市售VD極少見到5000 IU以上的,如果自己買來吃,想中毒都難,除非個別特殊體質、或當糖球吃的蠢貨。
製造商、食品提出廠家、不合格的醫生,這些才是真正的罪魁。
LZ所給出的文章中列出的主要原因摘錄:
Causes of vitamin D toxicity
Formulation or fortification errors
studies of fortified foodstuffs revealed substantial manufacturing errors, confirming marked differences between the stated and actual doses 21. Overfortification of vitamin D in milk resulted in hypervitaminosis D in the local population, leading to at least 56 cases; 41 required hospitalization and there were two deaths 22, reinforcing the need for careful ongoing production monitoring 23.
Inappropriate prescribing or dispensing
High‐dose formulations are a particular cause for concern. Stoss therapy for vitamin D deficiency, with high doses of vitamin D over relatively short periods, progressing to much lower maintenance doses, has encouraged the development of high‐dose vitamin D therapies (60 000 IU and above). With evidence indicating that doses of 10 000 IU day–1 or below do not cause vitamin D toxicity 15, and that such doses are effective in resolving vitamin D deficiency 38, it may seem that having super‐strength doses might expose subjects to unnecessary risk through either errant prescribing or inappropriate self‐medication. Indeed, vitamin D toxicity is described in association both with high‐dose over‐the‐counter supplements 39 being taken too frequently and prescribed in error by the physician
Inappropriate administration of vitamin D
A single dose of 2 000 000 IU of vitamin D was given in error to two nursing home residents 67, leading to a call to replace multiple use bottles with smaller single‐unit dose formulations.