ACE2 表達的含量多少和這個病情嚴重性不相關

2006 paper

Epidemiologic data suggested that there was an obvious predominance of young adult patients with a slight female proneness in severe acute respiratory syndrome (SARS). The angiotensin-converting enzyme 2 (ACE2) was very recently identified as a functional receptor for SARS virus and is therefore a prime target for pathogenesis and pharmacological intervention. Rats of both genders at three distinct ages (young-adult, 3 months; middle-aged, 12 months; old, 24 months) were evaluated to determine the characteristic of ACE2 expression in lung and the effect of aging and gender on its expression. ACE2 was predominantly expressed in alveolar epithelium, bronchiolar epithelium, endothelium and smooth muscle cells of pulmonary vessels with similar content, whereas no obvious signal was detected in the bronchiolar smooth muscle cells. ACE2 expression is dramatically reduced with aging in both genders: young-adult vs. old P < 0.001 (by 78% in male and 67% in female, respectively) and middle-aged vs. old P < 0.001 (by 71% in male rats and 59% in female rats, respectively). The decrease of ACE2 content was relatively slight between young-adult and middle-aged groups (by 25% in male and 18% in female, respectively). Although there was no gender-related difference of ACE2 in young-adult and middle-aged groups, a significantly higher ACE2 content was detected in old female rats than male. In conclusion, the more elevated ACE2 in young adults as compared to aged groups may contribute to the predominance in SARS attacks in this age group.

 

google translation

流行病學數據表明，在嚴重急性呼吸綜合征（SARS）中，年輕的成年患者具有明顯的女性輕度傾向。血管緊張素轉換酶2（ACE2）最近被確定為SARS病毒的功能受體，因此是發病機理和藥理幹預的主要目標。評估了兩種性別的大鼠在三個不同的年齡（成人3個月；中年12個月；年齡24個月），以確定ACE2在肺中的表達特征以及衰老和性別對其表達的影響。 ACE2主要在肺泡上皮，細支氣管上皮，內皮和肺血管平滑肌細胞中表達，含量相似，而在細支氣管平滑肌細胞中未檢測到明顯的信號。 ACE2的表達隨年齡的增長而顯著降低：青年與老年P <0.001（男性分別降低78％和女性67％）和中老年與老年P <0.001（男性降低71％）大鼠和59％的雌性大鼠）。 ACE2含量的減少在年輕人和中年組之間相對較小（男性分別降低25％，女性降低18％）。盡管在青年和中年組中沒有性別相關的ACE2差異，但在老年雌性大鼠中檢出的ACE2含量明顯高於雄性。總之，與年齡組相比，年輕人中ACE2的升高可能是該年齡組SARS發作的主要原因。