of synthetic drugs. The new findings can be summarized as follows: “

 

“Phytopreparations are applicable primarily for the treatment of moderate or moderately severe diseases. This limitation is often designated "for stage or grade I and II" of any disease. In addition phytopreparations can also be used as adjuvants in combination with a strongly acting chemosynthetic drug.”

 

“The positive clinical results obtained with phytopreparations fully justify this type of classification.”  

  

“As shown in several comparative clinical trials (21), several phytopreparations that were selected according to the above criteria showed full therapeutic equivalence with chemotherapeutics and had no adverse effects. “

 

 “If one compares the concentrations of the active compounds of an herbal drug with those of a strongly acting chemotherapeutic drug, it is evident that most phytopreparations exert their effects at a much lower concentration. The ratio can be 1:10 or more. This difference can be explained by potentiating synergistic effects caused by the various compounds in a raw herbal drug or extract when no interactions between the several compounds are likely or when interactions can be excluded on the basis of pharmacologic experiments. The measurement of synergistic effects can be made with a two-component mixture of substances according to the isobol method of Berenbaum (22), but it is not applicable for herbal extracts. 

 

Therefore, an indirect method using the results of clinical trials can be used: for example, if 1 g of a plant extract containing a total amount of 1% bioactive compounds (approximately 10 mg) is found to be therapeutically equivalent to approximately 100 mg of a synthetic substance at a given equal indication (as evidenced in a clinical trial), the bioactive compounds of the extract may possess polyvalent activities and exhibit a synergistic (potentiating or overadditive) pharmacologic effect. This conclusion is justified if the single components of the bioactive compounds alone have very low pharmacologic activities. Furthermore, it must be concluded that the activities of the single components are directed against different pharmacologic targets. In this context, it should not be assumed that a 5- to 10-fold potentiation of an overall pharmacologic effect is caused only by an increased solubility and by the enhanced oral uptake of the compounds of the extract by the gut.”

 

 “Another phenomenon observed for many phytopreparations is dose-dependent pharmacologic or therapeutic reversal effects if the same preparations are applied at high and very low doses. For example, the cytostatically acting vincristine, which usually is applied in vivo in milligram concentrations, can activate the nonspecific immune system in minute (microgram or nanogram) quantities (23). “

 

“Many phytopreparations exhibit no immediate pharmacologic or therapeutic effects and achieve their optimal efficacy only after long-term treatment. This effect has been demonstrated in an in vivo study with a Crataegus extract, which resulted in an increase in myocardial blood circulation only after a 3-week application (24).”

 

“These new findings need a scientific explanation, especially where the mechanisms of action and possible interactions are concerned. There is a general consensus that these described phenomena, which at present have no rationale, must be elucidated by thorough and systematic research at a molecular level.”

 

Note: In above paper, that “Many phytopreparations exhibit no immediate pharmacologic or therapeutic effects and achieve their optimal efficacy only after long-term treatment” maybe caused by following reasons:

 

Lack of potentiating synergistic effects by adding more bioactive constituents from other drugs, just as the principle of compound prescription of TCM.

 

Insufficient in drugs’ dose. Many natural drugs are no poisons and dose-dependent, which allowing to be used in a higher dose.

 

The therapeutic mechanism of the natural drugs is regulatory rather than allopathic, so that the effect only appeared after the overall physical condition being regulated back to normal. This point is the main advantage of natural drugs.

 

8.. The origin of the Orthomolecular Medicine

 

Orthomolecular medicine describes the practice of preventing and treating disease by providing the body with optimal amounts of substances which are natural to the body.

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8.1.. Dr. Abram Hoffer, the initiator of the use of the megavitamin therapy

 

Abram Hoffer (1917 – 2009) was a Canadian biochemist, physician, and psychiatrist known for his "adrenochrome hypothesis" of schizoaffective disorders. According to Hoffer, megavitamin therapy and other nutritional interventions are potentially effective treatments for schizophrenia and other diseases.[citation needed] Hoffer was also involved in studies of LSD as an experimental therapy for alcoholism and the discovery that high-dose niacin can be used to treat high cholesterol and other dyslipidemias. Hoffer's ideas about megavitamin therapy to treat mental illness are not accepted by the medical community.

 

8.2.. William Wilson, the setter for the promotion of megavitamins

 

William Griffith Wilson (1895 – 1971), also known as Bill Wilson or Bill W., was the co-founder of Alcoholics Anonymous (AA). AA is an international mutual aid fellowship with about 2 million members worldwide belonging to approximately 10,000 groups, associations, organizations, cooperatives, and fellowships of alcoholics helping other alcoholics achieve and maintain sobriety.

 

In New York 1960, Abram Hoffer introduced to Bill that high-dose vitamins could help alcoholics. Bill started taking niacin 3 grams per day. Within weeks, the fatigue and depression that had afflicted him for years disappeared. He assigned niacin to his 30 good friends to try, and they all achieved the same effect. Then Bill promoted the use of megavitamins in AA.

 

Later, Bill was excluded from AA members. These Bill-appointed doctor members felt he had no reason to use vitamins as a cure. For this reason, in December 1965, he wrote to distribution to AA members, in which he used B-3, and the name B-3 is popular used now globally.

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8.3.. Dr. Linus Pawling, the proposer of the Orthomolecular Medicine

 

The orthomolecular medicine was proposed by Linus Pawling in his 1968 article "Orthomolecular Psychiatry" in the journal "Science" after read the paper of Bill Wilson.

 

Dr. Linus Carl Pawling 1901 –1994) was an American chemist, biochemist, chemical engineer, peace activist, author, and educator. He published more than 1,200 papers and books, of which about 850 dealt with scientific topics. New Scientist called him one of the 20 greatest scientists of all time, and as of 2000, he was rated the 16th most important scientist in history. For his scientific work, Pauling was awarded the Nobel Prize in Chemistry in 1954. For his peace activism, he was awarded the Nobel Peace Prize in 1962.

 

Pauling was one of the founders of the fields of quantum chemistry and molecular biology.[9] His contributions to the theory of the chemical bond include the concept of orbital hybridisation and the first accurate scale of electronegativities of the elements. Pauling also worked on the structures of biological molecules, and showed the importance of the alpha helix and beta sheet in protein secondary structure.

