膽固醇看來的確是被冤枉了

根據 Sachdeva et al 在 Am Heart J (157:111-117, 2009)雜誌的報導， 近50%的心血管病人的LDL-膽固醇是正常的。這就說明膽固醇不可能是心血管病的病因。否則大多數病人的膽固醇應該是高於正常值。

 

另外一個報導 （Cardiol J, 16:227-233, 2009)顯示，LDL-膽固醇正常的心髒病病人 （LDL-C ＜or =105 mg /dL）3年的死亡率高於LDL-C ＞105mg /dL的心髒病病人 （14.8% vs 7.1%)。這個報導表明膽固醇低可能不利於健康。

 

Lancet. 2001 Aug 4;358(9279):351-5.

Cholesterol and all-cause mortality in elderly people from the Honolulu Heart Program: a cohort study.

Schatz IJ, Masaki K, Yano K, Chen R, Rodriguez BL, Curb JD.

Source

Clinical Epidemiology and Geriatrics Division, Department of Medicine, John A Bums School of Medicine, University of Hawaii at Manoa, 1356 Lusitana Street, 7th Floor, Honolulu, HI 96813-2427, USA. [e-mail]

Abstract

BACKGROUND:

A generally held belief is that cholesterol concentrations should be kept low to lessen the risk of cardiovascular disease. However, studies of the relation between serum cholesterol and all-cause mortality in elderly people have shown contrasting results. To investigate these discrepancies, we did a longitudinal assessment of changes in both lipid and serum cholesterol concentrations over 20 years, and compared them with mortality.

METHODS:

Lipid and serum cholesterol concentrations were measured in 3572 Japanese/American men (aged 71-93 years) as part of the Honolulu Heart Program. We compared changes in these concentrations over 20 years with all-cause mortality using three different Cox proportional hazards models.

FINDINGS:

Mean cholesterol fell significantly with increasing age. Age-adjusted mortality rates were 68.3, 48.9, 41.1, and 43.3 for the first to fourth quartiles of cholesterol concentrations, respectively. Relative risks for mortality were 0.72 (95% CI 0.60-0.87), 0.60 (0.49-0.74), and 0.65 (0.53-0.80), in the second, third, and fourth quartiles, respectively, with quartile 1 as reference. A Cox proportional hazard model assessed changes in cholesterol concentrations between examinations three and four. Only the group with low cholesterol concentration at both examinations had a significant association with mortality (risk ratio 1.64, 95% CI 1.13-2.36).

INTERPRETATION:

We have been unable to explain our results. These data cast doubt on the scientific justification for lowering cholesterol to very low concentrations (<4.65 mmol/L) in elderly people.

 

 

 

 

所有跟帖： 

• 人離了膽固醇不可能存活，LDL, HDL, TDL,TGC,,,,, -弓尒- ♂ (0 bytes) () 05/22/2013 postreply 21:00:56

• 沒錯，足夠的膽固醇對健康很重要，人為的降低可能有害。。 -ERommel- ♂ (0 bytes) () 05/22/2013 postreply 21:09:22

• 不能多， 也不能木有~：） -弓尒- ♂ (0 bytes) () 05/23/2013 postreply 09:56:32

• 關鍵的問題是，多高算太多，按目前標準，正常值很可能算過低了：） -ERommel- ♂ (0 bytes) () 05/23/2013 postreply 17:41:29

• 啊，又被誤導了？ -husky- ♂ (0 bytes) () 05/22/2013 postreply 23:31:56

• 不少報導顯示致少現在定的正常值是誤導 -ERommel- ♂ (0 bytes) () 05/23/2013 postreply 17:43:38

• 看來醫生都把我們給忽悠了。 -大臭臭- ♀ (0 bytes) () 05/23/2013 postreply 08:30:16

• 其實很多醫生完全是按專家製定的標準辦事，自己不搞研究是發現不了問題的 -ERommel- ♂ (0 bytes) () 05/23/2013 postreply 17:45:30

• 回複：膽固醇看來的確是被冤枉了 -clz9876- ♂ (53 bytes) () 05/23/2013 postreply 15:27:56

• 沒錯，有研究顯示低膽固醇增加患癌症的概率 -ERommel- ♂ (561 bytes) () 05/23/2013 postreply 17:58:30

• 科學就是扯蛋，所以公開發表，也沒知識產權 -善念真言- ♂ (0 bytes) () 05/24/2013 postreply 05:54:53

• 也不能這麽說，真正的科學還是能為人類服務的 -ERommel- ♂ (0 bytes) () 05/24/2013 postreply 19:14:17

• 真正的科學其實是神學，能為人類服務的科學也沒知識產權，真正的能為人類服務的是技術 -善念真言- ♂ (0 bytes) () 05/24/2013 postreply 19:48:12

• 科技常常是混在一起說的，但是科學多指對一些現象本質的認知，技術則是用這些認知去實現一些功能。 -這個星球有點軸- ♂ (0 bytes) () 05/25/2013 postreply 08:20:55

• 科學多指對一些現象的解釋，技術則是利用這些現象，跟科學解釋無關 -善念真言- ♂ (0 bytes) () 05/25/2013 postreply 15:57:02

• 不可能和解釋無關吧？簡單粗放的技術可以直接來源於現象，稍微複雜一些的技術則恐怕需要用解釋所產生原理來計算和輔助設計了。 -這個星球有點軸- ♂ (0 bytes) () 05/25/2013 postreply 18:26:38

• 我說過了，因為你也說過了，科學沒你說的那麽牛，也沒我說的那麽不牛，市場價值為零 -善念真言- ♂ (0 bytes) () 05/26/2013 postreply 16:56:04

• 扯蛋倒說不上，更多的隻是認識還不夠充分或發生了錯誤而矣。這類認知的東西，本也不需要產權。 -這個星球有點軸- ♂ (0 bytes) () 05/25/2013 postreply 08:22:51

• 科學倒也說不上，認識永遠也不夠充分，隻是近似而矣。這類解釋的東西，本沒價值。 -善念真言- ♂ (0 bytes) () 05/25/2013 postreply 15:58:53

• 技術也是不斷改進，無限優化而矣，根據實踐和新的解釋優化，產生新的價值，所以解釋的價值是通過技術實現的罷了~~ -這個星球有點軸- ♂ (0 bytes) () 05/25/2013 postreply 18:29:32

• 不管怎麽說，市場不給它價值，得國家出錢搞科學研究 -善念真言- ♂ (0 bytes) () 05/26/2013 postreply 16:57:01