SARS-CoV-2 RNA reverse-transcribed and integrated into the human genome
Liguo Zhang1, Alexsia Richards1, Andrew Khalil1, 2, 3, Emile Wogram1, Haiting Ma1, Richard A.
Young1, 4, Rudolf Jaenisch1, 4
1Whitehead Institute for Biomedical Research, Cambridge, MA, USA.
2John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
3Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.
10.1101/2020.12.12.422516;
Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues
Liguo Zhang, Alexsia Richards, M. Inmaculada Barrasa, Stephen H. Hughes, Richard A. Young, and Rudolf Jaenisch
aWhitehead Institute for Biomedical Research, Cambridge, MA 02142;
bHIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702;
cDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142
10.1073/pnas.2105968118
