中國當局曾否認蝙蝠為病毒病源。
PRC-CDC Once Had Denied Natural Bats as SARS-2 Origin..
中國當局曾否認蝙蝠為病毒病源。
直言簡評，2021-06-27。
https://zhiyanleback.blogspot.com/p/prc-cdc-once-had-denied-natural-bats-as_27.html
https://www.youtube.com/watch?v=CmplmlxFSEQ&t=22s
世衛組織和中國的聯合調查說，自然蝙蝠是本次疫情的病毒病源，實驗室病源是極不可能的。一年多來，凡是持有實驗室病源看法者，就會被主流科學界及其媒體以及中國方麵扣上‘陰謀論’的帽子而予以封殺封口；中國方麵則將其稱為‘抹黑’中國的敵人。
然而，疫情在中國規模爆發初期，譬如2020-01-18及之前，中國當局主管部門（中疾控）十分明確地否認蝙蝠病源說，且語氣強烈地把該說法稱為‘謠言’（在中國大陸，被稱為‘謠言’者往往會被封殺封閉、甚至被抓去關押）。同時，該當局說明，病毒之所以‘新’的主要依據是可以人傳人，盡管他們和世衛組織聯手多時說‘沒證據證明人傳人’、直到2020-01-20蓋不住了、才公開說可人傳人。
約兩周後，以武漢病毒所石正麗給實驗室病源扣上‘陰謀論’帽子的聲明為標誌，中國當局公開轉變，把病源歸於自然蝙蝠、抨擊實驗室病源說為‘陰謀論’。前後與此並行，中國當局聯手世衛組織，猛烈譴責美國川普當局為防疫而采取的旅行限製措施，縱容來自中國的攜帶病毒的旅客把病毒傳播到美國和世界各地，為其稍後開始‘甩鍋’和把病毒病源歸於美國和其它西方國家、提供了全球性的大規模疫情條件。直到現在，中國方麵還在用美國等西方國家疫情規模很大而說病源在美國；其做法，就好比一個縱火者以鄰居火勢很大而說鄰居是縱火者的無賴栽贓做法一樣。
世衛組織和中國方麵的聯合調查開始前，世衛組織項目負責人發表聲明做了調查結論，說病源是自然蝙蝠、說實驗室病源‘極不可能’，即：調查還沒開始，結論已經按中國方麵需要而做好了。在聯合國的曆史上，就全球重大問題而做出如此公開違規的事情，恐怕是第一次。
與此並行，中國方麵刪除了許多疫情和病毒的檔案記錄。其中一個，是中科院媒體發布的武漢當地病例Wuhan-Hu-1。該病例說明，2019年11月20日，中國武漢地區就有確診和住院護理的新冠病毒疫情發生了，而不是世衛組織和中國的聯合調查報告說的2019年12月08日前、中國沒有病例。這故事說明，最遲2019年09月，新冠病毒就已經在中國武漢地區規模傳播了。這故事也說明，世衛組織和中國的聯合調查報告涉嫌嚴重作弊。
該病例刪除了，然而，中國方麵無法刪除就該病例而在國際社會發表的醫學報告和論文、以及那些報告和論文所使用的病毒基因數據（按國際社會慣例，作者可以撤回論文報告，但該論文原件保留存檔、讀者還可以看到）。該基因數據說明：病毒含有自然病毒沒有而人類特有的cct-cgg-cgg-gca四個密碼子，這就足以說明新冠病毒來自實驗室而不是自然蝙蝠；不同版本出現規模集中的變異，而這類變異是不可能在自然界短期出現、在實驗室條件下卻完全可以做到的，即這也可說明病毒來自實驗室。
簡而言之，本文引用的事實根據說明，本次疫情病源足夠清楚：病毒來自實驗室，全球規模疫情來自世衛組織和中國方麵聯手縱容疫情全球擴散。附後是與美國人士交流的文字。估計公開後，中國方麵可能再次刪除相關記錄和數據，為證據存檔故而拖延了三兩天才於此公開發表。如下：
PRC-CDC Once Had Denied Natural Bats as SARS-2 Origin.
By Zhiyan-Le, 2021-06-25.
https://zhiyanleback.blogspot.com/p/prc-cdc-had-denied-natural-bats-as-sars.html
WHO-China joint report set natural bats, such as RaTG13, as the SARS-2 origin and stated that lab-leak (or made) as most unlikely. For more than a year, if you say that the SARS-2 origin comes from lab rather than from natural bats, you can be labeled as a conspiracy theorist. The PRC authorities have been especially doing such labeling. If you say that the PRC officials had known SARS-2 can do H2H/P2P (human-to-human/person-to-person transmission) at the pandemic early stage, the PRC authorities will title you as an enemy of anti-China.
