謝維院長 福耀科技大學生命與健康科學學院

謝維院長 福耀科技大學生命與健康科學學院

https://lhs.fyust.edu.cn/szdw/jstd/xw.htm?

研究方向：突觸/環路發育調控與認知疾病機製

Email：[e-mail]

個人簡曆

1963年9月出生，安徽人，博士畢業於南京大學生物化學與分子生物學專業，1996年12月至2001年8月先後在美國羅徹斯特大學醫學中心和加拿大多倫多大學附屬病童醫院（SickKids）接受博士後訓練。2001年9月作為教育部“長江學者”特聘教授，受聘為東南大學基礎醫學院遺傳學研究中心主任，擔任博士生導師；領銜申報東南大學第一個生命科學領域博士授權點（遺傳學）獲準；2003年獲準建設“發育與疾病相關基因”教育部重點實驗室，擔任實驗室主任；2004年4月至2009年11月擔任東南大學基礎醫學院院長，2009年12月至2019年12月擔任東南大學生命科學研究院院長，期間完成了東南大學生物學一級學科碩士點、博士點、博士後流動站的建設、協助基礎醫學博士點的獲準；2019年領銜論證成立生命科學與技術學院，獲得東南大學批準，謝維任學院學術委員會主任、東南大學首席教授。

謝維教授先後獲得國家自然科學基金（麵上、重點）、中-加合作項目、國家傑出青年科學基金（2003年）、美國NIH基金（RO3）、國家“973”重大基礎研究項目、國家科技創新2030-“腦科學與類腦研究”（“國家腦計劃”）重大研究項目（首席科學家）等資助。長期從事腦發育的遺傳控製、跨細胞與跨係統信號調節機製和抗體工程靶向藥的研究。發現了自閉症關聯基因參與調控突觸、環路發育；解析了調控社交行為的多條神經環路等；指導創業團隊研發抗體靶向藥，已獲得臨床試驗許可證6張（中、美），其中兩款藥物分別在臨床I、II期實驗。

1992年9月-1995年10月

南京大學 生化與分子生物學 研究生 博士

1988年9月-1991年7月

南京鐵道醫學院（現東南大學醫學院） 微生物與免疫學 研究生 碩士

發表的文章

1... Dandan Lv, An Liu*, Ziyue Yi, Mingdao Mu, Miao Wu, Xingcan Li, Kun Cao, Ruining Liu, Zhengping Jia, Junhai Han, Wei Xie*. Neuroligin 1 Regulates Autistic-Like Repetitive Behavior through Modulating the Activity of Striatal D2 Receptor-Expressing Medium Spiny Neurons. Adv Science (Weinh). 2025 Feb;12(5):e2410728.摘要

限製性和重複性行為（RRB）是自閉症譜係障礙（ASD）的主要症狀之一，對個體健康構成重大風險，且患病率日益上升。然而，RRB產生的具體細胞和神經環路機製尚不清楚。本研究發現，背側紋狀體中表達多巴胺受體D2的中型棘狀神經元（D2-MSN）中ASD相關蛋白神經連接蛋白1（NLGN1）的缺失與自我梳理和挖掘行為的持續時間和頻率相關。NLGN1缺陷的D2-MSN處於過度激活狀態，這與過度自我梳理和挖掘行為相關。抑製D2-MSN的活性可以減少這些RRB的持續時間和頻率。此外，研究還表明，自我梳理和挖掘行為的產生依賴於D2-MSN不同的活性模式。最後，通過單核RNA測序（sn-RNAseq）和蛋白質檢測驗證，發現Nlgn1缺陷小鼠中蛋白激酶C（PKC）的過度激活導致了過度重複行為和神經元興奮性增強。本研究提出了自我梳理和挖掘行為產生的潛在機製，並提出了自閉症譜係障礙（ASD）可能的治療和幹預措施。

2... Peng Xie, Juan Shen, Yi Yang, Xinrui Wang, Wei Liu, Hailong Cao, Yanying Zheng, Chen Wu, Guangyao Mao, Linjin Chen, Jingjing He, Weiheng Zheng, Zepu Yang, Xiao Zhang, Xu Jiang, Xianfa Yang, Ke Fang, Zhao Zhang, Xin Xue, Xueting Chen, Chaoyi Wang, Xing Liu, Ling Liu, Xuebiao Yao, Naihe Jing, Wei Xie, Jin Liu, Hua Cao, Zhuojuan Luo*, Xiaodong Fang*, Chengqi Lin*. Digital reconstruction of full embryos during early mouse organogenesis. Cell, 2025, 188, 1-19.