 

Pauling's approach combined methods and results from X-ray crystallography, molecular model building, and quantum chemistry. His discoveries inspired the work of James Watson, Francis Crick, and Rosalind Franklin on the structure of DNA, which in turn made it possible for geneticists to crack the DNA code of all organisms.

 

In his later years he promoted nuclear disarmament, as well as orthomolecular medicine, megavitamin therapy, and dietary supplements.

 

None of the latter have gained much acceptance in the mainstream scientific community, but got a lot of criticizing and being refused to fund his clinical trial.

 

9.. The overcrowded hospitals of Canada

 

Jan 22, 2020, article Some of Ontario's biggest hospitals are filled beyond capacity nearly every day, new data reveals reports that Overcrowding has become so common in Ontario hospitals that patient beds are now placed in hallways and conference rooms not only at times of peak demand, but routinely day after day, research by CBC News reveals.

 

CBC News analyzed data for all 169 acute care hospital sites in the province during this six-month time frame. Some of the key findings:

 

83 hospitals were beyond 100 per cent capacity for more than 30 days.

39 hospitals hit 120 per cent capacity or higher for at least one day.

40 hospitals averaged 100 per cent capacity or higher.

 

An expert on hospital administration calls the figures "astonishing" and says they demonstrate that overcrowding is now a widespread phenomenon around Ontario.

 

"These are really big numbers," said Donald Redelmeier, a professor of medicine at University of Toronto. He said the data show the hallway medicine problem is neither occasional nor restricted to a few hospitals.

 

Root causes

 

The number of acute care hospital beds in Ontario has stayed effectively the same for 20 years, at around 20,000 while the province's population has grown by three million people. Ontario now has fewer acute care hospital beds per capita than any other province: 1.4 beds for every 1,000 people. That's on par with Mexico, and half the number in the U.S.

 

Long waits, too few beds — Ontario healthcare indicators going in 'wrong direction:' report.

 

 Please forget synthetic drugs of antibiotics, and turn to make easy available of OTC tablets of Chinese medicinals and vitamins. Then patients can treat diseases by self-help without the needs of hospitals.

 

The formula of Chinese medicine integrates with vinegar, Vitamin C and vitamin B3 can treat most of patients

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10.. The best doctor for treating social diseases

 

In this concern, Mar. 26, 2019, I once wrote article John Keynes expressed his depressed mood by his epitaph, in which, I discussed the efforts of Keynes in trying cure of social diseases, but failed; for time saving, I copy the article as below.

I have a hope to get a photo of the Tombstone of John Keynes, it said that he once wrote the epitaph for himself in advance; I eagerly searched in libraries and later Googled on Internet for great many years, but until right now, there only Mandarin version is available. I translated it as follow.

 

--- Don't be sad for me, my friend; please do not tear for me.

--- Because of, in the future, I will never have to work exhaustedly again.

--- The heaven will be resounded with the hymns and sweet music.

--- But, for me, will be never to sing anymore.

 

As an unordinary contributed economist, in the life time, Keynes has been in enjoying the respect that enough made anyone to be complacent, but, the epitaph showed that Keynes was tortured in depressed mood, which inspired me to think of his disappointed experiences, especially his good suggestions were rejected during the talks of Treaty of Versailles and Bretton Woods system. I clearly felt that as an unordinary sober British Man, it was unordinary painful for that had to be lived among the crowd of ignorant people who were without mentality for reasoning the bad consequence.

 

The unordinary annoyed for the unordinary sober Man was in helpless seeing that human beings will never get rid of the kidnapping of confused ideologies, and will be irreversibly devalued as only instinct of endless fighting politically, socially and between countries, without brain cells for logical reasoning bad consequence under universal values crowned Fundamentalisms that rooted in the ignorant Universalism. Even if some people can luckily keep their sober minds but have to be kidnapped towards the ignorant way.

 

Maybe, due to such a depressed reality forced his thinking of The end of laissez-faire, by which Keynes tried to knock those mental retarded. "These many elements have contributed to the current intellectual bias, the mental make-up, the orthodoxy of the day. The compelling force of many of the original reasons has disappeared but, as usual, the vitality of the conclusions outlasts them. To suggest social action for the public good to the City of London is like discussing the Origin of Species with a bishop sixty years ago. The first reaction is not intellectual, but moral. An orthodoxy is in question, and the more persuasive the arguments the graver the offence. Nevertheless, venturing into the den of the lethargic monster, at any rate I have traced his claims and pedigree so as to show that he has ruled over us rather by hereditary right than by personal merit.”

 

Today, looking around the world in 93 years later, those Keynes worried ideologies are still used in harming human society. The Invisible Hand or Market Fundamentalism that was dubbed from laissez-faire has been recklessly play its role with economic disasters, Democratic Fundamentalism has been effectively malfunctioning government, The hope of human beings is at getting rid of such abduction as that of Keynes hoped, but that is extremely difficult.

 

Such inconvincible behavior of humans is not from people’s bad intention, but is from their believed good that reasoned by their brain. However, the reasoning function of human brain must be backed by acquired knowledge. A person cannot proper reason on something that has no related knowledge in memory, so that they may mal-reason the bad as good. Such as, the people who were instilled by the only thoughts of Montesquieu, she or he will never understand the advantage of technocratic democracy, it was the clear way of dictatorship since it is without the play of election, and especially it dared dump their proud of opposition encouraged political fighting into garbage bin.

 

May 26, 2017, article What science can reveal about the psychological profiles of terrorists reports that, according to the research in imprisoned Columbian paramilitaries, in compared with non-criminals, the terrorists have no differences in the terms of IQ or executive functioning besides the difference in moral cognition, the terrorists had distorted moral reasoning, to link this with the reports that people kill others in imitation of a horror film scene; we can infer that it is acquired knowledge in dominating people’s behaving. This was the reason that good suggestions of Keynes were rejected, due to at that time, no one has related knowledge for reasoning his concern.

