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木耳有毒！翻白草治糖尿病！----政府在澄清真相中的腳色 2010-05-01 10:29:06
信息時代的一代特征，是阿狗阿貓都能發言，奸商可以發廣告，壞人可以誹謗別人，競爭者可以釋放虛假信息敗壞對手的信譽。政府的科研和權力機構應該在澄清真相中扮演腳色。當然，現在的狀況不理想。
舉例，免。
我今天隻講一個日常生活碰到的食物安全，以及不花錢治大病的偏方可靠性問題。
到網上檢索：“新鮮木耳有毒”，可以得到成千上萬的結果，支持這個說法。
實際上，我自己親身試驗，從枯樹枝上采摘新鮮木耳，立即炒菜吃掉。從來沒有中毒。好吃得很。
那麽，這個錯誤的信息來源是誰？為什麽發布如此誤導人的信息？是否應該給讀者造成的損失負責？要不要將他逮捕法辦？
這些問題，沒有答案。
類似問題得不到解決。
再舉例，糖尿病人越來越多。治療糖尿病成為網上的熱點討論。永遠沒有定論。隨便一個說法，總是有正反兩種說法。讓讀者無所適從。
比如，翻白草治糖尿病，請大家到網上檢索，看看。說沒用的人很多。那麽有沒有科學根據呢？正反雙方都是簡單的經驗表達。基本上沒有絲毫的科學嚴謹，處於街坊大媽鬥嘴吵架的檔次。
以我的生物化學和醫學的紮實訓練，決定花點時間，稍微深入鑽下去，看看嚴格的科學研究，是否有人做，結果如何？
答案：有。
南京中醫藥大學研究結果用外文報道了試驗結果。他們用翻白草的簡單提取物在小白鼠身上做試驗，發現：1）在正常健康老鼠身上沒有降血糖，2）在糖尿病老鼠身上發現，可以顯著降血糖。
說明：翻白草治糖尿病，不是空穴來風，是有科學根據的。這個試驗結果，在外國發表的，中國人當中，知道得不多。而那些相反經驗的人，要從自身找原因了。
Anti-diabetic effect of standardized extract of Potentilla discolor Bunge and identification of its active components
Jie Yang 1, Hong Chen 1, Li Zhang 1, Qiang Wang 1 *, Mao-Xiang Lai 2
1Department of Chinese Materia Medica Analysis, Pharmaceutical University, Nanjing 210009, People\'s Republic of China
2Guangxi Academy of Chinese Medicine and Pharmaceutical Science, Guangxi 530022, People\'s Republic of China
email: Qiang Wang (qwang49@163.com)
*Correspondence to Qiang Wang, Department of Chinese Materia Medica Analysis, China Pharmaceutical University, Nanjing 210009, People\'s Republic of China
Keywords
Potentilla discolor • diabetes • triterpenes • flavonoids • glycogen phosphorylase
Abstract
Potentilla discolor Bunge, a Chinese folk medicine, has been used for the treatment of diabetes for many years. Unfortunately, little information is available on its bioactive components and mechanism of action. We report the anti-diabetic effect of P. discolor on normal and alloxan-induced diabetic mice, as well as the possible constituents and mechanism responsible for this activity. We found that the standardized extract of P. discolor (EPD) had little effect on the glucose levels of normal mice, while a dose-dependent hypoglycemic effect was observed in diabetic mice. Glucose tolerance test data indicated that there was a significantly higher rate of glucose disposal after EPD treatment. Phytochemical characterization indicated that the major components of EPD were triterpenes and flavonoids that could inhibit the activity of glycogen phosphorylase (GP) in vitro. Tormentic acid, asiatic acid, and potengriffioside A exhibited inhibitory effects on GP (IC50=90.6, 65.4, and 85.9 µM, respectively). The inhibition on GP may be one molecular mechanism through which EPD ameliorates hyperglycemia. These results suggest P. discolor extract may offer an alternate treatment for diabetes. Drug Dev Res, 2009. © 2009 Wiley-Liss, Inc.
