這個問題好像不好回答。但反過來問就容易答了：是不是得了癌症膽固醇會變低呢？是的，特別是肝癌，直接影響了膽固醇的合成。

來源: 吃與活於 2016-10-19 11:18:04 [檔案] [博客] [舊帖] [給我悄悄話] 本文已被閱讀：次 (6860 bytes)

回答: 膽固醇太低易得癌症，這個說法對嗎？由 Gbdjw 於 2016-10-19 10:53:36

2011 Apr 20;29(12):1592-8. doi: 10.1200/JCO.2010.31.5200. Epub 2011 Mar 21.

Total cholesterol and cancer risk in a large prospective study in Korea.

Kitahara CM¹, Berrington de González A, Freedman ND, Huxley R, Mok Y, Jee SH, Samet JM.

Author information

Abstract

PURPOSE:

To further clarify the relationship between total cholesterol and cancer, which remains unclear.

METHODS:

We prospectively examined the association between total cholesterol and site-specific and all-cancer incidence among 1,189,719 Korean adults enrolled in the National Health Insurance Corporation who underwent a standardized biennial medical examination in 1992 to 1995 and were observed for 14 years until cancer diagnosis or death.

RESULTS:

Over follow-up, 53,944 men and 24,475 women were diagnosed with a primary cancer. Compared with levels less than 160 mg/dL, high total cholesterol (≥ 240 mg/dL) was positively associated with prostate cancer (hazard ratio [HR], 1.24; 95% CI, 1.07 to 1.44; P trend = .001) and colon cancer (HR, 1.12; 95% CI, 1.00 to 1.25; P trend = .05) in men and breast cancer in women (HR, 1.17; 95% CI, 1.03 to 1.33; P trend = .03). Higher total cholesterol was associated with a lower incidence of liver cancer (men: HR, 0.42; 95% CI, 0.38 to 0.45; P trend < .001; women: HR, 0.32; 95% CI, 0.27 to 0.39; P trend < .001), stomach cancer (men: HR, 0.87; 95% CI, 0.82 to 0.93; P trend ≤ .001; women: HR, 0.86; 95% CI, 0.77 to 0.97; P trend = .06), and, in men, lung cancer (HR, 0.89; 95% CI, 0.82 to 0.96; P trend < .001). Results for liver cancer were slightly attenuated after additional adjustment for liver enzyme levels and hepatitis B surface antigen status (men: HR, 0.60; P trend < .001; women: HR, 0.46; P trend = .003) and exclusion of the first 10 years of follow-up (men: HR, 0.59; P trend < .001; women: HR, 0.44; P trend < .001). Total cholesterol was inversely associated with all-cancer incidence in both men (HR, 0.84; 95% CI, 0.81 to 0.86; P trend < .001) and women (HR, 0.91; 95% CI, 0.87 to 0.95; P trend < .001), but these associations were attenuated after excluding incident liver cancers (men: HR, 0.95; P trend < .001; women: HR, 0.98; P trend = .32).

CONCLUSION:

In this large prospective study, we found that total cholesterol was associated with the risk of several different cancers, although these relationships differed markedly by cancer site.

PMID:: 21422422
PMCID:: PMC3082977
DOI:: 10.1200/JCO.2010.31.5200

Fig 1.

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Hazard ratios and 95% CIs for total cholesterol (per 20 mg/dL) in relation to site-specific cancer incidence in (A) Korean men and (B) Korean women in the Korean Cancer Prevention Study (1992 to 2006). Models used attained age as the underlying time metric and were adjusted for cigarette smoking, alcohol drinking, body mass index, fasting serum glucose, hypertension, and physical activity.