滅活病毒疫苗

Inactivated (killed) virus vaccines

Similar to attenuated vaccines, inactivated virus vaccines contain whole virus particles, but in this case without live genetic material. The RNA or DNA of the virus is usually destroyed chemically or by heat, leaving the immunogenic elements unaltered.  These vaccines elicit an antibody-mediated immune response but usually not a cell-mediated one. This means that, although generally considered safer than live vaccines, the immunity conferred by inactivated vaccines is weaker. Adjuvants – molecules that stimulate the immune system – are often included with inactivated vaccines to give a stronger immune response.

https://www.intvetvaccnet.co.uk/blog/covid-19/vaccine-eight-types-being-tested

 

科興疫苗在二期臨床總結裏說:“我們的研究設計不包括對CD8細胞介質的免疫反應的評估。因為認為滅活疫苗不會誘導CD8 T細胞反應。"

https://www.thelancet.com/article/S1473-3099(20)30843-4/fulltext

 

所有跟帖： 

• 滅活不激活CD8+T是免疫學共識，也許因此細胞免疫作用可忽略。但它激活CD4+T，因而說它不激活細胞免疫係統並不十分準確。 -業餘城管- ♂ (0 bytes) () 08/05/2021 postreply 13:03:57

• These vaccines elicit an antibody-mediated immune response but u -TBz- ♂ (274 bytes) () 08/05/2021 postreply 13:08:52

• 對，我們說的不矛盾。細胞免疫係統被“攪動”但不激發有效的抗病毒的細胞免疫作用，主要是B細胞體液免疫發揮作用。 -業餘城管- ♂ (0 bytes) () 08/05/2021 postreply 13:17:37