癌變需要oncogene和tumor suppressor都(不是同時)出錯,幾乎是cancer cell biologists的共識,您可以自己去查,恕不提供文獻。如您不信,也沒有問題。
如果您認為30億堿基和29億堿基是重大差異,我不予解釋。以前還有9億的說法。
另外,多少蛋白質,其實也有多種說法,現僅舉下列較近說法:
One of the teams, led by Akhilesh Pandey from Johns Hopkins University, identified and annotated proteins encoded by 17,294 genes -- that accounts for around 84 percent of all the genes in the human genome that are predicted to encode proteins (that number is estimated at 19,629, if you’re curious). The team extracted proteins from samples of 30 different tissues, then used enzymes to cut them into small pieces called peptides. They ran the peptides through a series of instruments to identify and measure their relative abundance.
The other team, led by Bernhard Kuster of Technische Universit?t München (TUM) in Germany, assembled protein evidence for over 18,000 genes (or 92 percent of the entire proteome) by compiling raw mass spec data from databases and other analyses that were already available. These include a core of 10,000–12,000 proteins expressed in several different tissues, and to fill in the gaps, they generated their own mass spec data by analyzing 60 human tissues, 13 body fluids, and 147 cancer cell lines.
(鏈接:http://www.iflscience.com/health-and-medicine/first-complete-mapping-human-proteome-discovers-193-new-proteins)
這些Publications是可以查到的。