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Ritter reaction

(2023-03-25 09:17:09) 下一個

The Ritter reaction is a chemical reaction that transforms a nitrile into an N-alkyl amide using various electrophilic alkylating reagents. The original reaction formed the alkylating agent using an alkene in the presence of a strong acid.

Ritter-Reaktion 1d.svg

The Ritter reaction proceeds by the electrophilic addition of either a carbenium ion or covalent species to the nitrile. The resulting nitrilium ion is hydrolyzed to the desired amide.

Ritter reaction mechanism, step by step..jpg

 
 
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