 

Such ignorance was the one of the reasons that “the compelling force of many of the original reasons has disappeared but, as usual, the vitality of the conclusions outlasts them.”

 

In comparison, the Italian was really smart, they have self enlightened for getting rid of the harm of confused ideologies, it was not by revolutionary action, but by smartly touch-up on policies with Gov-holding veto power to intervene the operation enterprises to have avoided the harm of the side effect of Market Fundamentalism, and by naming technocratic cabinet avoided the harm of the side effect of Democratic Fundamentalism. Even if in Ancient time China, the Italian missionaries had also showed unique talent in dealing with thorny social problems with enjoying the rewards of Royal salary of China.

 

The humanized practice of Italian inspired me to write artice The enlightenment of the Italians for modern social governance by comparison with contrast facts, introduced the smart practice of the Italians in social governance, based on which discussed the side effects of the Market Fundamentalism, and Democratic Fundamentalism. As the confused ideologies, the universal values crowned Fundamentalisms are the root source of the chaotic of the world.

 

Please look at the world today, trade fights, terror attacks, endless wars, endless refugees, endless production of weapons that are able to times self-destruction, human beings that self-proclaimed as higher animals have never lived in a way as that of higher animal should be, but have been living in a way that is even more ignorance than that of wild animals, because of the intelligence of higher animal misused on barbaric way. It is the high time, that as so called higher animals have to review that how to live a way as that of qualified higher animal should be.

 

The successful trial of the Italian created a feasible experience for dealing with thorny problems globally, which is not bloody revolution as that of French did in 1789, but optimizing touch up on the policies in social governance. The development of human society must be improved in step by step and in a little by a little gradually, with the concern that step-pace of social advancement cannot go beyond people's psychological endurance too much.

 

Though, the social advancement is for the better life of people, but, good intention has a side effect also, which is that any social change will cause people’s panic for potential crisis from the uncertain future, which is the one of reasons of the criticisms on China’s Belt and Road Initiative; so that we must be very careful to reduce the psychological harm for the people at the time when we make social improvement; and more meaningfully, that reduce the panic of people is the only way to reduce the social resistance for social development.

 

This was the reason that China set economic test zone at first to try the practical outcomes of some policies for further practice nationally. Besides those obtained valuable experience can help to reduce the harm of the potential mistake, as my view, there is still significant advantage that hearsay information from the practice within the test zone can help people in psychological preparation as that of vaccination for reducing the panic mentality.

 

On 12th Annual Meeting of the Inter Action Council 1994, in the interview of CCTV, the 15th Prime Minister of Canada Dr. Pierre Trudeau made a comment about the practice of Deng Xiaoping: “Deng has principle, he knew where the objectives were; he was following and putting practice of those principles. He was pragmatic, as he said you can use different routes to come to same aim, the ends are always the same: the strength of China, the unity of China, and the stability of China.”

 

Among great many comments about Deng Xiaoping and the success of economic development of China, this was the most nature-touching one. As my view this was the reason that, under the tenure of Dr. Pierre Trudeau, in Canada, the social development index and quality of life has been among the highest in the world. In comparison with Dr. Pierre Trudeau, many democratic players are just with a talent as that of the street boys or street girls in enjoying partisan ganged childish play.

 

Above was the reason that China achieves success in the development of the economy with lesser mistakes. Now it is the time of the Italians.

 

The chaotic reality, especially the trouble of endless refugees lessons us that ensuring people of all country make a living in their own home place is the best way for world peace. For this concern, we need to improve the social governance for all countries, and avoid the negative affect from other countries.

 

1.. To advance Democratic Fundamentalism by Technocratic Democracy under naturally formation of the lawmaker team with technocrats who have reached certain qualifications academically and socially, by which way, at the time enjoyed advantage of the democracy, but also avoided the disadvantage of democracy.

 

2.. To advance Market Fundamentalism by Gov-control the cornerstones of the economy, thereby avoid to be destroyed by those ignorant people who take wrong as right. Currently, the financial industry, agro-industry, and the cross-border transmission of digital data must be kicked out from any kind of negotiations.

 

Because of that over developed financial instruments can totally destroy the economy of a country, the cheaper imports can easily destroy the agro-industry of a country, and the cross-border transmission of digital data can be used to harm other countries by those low quality politicians.

                                                --- Frank  Mar. 26,  2019  in Waterloo, Ontario, Canada

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11.. Why western medicine declines, but Chinese medicine rises

 

For reducing the medical burden of people and unload overloaded hospitals, we have to develop cheaper medications as that of chewing gums by daily diet and natural medicinals, based on the medical principle of Daoism in promoting natural balance to overcome diseases by enhanced autoimmunity, thereby enable patients to treat disease in home self-help.

 

However, the good idea is extremely difficult to be implemented clinically, since it needs to accept the philosophy of Daoism at first and this is the dead barrier that is not easy to overcome, because the resistance comes from ideology and from a long-standing convinced the way in disease treatment must be looking pathogens for killing and which is the only way that meets scientific validation. Such a sense has been integrated into the bone marrow of people, so that they nearly hate the practice of Daoism conducted practice of Traditional Chinese Medicine - TCM. For instance:

 

Oct 1, 2018, on forbes.com there was article WHO Endorses Traditional Chinese Medicine. Expect Deaths To Rise, the writer was Steven Salzberg who self introduced as “the Bloomberg Distinguished Professor of Biomedical Engineering, Computer Science, and Biostatistics at Johns Hopkins University.” In article, this Distinguished Professor said that:

 

“A few days ago, a news story in the journal Nature reported that the World Health Organization, which is supposed to be devoted to improving the health and medical care of people around the globe, will for the first time endorse a belief system called "traditional Chinese medicine." I'm labeling TCM a belief system because that's what it is–but the WHO will be endorsing it as a set of medical practices.”

 

“As the Nature article points out, TCM has been a scam for decades: it was revived and heavily promoted in China by former dictator Mao Zedong, who didn't believe in it himself, but pushed it as a cheap alternative to real medicine. I won't go over that again here, but see these stories from Alan Levinovitz in Slate and David Gorski at Science-based Medicine.”

