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Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize.

Séralini GE, Clair E, Mesnage R, Gress S, Defarge N, Malatesta M, Hennequin D, de Vendômois JS.

Source

University of Caen, Institute of Biology, CRIIGEN and Risk Pole, MRSH-CNRS, EA 2608, Esplanade de la Paix, Caen Cedex 14032, France. [e-mail]

Abstract

The health effects of a Roundup-tolerant genetically modified maize (from 11% in the diet), cultivated with or without Roundup, and Roundup alone (from 0.1 ppb in water), were studied 2 years in rats. In females, all treated groups died 2-3 times more than controls, and more rapidly. This difference was visible in 3 male groups fed GMOs. All results were hormone and sex dependent, and the pathological profiles were comparable. Females developed large mammary tumors almost always more often than and before controls, the pituitary was the second most disabled organ; the sex hormonal balance was modified by GMO and Roundup treatments. In treated males, liver congestions and necrosis were 2.5-5.5 times higher. This pathology was confirmed by optic and transmission electron microscopy. Marked and severe kidney nephropathies were also generally 1.3-2.3 greater. Males presented 4 times more large palpable tumors than controls which occurred up to 600 days earlier. Biochemistry data confirmed very significant kidney chronic deficiencies; for all treatments and both sexes, 76% of the altered parameters were kidney related. These results can be explained by the non linear endocrine-disrupting effects of Roundup, but also by the overexpression of the transgene in the GMO and its metabolic consequences.

Copyright © 2012 Elsevier Ltd. All rights reserved.

Comment in

• The SFPT feels compelled to point out weaknesses in the paper by Séralini et al. (2012). [Food Chem Toxicol. 2013]
• Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize. [Food Chem Toxicol. 2013]
• Food and chemical toxicology. [Food Chem Toxicol. 2013]
• Adverse effects in a feeding study of a GM derived corn in rats. [Food Chem Toxicol. 2013]
• Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize. [Food Chem Toxicol. 2013]
• Response to original research article, in press, corrected proof, ‘‘Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize’’. [Food Chem Toxicol. 2013]
• A comment on "Séralini, G.-E., et al., Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize. Food Chem. Toxicol. (2012)," http://dx.doi.org/10.1016/j.fct.2012.08.005. [Food Chem Toxicol. 2013]
• Re: Séralini, G.-E., et al. Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize. Food Chem. Toxicol. (2012). [Food Chem Toxicol. 2013]
• It does not become the quality of a journal such as Food and Chemical Toxicology to publish such poor work. [Food Chem Toxicol. 2013]
• Comment on "Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize" by Séralini et al. [Food Chem Toxicol. 2013]
• Problems lie at several levels and bring into serious question the quality and standard of the editorial processes in your journal. [Food Chem Toxicol. 2013]
• Serious inadequacies regarding the pathology data presented in the paper by Séralini et al. (2012). [Food Chem Toxicol. 2013]
• My comments about the paper do not adequately describe the serious failures that have occurred in the peer review process at FCT. [Food Chem Toxicol. 2013]
• Toxicity of Roundup-tolerant genetically modified maize is not supported by statistical tests. [Food Chem Toxicol. 2013]
• We request a serious reconsideration of the recent paper by Seralini et al. alleging tumorigenesis in rats resulting from consumption of corn derived from crops improved through biotechnology (Séralini et al., 2012). [Food Chem Toxicol. 2013]
• Science requires the dispassionate presentation of information. [Food Chem Toxicol. 2013]
• Comments on "Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize". [Food Chem Toxicol. 2013]
• Answers to critics: Why there is a long term toxicity due to a Roundup-tolerant genetically modified maize and to a Roundup herbicide. [Food Chem Toxicol. 2013]

PMID:

22999595

[PubMed - indexed for MEDLINE]