Food Funct., 2013, 4, 1304
Dietary approaches to improving atheroprotective HDL
functions
Catherine J. Andersen and Maria Luz Fernandez*
High-density lipoproteins (HDL) are known to protect against cardiovascular disease (CVD). In addition to
facilitating reverse cholesterol transport to remove excess lipids from the body – including atherosclerotic
plaques – HDL exhibits antioxidant, anti-inflammatory, vasodilatory, and antithrombotic activities.
Together, these properties contribute to the overall atheroprotective nature of HDL. However, similar to
many other physiological pathways, these HDL parameters are known to become dysregulated in
conditions of metabolic disease. Further, research suggests these alternative HDL properties may be
regulated independently of blood HDL-cholesterol (HDL-C) levels, and must therefore be considered
when designing HDL-targeted therapies. To date, a number of dietary strategies have been investigated
to assess the effect of dietary components on functional properties of HDL beyond HDL-C. This review
will highlight the bioactive nutrients, functional foods, and dietary programs known to modulate HDL
function as a means of reducing CVD.
其中詳細提到, Dietary cholesterol 是一個有效的方法
Dietary approaches to improving atheroprotective HDL
functions
Catherine J. Andersen and Maria Luz Fernandez*
High-density lipoproteins (HDL) are known to protect against cardiovascular disease (CVD). In addition to
facilitating reverse cholesterol transport to remove excess lipids from the body – including atherosclerotic
plaques – HDL exhibits antioxidant, anti-inflammatory, vasodilatory, and antithrombotic activities.
Together, these properties contribute to the overall atheroprotective nature of HDL. However, similar to
many other physiological pathways, these HDL parameters are known to become dysregulated in
conditions of metabolic disease. Further, research suggests these alternative HDL properties may be
regulated independently of blood HDL-cholesterol (HDL-C) levels, and must therefore be considered
when designing HDL-targeted therapies. To date, a number of dietary strategies have been investigated
to assess the effect of dietary components on functional properties of HDL beyond HDL-C. This review
will highlight the bioactive nutrients, functional foods, and dietary programs known to modulate HDL
function as a means of reducing CVD.
其中詳細提到, Dietary cholesterol 是一個有效的方法
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