說到點子上了， 這裏就有一篇。

https://www.ncbi.nlm.nih.gov/pubmed/30624776

 

 

J Cell Physiol. 2019 Aug;234(8):13977-13983. doi: 10.1002/jcp.28083. Epub 2019 Jan 9.

A variant in CYP2R1 predicts circulating vitamin D levels after supplementation with high-dose of vitamin D in healthy adolescent girls.

Khayyatzadeh SS^1,2, Mehramiz M^3,4, Esmaeily H⁵, Mirmousavi SJ⁶, Khajavi L³, Salehkhani FN³, Hanachi P⁷, Bahrami-Taghanaki H⁸, Eslami S⁹, Vatanparast H¹⁰, Ferns GA¹¹, Avan A^3,4, Ghayour-Mobarhan M³.

Author information

 

Abstract

AIM:

The determinants of serum vitamin D seems to be the environmental factors (dietary and supplementary intake and exposure to ultraviolet light) and genetic factors. We aimed to study the relationship between a vitamin D-associated genetic polymorphism and serum 25(OH)D concentrations in healthy adolescent girls in Iran, and its effects on a high-dose supplement of vitamin D.

MATERIAL AND METHOD:

A total of 616 healthy adolescent girls with mean age 15 received 50,000 IU of vitamin D3 weekly over 9 weeks. Serum vitamin D levels and other metabolic factors were measured at baseline and after the intervention. The genotyping of the CYP2R1 variant (rs10741657) was performed by TaqMan genotyping assays.

RESULTS:

Regardless of the genetic background, at baseline, 87% of adolescent girls were vitamin D deficient (serum 25(OH)D level < 50 nmol/l). High-dose supplementation with VitD reduced the proportion of girls who were deficient substantially to about 24%. The genetic analysis revealed that although at baseline there was not a gene-vitamin D association ( p trend = 0.1), the response to supplementation appeared to be modulated by this variant ( p trend < 0.001). However, other anthropometric and biochemical measures were not affected by this intervention, over this short period. Serum 25(OH)D was increased in all participants although the carriers of the minor A allele seemed to be better responders so that the percentages of the change serum vitamin D in the holder of AA and AG genotypes were 539.4 ± 443.1 and 443.7 ± 384.6, respectively, compared with those with common GG genotype (363.3 ± 354.0). Our regression analysis revealed that the probability of an increase in serum 25(OH)D in a participant with AA genotype was 2.5-fold greater than those with a GG genotype (OR = 2.5 (1.4-4.4); p value = 0.002).

CONCLUSION:

Based on our findings, it appears that the rs10741657 variant of the CYP2R1 gene modulates the response to high-dose of vitamin D supplementation.

© 2019 Wiley Periodicals, Inc.

KEYWORDS:

CYP2R1; rs10741657; supplementation; vitamin D

PMID:

30624776

DOI:

10.1002/jcp.28083

所有跟帖： 

• 謝謝。我拍腦門的一個小推測，啟發和證實都由你提供了。 -虎嗅薔薇- ♀ (0 bytes) () 11/01/2019 postreply 15:39:41

• 這腦門 -吃與活- ♂ (177 bytes) () 11/01/2019 postreply 15:51:40

• 上麵畫了個大大的“王” -fuz- ♂ (0 bytes) () 11/01/2019 postreply 21:43:41