麻州General 2011 和MD Anderson2016， 日本的2017文獻：都還沒有能研究proton therapy是否會降低germinoma病人二次腫瘤機會。但放射線dose distribution更好些。。。
1. MD Anderson的：http://bbs.wenxuecity.com/health/783455.html
Proton radiotherapy for pediatric central nervous system germ cell tumors: early clinical outcomes.
Author information
- 1
- Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. smacdonald@partners.org
Abstract
PURPOSE:
To report early clinical outcomes for children with central nervous system (CNS) germ cell tumors treated with protons; to compare dose distributions for intensity-modulated photon radiotherapy (IMRT), three-dimensional conformal proton radiation (3D-CPT), and intensity-modulated proton therapy with pencil beam scanning (IMPT) for whole-ventricular irradiation with and without an involved-field boost.
METHODS AND MATERIALS:
All children with CNS germinoma or nongerminomatous germ cell tumor who received treatment at the Massachusetts General Hospital between 1998 and 2007 were included in this study. The IMRT, 3D-CPT, and IMPT plans were generated and compared for a representative case.
RESULTS:
Twenty-two patients were treated with 3D-CPT. At a median follow-up of 28 months, there were no CNS recurrences; 1 patient had a recurrence outside the CNS. Local control, progression-free survival, and overall survival rates were 100%, 95%, and 100%, respectively. Comparable tumor volume coverage was achieved with IMRT, 3D-CPT, and IMPT. Substantial normal tissue sparing was seen with any form of proton therapy as compared with IMRT. The use of IMPT may yield additional sparing of the brain and temporal lobes.
CONCLUSIONS:
Preliminary disease control with proton therapy compares favorably to the literature. Dosimetric comparisons demonstrate the advantage of proton radiation over IMRT for whole-ventricle radiation. Superior dose distributions were accomplished with fewer beam angles utilizing 3D-CPT and scanned protons. Intensity-modulated proton therapy with pencil beam scanning may improve dose distribution as compared with 3D-CPT for this treatment.
Copyright © 2011 Elsevier Inc. All rights reserved.
3. 日本人的 ：A comparative study of dose distribution of PBT, 3D-CRT and IMRT for pediatric brain tumors.
Takizawa D, Mizumoto M, Yamamoto T, Oshiro Y, Fukushima H, Fukushima T, Terunuma T, Okumura T, Tsuboi K, Sakurai H.
Radiat Oncol. 2017 Feb 22;12(1):40. doi: 10.1186/s13014-017-0775-2.
- PMID:
