有個研究表明：中年膽固醇高是阿茲海默病的危險因素。若後來膽固醇大幅度降低，表明身體出現可能與阿茲海默病有關的健康問題。

Cholesterol in mild cognitive impairment and Alzheimer's disease in a birth cohort over 14 years.

“Our findings confirm a previous report by Solomon et al. [4] suggesting a bidirectional relationship between TC levels and MCI/AD diagnosis such that high TC levels in midlife is a risk factor for subsequent dementia, while an observed decrease of TC levels after midlife may reflect ongoing disease processes. Thus, our results support findings [10] describing a more pronounced decline in TC among those who develop AD at least 15 years before a clinical diagnosis [26].”

 AD：Alzheimer's disease

MIC：mild cognitive impairment

TC：total cholesterol