抗N蛋白的抗體雖然出現早,滴度高,但不具有中和作用。我估計對清除被感染細胞有作用,但未見到過研究論文。
第2篇論文的結論/討論部分,對N蛋白抗體說的很直接:
“Interestingly, serum from healthy individuals who exhibited binding antibodies against N-protein but not against the S-RBD did not exhibit neutralizing activity. These results suggest that binding antibodies against N-protein do not correlate with having S-RBD–binding antibodies or possessing neutralizing capacity.” (【Heterogeneous antibodies against SARS-CoV-2 spike receptor binding domain and nucleocapsid with implications for COVID-19 immunity】, https://insight.jci.org/articles/view/142386 )