小鼠早期器官發生過程中完整胚胎的數字化重建

亮點  在早期器官發生過程中，以單細胞分辨率重建完整數字胚胎, 構建中胚層和內胚層譜係的時空圖譜和信號通路圖譜, 識別胚-胚外界麵處的原基決定區 (PDZ), 表征參與器官原基形成的跨胚層信號

總結  早期器官發生是胚胎發育的關鍵階段，其特點是廣泛的細胞命運決定以啟動器官形成，但也極易出現發育缺陷。在此，我們對來自 6 個 E7.5-E8.0 胚胎的 285 個連續切片進行了分析，以單細胞分辨率構建了早期器官發生過程中的完整時空轉錄組和信號通路圖譜。通過開發 SEU-3D，我們重建了數字胚胎，從而能夠在天然的空間環境中研究區域化的基因表達。我們建立了一種基於空間信息的基因-細胞共嵌入方法，係統地構建了內胚層和中胚層衍生物的空間圖譜，並闡明了跨胚層和細胞類型的信號網絡。此外，我們還表征了在胚胎發育第7.75天（E7.75）沿胚胎-胚外界麵形成的原基決定區（PDZ），並揭示了協調的信號通訊促進了心髒原基的形成。總而言之，這種高分辨率的“數字胚胎”為早期器官發生提供了重要的見解，並為研究發育和疾病提供了一個獨特的空間平台。

3. Shiqi Zhu, Peng Xie, Yi Yang, Yan Wang, Chuanxin Zhang, Yu Zhang, Shuhan Si, Jin Zhang, Jingjing He, Hao Si, Ke Fang, Binbin Ma, Xu Jiang, Lindi Huang, Jiamin Li, Tian Min, Beihong Zheng, Lincui Da, Dianliang Lin, Kun Gao, Yuanyuan Li, Mingtao Huang, Fengchang Qiao, Haiqin Huo, Haoyang Feng, Han Zhao, Zijiang Chen, Zhengfeng Xu, Jing Xie, Hua Cao, Jin Liu, Xuebiao Yao, Wei Xie, Yan Sun, Keliang Wu, Bo Xiong, Ping Hu*, Zhuojuan Luo*, Chengqi Lin*. Maternal ELL3 loss-of-function leads to oocyte aneuploidy and early miscarriage. Nat Struct Mol Biol. 2025 Feb;32(2):381-392.

4... Yu Zhao, Junhua Geng*, Zhu Meng, Yichen Sun, Mengzhu Ou, Lizhong Xu, Moyi Li, Guangming Gan, Menglong Rui, Junhai Han, Wei Xie*. Neurexin facilitates glycosylation of Dystroglycan to sustain muscle architecture and function in Drosophila. Commun Biol. 2024, Nov. 9; 7:1481.

1. Rui Dang, An Liu*, Yu Zhou, Xingcan Li, Miao Wu,Kun Cao,Yanghong Meng, Haiwang Zhang, Guangming Gan, Wei Xie* & Zhengping Jia*. Astrocytic neuroligin 3 regulates social memory and synaptic plasticity through adenosine signaling in male mice. Nat Commun 2024, 15, 8639.

2. Mingdao Mu*, Haoyu Sun, Shuyan Geng, Tianxiang Xu, Chuanyao Sun, Zixu Zhang, Sibie Meng, Moyi Li, An Liu, Zhiyuan Yang and Wei Xie*. Neurexin-3 in the paraventricular nucleus of the hypothalamus regulates body weight and glucose homeostasis independently of food intake. Mol Brain, 2024, 17:49.

