Katalin Karikó, PhD, is a renowned biochemist and researcher known for her contributions to mRNA technology and the development of COVID-19 vaccines. She specializes in ribonucleic acid (RNA)-mediated mechanisms, particularly in vitro-transcribed messenger RNA (mRNA) for protein therapies.
More than 15 years ago, Karikó and her colleague Drew Weissman discovered a way to modify mRNA and developed a delivery technique using lipid nanoparticles to ensure that mRNA reaches the appropriate part of the body to trigger an immune response against diseases.
In 2023, Karikó and Weissman were awarded the Nobel Prize in Medicine for their groundbreaking discoveries in mRNA technology. mRNA was discovered in the early 1960s, and research on its delivery into cells began in the 1970s. Karikó’s work has played a significant role in the development of mRNA vaccines, including the COVID-19 vaccines.
**
Katalin Karikó is a Hungarian-American biochemist who specializes in ribonucleic acid-mediated mechanisms, particularly in vitro-transcribed messenger RNA for protein replacement therapy. Wikipedia
“Ten years ago I was kicked out and forced to retire.”
Our new medicine laureate Katalin Karikó told us how much it means to be awarded the Nobel Prize after a scientific career that has been full of challenges. Ten years ago, Karikó was still doing all her experiments by hand but today she has been awarded the medicine prize for her research on mRNA, which led to the development of COVID-19 vaccines.
39,441 views Oct 2, 2023 Nobel Prize Conversations
The call from Stockholm woke Katalin Karikó at her home outside Philadelphia. Initially in disbelief, in this interview with Adam Smith, recorded soon after she had learnt of the award of the Nobel Prize for discoveries that accelerated the introduction of vaccines for Covid-19, she recalls her journey from Hungary and some of the setbacks on the path to the mRNA vaccines. "10 years ago I was here in October, because I was kicked out and forced to retire!" Her advice is to not to dwell on the problems: "You have to focus on the things you can change."
“Ten years ago I was kicked out and forced to retire.”
Our new medicine laureate Katalin Karikó told us how much it means to be awarded the Nobel Prize after a scientific career that has been full of challenges. Ten years ago, Karikó was still doing all her experiments by hand but today she has been awarded the medicine prize for her research on mRNA, which led to the development of COVID-19 vaccines.
She was demoted, doubted and rejected. Now, her work is the basis of the Covid-19 vaccine
By Leah Asmelash and AJ Willingham, CNN
Updated 10:59 PM EST, Wed December 16, 2020
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Doctor: Covid-19 BA.5 variant is highly transmissible
02:31
[Fauci]
Dr. Fauci explains why new BA.5 subvariant is concerning
04:58
[Katalin Karikó 12/14/2020 cpt vpx]
Scientist reveals how she celebrated successful vaccine trials
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[gupta screengrab vpx]
Will approaching winter mean new Covid-19 surge?
04:20
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[hong kong tourism]
See how Hong Kong is trying to revitalize itself after Covid-19
02:23
CNN —
Covid-19 vaccines are starting to roll out in several countries, a momentous breakthrough that hopefully signals a light at the end of this dark pandemic. For Katalin Karikó, the moment is particularly special.
Karikó has spent decades of her career researching the therapeutic possibilities of mRNA, a component of DNA that is considered to be one of the main building blocks of life. Through multiple setbacks, job losses, doubt and a transatlantic move, Karikó stood by her conviction: That mRNA could be used for something truly groundbreaking. Now, that work is the basis of the Covid-19 vaccine.
From Hungary to the US
Karikó, 65, began her career in her native Hungary in the 1970s, when mRNA research was new and the possibilities seemed endless. But the call of the American dream (and more researching and funding opportunities) took root.
In 1985, she and her husband and young daughter left Hungary for the US after she got an invitation from Temple University in Philadelphia. They sold their car, Karikó told The Guardian, and stuffed the money – an equivalent of about $1,200 – in their daughter’s teddy bear for safekeeping.
RNA contains four bases, abbreviated A, U, G, and C, corresponding to A, T, G, and C in DNA, the letters of the genetic code. Karikó and Weissman knew that bases in RNA from mammalian cells are frequently chemically modified, while in vitro transcribed mRNA is not. They wondered if the absence of altered bases in the in vitro transcribed RNA could explain the unwanted inflammatory reaction. To investigate this, they produced different variants of mRNA, each with unique chemical alterations in their bases, which they delivered to dendritic cells. The results were striking: The inflammatory response was almost abolished when base modifications were included in the mRNA. This was a paradigm change in our understanding of how cells recognize and respond to different forms of mRNA. Karikó and Weissman immediately understood that their discovery had profound significance for using mRNA as therapy. These seminal results were published in 2005, fifteen years before the COVID-19 pandemic.
