B cell development culminates in the formation of plasma cells, potent secretors of the immunoglobulins (Ig), proteins crucial for the health of the organism. Two distinctive and crucial steps are required during B cell differentiation. First, variable gene segments encoding the antigen-binding region of Ig undergo directed rearrangement through a process known as V(D)J recombination. Second, alternative processing of the Ig heavy chain mRNA transcript enables plasma cells to secrete high levels of Ig protein.
Please note that at this point, immunity is still not acquired. Immunity is only acquired after antibody exposure to antigens. You confused genes inolved in the immune system with immunity.
The VDJ gene segments and C segments all exist in germline cells. Also the genes encoding proteins inolved in VDJ rearrangements are also present in the germline cells.
Antibody diversity comes from 3 factors:
1) Germline diversity - multigene families
2) Diversity due to DNA rearrangement
3) Diversity due to somatic hypermutations
My advice to you: don't attack people. Watch out for overinterpretations or misinterpretations.
(Sorry no Chinese input on this computer).
Please note that at this point, immunity is still not acquired. Immunity is only acquired after antibody exposure to antigens. You confused genes inolved in the immune system with immunity.
The VDJ gene segments and C segments all exist in germline cells. Also the genes encoding proteins inolved in VDJ rearrangements are also present in the germline cells.
Antibody diversity comes from 3 factors:
1) Germline diversity - multigene families
2) Diversity due to DNA rearrangement
3) Diversity due to somatic hypermutations
My advice to you: don't attack people. Watch out for overinterpretations or misinterpretations.
(Sorry no Chinese input on this computer).
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