3. Haiyan Sun*, Yu Shen, Pengtao Ni, Xin Liu, Yan Li, Zhentong Qiu, Jiawen Su, Yihan Wang, Miao Wu, Xiangxi Kong, Jun-Li Cao*, Wei Xie*, and Shuming An*. Autism-associated neuroligin-3 deficiency in medial septum causes social deficits and sleep loss in mice. J Clin Invest. 2024 Jul 25:e176770.

4. Siqi Peng, Xiuqi Yang, Sibie Meng, Fuyuan Liu, Yaochen Lv, Huiquan Yang, Youyong Kong, Wei Xie, Moyi Li*. Dual circuits from hippocampus facilitate naive social 2 transfer of observational fear. Cell Reports, 2024 May 27;43(6):114277.

5. Qiaoyun Ren, Susu Wang, Junru Li, Kun Cao, Mei Zhuang, Miao Wu, Junhua Geng, Zhengping Jia, Wei Xie, An Liu*. Novel social stimulation ameliorates memory deficit in Alzheimer's disease model through activating α-secretase. J Neurosci. 2024 Feb 28:e1689232024. (This Week in The Journal)

6. Siyan Meng, Xiaoxu Liu, Shiqi Zhu, Peng Xie, Haitong Fang, Qingyun Pan, Ke Fang, Fanfan Li, Jin Zhang, Zhuanzhuan Che, Quanyong Zhang, Guangyao Mao, Yan Wang, Ping Hu, Kai Chen, Fei Sun, Wei Xie, Zhuojuan Luo*, Chengqi Lin*. Young LINE-1 transposon 5' UTRs marked by elongation factor ELL3 function as enhancers to regulate naïve pluripotency in embryonic stem cells. Nat Cell Biol. 2023 Sep;25(9):1319-1331.

7. Yichen Sun, Moyi Li*, Junhua Geng, Sibie Meng, Renjun Tu, Yan Zhuang, Mingkuan Sun, Menglong Rui, Mengzhu Ou，Guangling Xing, Travis K Johnson, Wei Xie*. Neuroligin 2 Governs Synaptic Morphology and Function Through RACK1-Cofilin Signaling in Drosophila. Commun Biol. 2023 Oct 18;6(1):1056.

8. Xiaofeng Han, Shuxia Guo, Nan Ji, Tian Li, Jian Liu, Xiangqiao Ye, Yi Wang, Zhixi Yun, Feng Xiong, Jing Rong, Di Liu, Hui Ma, Yujin Wang, Yue Huang, Peng Zhang, Wenhao Wu, Liya Ding, Wei Xie, Lijuan Liu, Liwei Zhang*, Hanchuan Peng*. Whole Human-Brain Mapping of Single Cortical Neurons for Profiling Morphological Diversity and Stereotypy. Science Adv, 2023, 9(41): eadf3771.

9. Rui Dang, Yu Zhou, Yue Zhang, Die Liu, Miao Wu, An Liu, Zhengping Jia* & Wei Xie*. Regulation of Social Memory by Lateral Entorhinal Cortical Projection to Dorsal Hippocampal CA2. Neurosci Bull, 2022 https://doi.org/10.1007/ s12264-021-00813-6.

10. Hanchuan Peng*, Peng Xie,#, Lijuan Liu#, Yimin Wang, Lei Qu, Hui Gong, Xiuli Kuang, Shengdian Jiang, Anan Li, Zongcai Ruan, Liya Ding, Mengya Chen, Tanya L. Daigle, Zhangcan Ding, Yanjun Duan, Aaron Feiner, Ping He, Chris Hill, Karla E. Hirokawa, Guodong Hong, Lei Huang, Sara Kebede, Hsien-Chi Kuo, Rachael Larsen, Phil Lesnar, Longfei Li, Qi Li, Xiangning Li, Yaoyao Li, Yuanyuan Li, An Liu, et al, Yefeng Zheng, Zhongze Gu, Wei Xie, Christof Koch, Qingming Luo, Julie A. Harris, Yun Wang, Hongkui Zeng*. Complete whole-brain single neuron reconstruction reveals morphological diversity in molecularly defined striatal, thalamic, cortical and claustral neuron types. Nature, 2021, 598:174-181.