[1]Neill, U. S. (2021). A conversation with Katalin Karikó. J. Clin. Invest., 131(21). doi: 10.1172/JCI155559
[2]Kolata, G. (2021). Kati Kariko Helped Shield the World From the Coronavirus. N.Y. Times. Retrieved from https://www.nytimes.com/2021/04/08/health/coronavirus-mrna-kariko.html
[3]Hargittai, I., & Hargittai, M. (2021). Our science and the Covid-19 pandemic—Katalin Karikó’s research idea and her perseverance. Struct. Chem., 32(4), 1353. doi: 10.1007/s11224-021-01797-9
[4]Susan Francia Dream Big! (2023). Retrieved from https://www.susanfrancia.com/about-me
[5]Katalin Karikó and Drew Weissman Awarded Horwitz Prize for Pioneering Research on COVID-19 Vaccines. (2021). Retrieved from https://www.cuimc.columbia.edu/news/horwitz-prize-2021
[6]How Scientists Drew Weissman (MED’87, GRS’87) and Katalin Karikó Developed the Revolutionary mRNA Technology Inside COVID Vaccines. (2021). Retrieved from https://www.bu.edu/articles/2021/how-drew-weissman-and-katalin-kariko-developed-mrna-technology-inside-covid-vaccines
[7]Johnson, C. Y. (2021). A scientific hunch. Then silence. Until the world needed a lifesaving vaccine. Washington Post. Retrieved from https://www.washingtonpost.com/science/2021/10/01/drew-weissman-mrna-vaccine
[8]Drew Weissman | Yale 2022. (2023, October 02). Retrieved from https://yale2022.yale.edu/honorary-degrees/drew-weissman
[9]Lloreda, C. L. (2021). Messenger RNA vaccine pioneer Katalin Karikó shares her long journey to Covid-19 vaccines. STAT. Retrieved from https://www.statnews.com/2021/07/19/katalin-kariko-messenger-rna-vaccine-pioneer
[10]Healy, M. (2023). Scientists whose work paved way for COVID vaccines win Nobel. Los Angeles Times. Retrieved from https://www.latimes.com/science/story/2023-10-02/kariko-weissman-mrna-covid-vaccine-nobel-prize
Nobel Prize committee cites UCI’s Phillip Felgner
Phillip Felgner, UCI professor in residence of physiology & biophysics
Today, the Nobel Prize committee awarded this year’s honor in physiology or medicine to Katalin Karikó and Drew Weissman of the University of Pennsylvania for research leading to mRNA vaccines. But it’s also worth celebrating that their discoveries wouldn’t have been possible without the contributions of Phillip Felgner, UCI professor in residence of physiology & biophysics, whose work in the 1990s explored the use of mRNA as a potential vaccine platform. In fact, the advanced scientific information that the Nobel committee posted for the award mentions Felgner’s contributions to the development of these vaccines. Felgner directs UCI’s Vaccine Research and Development Center, and he received the 2022 Robert Koch Prize and Spain’s Princess of Asturias Award for Technical and Scientific Research for his contributions to the creation of mRNA vaccines. Congratulations, Phil.
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體育娃其實更要小心，由於輸贏決定一切，不少體育隊的文化很不健康
以前看過一個計算，根據pension公式 ，最賺的辦法是
Niche 高中排名
發現這個老印家長 very funny
在 NPR 聽到這個老印媽媽，女兒在 S。她女兒說
Cal 要改簡稱了？還是改成 Berkeley 好
您的位置： 文學城 ? 論壇 ? 子女教育 ? 這次得諾貝爾獎的 Katalin Karikó
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Live or die: Katalin Karikó Hungarian Nobel4Covid Vaccine
TJKCB(2023-10-02 12:30:07)評論(4)
Katalin Karikó, PhD, is a renowned biochemist and researcher known for her contributions to mRNA technology and the development of COVID-19 vaccines. She specializes in ribonucleic acid (RNA)-mediated mechanisms, particularly in vitro-transcribed messenger RNA (mRNA) for protein therapies.
More than 15 years ago, Karikó and her colleague Drew Weissman discovered a way to modify mRNA and developed a delivery technique using lipid nanoparticles to ensure that mRNA reaches the appropriate part of the body to trigger an immune response against diseases.