 

“Finally, why would the World Health Organization start pushing a set of unscientific practices that are likely to harm people's health? Support for TCM grew during the tenure of former WHO director Margaret Chan, who ran the WHO until 2017 and who had close ties to China. When Nature tried to contact Dr. Chan, the WHO responded that Chan ‘is not answering questions on matters related to the WHO.’”

 

The journal Nature is on top of medical publications with decisive influence in leading people’s medical views, and the views of professor Steven Salzberg on TCM represent the views of the majority of the people globally, includes the most of people in China of the mother country of TCM. Due to the Steven Salzberg has self introduced as Distinguished Professor, what he said will produce great negative influence on the application of the medical approach in following the principle of TCM that rooted on Daoism.

 

I believe that my views on TCM are completely different from those of the journal Nature and Distinguished Professor Steven Salzberg, and it will be difficult for people to believe. To do this, I must introduce myself and prove that I am not mentally ill or alcoholic, and what I said are based on the systematic studying. The comments of the outstanding journal Nature and the Distinguished Professor are just in hearsay or subjective assertions.

 

They were full hearted fighting for good, but actually were in promoting bad, because so called scientific western medicine has been actually developing on questionable way by viewing human body as inhuman. If we view carefully, such a humane manner is common in the West politically and socially.

 

I am a senior researcher on the profession of metal materials once worked in a big Research Institute; my career time was mainly spent in the Libraries and Laboratories. Due to the particularity of the scientific research, I was more time in Libraries than in Laboratories with enough time for free reading. The biggest gain of my research career was that I have been forced to calm the mind with a hobby of long time concentrated on delving into specific subject until being made clear.

 

Besides my profession, I spent most of spare time on the study of TCM, especially, those modern studies on bioactive substances and pharmacological effects (LD50s) of natural Chinese medicinals that Chinese ancestors medically identified 11,146 medicinal plants, 1581 medicinal animals and 80 medicinal minerals with nearly 100 thousands of experience-based formulas, which covering almost all known diseases.

 

The natural medicinal materials used in TCM have bioactive constituents with the therapeutic effect that is similar to that of synthetic ones in killing the pathogens and the nutritional effect that is similar to that of orthomolecular medicine. Some of Chinese medicinals can improve human autoimmunity through boosting the weight gains of immune organs, increasing the number and activity of the phagocytes, NK cells and so on.

 

Extensive reading has inevitably led me to the comparison between TCM and western medicine.

 

The western medicine - WM is guided by Reductionism that views human body as a mechanical combination of the inanimate parts and in trying to study the mechanism of life and diseases through isolated microscopic parts by infinitely subdividing human body into the microstructure of proteins, genes, and in treating diseases by looking pathogen and developing specific pill for killing.

 

To be honest, Western medicine has made a significant contribution to human health, both in the past and now. Today we even can make life by genetic technology in a tube. So public have been convinced that modern WM is most advanced, most scientific and most reliable, which has been integrated into the blood and bone marrow of all people.

 

However, because human body is a complex system that various organs are closely interconnected with interdependent and interacting, there are many unpredictable factors in affecting the development of diseases, especially the psychological factors. Many objective facts have proven that the medical route under the guidance of Reductionism is not sustainable feasibly, for instance:

 

In 2003, the Human Genome atlas was completed. It is a big success of WM. Many of us happy for that we could uproot diseases and gotten a new powerful therapeutic approach to diagnose and cure diseases. Nevertheless, now 17 years have been passed, there are no genetic therapy can be reliably used clinically than that we once hot expected. Because that even a single disease is associated with hundreds genome segments, so it is very difficult to be used clinically in a short time.

 

Therefore, those believed as most advanced, most scientific, most reliable genetic therapies are only hopeful flowers that may need long time, and more study to bear enjoyable fruits. I believed that, this fruit cannot mature forever, because it cannot uproot the stress or psychological pressure – the main inducement of the diseases.

 

Jan. 8th 2008, article Report: Stress Causes Everything indicates that: “Stress, to put it bluntly, is bad for you. It can kill you, in fact. A study reveals that stress causes deterioration in everything from your gums to your heart and can make you more susceptible to everything from the common cold to cancer. Thanks to new research crossing the disciplines of psychology, medicine, neuroscience, and genetics, the mechanisms underlying the connection are rapidly becoming understood.”

 

The fact that Stress Causes Everything showed the wrong of the Reductionism in treating human beings as inhuman as inanimate assembly in ignoring psychological factors. It is just the deficiency in philosophy to have led western medicine to the deviations with right way in medical practice.

 

It is not only there were no suitable synthetic drugs for some diseases, such as, super bugs; but also, those existing drugs were not all safe; the side effects of some of them are becoming new life-threats. More terrible is that the cost of medications is soaring up, due to some people take the medical activities as the tools to loot money in contempt of life. It is just like the earthquake in Japan, coupled with the Tsunami, which was not enough, followed by nuclear radiation from the leaking of nuclear power station.

 

WM fails in the treatment of communicable diseases: Recent years, some pathogenic-bacteria were crowned as super-bug because they have developed resistance to the existing class of antibiotics in short time after drugs putting in use. New antibiotic research is facing challenging in the competing against the mutation of virus. More time and spending are needed for antibiotic updating. So that many super drug-makers have abandoned the research in antibiotics. Simultaneity some drugs was withdrawn from market because of serious negative effect. It will cause no effective antibiotics to fight with infectious diseases.

 

Such as: In the United States, deadly mystery superbugs kills soldiers and causes to amputate limbs among troops wounded in Iraq, because no antibiotics were effective for the infections, even for a slight wound.

 

David Picard, CEO and the co-founder of Moleac, a biopharmaceutical company based in Singapore, in his article THE RISE of Traditional Chinese Medicine, said that “Western pharmaceutical companies now spend over US$800 million on average to get a new drug approved.” 

 

“This cost includes the lengthy and complex clinical development process which sees many potential drugs fall by the wayside, either because they do not work or because they cause unacceptable side effects.”

 

“Only around one in 17 candidate drugs identified make it to market.”

 

“If the drug being researched fails in the development process the losses can be considerable.”