11. Yuqian Shen, Zi Chao Zhang, Shanshan Cheng, An Liu, Jian Zuo, Shuting Xia, Xian Liu, Wenhua Liu, Zhengping Jia, Wei Xie, Junhai Han*. PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation. Mol Cell, 2021, 81:1425-1438.

12. Wei Xie*, Cheng-Qi Lin, Jian Li, Mo-Yi Li. Decoding brain encoded by genome. Yi Chuan (Hereditas Beijing), 2021 May 20;43(5):393-396.

13. Moyi Li*, Yan Zhuang, Ranjan Batra, James D. Thomas, Mao Li, Curtis A Nutter, Marina M. Scotti, Helmut A Carter, Zhan Jun Wang, Xu Sheng Huang, Chuan Qiang Pu, Maurice S. Swanson, Wei Xie*. HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy. Proc Natl Acad Sci U S A. 2020,117(10): 5472-5477.

14. Xuechen Zhou, Rui Hao, Chen Chen, Zhipeng Su, Linhong Zhao, Zhuojuan Luo, Wei Xie*. Rapid Delivery of Nanobodies/ VHHs into Living Cells via Expressing In Vitro-Transcribed mRNA. Mol Therapy - Methods & Clinical Development, 2020, 17:401-408.

15. Guanglin Xing, Moyi Li, Menglong Rui, Nana Tao, Yan Zhuang, Huihui Lv, Junhai Han, Zhengping Jia*, and Wei Xie*. Neuroligin 1 Regulates Postsynaptic Actin Cytoskeleton via WAVE Regulatory Complex in Drosophila Neuromuscular Junction, eLife, 2018, DOI: 10.7554/eLife.30457.

16. Zikai Zhou, An Liu, Shuting Xia, Celeste Leung, Junxia Qi, Yanghong Meng, Wei Xie, Pojeong Park, Graham L. Collingridge*, Zhengping Jia*. The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning. Nat Neurosci, 2018, 21(1):50-62.

17.  Jun Wu, Yao Tian, Guanglin Xing, Nana Tao, Huihui Lv, Junhai Han, Chengqi Lin and Wei Xie*. Proteolytic Maturation of Drosophila Neuroligin 3 by Tumor Necrosis Factor α-converting Enzyme in the Nervous System. BBA-General, 2018, 1862(3):440-450.

18. Xinwang Zhang, Menglong Rui, Guangming Gan, Cong Huang, Jukang Yi, Huihui Lv, Junhai Han, and Wei Xie*. Neuroligin 4 regulates synaptic growth via the bone morphogenetic protein (BMP) signaling pathway at the Drosophila neuromuscular junction. J Biol Chem, 2017, 292(44):17991-18005.

19. Menglong Rui, Jinjun Qian, Lijuan Liu, Yihan Cai, Huihui Lv, Junhai Han, Zhengping Jia and Wei Xie*. The neuronal protein neurexin directly interacts with the Scribble-Pix complex to stimulate F-actin assembly for presynaptic vesicle clustering. J Biol Chem, 2017, 292(35):14334-14348.

20. Renjun Tu, Jinjun Qian, Menglong Rui, Nana Tao, Mingkuan Sun, Yan Zhuang, Huihui Lv, Junhai Han, Moyi Li, Wei Xie*. Proteolytic cleavage is required for Neuroligin 2 maturation and function in Drosophila. JMCB, 2017, 9(3):231-242.

