http://stroke.ahajournals.org/content/42/3/838.full
Take-Home Messages for Clinicians
-
(i) High homocysteine levels are associated with increased risk of both stroke and coronary heart disease.
-
(ii) Homocysteine can be lowered with folic acid (2.5 mg) and B-complex vitamin (50 mg B6 and 1 mg B12) supplements.
-
(iii) The routine use of HLT for cardiovascular prevention is not supported by the current available evidence.
-
(iv) Individuals with ischemic stroke and hyperhomocysteinemia may benefit from HLT for secondary prevention.
-
(v) Although Vitamin B complex does not appear to have major side effects, caution must be exercise in patients with renal failure or decreased glomerular filtration rate.