Antioxid Redox Signal. 2012 Jul 1;17(1):119-40. doi: 10.1089/ars.2012.4612. Epub 2012 Apr 20.
Hydrogen sulfide in biochemistry and medicine.
Predmore BL1, Lefer DJ, Gojon G.
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1Department of Surgery-Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
SIGNIFICANCE:
An abundance of experimental evidence suggests that hydrogen sulfide (H(2)S) plays a prominent role in physiology and pathophysiology. Many targets exist for H(2)S therapy. The molecular targets of H(2)S include proteins, enzymes, transcription factors, and membrane ion channels.
RECENT ADVANCES:
Novel H(2)S precursors are being synthesized and discovered that are capable of releasing H(2)S in a slow and sustained manner. This presents a novel and advantageous approach to H(2)S therapy for treatment of chronic conditions associated with a decline in endogenous H(2)S, such as diabetes and cardiovascular disease.