In 2023, Karikó and Weissman were awarded the Nobel Prize in Medicine for their groundbreaking discoveries in mRNA technology. mRNA was discovered in the early 1960s, and research on its delivery into cells began in the 1970s. Karikó’s work has played a significant role in the development of mRNA vaccines, including the COVID-19 vaccines.
**
Katalin Karikó is a Hungarian-American biochemist who specializes in ribonucleic acid-mediated mechanisms, particularly in vitro-transcribed messenger RNA for protein replacement therapy. Wikipedia
“Ten years ago I was kicked out and forced to retire.”
Our new medicine laureate Katalin Karikó told us how much it means to be awarded the Nobel Prize after a scientific career that has been full of challenges. Ten years ago, Karikó was still doing all her experiments by hand but today she has been awarded the medicine prize for her research on mRNA, which led to the development of COVID-19 vaccines.
39,441 views Oct 2, 2023 Nobel Prize Conversations
The call from Stockholm woke Katalin Karikó at her home outside Philadelphia. Initially in disbelief, in this interview with Adam Smith, recorded soon after she had learnt of the award of the Nobel Prize for discoveries that accelerated the introduction of vaccines for Covid-19, she recalls her journey from Hungary and some of the setbacks on the path to the mRNA vaccines. "10 years ago I was here in October, because I was kicked out and forced to retire!" Her advice is to not to dwell on the problems: "You have to focus on the things you can change."
“Ten years ago I was kicked out and forced to retire.”
Our new medicine laureate Katalin Karikó told us how much it means to be awarded the Nobel Prize after a scientific career that has been full of challenges. Ten years ago, Karikó was still doing all her experiments by hand but today she has been awarded the medicine prize for her research on mRNA, which led to the development of COVID-19 vaccines.
She was demoted, doubted and rejected. Now, her work is the basis of the Covid-19 vaccine
By Leah Asmelash and AJ Willingham, CNN
Updated 10:59 PM EST, Wed December 16, 2020
Video Ad Feedback
[Jill Biden]
Jill Biden speaks out after President Biden contracts Covid-19
00:45
[brian china economic crisis wang 0715]
'I'm losing my mind': Chinese depositor loses life savings in bank
03:58
[LOS ANGELES, CALIFORNIA - APRIL 21: A man is asked to cough into his arm as part of testing for COVID-19, by a member of the Los Angeles Fire Department wearing personal protective equipment (PPE) in Skid Row, amidst the coronavirus pandemic on April 21, 2020 in Los Angeles, California. 43 people tested positive for COVID-19 at one nearby Skid Row homeless shelter. (Photo by Mario Tama/Getty Images)]
Doctor: Covid-19 BA.5 variant is highly transmissible
02:31
[Fauci]
Dr. Fauci explains why new BA.5 subvariant is concerning
04:58
[Katalin Karikó 12/14/2020 cpt vpx]
Scientist reveals how she celebrated successful vaccine trials
03:57
[gupta screengrab vpx]
Will approaching winter mean new Covid-19 surge?
04:20
[china corona nyc]
Artist wears 27 hazmat suits to protest China's policies
03:08
[hong kong tourism]
See how Hong Kong is trying to revitalize itself after Covid-19
02:23
[Late night Joe Biden]
See late night reactions to President Biden claiming pandemic over
01:45
[Patient using video game treatment long haul covid gupta pkg vpx]
Dr. Gupta: This treatment for 'brain fog' from long-Covid just might surprise you
04:05
Aaron Rodgers tells Joe Rogan why he didn't get vaccinated for Covid
02:16
[BARTLETT, ILLINOIS - MAY 01: Seven-year-old Hamza Haqqani, a 2nd grade student at Al-Huda Academy, uses a computer to participate in an E-learning class with his teacher and classmates while at his home on May 01, 2020 in Bartlett, Illinois. Al-Huda Academy, an Islam based private school that teaches pre-school through the 6th grade students, has had to adopt an E-learning program to finish the school year after all schools in the state were forced to cancel classes in an attempt to curtail the spread of the COVID-19 pandemic. (Photo by Scott Olson/Getty Images)]
How Covid upended children's lives
10:16
[hotez vpx]
'Wasn't too surprising': Doctor reacts to Biden's positive Covid test
02:50
[video thumbnail wuhan market 1]
New studies suggest Covid-19 likely originated from Wuhan wet market
01:39
[Dr. Anthony Fauci]
Dr. Fauci gives update on Biden's Covid-19 infection
05:50
[doctor jonathan reiner]
'This was entirely predictable': Doctor on Biden testing positive for Covid-19
01:22
[Jill Biden]
Jill Biden speaks out after President Biden contracts Covid-19
00:45
[brian china economic crisis wang 0715]
'I'm losing my mind': Chinese depositor loses life savings in bank
03:58
[LOS ANGELES, CALIFORNIA - APRIL 21: A man is asked to cough into his arm as part of testing for COVID-19, by a member of the Los Angeles Fire Department wearing personal protective equipment (PPE) in Skid Row, amidst the coronavirus pandemic on April 21, 2020 in Los Angeles, California. 43 people tested positive for COVID-19 at one nearby Skid Row homeless shelter. (Photo by Mario Tama/Getty Images)]
Doctor: Covid-19 BA.5 variant is highly transmissible
02:31
[Fauci]
Dr. Fauci explains why new BA.5 subvariant is concerning
04:58
[Katalin Karikó 12/14/2020 cpt vpx]
Scientist reveals how she celebrated successful vaccine trials
03:57
[gupta screengrab vpx]
Will approaching winter mean new Covid-19 surge?
