JMA：服用複合維生素降低中老年男性患癌風險

作者：Michael Gaziano 來源：JAMA 發布時間：2012-11-1 15:56:57 選擇字號：小 中 大

服用複合維生素降低中老年男性患癌風險     美國研究人員近日發表的研究報告顯示，每日服用複合維生素可以降低50歲以上男性的患癌風險。   約5萬名50歲以上男醫生參加了這項受美國國家衛生研究院資助的研究，他們每天服用一片善存複合維生素或者安慰劑。超過10年的研究結束後，研究人員發現，服用維生素的人總體患癌率比服用安慰劑的人低8%，前者的癌症死亡率也顯著下降。   相關研究報告當天發表在《美國醫學會雜誌》網絡版上，同時也在美國癌症研究協會年會上公布。領導研究的布裏格姆婦科醫院副教授霍華德·塞索表示，他們目前還不清楚複合維生素中的哪種維生素或礦物質在抗癌方麵發揮了作用，研究結果能否適用於女性及50歲以下男性也不清楚。布裏格姆婦科醫院是哈佛大學醫學院的附屬教學醫院。   美國疾病控製和預防中心公布的數據顯示，美國約半數成年人每天服用膳食補充劑，其中複合維生素最為常見。（來源：新華社 任海軍）   Multivitamins in the Prevention of Cancer in Men  The Physicians' Health Study II Randomized Controlled Trial J. Michael Gaziano, MD, MPH; Howard D. Sesso, ScD, MPH; William G. Christen, ScD; Vadim Bubes, PhD; Joanne P. Smith, BA; Jean MacFadyen, BA; Miriam Schvartz, MD; JoAnn E. Manson, MD, DrPH; Robert J. Glynn, ScD; Julie E. Buring, ScD [+] Author Affiliations JAMA. 2012;308(18):1871-1880. doi:10.1001/jama.2012.14641.   Context  Multivitamin preparations are the most common dietary supplement, taken by at least one-third of all US adults. Observational studies have not provided evidence regarding associations of multivitamin use with total and site-specific cancer incidence or mortality. Objective  To determine whether long-term multivitamin supplementation decreases the risk of total and site-specific cancer events among men. Design, Setting, and Participants  A large-scale, randomized, double-blind, placebo-controlled trial (Physicians' Health Study II) of 14 641 male US physicians initially aged 50 years or older (mean [SD] age, 64.3 [9.2] years), including 1312 men with a history of cancer at randomization, enrolled in a common multivitamin study that began in 1997 with treatment and follow-up through June 1, 2011. Intervention  Daily multivitamin or placebo. Main Outcome Measures  Total cancer (excluding nonmelanoma skin cancer), with prostate, colorectal, and other site-specific cancers among the secondary end points. Results  During a median (interquartile range) follow-up of 11.2 (10.7-13.3) years, there were 2669 men with confirmed cancer, including 1373 cases of prostate cancer and 210 cases of colorectal cancer. Compared with placebo, men taking a daily multivitamin had a statistically significant reduction in the incidence of total cancer (multivitamin and placebo groups, 17.0 and 18.3 events, respectively, per 1000 person-years; hazard ratio [HR], 0.92; 95% CI, 0.86-0.998; P = .04). There was no significant effect of a daily multivitamin on prostate cancer (multivitamin and placebo groups, 9.1 and 9.2 events, respectively, per 1000 person-years; HR, 0.98; 95% CI, 0.88-1.09;P = .76), colorectal cancer (multivitamin and placebo groups, 1.2 and 1.4 events, respectively, per 1000 person-years; HR, 0.89; 95% CI, 0.68-1.17; P = .39), or other site-specific cancers. There was no significant difference in the risk of cancer mortality (multivitamin and placebo groups, 4.9 and 5.6 events, respectively, per 1000 person-years; HR, 0.88; 95% CI, 0.77-1.01; P = .07). Daily multivitamin use was associated with a reduction in total cancer among 1312 men with a baseline history of cancer (HR, 0.73; 95% CI, 0.56-0.96; P = .02), but this did not differ significantly from that among 13 329 men initially without cancer (HR, 0.94; 95% CI, 0.87-1.02; P = .15; P for interaction = .07). Conclusion  In this large prevention trial of male physicians, daily multivitamin supplementation modestly but significantly reduced the risk of total cancer. 原文鏈接：http://jama.jamanetwork.com/article.aspx?articleid=1380451

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• BMJ：大量補鈣使女性死亡風險（主要是心髒病）加倍 -dudaan- ♂ (3963 bytes) () 02/14/2013 postreply 18:45:21

• 這個數據的解讀需要謹慎 -華山97- ♂ (346 bytes) () 02/14/2013 postreply 22:30:31

• 謝謝老T和老杜。 -惡俗老狼- ♂ (174 bytes) () 02/14/2013 postreply 18:50:32

• 真理。 -薛成- ♂ (0 bytes) () 02/15/2013 postreply 00:35:17

• 中文翻譯有一個明顯錯誤 -華山97- ♂ (1002 bytes) () 02/14/2013 postreply 22:09:14

• 另外，這類研究所謂的“顯著”作用，應該是統計學意義上的“顯著”，就是說，兩個對照 -slacker- ♂ (677 bytes) () 02/15/2013 postreply 11:22:49

• Co! 回複：另外，這類研究所謂的“顯著”作用，應該是統計學意義上的“顯著”，就是說，兩個對照 -houtou72- ♂ (89 bytes) () 02/15/2013 postreply 17:10:30

• 每1000人，並不是隻有1000人參與試驗 -TBz- ♂ (0 bytes) () 02/15/2013 postreply 17:25:31

• 謝糾正 -TBz- ♂ (0 bytes) () 02/15/2013 postreply 23:15:55