However, right at the early time of this pandemic happening in China, the PRC authorities took bat-origin as rumors with clear acknowledge of H2H/P2P virus. Here is a PRC-CDC publication dated of 2020-01-18 and titled as [Five Rumors You Cannot Believe]:
關於武漢病毒性肺炎，這5大謠言 千萬別信！
China CDC 2020-01-18
http://www.chinacdc.cn/jkzt/crb/qt/szkb_11803/jszl_2275/202001/t20200118_211265.html
謠言4：SARS沒消失過，一直寄生蝙蝠。
真相：2002年-2003年，我國暴發SARS疫情，近十多年，我國再未發現SARS病例，目前在蝙蝠體內也沒有檢測發現人SARS冠狀病毒。
謠言5：武漢肺炎病毒為由來已久的非典類科羅納病毒。
真相：網上盛傳的“科羅納病毒”是由coronavirus(冠狀病毒)音譯而來，引起武漢病毒性肺炎疫情的病原體為一種新的冠狀病毒，不是SARS病毒。目前調查顯示，該病毒人際間傳播能力和致病性均較SARS弱。(see below, Picture 01).
It says (Google Online Translation):
Rumor 4: SARS has never disappeared, and bats have been parasitic.
The truth: The SARS epidemic broke out in my country from 2002 to 2003. In the past ten years, no SARS cases have been found in our country, and no human SARS coronavirus has been detected in bats.
Rumor 5: Wuhan Pneumonia Virus is the long-standing SARS Coronavirus.
The truth: The “Corona virus” that is widely circulated on the Internet is a transliteration of coronavirus (coronavirus). The pathogen causing the Wuhan Viral Pneumonia Epidemic is a new coronavirus, not SARS. Current investigations show that the human-to-human transmission and pathogenicity of the virus are weaker than those of SARS. #
And the PRC-CDC drawing marked a big [NO] re the bat-origin. 
Note: The above record shows that the term [Wuhan Virus] or [Wuhan pneumonia] was created by PRC itself and was used for some time, not created by ex-President Trump (as so many media reported).
Note: The publication date is 2020-01-18. That is, in very early stage of this pandemic started in PRC, hot debate re SARS-2 origin was already going on among many Chinese, forcing PRC-CDC to express its views. About two weeks later, Feb.02 2020. Dr. Shi Zhengli of PRC-WIV stated that lab-made/leak is a conspiracy theory and that the SARS-2 origin is natural bats; meanwhile, Mr. Bai Chunli, President of the PRC NAS (the top boss of PRC-WIV and the like), told the US NAS that the SARS-2 origin is natural bats. Few days later, Lancet issued a co-signed letter saying the same with a strong toning to label lab-made/leak as politically motivated conspiracy theory.
Moreover, the WHO-China joint report set the first group of pandemic cases in China at Dec.08 2019. For this purpose, the PRC authorities deleted a medical record that shows a confirmed and hospitalized case is dated from Nov.20 to Nov.26 of 2019, in Wuhan City, (see below, Picture 02), meaning that, in PRC, SARS-2 virus had been spreading since Sept-2019 for the latest. And it just happened that, 2019-09-18, Wuhan City hosted a real time exercise re pandemic emergencies, for which PRC-WIV provided SARS-2 samples and test/ treatment tech/skills (this is the most likely event re SARS-2 leaks, although the leaker may not necessarily be Dr. Shi Zhengli of PRC-WIV.).
No doubt, the above record put the WHO-China joint report not hold any more, at least, its relevant date and the origin bat are knowingly misleading.
Worth noting: re the above deleted record, it has a SARS-2 genomic sequence with three versions. The alignment of its version 1 and 3 is as follows:
GenBank: MN908947,.
Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome.
https://www.ncbi.nlm.nih.gov/nuccore/MN908947
V1 (version 1): 30473 bp; V3 (version 3): 29903 bp.