 

“Pfizer, for example, recently wrote off around US$1 billion and 15 years of research and development after its experimental cholesterol drug failed to make the cut.”

 

“The industry is under increased pressure to develop new blockbuster drugs as patents expire, and to cut innovation costs. “

 

WM also fails in non-communicable diseases: Also became increasingly severe due to have no ideal drugs. Such as mental disorder, cancer, hypertension, obesity, diabetes, cardiovascular disease, chronic fatigue syndrome, and so on. Due to they are degenerative without pathogens for killing.

 

As a way in no way, in Sep. 13, 2007, Canadian Cancer Society and the National Cancer Institute of Canada has launched a large, multi-year international study to try to find a way to help the hundreds of thousands of men diagnosed with prostate cancer every year, decide whether to opt for potentially life-altering treatments or choose a watch-and-wait approach. They hoped that Surveillance Therapy against radical treatment would resolve one of the thorniest dilemmas in prostate cancer care. Because of current therapy of chemo and radiation will cause the cancer degenerated faster.

 

Many convincing facts prove that the approach of WM under the guidance of the Reductionism is unsustainable.

 

Then, where is the way out? The rational gentleman David Picard, the CEO and the co-founder of Moleac has found the best way.

 

April 12, 2012, article Moleac takes Traditional Chinese Medicine to the world said that, “The approach of adopting Traditional Chinese Medicine (TCM) by Moleac to fill therapeutic gap in Western treatment is not only innovative but is also highly efficient in terms of product commercialization. As the efficacy of Neuroaid is proven, Moleac has been able to develop the drug with relatively low investments and commercialize it in a relatively shorter span of time. Similarly, Moleac has its base in Asia where understanding of traditional medicine was more established and is now developing towards Western Europe where its French subsidiary, Moleac Europe, is preparing the launch of Neuroaid derivatives and the implementation of clinical trials.”

 

TCM is guided by the philosophy of Daoism that dialectically views everything is in the unity of opposites universally, and the universe is a system of the unity of opposites, which is composed of many subsystem with own feature of unity of opposites. The all components are in the state of dynamic balance through continuous self-regulation.

 

This primitive philosophical view of Daoism that generated in thousands of years ago is well coinciding with the modern scientific discoveries in nature world. For example：

 

In micro perspective, as small as atom, extranuclear electrons cloud with the nucleus are both in the state of attraction and repulsion, the electronics rotating around the nucleus in dynamic equilibrium. They are in the state of unity of opposites. Atoms are the basic components to compose of the natural materials. 

In macro perspective, the planets with the sun in solar system, and the solar system with other galaxies are all in the continuously rotating in the state of self-regulation by attraction and repulsion of each other. They are also in the state of dynamic equilibrium of unity of opposites.

In medical field, Daoism conducted the development of TCM, it was not only its philosophical concept, but also its terminology was directly applied into TCM. Under the guidance of Daoism, human life has been viewed as one of the components of the unity of opposites universally.

Daoism regards our bodies as organic wholes, with all parts interconnected and interacted of each other and psychological factors in playing decisive role in the development of disease. A well-balanced body will form an effective self-defense system that can resist diseases. Illnesses only occur when some parts of the body are out of balance.

Therefore, the treatments of TCM do not directly target to kill pathogens but to bring back the natural balance. It achieves the purpose by natural therapeutic approaches, such as, natural medicinals, acupuncture and physical exercises, etc.

 

Compared with Western medicine, TCM was believed as most primitive, most unscientific, and most unreliable. However, many modern researches have inadvertently proven the outstanding of TCM. Its holistic perspective with emphasizing the decisive role of psychological factors on the development of diseases is most rational and scientific.

 

Until last century, in west medicine, the study on the relation of psychology and human health is activated.

 

Such as, Henry K. Beecher’s The Powerful Placebo (1955), George Engel’s Biopsychosocial model (1977), the crossing disciplines research proved that Stress Causes Everything (2008), Ohio State University’s Socially active environment can cause cancer tumors to shrink and even disappear (2010). Those findings clearly indicated that, for most diseases, negative psychology plays inducement effect and positive psychological has therapeutic effect.

 

On this point, TCM is much admirable. In thousand years ago, TCM practitioners have found the similar fact that diseases treatment is seven-tenth in psychotherapy and only three-tenth in medication. Suppose we take the placebo effect as a kind of psychotherapy, then the proportion of seven-tenth in psychotherapy is close to the modern scientific statistics from the double-blind clinical trials, which was “placebos are effective in 50 or 60 percent of subjects with certain conditions.” And “some researchers maintain that there is not adequate evidence from studies to prove that the new (antipsychotic) drugs are more effective than placebos.”

 

The emergence of system biology is showing that the rational people in Western medicine is starting to step toward the Holistic way with enlarging the scope of medical analysis. Essentially says, it was that some rational people in Western medicine is turning its eyes towards the ancient holistic medical approach of TCM from the level philosophical root after hitting on the wall.

 

For Chinese medicine, it is not only view human life as emotional alive from the level of philosophy, but the treatment is also in playing the role of psychotherapy by improving physiologically. From a subjective point of view, the treatment of Chinese medicine is focusing on the restoration of the physical balance by natural medicinals; but the objective actual treatment effect is to restore the deteriorated body by the harm of the stress.

 

For a long time, until right now, the WM has been playing a dominant role in the treatment of diseases worldwide. Due to its therapeutic advantage and the reasons for market competition (See The Truth About The Rockefeller Drug Empire), in China, there were attempts to abolish TCM and promote WM instead. Even same events occurred in Japan. however, recently Japan has redressed their positive attitude and develop many drugs based on TCM.

 

Because the treatment of TCM conforms to the reality of human life physiologically and psychologically, it has made great satisfied therapeutic effect. If, Google on the internet by key words Traditional Chinese Medicine or TCM, you will find that Chinese medicine has shown advantages in the treatment of various diseases in both of infectious and non-infectious.