Received: 14 July 2009; Accepted: 13 September 2009
信息時代的一代特征，是阿狗阿貓都能發言，奸商可以發廣告，壞人可以誹謗別人，競爭者可以釋放虛假信息敗壞對手的信譽。政府的科研和權力機構應該在澄清真相中扮演腳色。當然，現在的狀況不理想。
舉例，免。
我今天隻講一個日常生活碰到的食物安全，以及不花錢治大病的偏方可靠性問題。
到網上檢索：“新鮮木耳有毒”，可以得到成千上萬的結果，支持這個說法。
實際上，我自己親身試驗，從枯樹枝上采摘新鮮木耳，立即炒菜吃掉。從來沒有中毒。好吃得很。
那麽，這個錯誤的信息來源是誰？為什麽發布如此誤導人的信息？是否應該給讀者造成的損失負責？要不要將他逮捕法辦？
這些問題，沒有答案。
類似問題得不到解決。
再舉例，糖尿病人越來越多。治療糖尿病成為網上的熱點討論。永遠沒有定論。隨便一個說法，總是有正反兩種說法。讓讀者無所適從。
比如，翻白草治糖尿病，請大家到網上檢索，看看。說沒用的人很多。那麽有沒有科學根據呢？正反雙方都是簡單的經驗表達。基本上沒有絲毫的科學嚴謹，處於街坊大媽鬥嘴吵架的檔次。
以我的生物化學和醫學的紮實訓練，決定花點時間，稍微深入鑽下去，看看嚴格的科學研究，是否有人做，結果如何？
答案：有。
南京中醫藥大學研究結果用外文報道了試驗結果。他們用翻白草的簡單提取物在小白鼠身上做試驗，發現：1）在正常健康老鼠身上沒有降血糖，2）在糖尿病老鼠身上發現，可以顯著降血糖。
說明：翻白草治糖尿病，不是空穴來風，是有科學根據的。這個試驗結果，在外國發表的，中國人當中，知道得不多。而那些相反經驗的人，要從自身找原因了。
Anti-diabetic effect of standardized extract of Potentilla discolor Bunge and identification of its active components
Jie Yang 1, Hong Chen 1, Li Zhang 1, Qiang Wang 1 *, Mao-Xiang Lai 2
1Department of Chinese Materia Medica Analysis, Pharmaceutical University, Nanjing 210009, People\'s Republic of China
2Guangxi Academy of Chinese Medicine and Pharmaceutical Science, Guangxi 530022, People\'s Republic of China
email: Qiang Wang (qwang49@163.com)
*Correspondence to Qiang Wang, Department of Chinese Materia Medica Analysis, China Pharmaceutical University, Nanjing 210009, People\'s Republic of China
Keywords
Potentilla discolor • diabetes • triterpenes • flavonoids • glycogen phosphorylase
Abstract
Potentilla discolor Bunge, a Chinese folk medicine, has been used for the treatment of diabetes for many years. Unfortunately, little information is available on its bioactive components and mechanism of action. We report the anti-diabetic effect of P. discolor on normal and alloxan-induced diabetic mice, as well as the possible constituents and mechanism responsible for this activity. We found that the standardized extract of P. discolor (EPD) had little effect on the glucose levels of normal mice, while a dose-dependent hypoglycemic effect was observed in diabetic mice. Glucose tolerance test data indicated that there was a significantly higher rate of glucose disposal after EPD treatment. Phytochemical characterization indicated that the major components of EPD were triterpenes and flavonoids that could inhibit the activity of glycogen phosphorylase (GP) in vitro. Tormentic acid, asiatic acid, and potengriffioside A exhibited inhibitory effects on GP (IC50=90.6, 65.4, and 85.9 µM, respectively). The inhibition on GP may be one molecular mechanism through which EPD ameliorates hyperglycemia. These results suggest P. discolor extract may offer an alternate treatment for diabetes. Drug Dev Res, 2009. © 2009 Wiley-Liss, Inc.
Received: 14 July 2009; Accepted: 13 September 2009
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