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這種情況下的確生存期不長了，下麵文獻僅供參考。祝福！

https://www.ncbi.nlm.nih.gov/pubmed/17710443

Support Care Cancer. 2008 Apr;16(4):387-92. Epub 2007 Aug 21.

Cancer-associated hypercalcemia treated with intravenous diphosphonates: a survival and prognostic factor analysis.

Penel N¹, Dewas S, Doutrelant P, Clisant S, Yazdanpanah Y, Adenis A.

Author information

• ¹Département de Cancérologie Générale, Centre Oscar Lambret, Lille, France. [e-mail]

Abstract

BACKGROUND:

Cancer-associated hypercalcemia (CAH) is the most frequent metabolic disorder in cancer patients. We retrospectively reviewed the outcome and prognostic factors for patients with CAH being treated with standard intravenous disphosphonates.

MATERIALS AND METHODS:

Two hundred sixty patients were reviewed. Overall survival and prognostic factors were analyzed. Relative risks (RR) for early death (within 60 days) were assessed (Fischer exact test and logistic regression model).

RESULTS:

Median survival was 64 days (range, 12-1,955+). Multivariate analysis identified the following factors as poor survival predictors: serum corrected calcium >2.83 mmol/l [hazard ratio (HR) = HR 2.21], albuminemia <35.5 (HR 2.41), squamous cell carcinoma (HR 2.64), bone metastasis (HR 1.44), and liver metastasis (HR 2..22). One hundred twenty-one patients died within 60 days. For those patients, the logistic regression model identified four independent predicting factors for early death: calcemia >2.83 mmol/l (RR 5.07), hypoalbuminemia (RR 7.42), liver metastasis (RR 4.34), and squamous cell carcinomas (RR 2.21).

DISCUSSION:

Despite intravenous diphosphonate, CAH is still associated with poor outcome. Simple bedside parameters may estimate the risk of early deaths.

PMID:

17710443

DOI:

10.1007/s00520-007-0322-z

 

Fig. 1

Survival after first episode of hypercalcemia treated by diphosphonates according to selected prognostic factors. The patients were classified according to four independent predicting factors: serum-corrected calcium > 2.83 mmol/l, albuminemia < 35 g/l, squamous cell cancer type, and presence of liver or bone metastases. Score = 0 (absence of predicting factor), score = 1 (presence of 1 predicting factors), and score = 2 (presence of two or more predicting factor)

 

two or more predicting factor)

 

Table 4

Predicting factors for early deaths

Variables	Patients surviving < 60 days (early death; n = 121)	Patients surviving > 60 days (n = 139)	p valuea	Adjusted odd ratio (95% CI)
Serum albumin-corrected calcium
>2.83 mmol/l	94 (77.6%)	27 (19.4%)	0.001	5.07 [2.47–10.41]
≤2.83 mmol/l	27 (22.4%)	112 (80.6%)		Reference
Albuminemia
<35 g/l	97 (80.1%)	24 (17.2%)	0.001	7.42 (3.65–15.06)
≥35 g/l	24 (19.9%)	115 (82.8%)		Reference
Squamous cell carcinomas	64 (52.8%)	41 (29.4%)	0.027	2.21 (1.09–4.48)
Other histological subtypes	57 (47.2%)	98 (70.6%)		Reference
Presence of liver metastasis	46 (38.0%)	20 (14.3%)	0.001	4.34 (1.86–10.10)
Absence of liver metastasis	77 (72.0%)	119 (85.7%)		Reference

^aThe multivariate analysis is based on a stepwise logistic regression model

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• 好的，謝謝 -financewoman- ♀ (0 bytes) () 11/30/2016 postreply 07:16:54