can mRNA vaccine cross the BBB (blood rain barrier)?

It seems that the LNPs (lipid nanoparticles) that contain the mRNA of Covid-19 vaccines from BioNTech and Moderna do - at low doses - pass the BBB. This is mentioned by the EMA several times in their report, for example p. 54 and discussed in the comments of an article on Derek Lowe's blog.

If that's indeed the case, what would happen once the mRNA + nanolipid reach the brain? Which cells would pick up the LNPs and for how long would they stay in the brain? If there is cells that can transform this mRNA in proteins, where will these proteins then go, and for how long will they stay in the brain? What about the LNPs: what can/will the brain do with the remaining lipids?

More readings:

https://www.reddit.com/r/askscience/comments/nhcl0o/mrna_vaccines_what_become_the_lnps_that_cross_the/

https://blogs.sciencemag.org/pipeline/archives/2021/01/11/rna-vaccines-and-their-lipids#comment-336216 

 

所有跟帖： 

• 由於納米質粒帶正電，如果質粒進入血液，穿越腦血屏障是可能的。 -欲千北- ♂ (0 bytes) () 06/15/2021 postreply 14:28:48