一個報道,二重天地

本帖於 2021-01-28 07:06:39 時間, 由普通用戶 fuz 編輯

晨起,迷迷糊糊,掃過一篇報道。咋看,覺得是好消息。閉眼一想,有點不對勁。再琢磨,毛骨悚然。

報道:https://mobile.reuters.com/article/amp/idUSKBN29W31

標題:Pfizer vaccine only slightly less effective against key South African mutations - study

從標題看,是個好消息: vaccine will still work against these new variants.

下麵一段文中提到怎麽得出這個結論的:用疫苗接種者身上誘導出來的抗體對病毒的中和滴定度來評估其有效性。

"Pfizer Inc and BioNTech's COVID-19 vaccine appeared to lose only a small bit of effectiveness against an engineered virus with three key mutations from the new coronavirus variant found in South Africa,according to a laboratory study conducted by the U.S. drugmaker.

The study by Pfizer and scientists from the University of Texas Medical Branch (UTMB), which has not yet been peer-reviewed, showed a less than two-fold reduction in antibody titer levels, indicating the vaccine would likely be effective in neutralizing a virus with the so-called E484K and N501Y mutations found in the South African variant.

The study here was conducted on blood taken from people who had received the vaccine. "

 

可扣細節,看到大坑了:"an engineered virus with three key mutations from the new coronavirus variant found in South Africa"

所用的病毒是按南非變種,人工合成的!!!

更糟的是,作者們滋滋不倦的還要接著合成

 "The scientists are currently engineering a virus with the full set of mutations and expect to have results from that in around two weeks, according to Pei-Yong Shi, an author of the study and a professor at UTMB."

.........

 "The study also showed even better results against several key mutations from the highly transmissible UK variant of the virus. Shi said they were also working on an engineered virus with the full set of mutations from that variant as well."

 

俺就搞不明白,這位'德大'(UTMB)的“Shi"到底咋想的呢?難道沒看到武漢那個水深火熱中的“石”?

還是想要證明其實驗室比“石”厲害,有本事整出各種病毒?!

可萬一,腦子一迷胡,手抖了一下,加錯點啥,或按差了鍵,整出些更邪乎的新變種。

再不小心逛街時放個屁,嘣出來幾個……………

這世界豈不更精彩。

 

這秧秧大國,咋就沒人管這事呢?

 

請德大的朋友,轉告那位Shi:

一念天堂 一念地獄 (the difference between heaven and hell lies in your way of thinking)

阿彌陀佛

所有跟帖: 

我也有一事不明 -dudaan- 給 dudaan 發送悄悄話 dudaan 的博客首頁 (185 bytes) () 01/28/2021 postreply 05:40:00

科研要有經濟支撐。近幾十年來的傾向是:定製。所以,俺換了職業做數據庫,可仍免不了被“按摩”。 -fuz- 給 fuz 發送悄悄話 fuz 的博客首頁 (0 bytes) () 01/28/2021 postreply 05:47:49

看了你的貼,我懷疑哥倫比亞大學的“Ho"是不是也在搞人造病毒變異 -dudaan- 給 dudaan 發送悄悄話 dudaan 的博客首頁 (0 bytes) () 01/28/2021 postreply 05:54:33

再生元的抗體的研發不需要活病毒和變異體 -xintian- 給 xintian 發送悄悄話 xintian 的博客首頁 (211 bytes) () 01/28/2021 postreply 06:48:30

測定是否有效需要病毒 -dudaan- 給 dudaan 發送悄悄話 dudaan 的博客首頁 (0 bytes) () 01/28/2021 postreply 07:12:57

實驗室階段的體外測試並不需要活病毒,臨床試驗是直接上人體給藥,感染以後再分析病毒的類型 -xintian- 給 xintian 發送悄悄話 xintian 的博客首頁 (0 bytes) () 01/28/2021 postreply 07:20:12

我非此業內人士,你看下麵Fuz所說 -dudaan- 給 dudaan 發送悄悄話 dudaan 的博客首頁 (0 bytes) () 01/28/2021 postreply 07:23:00

The engineered virus strains are for vaccine use. You need to en -twoboys_mom- 給 twoboys_mom 發送悄悄話 (116 bytes) () 01/28/2021 postreply 07:07:13

再仔細看看,好好想想。那些試驗怎麽做的 -fuz- 給 fuz 發送悄悄話 fuz 的博客首頁 (0 bytes) () 01/28/2021 postreply 07:09:03

please specify -twoboys_mom- 給 twoboys_mom 發送悄悄話 (0 bytes) () 01/28/2021 postreply 07:09:30

這類抗體中和效價測定,要用培養的“活病毒”,和分離的抗血清。以往,病毒從病人身上分離、培養,不是合成的。方法見內 -fuz- 給 fuz 發送悄悄話 fuz 的博客首頁 (133 bytes) () 01/28/2021 postreply 07:16:14

I don't see much difference. It's a very routine procedure. -twoboys_mom- 給 twoboys_mom 發送悄悄話 (0 bytes) () 01/28/2021 postreply 08:18:15

關鍵在“合成製造病毒”,會不會造出超級病毒。這屬於監管程序。臨床上測抗體中和,應該使用來自病人的毒株 -fuz- 給 fuz 發送悄悄話 fuz 的博客首頁 (0 bytes) () 01/28/2021 postreply 08:44:27

I see your point. We are living in a risky world. Double sword. -twoboys_mom- 給 twoboys_mom 發送悄悄話 (0 bytes) () 01/28/2021 postreply 08:47:36

Pseudovirus,就是合成了一個有S蛋白但沒其它成分的病毒,試驗都是用假病毒做的,否則就需要P4實驗室,美國也沒幾個 -朱頭山- 給 朱頭山 發送悄悄話 朱頭山 的博客首頁 (0 bytes) () 01/28/2021 postreply 09:00:44

文章開篇“ We engineered three SARS-CoV-2 viruses containing key spik -fuz- 給 fuz 發送悄悄話 fuz 的博客首頁 (28946 bytes) () 01/28/2021 postreply 09:11:55

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