04:20
[china corona nyc]
Artist wears 27 hazmat suits to protest China's policies
03:08
[hong kong tourism]
See how Hong Kong is trying to revitalize itself after Covid-19
02:23
CNN —
Covid-19 vaccines are starting to roll out in several countries, a momentous breakthrough that hopefully signals a light at the end of this dark pandemic. For Katalin Karikó, the moment is particularly special.
Karikó has spent decades of her career researching the therapeutic possibilities of mRNA, a component of DNA that is considered to be one of the main building blocks of life. Through multiple setbacks, job losses, doubt and a transatlantic move, Karikó stood by her conviction: That mRNA could be used for something truly groundbreaking. Now, that work is the basis of the Covid-19 vaccine.
From Hungary to the US
Karikó, 65, began her career in her native Hungary in the 1970s, when mRNA research was new and the possibilities seemed endless. But the call of the American dream (and more researching and funding opportunities) took root.
In 1985, she and her husband and young daughter left Hungary for the US after she got an invitation from Temple University in Philadelphia. They sold their car, Karikó told The Guardian, and stuffed the money – an equivalent of about $1,200 – in their daughter’s teddy bear for safekeeping.
RNA contains four bases, abbreviated A, U, G, and C, corresponding to A, T, G, and C in DNA, the letters of the genetic code. Karikó and Weissman knew that bases in RNA from mammalian cells are frequently chemically modified, while in vitro transcribed mRNA is not. They wondered if the absence of altered bases in the in vitro transcribed RNA could explain the unwanted inflammatory reaction. To investigate this, they produced different variants of mRNA, each with unique chemical alterations in their bases, which they delivered to dendritic cells. The results were striking: The inflammatory response was almost abolished when base modifications were included in the mRNA. This was a paradigm change in our understanding of how cells recognize and respond to different forms of mRNA. Karikó and Weissman immediately understood that their discovery had profound significance for using mRNA as therapy. These seminal results were published in 2005, fifteen years before the COVID-19 pandemic.
“Ten years ago I was kicked out and forced to retire.”
Our new medicine laureate Katalin Karikó told us how much it means to be awarded the Nobel Prize after a scientific career that has been full of challenges. Ten years ago, Karikó was still doing all her experiments by hand but today she has been awarded the medicine prize for her research on mRNA, which led to the development of COVID-19 vaccines.
39,441 views Oct 2, 2023 Nobel Prize Conversations
The call from Stockholm woke Katalin Karikó at her home outside Philadelphia. Initially in disbelief, in this interview with Adam Smith, recorded soon after she had learnt of the award of the Nobel Prize for discoveries that accelerated the introduction of vaccines for Covid-19, she recalls her journey from Hungary and some of the setbacks on the path to the mRNA vaccines. "10 years ago I was here in October, because I was kicked out and forced to retire!" Her advice is to not to dwell on the problems: "You have to focus on the things you can change."
Our new medicine laureate Katalin Karikó told us how much it means to be awarded the Nobel Prize after a scientific career that has been full of challenges. Ten years ago, Karikó was still doing all her experiments by hand but today she has been awarded the medicine prize for her research on mRNA, which led to the development of COVID-19 vaccines.