 

The great contribution of the civilization of the west is fabricated so many ideologies, such as, Universalism, Fundamentalism, Freedom, and too much brainless ideas are used in badly messing social governance to make bad under the name for good. Here, scientific or unscientific has been badly affect the use of effective cheaper natural medicinals. The scientific is taken as a reason for western medicine self-proclaimed as reliable, and the unscientific is used as an excuse to repel the application of effective natural medicinals.

 

The effective folk medicinals and experienced formula are unscientific. Then what has been doing of so called scientific in the medical field is to develop something with little positive effect than that of placebo, but with dead side effect to kill people.

 

In facing with difficulties in diseases treatment, it is time to embrace the medical fruits of ancient civilization globally, rather than refuse by the name of unscientific.

 

In this concern, among the medical fruits of ancient civilization globally, only the Traditional Chinese Medicine has a rational guidance of philosophy Daoism and systematic theory, with more choice available in diagnostic and treatment methods, and a large number of natural medicinals are available for choosing from.

 

Maybe it is just due to as layman of medicine, I am not poisoned by orthodox medical teaching, and so, there are no dogmas binding me in viewing the problem from different perspective. I firmly believed that the 2019-new coronavirus is easily curable. Not only the new coronavirus 2019, but also those diseases have been sentenced as incurable by the experts in western medicine can be cured with daily diet and natural medicinals as cheaper as that of the cachou.

 

My confidence is not only came from the understanding of Daoism and the magic therapeutic achievements of Chinese medicinals, but also came from the physiological findings on human body, such as, it is the gut microbiome in producing 95% of serotonin, neurons and the most neurotransmitters, and the magic of human body self-healing, such as that the men who live in a normal life after the half damaged brain was fully removed, the MRI scan on their brain showed that some neuron networks on the remained brain have developed as the function as that of lost brain.

 

It is true magic of human body in magic self-adaptation.

 

For getting the cachou of curing 2019 new crownavirus, the only thing that needs to do is to update the philosophy of disease treatment towards humanized way from Reductionism conducted western medicine to Daoism conducted Chinese medicine, from looking pathogens for killing to be promoting the restoration of natural physical balance. The process of the restoring balance is in boosting autoimmunity actually, and then the enhanced immune function will rubbish pathogens naturally.

 

Only our autoimmunity is the best warrior in effectively protecting us in health by fighting against pathogens.

 

I have expected that people will certainly doubt my above assertion as too arrogant and unreliable. For this concern, I specially prepared the section 7: My writings for proving the reliable of my talkative.

 

Large amount of studies have certainly provided me some optimized methods in treating illness for my families and my colleagues who failed in the treatment at hospitals. Of course, the cold or flu is in the first position.

 

For myself, the best treatment for flu is 500mg x 1 vinegar capsule combined with 500mg x 3 vitamin C pill. There studies were suggesting that vinegar can kill bacteria and virus by chemically changing their cell’s structure, which enabled vinegar with broad-spectrum bactericidal power, besides this magic function; vinegar also has wider range of benefit to our health. Obviously, the vinegar has intelligence in protect good by killing bad.

 

While, in there, vinegar is busy in killing flu virus, and vitamin C is in improving the work environment for vinegar by fixing our ill deteriorated body. As my experience, vitamin C can quickly eliminates the uncomfortable symptoms of flu, such as, fever, weakness, headaches, muscle aches and other discomforts. No doubt such a combination is perfect for quickly recovering from the state of the flu – the initiator of the most of the dead diseases.

 

I like to broad reading and write down my fantasy, as right now; here, I am eagerly doing something that has nothing to do with me. The big bother to such a habit is my brain easy fatigue and unable to follow my will. In such a situation, chewing sweet sugar balls with vitamin C pills are better than that of drinking coffee soup. I feel that brain fatigue is due to lack of energy supply, so that neurons strike.

 

As my experience, the mental work, especially, reading or writing, is unique that needs an extra sober brain, only relying on caffeine to stimulate our tired brain, the effect is limited.

 

There was a report that, in Beijing, during the Sino-US trade negotiations, US Treasury Secretary, Mnuchin and China Deputy Director of National Development and Reform Commission, Liu He, were both choosing to drink boiled water, rather than coffee. Their common experience was that coffee is likely to cause further fatigue.

 

I felt that chewing sugar balls and vitamin C pill together are better than that of taking coffee in boosting the work of brain, while sugar provides energy to neurons; the vitamin C is busying to create a better working environment for the neurons. Also I felt that too much coffee drinking has badly affected the quality of my sleep, but sugar and vitamin C will help me a good sleep to have my neurons a good rest.

 

There was clinical proof in supporting my feeling of vitamin C can quickly release the uncomfortable symptoms of flu.

 

The Journal of Molecular Biology, Volume 34, Number 2, 2019 publish article High Dose Vitamin C and Influenza: A Case Report to report that a 25-year-old Puerto Rican man who was in the severe flu on bed about a week time with fever, chills, muscle aches, headaches, and nausea, was cured simply by the intravenous of 50 grams of sodium ascorbate for a total of 3 times over 3 days. After first infusion, his physical strength improved and headaches were gone, after second infusion, he totally recovered without discernible side effects.

 

It is conceivable that such a result cannot be achieved by the treatment of any synthetic medicine. The main physiological function of vitamin C is to promote human autoimmunity and is essential.

 

It reported that in China, a nurse who returned to work after the infection of the new coronavirus was cured from the suffering of fever, nausea, and the most obvious feelings were pain, headache, muscle aches, and joint pain. That vitamin C cured Puerto Rican man had also suffered fever, chills, muscle aches and pains, headaches, and nausea.

 

Although, the causes of the disease between the two sufferers may be different, but, the basic symptoms are similar, since that vitamin C can cure Puerto Rican man, it will naturally cures the patients of China.

 

Viewing in this way, we can extend to a wider range of other diseases, maybe each disease has its own cause, but, their common symptoms may be similar to the above two patients in major, maybe, fever, chills, nausea, headache, muscle aches, joint pain, and more. Since that vitamin C can cure Puerto Rican man, it will naturally cure the patients in different diseases.

 

Besides Vitamin C, natural Chinese medicinals are the best in fighting against flu.

