每年用CT查肺癌本身也會致癌， 這就是另一個重大原因為什麽風險高的煙槍篩查才有意義

• 每年用CT查肺癌本身也會致癌， 這就是另一個重大原因為什麽風險高的煙槍篩查才有意義。特異性差，假陽性等等折騰是一大重要原因。Brenner DJ 是美國研究醫用放射線的利弊最有名的權威，不是之一。因為他團隊的努力，機場不用x光照旅客了。 
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Radiology. 2004 May;231(2):440-5.

Radiation risks potentially associated with low-dose CT screening of adult smokers for lung cancer.

Brenner DJ¹.

Author information

¹Center for Radiological Research, Columbia University, 630 W 168th St, New York, NY 10032, USA. [e-mail]

Abstract

PURPOSE:

To estimate the radiation-related lung cancer risks associated with annual low-dose computed tomographic (CT) lung screening in adult smokers and former smokers, and to establish a baseline risk that the potential benefits of such screening should exceed.

MATERIALS AND METHODS:

The estimated lung radiation dose from low-dose CT lung examinations corresponds to a dose range for which there is direct evidence of increased cancer risk in atomic bomb survivors. Estimated dose-, sex-, and smoking status-dependent excess relative risks of lung cancer were derived from cancer incidence data for atomic bomb survivors and used to calculate the excess lung cancer risks associated with a single CT lung examination at a given age in a U.S. population. From these, the overall radiation risks associated with annual CT lung screening were estimated.

RESULTS:

A 50-year-old female smoker who undergoes annual CT lung screening until age 75 would incur an estimated radiation-related lung cancer risk of 0.85%, in addition to her otherwise expected lung cancer risk of approximately 17%. The radiation-associated cancer risk to other organs would be far lower. If 50% of all current and former smokers in the U.S. population aged 50-75 years received annual CT screening, the estimated number of lung cancers associated with radiation from screening would be approximately 36,000, a 1.8% (95% credibility interval: 0.5%, 5.5%) increase over the otherwise expected number.

CONCLUSION:

Given the estimated upper limit of a 5.5% increase in lung cancer risk attributable to annual CT-related radiation exposure, a mortality benefit of considerably more than 5% may be necessary to outweigh the potential radiation risks.

所有跟帖： 

• 同意！謝謝你提供的文獻，Brenner是牛人呢，以前在會議上見過他一次，是keynote speaker -viewfinder- ♀ (0 bytes) () 06/10/2016 postreply 04:40:04

• 也謝謝你提供的文獻！ 你還見過Brenner呢， 多好。我這裏是不太知名的speaker以景仰的心情引用他的文章。。。 -誌在千裏- ♀ (90 bytes) () 06/10/2016 postreply 06:52:14