Cholesterol in mild cognitive impairment and Alzheimer's disease in a birth cohort over 14 years.
“Our findings confirm a previous report by Solomon et al. [4] suggesting a bidirectional relationship between TC levels and MCI/AD diagnosis such that high TC levels in midlife is a risk factor for subsequent dementia, while an observed decrease of TC levels after midlife may reflect ongoing disease processes. Thus, our results support findings [10] describing a more pronounced decline in TC among those who develop AD at least 15 years before a clinical diagnosis [26].”
AD:Alzheimer's disease
MIC:mild cognitive impairment
TC:total cholesterol