介紹一篇關於抗氧化劑與肺腺癌的文章

本文內容已被 [ fuz ] 在 2021-08-26 06:38:29 編輯過。如有問題,請報告版主或論壇管理刪除.

N-Acetyl-L-Cysteine (NAC), 中文名:N-乙酰-L-半胱氨酸

前些年挺流行的一種抗氧化劑,被人們用來抗炎症、防衰老………。還有些人用來清肺,治療肺氣腫。

 

但是,有利則有弊,麻煩來了。下麵的研究發現,這東東在小鼠誘發肺腺癌。

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795405/

The antioxidant N-acetylcysteine protects from lung emphysema but induces lung adenocarcinoma in mice

Oxidative stress is a major contributor to chronic lung diseases. Antioxidants such as N-acetylcysteine (NAC) are broadly viewed as protective molecules that prevent the mutagenic effects of reactive oxygen species. Antioxidants may, however, increase the risk of some forms of cancer and accelerate lung cancer progression in murine models. Here, we investigated chronic NAC treatment in aging mice displaying lung oxidative stress and cell senescence due to inactivation of the transcription factor JunD, which is downregulated in diseased human lungs. NAC treatment decreased lung oxidative damage and cell senescence and protected from lung emphysema but concomitantly induced the development of lung adenocarcinoma in 50% of JunD-deficient mice and 10% of aged control mice. This finding constitutes the first evidence to our knowledge of a carcinogenic effect of antioxidant therapy in the lungs of aged mice with chronic lung oxidative stress and warrants the utmost caution when considering the therapeutic use of antioxidants.

 

有興趣的,自己去看細節。

 

多餘的話

當下各種營養品、保健品、補品、精品、……品泛濫。

尤其是“抗氧化”、抗衰老之類的東東。切記,癌細胞可是永葆青春、活力四射的……

 

請不要趕時尚,花大錢,爭當第一批小老鼠。等個三五年,前浪消失在沙灘上……明白咋回事了,再下嘴不遲。

 

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