Inactivation of the p53 tumor suppressor is a frequent event in tumorigenesis. In addition to its role in blocking tumorigenesis, p53 hampers
malignant phenotypes such as tumor invasion and metastasis.
Here are two papers:
2011, http://gan.sagepub.com/content/2/4/466.full
2014, http://jcb.rupress.org/content/204/7/1191.full.pdf+html