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來源: 吃與活 於 2016-11-30 07:04:40 [] [博客] [舊帖] [給我悄悄話] 閱讀數 : (10319 bytes)

這種情況下的確生存期不長了，下麵文獻僅供參考。祝福！

https://www.ncbi.nlm.nih.gov/pubmed/17710443

2008 Apr;16(4):387-92. Epub 2007 Aug 21.

Cancer-associated hypercalcemia treated with intravenous diphosphonates: a survival and prognostic factor analysis.

Penel N1, Dewas S, Doutrelant P, Clisant S, Yazdanpanah Y, Adenis A.

Abstract

BACKGROUND:

Cancer-associated hypercalcemia (CAH) is the most frequent metabolic disorder in cancer patients. We retrospectively reviewed the outcome and prognostic factors for patients with CAH being treated with standard intravenous disphosphonates.

MATERIALS AND METHODS:

Two hundred sixty patients were reviewed. Overall survival and prognostic factors were analyzed. Relative risks (RR) for early death (within 60 days) were assessed (Fischer exact test and logistic regression model).

RESULTS:

Median survival was 64 days (range, 12-1,955+). Multivariate analysis identified the following factors as poor survival predictors: serum corrected calcium >2.83 mmol/l [hazard ratio (HR) = HR 2.21], albuminemia <35.5 (HR 2.41), squamous cell carcinoma (HR 2.64), bone metastasis (HR 1.44), and liver metastasis (HR 2..22). One hundred twenty-one patients died within 60 days. For those patients, the logistic regression model identified four independent predicting factors for early death: calcemia >2.83 mmol/l (RR 5.07), hypoalbuminemia (RR 7.42), liver metastasis (RR 4.34), and squamous cell carcinomas (RR 2.21).

DISCUSSION:

Despite intravenous diphosphonate, CAH is still associated with poor outcome. Simple bedside parameters may estimate the risk of early deaths.

PMID:
17710443
DOI:
10.1007/s00520-007-0322-z
 
Fig. 1

Survival after first episode of hypercalcemia treated by diphosphonates according to selected prognostic factors. The patients were classified according to four independent predicting factors: serum-corrected calcium > 2.83 mmol/l, albuminemia < 35 g/l, squamous cell cancer type, and presence of liver or bone metastases. Score = 0 (absence of predicting factor), score = 1 (presence of 1 predicting factors), and score = 2 (presence of two or more predicting factor)

 

two or more predicting factor)

 

Table 4

Predicting factors for early deaths

Variables

Patients surviving < 60 days (early death; n = 121)

Patients surviving > 60 days (n = 139)

p valuea

Adjusted odd ratio (95% CI)

Serum albumin-corrected calcium

>2.83 mmol/l

94 (77.6%)

27 (19.4%)

0.001

5.07 [2.47–10.41]

≤2.83 mmol/l

27 (22.4%)

112 (80.6%)

Reference

Albuminemia

<35 g/l

97 (80.1%)

24 (17.2%)

0.001

7.42 (3.65–15.06)

≥35 g/l

24 (19.9%)

115 (82.8%)

Reference

Squamous cell carcinomas

64 (52.8%)

41 (29.4%)

0.027

2.21 (1.09–4.48)

Other histological subtypes

57 (47.2%)

98 (70.6%)

Reference

Presence of liver metastasis

46 (38.0%)

20 (14.3%)

0.001

4.34 (1.86–10.10)

Absence of liver metastasis

77 (72.0%)

119 (85.7%)

Reference

aThe multivariate analysis is based on a stepwise logistic regression model

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• 好的，謝謝 -financewoman- ♀ 給 financewoman 發送悄悄話 (0 bytes) () 11/30/2016 postreply 07:16:54

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