To the best of our knowledge, this is the 1st meta-analysis to investigate the association between ALDH2 rs671 polymorphism and the overall cancer risk in Asians. In the present meta-analysis, 63 articles with 66 studies containing 25,682 cases and 47,455 controls were retrieved. A significant association between ALDH2 rs671 polymorphism and the overall cancer risk in Asians was observed. Further stratification analyses indicated that a significant association was also found in esophageal cancer, oral cancer, head and neck cancer, and UADT, while the evidence for other cancers is less, as colorectal cancer and hepatocellular cancer