來源: http://www.fpnotebook.com/Rheum/Spondylitis/AnkylsngSpndylts.htm
- Management: Non-pharmacologic
- Management: Medications
- First Line: NSAIDS
- Indomethacin (up to maximum of 50 mg PO tid)
- Tolmetin 400 mg PO tid-qid
- Second Line: NSAID refractory cases or NSAID Adjuncts
- Sulfasalazine 2-4g/day divided doses
- Effective peripheral arthritis
- Less effective for axial skeleton symptoms
- Methotrexate
- Effective for peripheral but not axial arthritis
- Local Corticosteroids injection
- For persistent synovitis and enthesopathy
- Sulfasalazine 2-4g/day divided doses
- Other agents potential benefit
- Pamidronate (Aredia) IV
- Tumor Necrosis Factor alpha agents
- Medications to avoid
- Avoid long term Systemic Corticosteroids
- Not generally effective in Ankylosing Spondylitis
- Avoid gold and Penicillamine
- Avoid long term Systemic Corticosteroids
- First Line: NSAIDS