21. Lina Liu, Yao Tian, Xiaoyan Zhang, Xinwang Zhang, Tao Li, Wei Xie, and Junhai Han*. Neurexin Restricts Axonal Branching in Columns by Promoting Ephrin Clustering. Deve Cell, 2017, 41:94-106. (Cover Story)

22. Yan Wang, Yang Shen, Qian Yang, Qian Dai, Yue Zhang, Xin Wang, Wei Xie, Zhuojuan Luo*, Chengqi Lin*. A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron. Nucleic Acids Res, 2017, 45(3):1177-1185.

23. Shuting Xia, Zikai Zhou, Celeste Leung, Yuehua Zhu, Xingxiu Pan, Maria Morena, Matthew N. Hill*, Wei Xie*, and Zhengping Jia*. p21-Activated Kinase 1 Restricts Tonic Endocannabinoid Signaling in the Hippocampus. eLife, 2016, 5:e14653.

24. An Liu, Zikai Zhou, Rui Dang, Guiqing He, Celeste Leung, Daniel Pak, Zhengping Jia*, and Wei Xie*. Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin mediated actin reorganization. J Cell Biol, 2016, 212:449-463. (Cover Story, w/COMMENTARY)

25. Tao Li, Yao Tan, Qian Li, Huiying Chen, Huihui Lv, Wei Xie, and Junhai Han*. Neurexin/NSF interaction regulates short-term synaptic depression. J Biol Chem 2015, 290(29):17656-67. (Papers of the Week, Cover Story, 2015 Best of Winner)

26. Xingxiu Pan, Xinxia Chang, Celeste Leung, Zikai Zhou, Feng Cao, Wei Xie*, Zhengping Jia*. PAK1 regulates cortical development via promoting neuronal migration and progenitor cell proliferation. Mol Brain, 2015, 8:36.

27. Guanglin Xing, Guangming Gan, Dandan Chen, Mingkuan Sun, Jukang Yi, Huihui Lv, Junhai Han, Wei Xie*. Drosophila Neuroligin3 Regulates Neuromuscular Junction Development and Synaptic Differentiation. J Biol Chem, 2014, 289(46): 31867-31877. (Paper of the Week)

28. Yi Li, Ziaki Zhou, Xinwang Zhang, Huawei Tong, Peipei Li, Zi chao Zhang, Zhengping Jia, Wei Xie* and Junhai Han*. Drosophila Neuroligin 4 regulates sleep through modulating GABA transmission. J Neurosci, 2013, 33:15545-15554.

29. Yao Tian, Yi Li, Mingkuan Sun, Wen Hu, Didi Wan, Jing Li, Junhai Han* and Wei Xie*. Neurexin Regulates Visual Function via Mediating Retinoid Transport to Promote Rhodopsin Maturation. Neuron, 2013, 140:413-422.

30. SUN MingKuan*, XIE Wei*. Cell Adhesion Molecules in Drosophila Synapse Development and Function. Sci China Life Sci, 2012, 55(1):20-26.

31. David Knight, Wei Xie and Gabrielle Boulianne*. Neurexins and Neuroligins: Recent Insights from Invertebrates. Mol Neurobiol, 2011, 44(3):426-440.

32. Mingkuan Sun, Guanglin Xing, Liudi Yuan, Guangming Gan, David Knight, Sheila Irene With, Cui He, Junhai Han, Xiankun Zeng, Ming Fang, Gabrielle L. Boulianne*, Wei Xie*. Neuroligin2 Is Required for Synapse Development and Function at the Drosophila Neuromuscular Junction. J Neurosci, 2011, 31(2):687-699. (This Week in The Journal)

33. Mingkuan Sun, Lijuan Liu Xiankun Zeng, Li Liu, Ming fang, Wei Xie*. Genetic Interaction between Neurexin and CAKI/CMG Is Important for the Synaptic Function in Drosophila Neuromuscular Junction. Neurosci Res, 2009, 64:362-71.

34. Xiankun Zeng, Mingkuan Sun, Li Liu, Fading Chen, Liuchan Wei, Wei Xie*. Neurexin-1 is required for synapse formation and larvae associative learning in Drosophila. FEBS Lett, 2007,581:2509-2516.