新冠VD療法

引子：

這是第一篇正式臨床研究，證明使用維生素D可以有效地減緩新冠病情。

羥奎加阿奇黴：26人，有一半的患者進了ICU，其中二人不治。

再加上VD：50人裏，隻有一位進去了，全部治愈。

這個不是奇跡，是什麽！

那個“XXXX望", 有這效果麽？

花點時間，認真看看，學點本事，也許救命。

 

News report

https://medium.com/@shinjieyong/the-first-clinical-trial-to-support-vitamin-d-therapy-for-covid-19-906a9d907468 

Oral calcifediol, the main metabolite of vitamin D3, reduced ICU admission from 50% to 2% among Covid-19 patients.

 

 

Published paper

Effect of Calcifediol Treatment and best Available Therapy versus best Available Therapy on Intensive Care Unit Admission and Mortality Among Patients Hospitalized for COVID-19: A Pilot Randomized Clinical study

https://www.sciencedirect.com/science/article/pii/S0960076020302764?via%3Dihub#bib0100

Highlights

•

The vitamin D endocrine system may have a variety of actions on cells and tissues involved in COVID-19 progression.

•

Administration of calcifediol or 25-hydroxyvitamin D to hospitalized COVID-19 patients significantly reduced their need for Intensive Care United admission.

•

Calcifediol seems to be able to reduce severity of the disease.

 

Participants

76 consecutive patients hospitalized with COVID-19 infection, clinical picture of acute respiratory infection, confirmed by a radiographic pattern of viral pneumonia and by a positive SARS-CoV-2 PCR with CURB65 severity scale (recommending hospital admission in case of total score > 1).

Procedures

All hospitalized patients received as best available therapy the same standard care, (per hospital protocol), of a combination of hydroxychloroquine (400 mg every 12 hours on the first day, and 200 mg every 12 hours for the following 5 days), azithromycin (500 mg orally for 5 days. Eligible patients were allocated at a 2 calcifediol:1 no calcifediol ratio through electronic randomization on the day of admission to take oral calcifediol (0.532 mg), or not. Patients in the calcifediol treatment group continued with oral calcifediol (0.266 mg) on day 3 and 7, and then weekly until discharge or ICU admission. Outcomes of effectiveness included rate of ICU admission and deaths.

Results

Of 50 patients treated with calcifediol, one required admission to the ICU (2%), while of 26 untreated patients, 13 required admission (50%) p value X2 Fischer test p < 0.001. Univariate Risk Estimate Odds Ratio for ICU in patients with Calcifediol treatment versus without Calcifediol treatment: 0.02 (95%CI 0.002-0.17). Multivariate Risk Estimate Odds Ratio for ICU in patients with Calcifediol treatment vs Without Calcifediol treatment ICU (adjusting by Hypertension and T2DM): 0.03 (95%CI: 0.003-0.25). Of the patients treated with calcifediol, none died, and all were discharged, without complications. The 13 patients not treated with calcifediol, who were not admitted to the ICU, were discharged. Of the 13 patients admitted to the ICU, two died and the remaining 11 were discharged.

Conclusion

Our pilot study demonstrated that administration of a high dose of Calcifediol or 25-hydroxyvitamin D, a main metabolite of vitamin D endocrine system, significantly reduced the need for ICU treatment of patients requiring hospitalization due to proven COVID-19. Calcifediol seems to be able to reduce severity of the disease, but larger trials with groups properly matched will be required to show a definitive answer.

附注

calcifediol (0.532 mg) 大約合20000IU。如果家裏有五千IU膠丸，首日服四粒，在第三天和第七天各服兩丸。

一共就八粒VD膠丸，也許幫你逃過一劫。

俺家裏現在隻有2000IU的，得趕緊去搶一甁5000的。不過一盤菜價而已。

再囉嗦一句，D3經肝髒再經腎髒轉化成calcifediol，後者直接作用於受體，……。這個轉化過程可能需要數日，故有研究說calcifediol效果比較好。可惜是處方藥，買不到。

 

續：在當地山姆店撈了一瓶五千單位的備用（不用於骨質疏鬆，沒必要帶K2）。

https://www.samsclub.com/p/mm-vitamin-d3-5000iu-400ct/prod17690276?xid=plp_product_1

 

 

PS

這篇講機理

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289092/

 

 

 

本帖原於兩個半月前發在健壇，目前新增病例激增，重發在此。

https://bbs.wenxuecity.com/health/925952.html