The Cost Of Creating A New Drug Now $5 Billion

http://www.forbes.com/sites/matthewherper/2013/08/11/how-the-staggering-cost-of-inventing-new-drugs-is-shaping-the-future-of-medicine/

The Cost Of Creating A New Drug Now $5 Billion, Pushing Big Pharma To Change

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How Much Does Pharmaceutical Innovation Cost? A Look At 100 Companies

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Money (Photo credit: 401(K) 2013)

No factor defines success and failure for a drug company more than this: Companies that invent more, better drugs at a lower cost do better than those that hemorrhage cash but never get an important product to market. Yet 19 in 20 medicines in experimental development fail, meaning a great many companies fail too.

For years, researchers, including one team from Tufts University and another at Eli Lilly, have estimated the cost of inventing and developing a drug at $1 billion or more. These estimates try to exclude costs not directly related to a drug’s approval and also don’t allow for any comparisons between companies. Last year, for the first time, I did something far cruder: I took the 15-year research spending of a group of big pharmaceutical companies and divided it by the number of new drugs (technically new molecular entities, the Food and Drug Administration’s term for drug molecules that have not been approved in any form for any use previously).

My conclusions based on this data are here:  How The Staggering Cost Of Inventing New Drugs Is Shaping The Future Of Medicine.

How Much They Cost: R&D Spending Per New Drug

	Company	Number of new drugs	10 year R&D spending ($MIL)	R&D per drug ($MIL)
1	Abbott	1	13183	13183
2	Sanofi	6	60768	10128
3	AstraZeneca	4	38245	9561
4	Hoffmann-La Roche	8	70928	8866
5	Pfizer	10	77786	7779
6	Wyeth	3	22702	7567
7	Eli Lilly	4	26710	6678
8	Bayer	5	33118	6624
9	Schering-Plough	3	18845	6282
10	Novartis	10	60727	6073
11	Takeda	4	24132	6033
12	Merck&Co	9	49133	5459
13	GlaxoSmithKline	11	57595	5236
14	J&J	13	67624	5202
15	Novo Nordisk	2	9251	4625
16	UCB	1	4325	4325
17	Yamanouchi	1	4321	4321
18	Fujisawa	1	4286	4286
19	Amgen	5	21350	4270
20	Astellas	3	12582	4194
21	Shionogi	1	3854	3854
22	Celgene	2	7193	3596
23	Bristol-Myers Squibb	9	30352	3372
24	Eisai	4	11534	2883
25	Teva	2	5763	2881
26	Biogen Idec	4	9470	2368
27	Vertex	2	4140	2070
28	Sunovion	1	1967	1967
29	Human Genome Sciences	1	1954	1954
30	Elan	1	1903	1903
31	Gilead	3	5527	1842
32	Exelixis	1	1789	1789
33	Lundbeck	2	3527	1763
34	Millennium	1	1593	1593
35	Genentech	4	6277	1569
36	Allergan	1	1559	1559
37	Baxter	3	4627	1542
38	Ipsen	1	1459	1459
39	Forest	4	5184	1296
40	Cephalon	1	1221	1221
41	Onyx	1	1219	1219
42	Sepracor	1	1170	1170
43	Alcon	1	1133	1133
44	Theravance	1	1010	1010
45	Genzyme	5	4814	963
46	Shire	4	3827	957
47	Arena	1	934	934
48	Watson	1	930	930
49	Adolor	1	877	877
50	Valeant	1	844	844
51	Schwarz	2	1545	772
52	NPS	1	756	756
53	Regeneron	3	2149	716
54	Affymax	1	660	660
55	Seattle Genetics	1	610	610
56	CV Therapeutics	1	599	599
57	ImClone	1	517	517
58	Dendreon	1	509	509
59	Alexion	1	490	490
60	The Medicines Company	1	455	455
61	Ariad	1	444	444
62	OSI	1	402	402
63	Talecris	1	396	396
64	Progenics	1	356	356
65	Actelion	1	346	346
66	Savient	1	339	339
67	Praecis	1	311	311
68	Vivus	1	309	309
69	MGI	1	294	294
70	Vicuron	1	286	286
71	Salix	2	560	280
72	Idenix	1	280	280
73	Mylan	3	762	254
74	Discovery Laboratories	1	228	228
75	Indevus	1	222	222
76	Cubist	1	220	220
77	Acorda	1	185	185
78	Ista	1	171	171
79	Optimer	1	171	171
80	Theratechnologies	1	164	164
81	MediGene	1	155	155
82	Vanda	1	150	150
83	Eyetech	1	144	144
84	ThromboGenics	1	137	137
85	BioMarin	3	403	134
86	Protalix	1	125	125
87	Amarin	1	122	122
88	Insmed	1	118	118
89	NeurogesX	1	89	89
90	Hyperion	1	87	87
91	Cypress Bioscience	1	82	82
92	New River	1	79	79
93	Aegerion	1	74	74
94	Sucampo	1	62	62
95	Fibrocell	1	62	62
96	Tercica	1	49	49
97	Pharmion	1	47	47
98	Kamada	1	37	37
99	Lev	1	26	26
100	OMRIX	1	15	15

 

所有跟帖： 

• 其中包括製藥公司高管坐商務艙去歐洲喝最貴的紅酒和打高爾夫球的費用 -dudaan- ♂ (185 bytes) () 10/06/2014 postreply 14:22:05

• 欣賞一下"世界上最豪華餐"吧.看看你認識幾道?有我們吃的便宜芒果和豆芽和也有風行健壇的藏紅花: -閩姑- ♀ (391 bytes) () 10/06/2014 postreply 14:58:40

• 保存了！ -dudaan- ♂ (0 bytes) () 10/06/2014 postreply 15:00:14

• 問你一件事,沒準你知道: -閩姑- ♀ (711 bytes) () 10/06/2014 postreply 15:59:58

• 這是熱水罐中的極性棒鏽蝕了，需要趕快更換 -dudaan- ♂ (328 bytes) () 10/06/2014 postreply 16:23:43

• 謝謝!是這個問題啊.這個熱水罐才5年,是不是我家的水用salt pellets, -閩姑- ♀ (35 bytes) () 10/06/2014 postreply 17:00:51

• 我朋友說每五年換一次極性棒，可以用三十年。不然最多十年。 -dudaan- ♂ (0 bytes) () 10/06/2014 postreply 17:59:03

• 這個數字隻包括R&D 的費用。 -26484915- ♂ (0 bytes) () 10/07/2014 postreply 10:51:37

• 人家去歐洲也是R & D的一部分。 -dudaan- ♂ (0 bytes) () 10/07/2014 postreply 11:12:18