患乳病癌人群中“攜帶BRCA1突變基因”的占 1-5%

1)The prevalence of BRCA mutation carriers in the general population is estimated at between 1/800 and 1/1000. BRCA1 and BRCA2 mutation frequencies in breast and ovarian cancer patients unselected for family history or age at onset are generally low (<1–7% for BRCA1 and 1–3% for BRCA2). Higher prevalence is associated with a family history of breast or ovarian cancer, young age at onset, male breast cancer or multiple tumors (bilateral breast cancer or breast and ovarian cancer in the same patient).

https://academic.oup.com/annonc/article/20/suppl_4/iv19/147413/BRCA-in-breast-cancer-ESMO-Clinical

2)Mutations in BRCA1 and BRCA2 are estimated to account for 5% of all breast cancers and 50% of hereditary breast cancers (from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374018/)

所有跟帖： 

• 謝謝，就是說乳病癌人群中95-99%是與“攜帶BRCA1突變基因”無關的。 -jck66- ♀ (0 bytes) () 04/02/2017 postreply 09:15:43

• 多數腫瘤年齡是另一個重要的危險因素, 但小孩生腫瘤與年齡關係就不是那麽大 -楊別青- ♂ (183 bytes) () 04/02/2017 postreply 09:16:31

• 年齡的增長帶來的危險主要是兩方麵：1）增加多個基因突變的機會。2）腫瘤細胞形成後難以被下降的免疫力清除而致腫瘤的發生 -楊別青- ♂ (0 bytes) () 04/02/2017 postreply 09:33:01

• 謝謝，就是說患乳癌的人群中95-99%是與“攜帶BRCA1突變基因”無關的。 -jck66- ♀ (0 bytes) () 04/02/2017 postreply 09:17:52