H2O2/DMSO體係水解腈製備酰胺

1989年，Alan R. Katritzky就報道了一種H2O2-K2CO3-DMSO體係水解腈為伯酰胺的方法【Synthesis 1989, 949】，室溫下，5-30分鍾就能完成反應，是一種非常實用的水解腈製備酰胺的方法。

此反應的機理研究報道於【Bulletin of the Chemical Society of Japan, 1981, 54, 793-799】

反應操作

 

To a stirred solution of 4-chlorobenzonitrile (1.37 g, 0.01 mol) in DMSO (3 ml), cooled in a ice bath, was added 30% H2O2 (1.2 ml) and K2CO3, the reaction was allowed to warm up to r.t. (strong exothermic effect was observed). After 5 min., distilled water (50 ml) was added, cooling applied, and the product was collected by filtration, yield 85%.

 

參考資料

1、J. Am. Chem. Soc. 1979, 101, 1291–1293

2、Bulletin of the Chemical Society of Japan, 1981, 54, 793-799

3、Synthesis 1989, 949

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