berberine並不殺益生菌，證據如下
1. "Berberine can activate TLR4/MyD88/NF-κB signal pathway to play an anti-inflammatory role, and increase the populations of Bacteroidetes, Clostridia, Lactobacillales, Prevotellaceae, Alloprevotella, Butyricimonas, Coprococcus, Ruminococcus, Lactobacillus, Akkermansia, Verrucomicrobia, reduce the populations of Bacteroidales, Lachnospiraceae, Rikenellaceae, Desulfovibrio, Streptococcaceae, Clostridiaceae, Prevotella, Proteus, Saccharibacteria, Deferribacteres, Actinobacteria, which affect the development of diabetes. 2. Berberine affects liver diseases by regulating FXR and NF-κB signaling pathways through intestinal flora. 3. Berberine down-regulate F:B (Firmicutes : Bacteroidetes) and up-regulate SCFA-producing bacteria Allobaculum, Bacteroides, Blautia, Butyricicoccus, Phascolarctobacterium, A. muciniphila and GLP-1R in obesity. 4. Berberine regulates hyperlipidemia by reducing Prevotella, Escherichia, Clostridium Sutterella and increase Bacteroides, Parabacteroides, Blautia, Enterobacter, Akkermansia, Escherichia-Shigella, Incertae sedis, Lachnospiraceae FCS020, Clostridium sensu stricto 1. 5. In Enteropatia, berberine enriched the relative abundance of Firmicutes and decreased Proteobacteria at the phylum level. Meanwhile, berberine increased the propotion of unclassified_f_Porphyromonadaceae, unclassified_f_Lachnospiraceae, Lactobacillus, unclassified_o_Clostridiales, Ruminococcus, Prevotella, Clostridium IV, and decreased Escherichia/Shigella at the genera level. 6. Berberine affect the development of Atherosclerosis by changing the amount of Verrucomicrobia, Akkermansia in Apoe (−/−) mice fed a high-fat diet in the intestine. "
Reference
https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2020.588517/full
2. "A significant decrease in the total bacterial population was observed in rats treated with BBR. BBR has a broad antibacterial spectrum including opportunistic pathogens (Staphylococcus, Streptococcus, Salmonella, Klebsiella, and Pseudomonas), inducing death of harmful intestinal microbiota (Escherichia coli), enhancing the composition of beneficial bacteria (Bifidobacterium adolescence, Lactobacillus acidophilus, and A.muciniphila) ( 85–89), and increasing the ratio of Phaeophyta to Bacteroides, etc. (90). All of these bacteria have a profound effect on blood glucose and lipids levels (91)."
Reference
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715767/#:~:text=A%20significant%20decrease%20in%20the,and%20lipids%20levels%20(91).
3. "Intervention with metformin or berberine modified the gut microbiome in db/db mice, increasing the number of SCFA-producing bacteria (e.g., Butyricimonas, Coprococcus, Ruminococcus) and reducing opportunistic pathogens (e.g., Prevotella, Proteus). An increased abundance of other probiotics including Lactobacillus and Akkermansia was also observed. Berberine and metformin can modulate the composition of the gut microbiome and reduce body weight, blood glucose levels, and intestinal inflammation in db/db mice, which demonstrates their effectiveness in the reduction of diabetic complications in this model. "
https://www.sciencedirect.com/science/article/pii/S0753332219314970?
但它確實抑製維生素B12和鐵的吸收，看來得斷斷續續服用。新出來的Dihydroberberine效力是berberine4倍，隻是研究的太少了，暫時不敢換成Dihydroberberine。
