nature: Cross-reactive serum and memory B-cell responses to spik

Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection

https://www.nature.com/articles/s41467-021-23074-3

Abstract

Pre-existing immunity to seasonal endemic coronaviruses could have profound consequences for antibody responses to SARS-CoV-2, induced from natural infection or vaccination. A first step to establish whether pre-existing responses can impact SARS-CoV-2 infection is to understand the nature and extent of cross-reactivity in humans to coronaviruses. Here we compare serum antibody and memory B cell responses to coronavirus spike proteins from pre-pandemic and SARS-CoV-2 convalescent donors using binding and functional assays. We show weak evidence of pre-existing SARS-CoV-2 cross-reactive serum antibodies in pre-pandemic donors. However, we find evidence of pre-existing cross-reactive memory B cells that are activated during SARS-CoV-2 infection. Monoclonal antibodies show varying degrees of cross-reactivity with betacoronaviruses, including SARS-CoV-1 and endemic coronaviruses. We identify one cross-reactive neutralizing antibody specific to the S2 subunit of the S protein. Our results suggest that pre-existing immunity to endemic coronaviruses should be considered in evaluating antibody responses to SARS-CoV-2.

 

所有跟帖： 

• 這是自然然雜誌的原文。其真正臨床意義，解釋了在新冠快速檢測中的出現的假陽性。 -fuz- ♂ (0 bytes) () 05/30/2021 postreply 05:20:15

• 單從摘要上看，此論文所研究的似乎是新冠抗體，新冠的快速檢驗查的是抗體還是病毒本身的基因序列？ -姬文伽- ♀ (256 bytes) () 05/30/2021 postreply 07:22:31

• 快速檢測都是測抗原抗體的，核酸測序目前的技術還是需要相對較長的時間 -想長肉肉- ♀ (0 bytes) () 05/30/2021 postreply 08:08:49

• 原來如此。快速檢測和核酸PCR檢測的原理都不一樣。 -姬文伽- ♀ (0 bytes) () 05/30/2021 postreply 10:59:10

• 同一類病毒，享有類似生物結構和遺傳物質。冠狀病毒的冠，是該類病毒的基本特征。但每種病毒的冠是不一樣的，如國王的冠，一看就知道 -fuz- ♂ (1811 bytes) () 05/30/2021 postreply 09:55:17

• 多謝多謝。解釋得真清楚。 -姬文伽- ♀ (0 bytes) () 05/30/2021 postreply 10:54:05