On single gene level, the two versions have an identity of 98% and a gap of 570-BP (Att. Ref-01). How come, in nature, this 570-BP change happened in about 2 months? On global codon level, the two versions have an obvious difference focusing on 2nd/3rd BP and G/T genes, and G has a positive and T as a negative changing gap. See below:
Table 01:
| Global Codon Freq. Distribution re MN908947 (versions 1 &3) | ||||||||
| V1 (10157 BP) | ||||||||
| 1st | 2nd | 3rd | avrg | 1st | 2nd | 3rd | avrg | |
| A | 3075 | 2903 | 3137 | 3038.33 | 30.3% | 28.6% | 30.9% | 29.91% |
| C | 2132 | 1610 | 1862 | 1868.00 | 21.0% | 15.9% | 18.3% | 18.39% |
| G | 1525 | 1909 | 2517 | 1983.67 | 15.0% | 18.8% | 24.8% | 19.53% |
| T | 3425 | 3735 | 2641 | 3267.00 | 33.7% | 36.8% | 26.0% | 32.17% |
| V3 (9967 BP) | ||||||||
| 1st | 2nd | 3rd | avrg | 1st | 2nd | 3rd | avrg | |
| A | 2855 | 3077 | 3020 | 2984.00 | 28.6% | 30.9% | 30.3% | 29.94% |
| C | 1583 | 1818 | 2091 | 1830.67 | 15.9% | 18.2% | 21.0% | 18.37% |
| G | 1877 | 2492 | 1494 | 1954.33 | 18.8% | 25.0% | 15.0% | 19.61% |
| T | 3652 | 2580 | 3362 | 3198.00 | 36.6% | 25.9% | 33.7% | 32.09% |
| Gap: V3 - V1. | ||||||||
| 1st | 2nd | 3rd | avrg | 1st | 2nd | 3rd | avrg | |
| A | -220 | 174 | -117 | -54.33 | -1.7% | 2.3% | -0.6% | 0.03% |
| C | -549 | 208 | 229 | -37.33 | -5.1% | 2.3% | 2.7% | -0.02% |
| G | 352 | 583 | -1023 | -29.33 | 3.8% | 6.2% | -9.8% | 0.08% |
| T | 227 | -1155 | 721 | -69.00 | 2.9% | -10.9% | 7.7% | -0.08% |
Re the above two questions, the PRC provider has not given a clear explanation on how those changes happened in two months.
Importantly, both versions have 4 codon CCT-CGG-CGG-GCA, which exist in human but not in natural viruses (See: Dr. Steven C. Quay: Bayesian Analysis of SARS-CoV-2 Origin, 27 January 2021).
In short, the above deleted record and its genomic data have no direct indication on SARS-2 origin, but they do support PRC-CDC’s 2020-01-18 statement: the SARS-2 origin does not come from natural bats.
Pic.01: Five Rumors You Cannot Believe (source: PRC-CDC, 2020-01-18)
Pic.02: A Deleted Record 被刪除的記錄。
| SARS2: PRC Case, 2019-11-20 | |
| Wuhan-Hu-1 | |
| https://bigd.big.ac.cn/ncov/genome/accession?q=Wuhan-Hu-1 | |
| Wuhan-Hu-1 | |
| MN908947 | |
| 基因組信息 | |
| 病毒株名 | Wuhan-Hu-1 |
| 序列號 | MN908947 |
| 宿主 | Homo sapiens |
| 數據來源 | GenBank |
| 采樣日期 | 12/30/2019 |
| 采樣地點 | China / Hubei / Wuhan |
| 相關ID | NC_045512, EPI_ISL_402125 |
| 序列完整度 | Complete |
| 質量評估 | 0/0/0/0/NO |
| 樣本提供單位 | |
| 數據遞交單位 | Shanghai Public Health Clinical Center & School of Public Health, Fudan University, Shanghai, China |
| 發布時間 | 1/20/2020 20:04 |
| 序列 | |
| 臨床信息 | |
| 年齡 | 41 |
| 性別 | M |
| 職業 | a worker of seafood market in Wuhan |
| 發作日期 | 11/20/2019 |
| 入院日期 | 11/26/2019 |
| 旅行史/接觸史 | NA |
| 嚴重程度 | NA |
| 病患狀態 | admitted to ICU after 3 days of treatment |
| 臨床症狀及潛伏天數 | fever(38.4℃), Cough, Sputum production, Dizzy, Weakness, Chess tightness, Dyspnoea; Chest radiographs were abnormal with air-space shadowing such as ground-glass opacities, focal consolidation and patchy consolidation in both lungs; Computed-tomography scans of the chest revealed bilateral focal consolidation, lobar consolidation and patchy consolidation, especially in the lower lung; A chest radiograph revealed a bilateral diffuse patchy and fuzzy shadow on day 5 after admission (day 11 after the onset of |
| 臨床檢測 | complete blood count test, blood chemistry tests, arterial blood gas test, chest radiographs, PCR, BALF, deep meta-transcriptomic sequencing |