 

As same as the 2019 new coronavirus, 2003 SARS was once also caused panic of people globally due to without treatment available in mainstream medicine. However, patients who were treated with pure Chinese medicine, there were no deaths, no sequelae, and no infection to the medical staff who served to patients; but the treatment by western medicine was just in the opposite.

 

The facts were clear that in above treatment, no one was specifically in targeting on the bacteria or virus, but were in targeting on the general restoration of the physical fitness of patients. It was simply hoped for helping people to feel better, and then the pathogens were willingly gone to let people feeling better. No any synthetic drugs can achieve such a therapeutic effect, except the fatal side effects.

 

Then, where is from of the magic therapeutic effects; the new finding provided answer.

 

Nov. 15, 2019 article World's Oldest People May Have Supercharged Immune Cells: “The secret to living past 110 may be an increase in killer cells in the bloodstream.” ”New research finds that "supercentenarians," or people who make it to 110 years of age or older, have higher-than-typical concentrations of a particularly rare type of T helper cell in their blood. These immune cells might protect the oldest of the old against viruses and tumors, leaving them in remarkably fine health throughout their long life spans.”

 

Chinese medicinals and Vitamins are just able to powerfully promote human autoimmunity.

 

There was study showed the vitamin B3 can promote autoimmune cells 1000 times powerful in killing bacteria.

 

Aug. 28, 2012, article Vitamin B3 May Help Kill Superbugs reports that “Nicotinamide, commonly known as vitamin B3, may help the innate immune system kill antibiotic-resistant staph bacteria, the so-called "superbugs". In lab work done with mice and human blood, researchers found high doses of the vitamin increased the ability of immune cells to kill the bacteria by 1,000 times.”

 

There were many findings in convincing me that the combo of vinegar, vitamin C and B3 combined with Chinese medicinals will be the best for killing 2019 new coronavirus and other diseases. So, I suggest that, please don’t only addict in the desire of developing magic pills or vaccine to kill or prevent germs and viruses. Our autoimmunity is the best assistant that can kill any germs and viruses.

 

Moreover, according to my personal trying the process of the B3 caused flushing and itching in section 3.5.. Myself test of the process of B3 taking effect, whether administrated orally or intravenously, within 20 minutes, the combo will be able to make patients start to gradually relieve the unpleasant symptoms and after several times administrations, the patients will walk out of hospital in three or five days.

 

There was proof for the efficacy of my formula that tested by vegetables and tea.

 

 Nov 22, 2013, article Plant Nutrient 'Cocktail' Kills Breast Cancer Cells reports that “researchers at Louisiana State University tested six known protective chemical nutrients from turmeric, soybeans, broccoli, grapes and tea. Individually, they were ineffective against cancer. But combined, they suppressed breast cancer cell growth in the lab by more than 80 percent, and eventually triggered the process leading to cell death.”

 

The findings show that even if the single ingredient has no therapeutic effect, but once it is used in combination as compound, it will produce magical effects far beyond conventional sense.

 

There was study in showing the magic of the combination of the medicinals with the effect that is far out of the effect of the medication.

 

Sep. 30, 2019, a study reported that triple commonly used drugs combination has extended the lifespan of fruit flies by 48%. The researchers suggest that a combination drug treatment may be helpful at preventing age-related diseases in people and other studies have proved that combination of botanicals can produce synergistic effects with reducing side effects.

 

Environmental Health Perspectives, Volume 107, Number 10, October 1999, published article Phytomedicine Research in Germany reports that, in Germany since 1980, more than 300 clinical studies have been carried out with standardized phytopharmaceuticals and gotten promising results.

 

“Several comparative clinical trials showed that these phytopharmaceuticals had full therapeutic equivalence with chemotherapeutics and had the simultaneus advantage of being devoid of any adverse effects. The mechanism of action of herbal drugs and their extract preparations, which differ in many respects from that of synthetic drugs or mono substances, can be characterized as a polyvalent action and interpreted as additive or, in some cases, potentiating.”

 

“In many cases, the overall pharmacologic effects and therapeutic efficacies derived not from a single compound but from several compounds generating additive or synergistic pharmacologic effects.”

 

“Many phytopreparations exhibit no immediate pharmacologic or therapeutic effects and achieve their optimal efficacy only after long-term treatment” maybe caused by following reasons:

 

“Lack of potentiating synergistic effects by adding more bioactive constituents from other drugs, just as the principle of compound prescription of TCM.”

 

“Insufficient in drugs’ dose. Many natural drugs are no poisons and dose-dependent, which allowing to be used in a higher dose.”

 

“The therapeutic mechanism of the natural drugs is regulatory rather than allopathic, so that the effect only appeared after the overall physical condition being regulated back to normal. This point is the main advantage of natural drugs.”

 

The studies confirmed the effective of Chinese medicinals, which was also in supporting the efficacy of the combo by edible vinegar, vitamins and Chinese medicinals, because that they all have their own therapeutic function when using independently and thus when combined use will produce more powerful therapeutic effect in far beyond expected.

 

Jan. 23, 2020, morning 2:30, above thought wake me up from sleep, I wrote article Edible vinegar, Vc, B3 and Chinese medicine may help cure new coronavirus pneumonia in Mandarin. For the concern of easily understanding by the westerners, I translate and add more as this topic.

 

The formula in that article translates as below.

Vinegar: 1 g / 50 kg, 2 times per day (preferably apple cider vinegar)

Vitamin C: 3 g / 50 kg, 6 times per day, or 50 g once per day

Vitamin B3: 1 g / 50 kg, 6 times per day

Astragalus 6 g / 50 kg, 6 times per day (pinyin: Huangqi, in the form of OTC pill or injection)

Salvia combo (Denshen compound) according to the instructions (pinyin: Fu Fang Dan Shen Pian, OTC pill or injection)

Xuefu Zhuyu Decoction 3 g / 50 kg, 4 times per day (pinyin: Xue Fu Zhu Yu Tang, OTC powder or injection)

 

It is preferred to add more OTC Chinese medicinal tablets or injections of He Shou Wu, Ci Wu Jia and Liu Wei Di Huang Wan, to be taken according to the medical instructions.

