看了樓下疫苗3期臨床試驗的protocol。覺得Peter Doshi對結果的疑問有道理

來源: huntridge 於 2021-01-13 18:38:19 [檔案] [博客] [舊帖] [給我悄悄話] 本文已被閱讀：次 (2969 bytes)

protocol是症狀結合PCR測試：Combined with a positive PCR test result”、

https://bbs.wenxuecity.com/health/945713.html

Peter Doshi質疑的是疑似情況：

https://blogs.bmj.com/bmj/2021/01/04/peter-doshi-pfizer-and-modernas-95-effective-vaccines-we-need-more-details-and-the-raw-data/

“Suspected covid-19”

All attention has focused on the dramatic efficacy results: Pfizer reported 170 PCR confirmed covid-19 cases, split 8 to 162 between vaccine and placebo groups. But these numbers were dwarfed by a category of disease called “suspected covid-19”—those with symptomatic covid-19 that were not PCR confirmed. According to FDA’s report on Pfizer’s vaccine, there were “3410 total cases of suspected, but unconfirmed covid-19 in the overall study population, 1594 occurred in the vaccine group vs. 1816 in the placebo group.”

打疫苗有疑似症狀的比placebo多15%。這結果本身是不是有些意外？由於PCR測試有高達30%的假陰性所以Peter Doshi對結果有疑問。要求更多細節和raw data。