Pfizer, 對目前己知變異株都有效

https://www.nejm.org/doi/full/10.1056/NEJMc2100362 昨天剛發表的論文。

Table 1. Summary Results on SARS-CoV-2 Vaccine Trial Efficacy and Viral Neutralization of the B.1.1.7, P.1, and 501Y.V2 Variants, as Compared with Preexisting Variants.*

Vaccine (Company)	Preexisting Variants			Neutralization by Pseudovirion or Live Viral Plaque Assay			Efficacy in Settings with 501Y.V2 Variant
	Sample Size	Efficacy in Preventing Clinical Covid-19	Efficacy in Preventing Severe Covid-19	B.1.1.7 Variant	P.1 Variant	501Y.V2 Variant
	no.	% (no. of events with vaccine vs. placebo)					%
Ad26.COV2.S (Johnson & Johnson)	43,783	66 (NA)	85 (NA)	NA	NA	NA	57†, 85‡
BNT162b2 (Pfizer)	34,922	95 (8 vs. 162)	90 (1 vs. 9)	Decrease by 2×	Decrease by 6.7×	Decrease by ≤6.5×	NA
mRNA-1273 (Moderna)	28,207	94 (11 vs. 185)	100 (0 vs. 30)	Decrease by 1.8×	Decrease by 4.5×	Decrease by ≤8.6×	NA
Sputnik V (Gamaleya)	19,866	92 (16 vs. 62)	100 (0 vs. 20)	NA	NA	NA	NA
AZD1222 (AstraZeneca)	17,177	67 (84 vs. 248)	100 (0 vs. 3)	NA	NA	Decrease by ≤86× to complete immune escape	22§

所有跟帖： 

• serum 隻顯示1/3中和功能。serum作用主要是抗體？T cells作用不變？ -huntridge- ♂ (657 bytes) () 03/25/2021 postreply 10:55:01

• 沒錯啊，即便中和效價不如對原株的效價，還是有保護作用啊。其它疫苗更糟啊 -fuz- ♂ (0 bytes) () 03/25/2021 postreply 11:44:41

• serum作用主要是抗體？是不是serum含有抗體不含T細胞？ -huntridge- ♂ (0 bytes) () 03/25/2021 postreply 11:49:24

• 中和抗體可以用血清滴度測量；細胞免疫發生在個體內，很難在體外測試。總不能拉幾個人來打變異株吧，那太不人道了 -fuz- ♂ (0 bytes) () 03/25/2021 postreply 11:53:18

• 看表格沒覺得Pfizer比Medorna好啊？ -sourbaby- ♀ (0 bytes) () 03/25/2021 postreply 10:55:40

• 那個mRNA的用量，m苗用100，p苗30。在效果差不多的情況下，當然選劑量低的。 -fuz- ♂ (0 bytes) () 03/25/2021 postreply 11:41:09