| 基礎病史 | no history of hepatitis, tuberculosis or diabetes |
| 其他病原菌感染 | negative Bacterial culture |
| 合並症 | NA |
| 臨床用藥和處理 | Glucocorticoid therapy,Antibiotic therapy ,Antiviral therapy ,Oxygen therapy |
| 生理生化指標追蹤 | Mild lymphopoenia (defined as less than 9 × 105 cells per ml) ; Elevated levels of C-reactive protein (41.4 mg l−1 of blood; reference range, 0–6 mg l−1) ;mild hypoxaemia with oxygen levels of 67 mm Hg |
| 出院日期 | NA |
| 相關文獻 | A new coronavirus associated with human respiratory disease in China. [PMID: 32015508] |
| 基因組變異統計 | |
| © 2020 National Genomics Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences | |
| No.1 Beichen West Road, Chaoyang District, Beijing 100101, China | |
Att. Ref 01:
| NIH BLAST: MN908947: V1 x V3 |
| Query Length: 30473 (v1) |
| Subject Length: 29903 (v3) |
| NW Score: 58571 |
| Identities: 29896/30473(98%) |
| Gaps: 570/30473(1%) |
| Query 1 CGGTGACGCATACAAAACATTCCCACCATACCTTCCCAGGTAACAAACCAACCAACTTTC 60 |
| || ||| || ||||||||||||||||||||||||||||||||| |
| Sbjct 1 ATT-AAAGGTTT------ATACCTTCCCAGGTAACAAACCAACCAACTTTC 44 |
| Query 29281 TGACCTACACAGCTGCCATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCA 29340 |
| |||||||||||| ||||||||||||||||||||||||||||||||||||||||||||||| |
| Sbjct 29265 TGACCTACACAGGTGCCATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCA 29324 |
| Query 29821 AATGTGTAAAATTAATTTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTCCTGG 29880 |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||| |
| Sbjct 29805 AATGTGTAAAATTAATTTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTT----- 29859 |
| Query 29881 GATCTTGATTTCAACAGCCTCTTCCTCATACTATTCTCAACACTACTGTCAGTGAACTTC 29940 |
| Sbjct ------------------------------------------------------------ |
| Query 29941 TAAAAATGGATTCTGTGTTTGACCGTAGGAAACATTTCAGTATTCCTTATCTTTAGAAAC 30000 |
| |||| |
| Sbjct 29860 --------------------------AGGA------------------------------ 29863 |
| Query 30001 CTCTGCAACTCAAGTGTCTCTGCCAAAGAGTCTTCAAGGTAATGTCAAATACCATAACAT 30060 |
| Sbjct ------------------------------------------------------------ |
| Query 30061 ATTTTTTAAGTTTTTGTATACTTCCTAGGAATATATGTCATAGTATGTAAAGAAGATCTG 30120 |
| Sbjct ------------------------------------------------------------ |
| Query 30121 ATTCATGTGATCTGTACTGTTAAGAAACACTTCAAAGGAAAACAACCTCTCATAGATCTT 30180 |
| Sbjct ------------------------------------------------------------ |
| Query 30181 CAAATCCTGTTGTTCTTGAGTTGGAATGTACAATATTCAGGTAGAGATGCTGGTACAAAA 30240 |
| ||||| |||||| |
| Sbjct 29864 -----------------------GAATG--------------------------ACAAAA 29874 |
| Query 30241 AAAGACTGAATCATCAGGCTATTAGAAAGATAAACTAGGCCTCTAACATAGTAACTTTAA 30300 |
| ||| ||| | ||| |
| Sbjct 29875 AAA----------------------AAAAAAAAA-------------------------- 29886 |
| Query 30301 CAGTTTGTACTTATACATATTTTCACATTGAAATATAGTTTTATTCATGACTTTTTTTGT 30360 |
| ||| |
| Sbjct 29887 ------------------------------AAA--------------------------- 29889 |
| Query 30361 TTTAGCTTCTCTGTCTTCCATTATTTCAAGCTGCTAAAAATTAAAAATATCCTATAGCAA 30420 |
| ||||| ||||| |
| Sbjct 29890 -----------------------------------AAAAA--AAAAA------------- 29899 |
| Query 30421 AGGGCTATGGCATCTTTTTGTAAAAATAAGGAAAGCAAGGTTTTTTGATAATC 30473 |
| |||| |
| Sbjct 29900 ---------------------AAAA 29903 |
| V1:23581 caggtatatgcgctagttatcagactcagactaattctcctcggcgggcacgtagtgtag |
| V3:23581 ttatcagactcagactaattctcctcggcgggcacgtagtgtagctagtcaatccatcat |
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