Discovery[edit]
In 1970, researchers from the University of Edinburgh performing cytogenetic research on a group of juvenile offenders in Scotland found an abnormal translocation in chromosome 1 of one of the boys, who also displayed characteristics of an affective psychological disorder.[6] After this initial observation, the boy's family was studied and it was found that 34 out of 77 family members displayed the same translocation. According to the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) (or DSM-IV) criteria, sixteen of the 34 individuals identified as having the genetic mutation were diagnosed with psychiatric problems. In contrast, five of the 43 unaffected family members were identified to have psychological indispositions. The psychiatric illnesses observed in the family ranged from schizophrenia and major depression to bipolar disorder and adolescent conduct disorder (which the original research subject had).[7] After studying this large Scottish family for four generations, in 2000, this gene was given the name "DISC1". The name was derived from the basis of the molecular nature of the mutation: the translocation directly disrupts the gene.[5]
https://en.wikipedia.org/wiki/DISC1
Goole 的翻譯：
發現
1970年，愛丁堡大學的研究人員對蘇格蘭一群少年犯進行細胞遺傳學研究，發現其中一名男孩的染色體1異常移位，他們也表現出情感心理障礙的特征。[6]在初步觀察之後，男孩的家人被研究，發現77名家庭成員中有34人呈現相同的易位。根據“精神障礙診斷與統計手冊（第四版）（第四版）”（或DSM-IV）標準，被確定為具有遺傳突變的34人中有16人被診斷患有精神病學問題。相比之下，43名未受影響的家庭成員中有5人被認定有心理上的偏見。家庭觀察到的精神疾病包括精神分裂症和重症抑鬱症，雙相情感障礙和青少年行為障礙（原始研究對象）[7]在這個大蘇格蘭家庭學習了四代後，2000年，該基因被命名為“DISC1”。該名稱源自突變分子性質的基礎：易位直接破壞基因[5]