 

The method of diluting vinegar for orally taking: here takes 5% vinegar as an example. Take one milligram of vinegar solution as one gram roughly, then the one milliliter of vinegar contains 0.05 grams of pure vinegar. Then 500 mg vinegar requires 10 ml of 5% vinegar. Add 300ml of water to dilute and drink, then immediately drink water to rinse mouth and throat. Otherwise, throat may be uncomfortable (maybe).

 

I often drank 5% vinegar in 25 ml for the concerning of sobering brain.

 

Above items and dosages are safe and must be used as combo. We may try it in critically ill patients first. Intravenous infusion will be able to take effect in a few minutes.

 

The combo is for the people who are just in the start stage of the flu in self feeling of, for the people who felt the flu is heavier may shorten the time interval for taking the combo to 3 hours. For the critically ill patients, must be treated by the intravenous infusion, in this case the Vitamin C may reach 50 g / 50 kg once daily (it is for adult and should be no difference for the people in 50 kg or 80 kg, unless over-weighted people), while other items keep in suggested amount.

 

My suggestion is a demonstration only from personal judgment based on partially experienced; I hope that the ingredients in the combo can be optimized in the clinical practice in both of the items and the dosages.

 

Above combo will be effective to any patients in regardless the causes. I hoped and believed that the combo can treat the both of acute and chronic diseases, and also it will be able to eliminate withdrawal syndromes quickly for the abusers in the Tobacco, Alcohol, and Drugs.

 

It is reported that the scientists in China and France have completed the gene sequencing of the 2019 new coronavirus. The most people would feel happy, it is really worth for happy, but, I have different view without happy at all. Since that we have enough reason to question that the gene sequence really can help us to develop effective treatments quickly.

 

Even if we can develop synthetic killer to 2019 new corona virus or vaccine according to its gene sequence, but the products may not work on all people and will be without any health benefits besides dead side effects to kill people on the way for good, since that is the routine route that the synthetic medications have been going on, which is just as same as that of some politicians in perfect human feature but their brains filled with inhuman stuff to make bad for good.

 

As same as that of other dilemmas that humans are in facing, the medical dilemma is also from the social governance being ignorance kidnapped, which helps the greedy instinct of some people running rampantly and driven medical activities to be over-commercialized. For the profit concern, the wolves maliciously devalue and force to abandon the use of cheap medications and force people to accept increasingly expensive synthetic drugs and have to involve in the play of tragedies - market - kill - recall.  

There was undeniable evidence for my assertion, it was that the founder and the advocators of the cheaper Orthomolecular Medicine, such as, vitamins, Dr. Abram Hoffer, Dr. Linus Pauling and their followers were all suffered opinions attacks, and were refused to fund for their clinic trial. Obviously, this is not a simple academic controversy, but it was greed of human animal instinct involved to purposefully destroy the development of the cheaper medicinal that is able to uproot the diseases in most basic level.

Please look at the sad reality in the universal healthcare of Canada. Jan. 22, 2020, CBC News reported the overcrowded situation in all 169 acute care hospital sites in the province of Ontario Canada where the meeting room and hallway are crowded by hospital beds: 

83 hospitals were beyond 100 per cent capacity for more than 30 days.

39 hospitals hit 120 per cent capacity or higher for at least one day.

40 hospitals averaged 100 per cent capacity or higher.

 

Under the freedom and rights, the democratic players may come up with various reasons to complain about, and got perfect reasons to fierce condemn government. But few people would think about the most basic reason – without effective medication to treat patients in so many different diseases by man-made refused the use of the cheapest effective medication that has been ready for over half a century, it is Orthomolecular Medicine and Chinese Medicine, they are just the magic that can cure patients in different diseases.

 

Now promisingly, under the 2019 new coronavirus that is in threat of all people without differentiation, officials and doctors would have to accept the old remedies. Suppose that people are able to self-help by my suggested combo, then will be rare people going to see doctors, no matter the sufferers of acute or chronic, and the patients in the “hallway healthcare” of Ontario’s hospitals will be able to walk back own home quickly.

 

I would like to provide further help for my suggestion, and here now, I would like to specially apologize for my poor English wording and possible mistakes, I am too anxious, too rushed to peace my mind for more times checking.

 

I am exhausted by the bad news from the wild spread of 2019 new coronavirus, the bad sleep made me more anxious and my brain is too dizzy to follow my will.

 

                --- Frank Jan. 29, 2020 in Waterloo, Canada

12.. My writings for proving the reliable of my talkative

 

In order to convincing people that this article is not simply collecting information for the attention of people, I list some of the articles I have written as follows. What is said here is based on decades of continuous studying.

 

June 16, 2013, Daoism - The Philosophy of Traditional Chinese Medicine

Dec. 21, 2011, Chinese Medicine - A Promising Therapeutic Approach

Jun. 26, 2018, The approaches for enhancing the social cornerstones of Canada 

July 26, 2010,  Western medicine & Chinese medicine

Nov. 30, 2013, The feasible steps for improving Canada's health care system radically

Dec. 21, 2011, Chinese Medicine can Improve Sleep

July 29, 2012,  Recover Mental Disorders by Chinese Medicine

July 29, 2012,  Chinese Medicine can Reduce Stress

Dec. 21, 2011, Chinese Medicine and immune system

Nov. 25, 2011. Chinese Medicine can reduce the harm of Stress

Dec. 21, 2011, Chinese Medicine and Heart Disease

July 29, 2012,  Chinese Medicine treats on A H1N1 Flu 2009

Dec. 21, 2011, Chinese Medicine and Sexual Function

July 29, 2012,  Chinese Medicine can accelerate Wound Healing

Dec. 22, 2011, Chinese Medicine can promote Cells Regeneration   

Aug, 23, 2014, Chinese medicine can reduce the suicide of sufferer with depression

Sep. 29, 2018, The medicinal use of Cabbage in China and modern medicinal studies

Jan. 22, 2019, Vinegar is magic versatile medicine with safest, handy and most affordable

June 25, 2013, My view on Entrepreneur and Enterprise inspired by Peter Shoore

May 18, 2016, How to save Canada's manufacturing from disappearing