其中ID rp1954，他妻子2010年是腸四期，提到locally curative的辦法，我的感覺是他用locally curative手術，盡量小的化療空窗期，來達到防止複發和擴散的目的。這個是他自己research總結出來的治療方案。對於他妻子應該是很有效果的。我問了我們手術醫生，他說絕對不會采取這種做法的。
coloncancersupport.colonclub.com/viewtopic.php?f=1&t=62073
My wife's multimodal treatment steps were, broadly:
neoadjuvant immune treatments (4 wks) + surgery 1 + an enhanced immune tx (1mo) + metronomic (daily) immunochemo (11+ months) + surgery 2 + immunochemos (8 yrs)
Fewer untreated gaps (e.g 5FU chemo still working 12 hours before surgery, immunochemo 24 hours after surgery, other chemistry still on during surgery), with more treatment chemistry or cancer pathways addressed - specifically targeted or specifically tested. Chemo even a few days before/after surgery would be a big advance for most hospitals. The principal goal here is to stop the spread of cancer, fast shrinkage or elimination is nice but not an absolute requirement if surgery can get it, or if immunochemo will slowly erode it away. We were able to hotrod oral 5FU with mild, targetable drugs (cimetidine, Celebrex, aspirin) and potent nutraceuticals to antitumor activity levels that regress cancer, even the resistant survivors and mutations. With carefully selected nutraceuticals to amplify chemo and to address other health problems, side benefits rather than side effects can be the norm.
Locally curative surgeries allow important piecemeal steps forward, but you have to prevent further spread. To me, daily immunochemo made a lot more sense for stage 4, and some papers' numbers backed that up. For a denied resection or spreading cancer, doubly so in my eyes.
