有很多研究認為高水果，蔬菜，魚，堅果，豆的攝取，低的肉，高脂奶製品和甜食，降低阿茲海默病的風險。

Despite differences in the analytic approaches, high adherence to dietary patterns characterised by higher intakes of fruits, vegetables, fish, nuts and legumes, and lower intake of meat, high-fat dairies and sweets, is consistently associated with reduced risk for AD.3 ,4 ,21 ,55–59

 

See comment in PubMed Commons below

BMJ Open. 2014 Jun 24;4(6):e004850. doi: 10.1136/bmjopen-2014-004850.

Nutrient intake and brain biomarkers of Alzheimer's disease in at-risk cognitively normal individuals: a cross-sectional neuroimaging pilot study.

Mosconi L¹, Murray J¹, Davies M¹, Williams S¹, Pirraglia E¹, Spector N¹, Tsui WH¹, Li Y¹, Butler T¹, Osorio RS¹, Glodzik L¹, Vallabhajosula S², McHugh P¹, Marmar CR³, de Leon MJ¹.

Author information

• ¹Department of Psychiatry, New York University School of Medicine, New York, USA.
• ²Department of Radiology, Citigroup Biomedical Imaging Center (CBIC), Weill Cornell Medical College, New York, New York, USA.
• ³Department of Psychiatry, New York University School of Medicine, New York, USA Steven and Alexandra Cohen Veterans Center for PTSD and TBI, New York, New York, USA.

Abstract

OBJECTIVE:

There is increasing evidence to suggest that diet, one of the most important modifiable environmental factors, may play a role in preventing or delaying cognitive decline and Alzheimer's disease (AD). This study examines the relationship between dietary nutrients and brain biomarkers of AD in cognitively normal individuals (NL) with and without AD risk factors.

DESIGN:

As part of an ongoing brain imaging study, participants received clinical and laboratory examinations, a neurocognitive test battery, positron emission tomography (PET) with (11)C-Pittsburgh Compound-B (PiB; a measure of amyloid-β (Aβ) load) and (18)F-fluorodeoxyglucose (FDG; a proxy of neuronal activity), and completed semiquantitative food frequency questionnaires.

SETTING:

Research centre affiliated with the Alzheimer's disease Core Center at New York University School of Medicine.

PARTICIPANTS:

49 NL individuals (age 25-72?years, 69% women) with dietary information, (11)C-PiB and (18)F-FDG PET scans were examined.

RESULTS:

Controlling for age and total caloric intake, higher intake of vitamin B12, vitamin D and ω-3 polyunsaturated fatty acid (PUFA) was associated with lower Aβ load in AD regions on PiB-PET, while higher intake of β-carotene and folate was associated with higher glucose metabolism on FDG-PET. β-carotene and folate were associated with reduced glucose metabolism for women, apolipoprotein E epsilon 4 (APOE4) carriers and participants with positive AD family history, but not for their risk-free counterparts. The associations of vitamin B12, vitamin D and ω-3 PUFA with PiB retention were independent of gender, APOE and family history. The identified nutrient combination was associated with higher intake of vegetables, fruit, whole grains, fish and legumes, and lower intake of high-fat dairies, meat and sweets.

CONCLUSIONS:

Our data provide a potential pathophysiological mechanism for epidemiological findings showing that dietary interventions may play a role in the prevention of AD. Longitudinal studies are needed to determine whether there is a direct link between nutrient intake, brain biomarkers and risk of AD.

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

KEYWORDS:

Nuclear Medicine; Nutrition & Dietetics; Radiology & Imaging

PMID:

24961717

[PubMed - in process]

 

PMCID:

PMC4078781

 

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所有跟帖： 

• 完全同意 -羽衣甘藍- ♂ (0 bytes) () 11/20/2015 postreply 18:33:25

• 人家明明說是具有相關性，您卻偏翻譯成因果性，研究對象也隻有49人，是個很初步的研究。 -pamperedpaws- ♀ (0 bytes) () 11/21/2015 postreply 04:27:49

• 降低風險=\=因果關係。文中引用的八篇文獻都得出類似的結論，所以說“很多研究”。 -吃與活- ♂ (0 bytes) () 11/21/2015 postreply 05:00:48

• A和B的減少相關，不能說成是A會減少B。引用結論或者是翻譯還是要嚴謹一些。 -pamperedpaws- ♀ (0 bytes) () 11/21/2015 postreply 15:41:18

• 說得對，我會注意。實際上“風險”一詞，意味著可能性，並不意味著必然性。 -吃與活- ♂ (0 bytes) () 11/21/2015 postreply 16:16:30