不是長效的。2012年的IDISA（美國傳染病協會）的推薦，可以使用一次性的青黴素G肌肉注射60萬單位（小於60磅體重的）

大於60磅體重的一次性注射是 120 萬單位。認為對於咽部的Strep感染有強效。。。

Treatment

Patients with acute group A streptococcal pharyngitis should be treated with an antibiotic that is likely to eradicate the organism, usually for 10 days. Penicillin or amoxicillin is commonly recommended because of its narrow spectrum of activity, few adverse effects, and modest cost. Alternative antibiotics for those with penicillin allergy include a first-generation cephalosporin, clindamycin, clarithromycin (Biaxin), or azithromycin (Zithromax). Table 2 summarizes antibiotic regimens for patients with and without penicillin allergy.

View/Print Table

Table 2.

Treatment Regimens for Group A Streptococcal Infection

DRUG	DOSE/DOSAGE	DURATION	RECOMMENDATION STRENGTH, QUALITY OF EVIDENCE
Patients without penicillin allergy
Penicillin V, oral	Children: 250 mg two or three times daily	10 days	Strong, high
	Adolescents and adults: 250 mg four times daily or 500 mg twice daily
Amoxicillin, oral	50 mg per kg once daily (maximum = 1,000 mg)	10 days	Strong, high
	Alternative: 25 mg per kg twice daily (maximum= 500 mg)
Penicillin G benzathine, intramuscular	< 60 lb (27 kg): 600,000 U	Single dose	Strong, high
	≥ 60 lb: 1,200,000 U
Patients with pencillin allergy
Cephalexin (Keflex), oral*	20 mg per kg per dose twice daily (maximum = 500 mg per dose)	10 days	Strong, high
Cefadroxil, oral*	30 mg per kg once daily (maximum = 1 g)	10 days	Strong, high
Clindamycin, oral	7 mg per kg per dose three times daily (maximum = 300 mg per dose)	10 days	Strong, moderate
Azithromycin (Zithromax), oral†	12 mg per kg once daily (maximum = 500 mg)	5 days	Strong, moderate
Clarithromycin (Biaxin), oral†	7.5 mg per kg per dose twice daily (maximum = 250 mg per dose)	10 days	Strong, moderate

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*—Avoid in individuals with immediate hypersensitivity to penicillin.

†—Resistance of group A streptococcus to these agents is well-known and varies geographically and temporally.

Adapted with permission from Shulman ST, Bisno AL, Clegg HW, et al. Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America. Clin Infect Dis. 2012;55(10):e89.

所有跟帖： 

• 不知依據是什麽？別又弄個李冰冰事件出來。 -薛成- ♂ (0 bytes) () 01/01/2016 postreply 17:20:58

• 估計是希望一次性把細菌殺光光。 -viewfinder- ♀ (0 bytes) () 01/01/2016 postreply 18:00:41

• 我在國內的經驗是，60萬單位青黴素G的一次性注射不會有多大效果。 -禦用文人- ♀ (0 bytes) () 01/01/2016 postreply 18:24:51

• 我印象中青黴素G的半衰期不長，血液濃度衰減很快。僅用一次，怎麽保證細菌被有效殺滅？不知哪位有這方麵的研究資料。 -薛成- ♂ (0 bytes) () 01/01/2016 postreply 18:49:14

• 文獻根據在這兒，發表在Jama上。但是發表日期太老。 -禦用文人- ♀ (22234 bytes) () 01/01/2016 postreply 19:26:29

• 看你們這麽說，這個一次性注射可能真是沒起到徹底治療strep的作用？那怎麽辦啊 -海水很鹹- ♀ (178 bytes) () 01/01/2016 postreply 22:50:36

• 謝謝老哥，新年快樂！ -薛成- ♂ (0 bytes) () 01/02/2016 postreply 01:37:34