Good News: Everyone develops long-term coronavirus immunity afte

https://www.businessinsider.com/long-term-coronavirus-immunity-t-cells-2020-8?amp

Some early studies have suggested that coronavirus antibodies fade relatively quickly, but that doesn't mean immunity vanishes.

A new study found that all participants infected with COVID-19 — even those with asymptomatic or mild cases and patients who didn't have detectable antibodies — developed virus-specific T cells.

T cells identify and kill infected cells, and B cells create new antibodies. Those cells can attack the virus if it ever returns.

So the new finding is strong evidence that all patients likely develop long-term immunity.

 

"Memory T cells will likely prove critical for long-term immune protection against COVID-19," the study authors wrote, adding that they "may prevent recurrent episodes of severe COVID-19."

That's because memory T cells can stick around for years, while antibody levels drop following an infection.

Even patients without antibodies have virus-specific T cells

The authors of the new study examined blood from 206 people in Sweden who had COVID-19 with varying degrees of severity. They found that regardless of whether a person had recovered from a mild or severe case, they still developed a robust T-cell response. Even coronavirus patients who did not test positive for antibodies developed memory T cells, the results showed.

 

 

PS:  The Study, published on Cell

https://www.cell.com/cell/fulltext/S0092-8674(20)31008-4?rss=yes

 

 

 

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Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19

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Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19

• Takuya Sekine 13
• André Perez-Potti 13
• Olga Rivera-Ballesteros 13
•  
• Hans-Gustaf Ljunggren 13
• Soo Aleman 13
• Marcus Buggert 13, 15
   
• Show all authors
• Show footnotes

Open AccessPublished:August 14, 2020DOI:https://doi.org/10.1016/j.cell.2020.08.017

 

 

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Highlights

• 1.
  Acute phase SARS-CoV-2-specific T cells display an activated cytotoxic phenotype
• 2.
  Broad and polyfunctional SARS-CoV-2-specific T cell responses in convalescent phase
• 3.
  Detection of SARS-CoV-2-specific T cell responses also in seronegative individuals

Summary

SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. We here systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits robust, broad and highly functional memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.

所有跟帖： 

• 好消息！請問夫子對中國最近開始接種的新冠疫苗如何評價？ -awr- ♀ (0 bytes) () 08/19/2020 postreply 18:35:44

• 唉，一言難盡呐 -fuz- ♂ (9055 bytes) () 08/19/2020 postreply 18:39:09

• 才看到夫子寫了這麽一大篇在這裏，謝謝你。 -awr- ♀ (0 bytes) () 08/20/2020 postreply 21:36:34

• 這說法統計上說也比較合理.美國感染者已經幾百萬,如真有2次感染可能,那2次感染人數決不會隻有"幾個"。LOL -老玩家- ♂ (666 bytes) () 08/19/2020 postreply 23:24:10

• 所謂的二次感染，大概率是一次感染沒有治好而已，被不準的檢測誤導。 -TBz- ♂ (146 bytes) () 08/20/2020 postreply 09:23:57

• 隻有這種可能啦。即使是國家抗疫功勳鍾南山也反複改變說法，可見國人科學研究的浮躁態度了。LOL -老玩家- ♂ (0 bytes) () 08/20/2020 postreply 10:14:31