小規模的臨床一期，證實mRNA 流感疫苗是安全的，並可以產生抗流感抗體，但水平較低，主要的缺陷是抗體消退比較快，

小規模的臨床一期，證實mRNA 流感疫苗是安全的，並可以產生抗流感抗體，但水平較低，主要的缺陷是抗體消退比較快，故預計提供保護的時間短，這一點與新冠疫苗很像。另外該實驗（臨床1期）主要是檢測疫苗的安全性，而非實際的抗流感感染的效果。

參見：

1. mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials, https://www.sciencedirect.com/science/article/pii/S0264410X19305626?via%3Dihub

 

2. mRNA flu shots move into trials, https://www.nature.com/articles/d41573-021-00176-7

部分段落的機器翻譯：

迄今為止，關於基於 mRNA 的流感疫苗報告的唯一人體數據來自 Moderna 首次進入臨床。從 2015 年底開始，該公司評估了兩種兩劑疫苗，每種疫苗都針對不同的禽流感病毒株設計。

根據前 Moderna 首席營銷官 Tal Zaks 的說法，這些試驗的主要目標是對公司的 mRNA 進行試運行。 “如果你想證明這項技術是有效的，最簡單的起點就是流感疫苗，”他說。他解釋說，對於流感，保護的相關性——可以預測疫苗功效的免疫參數測量——是明確定義的。也有成熟的疫苗可以參考臨床結果。

對於許多旁觀者來說，Moderna 的第一次試驗令人失望。盡管大多數接受較高劑量實驗性疫苗的研究參與者產生的流感特異性抗體滴度高於被認為具有保護作用的閾值（通過經過充分驗證的血凝抑製 (HAI) 測定法測量），但這些抗體水平在免疫接種後的幾個月內逐漸下降.這表明這些提供的保護可能是短暫的。根本無法檢測到 T 細胞免疫。

The only human data reported to date on an mRNA-based flu vaccine come from Moderna’s first foray into the clinic. Beginning in late 2015, the company evaluated a pair of two-dose vaccines, each designed against a different strain of avian influenza.

According to former Moderna CMO Tal Zaks, the main goal of those trials was to give the company’s mRNA a test run. “If you want to show that the technology works, the easiest place to start is with an influenza vaccine,” he says. With influenza, he explains, the correlates of protection — measurements of immune parameters that allow prediction of vaccine efficacy — are well defined. There are also established vaccines to reference clinical results to.

To many onlookers, Moderna’s first trials were a disappointment. Although most study participants who received higher doses of the experimental vaccines developed influenza-specific antibody titres above the threshold thought to be protective — as measured by the well-validated haemagglutination inhibition (HAI) assay — those antibody levels tapered off within just months of immunization. This suggests that the protection these offer might be short-lived. T-cell immunity was not detectable at all.

所有跟帖： 

• 抗體消失快,他們早就知道啊.當初疫苗他們應該設計打3針,如乙肝疫苗打3針.估計後悔莫及. -5181- ♂ (0 bytes) () 08/27/2022 postreply 16:16:01

• . -newxiaoshuye- ♂ (0 bytes) () 08/27/2022 postreply 18:01:06